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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Myc proto-oncogene protein'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Myc proto-oncogene protein


(Homo sapiens)
BDBM93880
PNG
(4-(7-Nitro-benzo[1,2,5]oxadiazol-4-ylamino)-benzoi...)
Show SMILES OC(=O)c1ccc(Nc2ccc([N+]([O-])=O)c3nonc23)cc1
Show InChI InChI=1S/C13H8N4O5/c18-13(19)7-1-3-8(4-2-7)14-9-5-6-10(17(20)21)12-11(9)15-22-16-12/h1-6,14H,(H,18,19)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimer...


Bioorg Med Chem Lett 23: 370-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.013
BindingDB Entry DOI: 10.7270/Q2WM1FPM
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens)
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
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Article
PubMed
n/an/a 6.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Myc signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction


Citation and Details

Article DOI: 10.1021/np300893n
BindingDB Entry DOI: 10.7270/Q2ZW1N83
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens)
BDBM50431277
PNG
((Z)-3,4,3'',5''-Tetramethoxystilbene | (Z)-3,4,3',...)
Show SMILES COc1cc(OC)cc(\C=C/c2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C18H20O4/c1-19-15-9-14(10-16(12-15)20-2)6-5-13-7-8-17(21-3)18(11-13)22-4/h5-12H,1-4H3/b6-5-
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Article
PubMed
n/an/a 6.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Myc signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction


Citation and Details

Article DOI: 10.1021/np300893n
BindingDB Entry DOI: 10.7270/Q2ZW1N83
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens)
BDBM50423921
PNG
(CHEMBL2312756)
Show SMILES [O-][N+](=O)c1ccc(Nc2ccccc2-c2ccccc2)c2nonc12
Show InChI InChI=1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.46E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimer...


Bioorg Med Chem Lett 23: 370-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.013
BindingDB Entry DOI: 10.7270/Q2WM1FPM
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens)
BDBM50423921
PNG
(CHEMBL2312756)
Show SMILES [O-][N+](=O)c1ccc(Nc2ccccc2-c2ccccc2)c2nonc12
Show InChI InChI=1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.80E+3n/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Binding affinity to human c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) expressed in Escherichia coli BL21 (DE3) by fluorescence polarizatio...


Bioorg Med Chem Lett 23: 370-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.013
BindingDB Entry DOI: 10.7270/Q2WM1FPM
More data for this
Ligand-Target Pair