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Found 218 hits Enz. Inhib. hit(s) with Target = 'Myristoyl-CoA:protein N-myristoyltransferase (Nmt)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50121716
PNG
((3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)be...)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccc(C)cn1
Show InChI InChI=1S/C25H25N3O3/c1-17-9-10-20(28-14-17)24(29)25-18(2)23-21(7-3-8-22(23)31-25)30-13-5-12-27-16-19-6-4-11-26-15-19/h3-4,6-11,14-15,27H,5,12-13,16H2,1-2H3
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n/an/a 0.390n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50121716
PNG
((3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)be...)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccc(C)cn1
Show InChI InChI=1S/C25H25N3O3/c1-17-9-10-20(28-14-17)24(29)25-18(2)23-21(7-3-8-22(23)31-25)30-13-5-12-27-16-19-6-4-11-26-15-19/h3-4,6-11,14-15,27H,5,12-13,16H2,1-2H3
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n/an/a 0.390n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207643
PNG
((1S,3R)-N-(2-(cyclopentanecarboxamido)benzo[d]thia...)
Show SMILES O=C(Nc1nc2ccc(NC(=O)[C@H]3CCC[C@H](C3)NCc3ccc4ccccc4c3)cc2s1)C1CCCC1
Show InChI InChI=1S/C31H34N4O2S/c36-29(22-7-2-3-8-22)35-31-34-27-15-14-26(18-28(27)38-31)33-30(37)24-10-5-11-25(17-24)32-19-20-12-13-21-6-1-4-9-23(21)16-20/h1,4,6,9,12-16,18,22,24-25,32H,2-3,5,7-8,10-11,17,19H2,(H,33,37)(H,34,35,36)/t24-,25+/m0/s1
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n/an/a 0.490n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207643
PNG
((1S,3R)-N-(2-(cyclopentanecarboxamido)benzo[d]thia...)
Show SMILES O=C(Nc1nc2ccc(NC(=O)[C@H]3CCC[C@H](C3)NCc3ccc4ccccc4c3)cc2s1)C1CCCC1
Show InChI InChI=1S/C31H34N4O2S/c36-29(22-7-2-3-8-22)35-31-34-27-15-14-26(18-28(27)38-31)33-30(37)24-10-5-11-25(17-24)32-19-20-12-13-21-6-1-4-9-23(21)16-20/h1,4,6,9,12-16,18,22,24-25,32H,2-3,5,7-8,10-11,17,19H2,(H,33,37)(H,34,35,36)/t24-,25+/m0/s1
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n/an/a 0.490n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50121720
PNG
((1-METHYL-1H-IMIDAZOL-2-YL)-(3-METHYL-4-{3-[(PYRID...)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nccn1C
Show InChI InChI=1S/C23H24N4O3/c1-16-20-18(29-13-5-10-25-15-17-6-4-9-24-14-17)7-3-8-19(20)30-22(16)21(28)23-26-11-12-27(23)2/h3-4,6-9,11-12,14,25H,5,10,13,15H2,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Nippon Roche Research Center



Assay Description
Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...


Chem Biol 9: 1119-28 (2002)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207640
PNG
(CHEMBL254011 | N-(2-(cyclobutanecarboxamido)benzo[...)
Show SMILES O=C(Nc1nc2ccc(NC(=O)C3CCCC(C3)NCc3ccc4ccccc4c3)cc2s1)C1CCC1
Show InChI InChI=1S/C30H32N4O2S/c35-28(21-7-3-8-21)34-30-33-26-14-13-25(17-27(26)37-30)32-29(36)23-9-4-10-24(16-23)31-18-19-11-12-20-5-1-2-6-22(20)15-19/h1-2,5-6,11-15,17,21,23-24,31H,3-4,7-10,16,18H2,(H,32,36)(H,33,34,35)
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n/an/a 2.30n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207640
PNG
(CHEMBL254011 | N-(2-(cyclobutanecarboxamido)benzo[...)
Show SMILES O=C(Nc1nc2ccc(NC(=O)C3CCCC(C3)NCc3ccc4ccccc4c3)cc2s1)C1CCC1
Show InChI InChI=1S/C30H32N4O2S/c35-28(21-7-3-8-21)34-30-33-26-14-13-25(17-27(26)37-30)32-29(36)23-9-4-10-24(16-23)31-18-19-11-12-20-5-1-2-6-22(20)15-19/h1-2,5-6,11-15,17,21,23-24,31H,3-4,7-10,16,18H2,(H,32,36)(H,33,34,35)
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n/an/a 2.30n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50109879
PNG
(CHEMBL155301 | Non peptidic, 4 | {3-[2-(2,3-Difluo...)
Show SMILES Cc1c(COc2cccc(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H24F2N2O3/c1-17-23(16-31-22-10-2-7-19(26)25(22)27)32-21-9-3-8-20(24(17)21)30-13-5-12-29-15-18-6-4-11-28-14-18/h2-4,6-11,14,29H,5,12-13,15-16H2,1H3
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n/an/a 4n/an/an/an/an/an/a



Nippon Roche Research Center



Assay Description
Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...


Chem Biol 9: 1119-28 (2002)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50109882
PNG
(3-(3-methyl-2-((2,3,4-trifluorophenoxy)methyl)benz...)
Show SMILES Cc1c(COc2ccc(F)c(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H23F3N2O3/c1-16-22(15-32-21-9-8-18(26)24(27)25(21)28)33-20-7-2-6-19(23(16)20)31-12-4-11-30-14-17-5-3-10-29-13-17/h2-3,5-10,13,30H,4,11-12,14-15H2,1H3
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n/an/a 5.70n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50109882
PNG
(3-(3-methyl-2-((2,3,4-trifluorophenoxy)methyl)benz...)
Show SMILES Cc1c(COc2ccc(F)c(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H23F3N2O3/c1-16-22(15-32-21-9-8-18(26)24(27)25(21)28)33-20-7-2-6-19(23(16)20)31-12-4-11-30-14-17-5-3-10-29-13-17/h2-3,5-10,13,30H,4,11-12,14-15H2,1H3
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n/an/a 5.70n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207627
PNG
(3-[(naphthalen-2-ylmethyl)-amino]-cyclohexanecarbo...)
Show SMILES O=C(Nc1nc2ccc(NC(=O)C3CCCC(C3)NCc3ccc4ccccc4c3)cc2s1)C1CCCCC1
Show InChI InChI=1S/C32H36N4O2S/c37-30(23-8-2-1-3-9-23)36-32-35-28-16-15-27(19-29(28)39-32)34-31(38)25-11-6-12-26(18-25)33-20-21-13-14-22-7-4-5-10-24(22)17-21/h4-5,7,10,13-17,19,23,25-26,33H,1-3,6,8-9,11-12,18,20H2,(H,34,38)(H,35,36,37)
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n/an/a 8.10n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207627
PNG
(3-[(naphthalen-2-ylmethyl)-amino]-cyclohexanecarbo...)
Show SMILES O=C(Nc1nc2ccc(NC(=O)C3CCCC(C3)NCc3ccc4ccccc4c3)cc2s1)C1CCCCC1
Show InChI InChI=1S/C32H36N4O2S/c37-30(23-8-2-1-3-9-23)36-32-35-28-16-15-27(19-29(28)39-32)34-31(38)25-11-6-12-26(18-25)33-20-21-13-14-22-7-4-5-10-24(22)17-21/h4-5,7,10,13-17,19,23,25-26,33H,1-3,6,8-9,11-12,18,20H2,(H,34,38)(H,35,36,37)
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n/an/a 8.10n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207621
PNG
((1R,3S)-3-[(naphthalen-2-ylmethyl)-amino]-cyclopen...)
Show SMILES O=C(Nc1nc2ccc(NC(=O)[C@@H]3CC[C@@H](C3)NCc3ccc4ccccc4c3)cc2s1)C1CCCC1
Show InChI InChI=1S/C30H32N4O2S/c35-28(21-6-2-3-7-21)34-30-33-26-14-13-25(17-27(26)37-30)32-29(36)23-11-12-24(16-23)31-18-19-9-10-20-5-1-4-8-22(20)15-19/h1,4-5,8-10,13-15,17,21,23-24,31H,2-3,6-7,11-12,16,18H2,(H,32,36)(H,33,34,35)/t23-,24+/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207621
PNG
((1R,3S)-3-[(naphthalen-2-ylmethyl)-amino]-cyclopen...)
Show SMILES O=C(Nc1nc2ccc(NC(=O)[C@@H]3CC[C@@H](C3)NCc3ccc4ccccc4c3)cc2s1)C1CCCC1
Show InChI InChI=1S/C30H32N4O2S/c35-28(21-6-2-3-7-21)34-30-33-26-14-13-25(17-27(26)37-30)32-29(36)23-11-12-24(16-23)31-18-19-9-10-20-5-1-4-8-22(20)15-19/h1,4-5,8-10,13-15,17,21,23-24,31H,2-3,6-7,11-12,16,18H2,(H,32,36)(H,33,34,35)/t23-,24+/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207632
PNG
(2-(cyclopentanecarboxamido)-N-(2-(naphthalen-2-ylm...)
Show SMILES O=C(Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1)C1CCCC1
Show InChI InChI=1S/C27H28N4O2S/c32-25(29-14-13-28-17-18-9-10-19-5-1-4-8-21(19)15-18)22-11-12-23-24(16-22)34-27(30-23)31-26(33)20-6-2-3-7-20/h1,4-5,8-12,15-16,20,28H,2-3,6-7,13-14,17H2,(H,29,32)(H,30,31,33)
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n/an/a 23n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207632
PNG
(2-(cyclopentanecarboxamido)-N-(2-(naphthalen-2-ylm...)
Show SMILES O=C(Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1)C1CCCC1
Show InChI InChI=1S/C27H28N4O2S/c32-25(29-14-13-28-17-18-9-10-19-5-1-4-8-21(19)15-18)22-11-12-23-24(16-22)34-27(30-23)31-26(33)20-6-2-3-7-20/h1,4-5,8-12,15-16,20,28H,2-3,6-7,13-14,17H2,(H,29,32)(H,30,31,33)
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n/an/a 23n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207626
PNG
(2-(cyclobutanecarboxamido)-N-(2-(naphthalen-2-ylme...)
Show SMILES O=C(Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1)C1CCC1
Show InChI InChI=1S/C26H26N4O2S/c31-24(28-13-12-27-16-17-8-9-18-4-1-2-5-20(18)14-17)21-10-11-22-23(15-21)33-26(29-22)30-25(32)19-6-3-7-19/h1-2,4-5,8-11,14-15,19,27H,3,6-7,12-13,16H2,(H,28,31)(H,29,30,32)
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n/an/a 28n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207626
PNG
(2-(cyclobutanecarboxamido)-N-(2-(naphthalen-2-ylme...)
Show SMILES O=C(Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1)C1CCC1
Show InChI InChI=1S/C26H26N4O2S/c31-24(28-13-12-27-16-17-8-9-18-4-1-2-5-20(18)14-17)21-10-11-22-23(15-21)33-26(29-22)30-25(32)19-6-3-7-19/h1-2,4-5,8-11,14-15,19,27H,3,6-7,12-13,16H2,(H,28,31)(H,29,30,32)
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n/an/a 28n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM43856
PNG
(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Show SMILES CCOc1ccc(cc1)S(=O)(=O)NN=C1CCS(=O)(=O)c2ccc(F)cc12
Show InChI InChI=1S/C17H17FN2O5S2/c1-2-25-13-4-6-14(7-5-13)27(23,24)20-19-16-9-10-26(21,22)17-8-3-12(18)11-15(16)17/h3-8,11,20H,2,9-10H2,1H3
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30n/a 30n/an/an/an/an/an/a



Nippon Roche Research Center



Assay Description
Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...


Chem Biol 9: 1119-28 (2002)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207602
PNG
(2-(cyclohexanecarboxamido)-N-(2-(naphthalen-2-ylme...)
Show SMILES O=C(Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1)C1CCCCC1
Show InChI InChI=1S/C28H30N4O2S/c33-26(30-15-14-29-18-19-10-11-20-6-4-5-9-22(20)16-19)23-12-13-24-25(17-23)35-28(31-24)32-27(34)21-7-2-1-3-8-21/h4-6,9-13,16-17,21,29H,1-3,7-8,14-15,18H2,(H,30,33)(H,31,32,34)
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n/an/a 34n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207602
PNG
(2-(cyclohexanecarboxamido)-N-(2-(naphthalen-2-ylme...)
Show SMILES O=C(Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1)C1CCCCC1
Show InChI InChI=1S/C28H30N4O2S/c33-26(30-15-14-29-18-19-10-11-20-6-4-5-9-22(20)16-19)23-12-13-24-25(17-23)35-28(31-24)32-27(34)21-7-2-1-3-8-21/h4-6,9-13,16-17,21,29H,1-3,7-8,14-15,18H2,(H,30,33)(H,31,32,34)
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n/an/a 34n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50057702
PNG
((S)-6-Amino-2-((S)-2-{2-[4-(6-amino-hexyl)-phenyl]...)
Show SMILES CC(C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC1CCCCC1)c1ccc(CCCCCCN)cc1
Show InChI InChI=1S/C32H55N5O4/c1-24(27-17-15-26(16-18-27)13-5-2-3-9-20-33)30(39)37-29(23-38)32(41)36-28(14-8-10-21-34)31(40)35-22-19-25-11-6-4-7-12-25/h15-18,24-25,28-29,38H,2-14,19-23,33-34H2,1H3,(H,35,40)(H,36,41)(H,37,39)/t24?,28-,29-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207605
PNG
(2-(2-chloronicotinamido)-N-(2-(naphthalen-2-ylmeth...)
Show SMILES Clc1ncccc1C(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C27H22ClN5O2S/c28-24-21(6-3-11-30-24)26(35)33-27-32-22-10-9-20(15-23(22)36-27)25(34)31-13-12-29-16-17-7-8-18-4-1-2-5-19(18)14-17/h1-11,14-15,29H,12-13,16H2,(H,31,34)(H,32,33,35)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207606
PNG
(CHEMBL253163 | N-(2-(naphthalen-2-ylmethylamino)et...)
Show SMILES O=C(NCCNCc1ccc2ccccc2c1)c1ccc2nc(NC(=O)c3ccccn3)sc2c1
Show InChI InChI=1S/C27H23N5O2S/c33-25(30-14-13-28-17-18-8-9-19-5-1-2-6-20(19)15-18)21-10-11-22-24(16-21)35-27(31-22)32-26(34)23-7-3-4-12-29-23/h1-12,15-16,28H,13-14,17H2,(H,30,33)(H,31,32,34)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207639
PNG
(2-(4-chlorobenzamido)-N-(2-(naphthalen-2-ylmethyla...)
Show SMILES Clc1ccc(cc1)C(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C28H23ClN4O2S/c29-23-10-7-20(8-11-23)27(35)33-28-32-24-12-9-22(16-25(24)36-28)26(34)31-14-13-30-17-18-5-6-19-3-1-2-4-21(19)15-18/h1-12,15-16,30H,13-14,17H2,(H,31,34)(H,32,33,35)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207639
PNG
(2-(4-chlorobenzamido)-N-(2-(naphthalen-2-ylmethyla...)
Show SMILES Clc1ccc(cc1)C(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C28H23ClN4O2S/c29-23-10-7-20(8-11-23)27(35)33-28-32-24-12-9-22(16-25(24)36-28)26(34)31-14-13-30-17-18-5-6-19-3-1-2-4-21(19)15-18/h1-12,15-16,30H,13-14,17H2,(H,31,34)(H,32,33,35)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207606
PNG
(CHEMBL253163 | N-(2-(naphthalen-2-ylmethylamino)et...)
Show SMILES O=C(NCCNCc1ccc2ccccc2c1)c1ccc2nc(NC(=O)c3ccccn3)sc2c1
Show InChI InChI=1S/C27H23N5O2S/c33-25(30-14-13-28-17-18-8-9-19-5-1-2-6-20(19)15-18)21-10-11-22-24(16-21)35-27(31-22)32-26(34)23-7-3-4-12-29-23/h1-12,15-16,28H,13-14,17H2,(H,30,33)(H,31,32,34)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207605
PNG
(2-(2-chloronicotinamido)-N-(2-(naphthalen-2-ylmeth...)
Show SMILES Clc1ncccc1C(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C27H22ClN5O2S/c28-24-21(6-3-11-30-24)26(35)33-27-32-22-10-9-20(15-23(22)36-27)25(34)31-13-12-29-16-17-7-8-18-4-1-2-5-19(18)14-17/h1-11,14-15,29H,12-13,16H2,(H,31,34)(H,32,33,35)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207609
PNG
(2-amino-N-(2-(naphthalen-2-ylmethylamino)ethyl)ben...)
Show SMILES Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C21H20N4OS/c22-21-25-18-8-7-17(12-19(18)27-21)20(26)24-10-9-23-13-14-5-6-15-3-1-2-4-16(15)11-14/h1-8,11-12,23H,9-10,13H2,(H2,22,25)(H,24,26)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207625
PNG
(2-acetamido-N-(2-(naphthalen-2-ylmethylamino)ethyl...)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C23H22N4O2S/c1-15(28)26-23-27-20-9-8-19(13-21(20)30-23)22(29)25-11-10-24-14-16-6-7-17-4-2-3-5-18(17)12-16/h2-9,12-13,24H,10-11,14H2,1H3,(H,25,29)(H,26,27,28)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207633
PNG
(CHEMBL252959 | N-(2-(naphthalen-2-ylmethylamino)et...)
Show SMILES O=C(Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C27H29N5O2S/c33-25(30-14-13-29-17-18-5-6-19-3-1-2-4-21(19)15-18)22-7-8-23-24(16-22)35-27(31-23)32-26(34)20-9-11-28-12-10-20/h1-8,15-16,20,28-29H,9-14,17H2,(H,30,33)(H,31,32,34)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207633
PNG
(CHEMBL252959 | N-(2-(naphthalen-2-ylmethylamino)et...)
Show SMILES O=C(Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C27H29N5O2S/c33-25(30-14-13-29-17-18-5-6-19-3-1-2-4-21(19)15-18)22-7-8-23-24(16-22)35-27(31-23)32-26(34)20-9-11-28-12-10-20/h1-8,15-16,20,28-29H,9-14,17H2,(H,30,33)(H,31,32,34)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207630
PNG
(CHEMBL401271 | tert-butyl 6-((2-(naphthalen-2-ylme...)
Show SMILES CC(C)(C)OC(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C26H28N4O3S/c1-26(2,3)33-25(32)30-24-29-21-11-10-20(15-22(21)34-24)23(31)28-13-12-27-16-17-8-9-18-6-4-5-7-19(18)14-17/h4-11,14-15,27H,12-13,16H2,1-3H3,(H,28,31)(H,29,30,32)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207625
PNG
(2-acetamido-N-(2-(naphthalen-2-ylmethylamino)ethyl...)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C23H22N4O2S/c1-15(28)26-23-27-20-9-8-19(13-21(20)30-23)22(29)25-11-10-24-14-16-6-7-17-4-2-3-5-18(17)12-16/h2-9,12-13,24H,10-11,14H2,1H3,(H,25,29)(H,26,27,28)
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Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207630
PNG
(CHEMBL401271 | tert-butyl 6-((2-(naphthalen-2-ylme...)
Show SMILES CC(C)(C)OC(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C26H28N4O3S/c1-26(2,3)33-25(32)30-24-29-21-11-10-20(15-22(21)34-24)23(31)28-13-12-27-16-17-8-9-18-6-4-5-7-19(18)14-17/h4-11,14-15,27H,12-13,16H2,1-3H3,(H,28,31)(H,29,30,32)
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Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207634
PNG
(CHEMBL252545 | N-(2-(naphthalen-2-ylmethylamino)et...)
Show SMILES O=C(NCCNCc1ccc2ccccc2c1)c1ccc2nc(NCc3ccccn3)sc2c1
Show InChI InChI=1S/C27H25N5OS/c33-26(30-14-13-28-17-19-8-9-20-5-1-2-6-21(20)15-19)22-10-11-24-25(16-22)34-27(32-24)31-18-23-7-3-4-12-29-23/h1-12,15-16,28H,13-14,17-18H2,(H,30,33)(H,31,32)
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Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207634
PNG
(CHEMBL252545 | N-(2-(naphthalen-2-ylmethylamino)et...)
Show SMILES O=C(NCCNCc1ccc2ccccc2c1)c1ccc2nc(NCc3ccccn3)sc2c1
Show InChI InChI=1S/C27H25N5OS/c33-26(30-14-13-28-17-19-8-9-20-5-1-2-6-21(20)15-19)22-10-11-24-25(16-22)34-27(32-24)31-18-23-7-3-4-12-29-23/h1-12,15-16,28H,13-14,17-18H2,(H,30,33)(H,31,32)
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Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207609
PNG
(2-amino-N-(2-(naphthalen-2-ylmethylamino)ethyl)ben...)
Show SMILES Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C21H20N4OS/c22-21-25-18-8-7-17(12-19(18)27-21)20(26)24-10-9-23-13-14-5-6-15-3-1-2-4-16(15)11-14/h1-8,11-12,23H,9-10,13H2,(H2,22,25)(H,24,26)
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n/an/a 100n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50034988
PNG
(11-Amino-undecanoic acid {(S)-1-[(S)-5-amino-1-(2-...)
Show SMILES NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC1CCCCC1
Show InChI InChI=1S/C28H55N5O4/c29-19-12-6-4-2-1-3-5-10-17-26(35)32-25(22-34)28(37)33-24(16-11-13-20-30)27(36)31-21-18-23-14-8-7-9-15-23/h23-25,34H,1-22,29-30H2,(H,31,36)(H,32,35)(H,33,37)/t24-,25-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50057684
PNG
((S)-6-Amino-2-((S)-2-{2-[4-(6-amino-hexyl)-phenyl]...)
Show SMILES NCCCCCCc1ccc(CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC2CCCCC2)cc1
Show InChI InChI=1S/C31H53N5O4/c32-19-8-2-1-4-12-25-14-16-26(17-15-25)22-29(38)35-28(23-37)31(40)36-27(13-7-9-20-33)30(39)34-21-18-24-10-5-3-6-11-24/h14-17,24,27-28,37H,1-13,18-23,32-33H2,(H,34,39)(H,35,38)(H,36,40)/t27-,28-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207631
PNG
(CHEMBL252751 | N-(2-(naphthalen-2-ylmethylamino)et...)
Show SMILES CCC(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C24H24N4O2S/c1-2-22(29)28-24-27-20-10-9-19(14-21(20)31-24)23(30)26-12-11-25-15-16-7-8-17-5-3-4-6-18(17)13-16/h3-10,13-14,25H,2,11-12,15H2,1H3,(H,26,30)(H,27,28,29)
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n/an/a 130n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207631
PNG
(CHEMBL252751 | N-(2-(naphthalen-2-ylmethylamino)et...)
Show SMILES CCC(=O)Nc1nc2ccc(cc2s1)C(=O)NCCNCc1ccc2ccccc2c1
Show InChI InChI=1S/C24H24N4O2S/c1-2-22(29)28-24-27-20-10-9-19(14-21(20)31-24)23(30)26-12-11-25-15-16-7-8-17-5-3-4-6-18(17)13-16/h3-10,13-14,25H,2,11-12,15H2,1H3,(H,26,30)(H,27,28,29)
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n/an/a 130n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207628
PNG
(CHEMBL253586 | cyclopentanecarboxylic acid (6-{3-[...)
Show SMILES O=C(CCNCc1ccc(cc1)-c1ccccc1)Nc1ccc2nc(NC(=O)C3CCCC3)sc2c1
Show InChI InChI=1S/C29H30N4O2S/c34-27(16-17-30-19-20-10-12-22(13-11-20)21-6-2-1-3-7-21)31-24-14-15-25-26(18-24)36-29(32-25)33-28(35)23-8-4-5-9-23/h1-3,6-7,10-15,18,23,30H,4-5,8-9,16-17,19H2,(H,31,34)(H,32,33,35)
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n/an/a 160n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50207628
PNG
(CHEMBL253586 | cyclopentanecarboxylic acid (6-{3-[...)
Show SMILES O=C(CCNCc1ccc(cc1)-c1ccccc1)Nc1ccc2nc(NC(=O)C3CCCC3)sc2c1
Show InChI InChI=1S/C29H30N4O2S/c34-27(16-17-30-19-20-10-12-22(13-11-20)21-6-2-1-3-7-21)31-24-14-15-25-26(18-24)36-29(32-25)33-28(35)23-8-4-5-9-23/h1-3,6-7,10-15,18,23,30H,4-5,8-9,16-17,19H2,(H,31,34)(H,32,33,35)
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n/an/a 160n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans N-myristoyltransferse


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50057677
PNG
(7-(4-Aminomethyl-phenyl)-hept-6-ynoic acid {(S)-1-...)
Show SMILES NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)CCCCC#Cc1ccc(CN)cc1)C(=O)NCCC1CCCCC1
Show InChI InChI=1S/C31H49N5O4/c32-20-9-8-13-27(30(39)34-21-19-24-10-5-3-6-11-24)36-31(40)28(23-37)35-29(38)14-7-2-1-4-12-25-15-17-26(22-33)18-16-25/h15-18,24,27-28,37H,1-3,5-11,13-14,19-23,32-33H2,(H,34,39)(H,35,38)(H,36,40)/t27-,28-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50057693
PNG
((S)-6-Amino-2-((S)-2-{2-[4-(5-amino-pentyl)-phenyl...)
Show SMILES NCCCCCc1ccc(CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC2CCCCC2)cc1
Show InChI InChI=1S/C30H51N5O4/c31-18-7-2-5-11-24-13-15-25(16-14-24)21-28(37)34-27(22-36)30(39)35-26(12-6-8-19-32)29(38)33-20-17-23-9-3-1-4-10-23/h13-16,23,26-27,36H,1-12,17-22,31-32H2,(H,33,38)(H,34,37)(H,35,39)/t26-,27-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50057679
PNG
((S)-2-{(S)-6-Amino-2-[(S)-2-(12-amino-dodecanoylam...)
Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCCN
Show InChI InChI=1S/C28H55N5O6/c1-21(2)19-23(28(38)39-3)33-26(36)22(15-12-14-18-30)32-27(37)24(20-34)31-25(35)16-11-9-7-5-4-6-8-10-13-17-29/h21-24,34H,4-20,29-30H2,1-3H3,(H,31,35)(H,32,37)(H,33,36)/t22-,23-,24-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50057707
PNG
((S)-2-{(S)-6-Amino-2-[(S)-2-(10-amino-decanoylamin...)
Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)CCCCCCCCCN
Show InChI InChI=1S/C26H51N5O6/c1-19(2)17-21(26(36)37-3)31-24(34)20(13-10-12-16-28)30-25(35)22(18-32)29-23(33)14-9-7-5-4-6-8-11-15-27/h19-22,32H,4-18,27-28H2,1-3H3,(H,29,33)(H,30,35)(H,31,34)/t20-,21-,22-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50057683
PNG
(11-Amino-undecanoic acid {(S)-1-[(S)-5-amino-1-(3-...)
Show SMILES NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCCC1CCCCCCC1
Show InChI InChI=1S/C31H61N5O4/c32-22-14-9-4-2-1-3-8-12-21-29(38)35-28(25-37)31(40)36-27(20-13-15-23-33)30(39)34-24-16-19-26-17-10-6-5-7-11-18-26/h26-28,37H,1-25,32-33H2,(H,34,39)(H,35,38)(H,36,40)/t27-,28-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Candida albicans (Yeast))
BDBM50057682
PNG
(7-(4-Aminomethyl-phenyl)-heptanoic acid {(S)-1-[(S...)
Show SMILES NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)CCCCCCc1ccc(CN)cc1)C(=O)NCCC1CCCCC1
Show InChI InChI=1S/C31H53N5O4/c32-20-9-8-13-27(30(39)34-21-19-24-10-5-3-6-11-24)36-31(40)28(23-37)35-29(38)14-7-2-1-4-12-25-15-17-26(22-33)18-16-25/h15-18,24,27-28,37H,1-14,19-23,32-33H2,(H,34,39)(H,35,38)(H,36,40)/t27-,28-/m0/s1
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n/an/a 340n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
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