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Compile Data Set for Download or QSAR

Found 107 hits Enz. Inhib. hit(s) with Target = 'NADPH oxidase 4'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NADPH oxidase 4


(Homo sapiens)
BDBM50326495
PNG
(2,3,8,9-tetrahydroxy-5-(2-hydroxy-5-nitrobenzyl)ph...)
Show SMILES Oc1ccc(cc1Cn1c2cc(O)c(O)cc2c2cc(O)c(O)cc2c1=O)[N+]([O-])=O
Show InChI InChI=1S/C20H14N2O8/c23-15-2-1-10(22(29)30)3-9(15)8-21-14-7-19(27)17(25)5-12(14)11-4-16(24)18(26)6-13(11)20(21)28/h1-7,23-27H,8H2
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n/an/a 170n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326485
PNG
(CHEMBL1243033 | N-4-(3-Amino-phenyl)-benzo[4,5]thi...)
Show SMILES Nc1cccc(Nc2ncnc3c4cc(N)ccc4sc23)c1
Show InChI InChI=1S/C16H13N5S/c17-9-2-1-3-11(6-9)21-16-15-14(19-8-20-16)12-7-10(18)4-5-13(12)22-15/h1-8H,17-18H2,(H,19,20,21)
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n/an/a 240n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326494
PNG
(2,3,8,9-tetrahydroxy-5-(3-nitrobenzyl)phenanthridi...)
Show SMILES Oc1cc2n(Cc3cccc(c3)[N+]([O-])=O)c(=O)c3cc(O)c(O)cc3c2cc1O
Show InChI InChI=1S/C20H14N2O7/c23-16-5-12-13-6-17(24)19(26)8-15(13)21(20(27)14(12)7-18(16)25)9-10-2-1-3-11(4-10)22(28)29/h1-8,23-26H,9H2
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n/an/a 260n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326493
PNG
(2-((2,3,8,9-tetrahydroxy-6-oxophenanthridin-5(6H)-...)
Show SMILES Oc1cc2n(Cc3ccccc3C#N)c(=O)c3cc(O)c(O)cc3c2cc1O
Show InChI InChI=1S/C21H14N2O5/c22-9-11-3-1-2-4-12(11)10-23-16-8-20(27)18(25)6-14(16)13-5-17(24)19(26)7-15(13)21(23)28/h1-8,24-27H,10H2
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n/an/a 590n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50065271
PNG
(3-(4-hydroxy-3,5-diisopropylbenzylidene)indolin-2-...)
Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccccc23)cc(C(C)C)c1O
Show InChI InChI=1S/C21H23NO2/c1-12(2)16-9-14(10-17(13(3)4)20(16)23)11-18-15-7-5-6-8-19(15)22-21(18)24/h5-13,23H,1-4H3,(H,22,24)/b18-11-
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n/an/a 630n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 680n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326483
PNG
(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-5-methoxy-4H...)
Show SMILES COc1cc(O)cc2oc(-c3ccc(O)c(O)c3)c(O)c(=O)c12
Show InChI InChI=1S/C16H12O7/c1-22-11-5-8(17)6-12-13(11)14(20)15(21)16(23-12)7-2-3-9(18)10(19)4-7/h2-6,17-19,21H,1H3
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n/an/a 740n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326491
PNG
(3-(3,4-dihydroxyphenyl)-2,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc2c(O)c(-c3ccc(O)c(O)c3)c(=O)oc2c1
Show InChI InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(20)13(14(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-19H
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n/an/a 790n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50318294
PNG
(CHEMBL1098724 | miquelianin)
Show SMILES OC[C@H]1O[C@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2/t13-,15-,17+,18-,21-/m1/s1
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n/an/a 830n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM7459
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
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n/an/a 850n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326482
PNG
((N'1E,N'2E)-N'1,N'2-bis(2,3-dihydroxybenzylidene)o...)
Show SMILES Oc1cccc(C=NNC(=O)C(=O)NN=Cc2cccc(O)c2O)c1O
Show InChI InChI=1S/C16H14N4O6/c21-11-5-1-3-9(13(11)23)7-17-19-15(25)16(26)20-18-8-10-4-2-6-12(22)14(10)24/h1-8,21-24H,(H,19,25)(H,20,26)
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n/an/a 910n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50043337
PNG
(2-Hydroxy-5-(2-hydroxy-benzylamino)-benzoic acid |...)
Show SMILES OC(=O)c1cc(NCc2ccccc2O)ccc1O
Show InChI InChI=1S/C14H13NO4/c16-12-4-2-1-3-9(12)8-15-10-5-6-13(17)11(7-10)14(18)19/h1-7,15-17H,8H2,(H,18,19)
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n/an/a 960n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326490
PNG
(1,1-diallyl-3-(5-hydroxy-4,6-dimethyl-2-oxoindolin...)
Show SMILES Cc1cc2NC(=O)C(=NC(=S)N(CC=C)CC=C)c2c(C)c1O
Show InChI InChI=1S/C17H19N3O2S/c1-5-7-20(8-6-2)17(23)19-14-13-11(4)15(21)10(3)9-12(13)18-16(14)22/h5-6,9,21H,1-2,7-8H2,3-4H3,(H,18,19,22,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50240897
PNG
(2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H...)
Show SMILES COc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(OC)c2=O
Show InChI InChI=1S/C17H14O7/c1-22-9-6-12(20)14-13(7-9)24-16(17(23-2)15(14)21)8-3-4-10(18)11(19)5-8/h3-7,18-20H,1-2H3
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n/an/a 1.02E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326486
PNG
(CHEMBL1243031 | N'-(3,4-dihydroxybenzylidene)-2-(3...)
Show SMILES Oc1ccc(C=NNC(=O)C(=O)c2cccc(c2)[N+]([O-])=O)cc1O
Show InChI InChI=1S/C15H11N3O6/c19-12-5-4-9(6-13(12)20)8-16-17-15(22)14(21)10-2-1-3-11(7-10)18(23)24/h1-8,19-20H,(H,17,22)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326484
PNG
(CHEMBL1243097 | N-4-(4-Amino-phenyl)-benzo[4,5]thi...)
Show SMILES Nc1ccc(Nc2ncnc3c4cc(N)ccc4sc23)cc1
Show InChI InChI=1S/C16H13N5S/c17-9-1-4-11(5-2-9)21-16-15-14(19-8-20-16)12-7-10(18)3-6-13(12)22-15/h1-8H,17-18H2,(H,19,20,21)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM7458
PNG
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
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n/an/a 1.13E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326489
PNG
(3-(3,4-dihydroxybenzylidene)-5-nitroindolin-2-one ...)
Show SMILES Oc1ccc(\C=C2/C(=O)Nc3ccc(cc23)[N+]([O-])=O)cc1O
Show InChI InChI=1S/C15H10N2O5/c18-13-4-1-8(6-14(13)19)5-11-10-7-9(17(21)22)2-3-12(10)16-15(11)20/h1-7,18-19H,(H,16,20)/b11-5-
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n/an/a 1.13E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326487
PNG
((N'1E,N'2E)-N'1,N'2-bis(3,4-dihydroxybenzylidene)o...)
Show SMILES Oc1ccc(C=NNC(=O)C(=O)NN=Cc2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C16H14N4O6/c21-11-3-1-9(5-13(11)23)7-17-19-15(25)16(26)20-18-8-10-2-4-12(22)14(24)6-10/h1-8,21-24H,(H,19,25)(H,20,26)
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n/an/a 1.16E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM7462
PNG
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
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n/an/a 1.20E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50043327
PNG
(2-Hydroxy-5-(2-hydroxy-benzylamino)-benzoic acid m...)
Show SMILES COC(=O)c1cc(NCc2ccccc2O)ccc1O
Show InChI InChI=1S/C15H15NO4/c1-20-15(19)12-8-11(6-7-14(12)18)16-9-10-4-2-3-5-13(10)17/h2-8,16-18H,9H2,1H3
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n/an/a 1.27E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326481
PNG
(CHEMBL1243188 | N1-(3-aminophenyl)-N2-(4-hydroxy-3...)
Show SMILES COc1cc(CCNC(=O)C(=O)Nc2cccc(N)c2)ccc1O
Show InChI InChI=1S/C17H19N3O4/c1-24-15-9-11(5-6-14(15)21)7-8-19-16(22)17(23)20-13-4-2-3-12(18)10-13/h2-6,9-10,21H,7-8,18H2,1H3,(H,19,22)(H,20,23)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50038199
PNG
(5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...)
Show SMILES OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C14H13NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-6,15-18H,7H2,(H,19,20)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326488
PNG
(CHEMBL1243095 | N-(3-(4-hydroxy-3-methoxybenzylide...)
Show SMILES COc1cc(\C=C2/C(=O)Nc3ccc(NC(C)=O)cc23)ccc1O
Show InChI InChI=1S/C18H16N2O4/c1-10(21)19-12-4-5-15-13(9-12)14(18(23)20-15)7-11-3-6-16(22)17(8-11)24-2/h3-9,22H,1-2H3,(H,19,21)(H,20,23)/b14-7-
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n/an/a 1.40E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326492
PNG
(2,3,8,9-tetrahydroxy-5-(2-(phenylsulfonyl)benzyl)p...)
Show SMILES Oc1cc2n(Cc3ccccc3S(=O)(=O)c3ccccc3)c(=O)c3cc(O)c(O)cc3c2cc1O
Show InChI InChI=1S/C26H19NO7S/c28-21-10-17-18-11-22(29)24(31)13-20(18)27(26(32)19(17)12-23(21)30)14-15-6-4-5-9-25(15)35(33,34)16-7-2-1-3-8-16/h1-13,28-31H,14H2
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n/an/a 1.58E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM4085
PNG
(2,3,8,9-tetrahydroxy-5-[(4-nitrophenyl)methyl]-5,6...)
Show SMILES Oc1cc2n(Cc3ccc(cc3)[N+]([O-])=O)c(=O)c3cc(O)c(O)cc3c2cc1O
Show InChI InChI=1S/C20H14N2O7/c23-16-5-12-13-6-17(24)19(26)8-15(13)21(20(27)14(12)7-18(16)25)9-10-1-3-11(4-2-10)22(28)29/h1-8,23-26H,9H2
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n/an/a 1.58E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50326480
PNG
(CHEMBL1243220 | N1-(3,4-dihydroxyphenethyl)-N2-(3-...)
Show SMILES Oc1ccc(CCNC(=O)C(=O)Nc2cccc(c2)[N+]([O-])=O)cc1O
Show InChI InChI=1S/C16H15N3O6/c20-13-5-4-10(8-14(13)21)6-7-17-15(22)16(23)18-11-2-1-3-12(9-11)19(24)25/h1-5,8-9,20-21H,6-7H2,(H,17,22)(H,18,23)
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n/an/a 1.64E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330742
PNG
(2-(2-Chlorophenyl)-5-[(1-methyl-1H-pyrazol-3-yl)me...)
Show SMILES CN(Cc1ccccc1)Cc1n(Cc2ccn(C)n2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C26H25ClN6O2/c1-30(15-18-8-4-3-5-9-18)17-23-25-21(14-24(34)32(23)16-19-12-13-31(2)28-19)29-33(26(25)35)22-11-7-6-10-20(22)27/h3-14,29H,15-17H2,1-2H3
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47n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330740
PNG
(2-(2-chlorophenyl)-4-((4-(3-methoxyphenyl)piperazi...)
Show SMILES COc1cccc(c1)N1CCN(Cc2n(C)c(=O)cc3[nH]n(-c4ccccc4Cl)c(=O)c23)CC1
Show InChI InChI=1S/C25H26ClN5O3/c1-28-22(16-29-10-12-30(13-11-29)17-6-5-7-18(14-17)34-2)24-20(15-23(28)32)27-31(25(24)33)21-9-4-3-8-19(21)26/h3-9,14-15,27H,10-13,16H2,1-2H3
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65n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359519
PNG
(CHEMBL1927157)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccn4)Cc3c2c1=O
Show InChI InChI=1S/C22H20ClN5O2/c23-16-7-1-2-8-18(16)28-22(30)21-17(25-28)12-20(29)27-11-5-10-26(14-19(21)27)13-15-6-3-4-9-24-15/h1-4,6-9,12,25H,5,10-11,13-14H2
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67n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359523
PNG
(CHEMBL1927147)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccc4)Cc3c2c1=O
Show InChI InChI=1S/C23H21ClN4O2/c24-17-9-4-5-10-19(17)28-23(30)22-18(25-28)13-21(29)27-12-6-11-26(15-20(22)27)14-16-7-2-1-3-8-16/h1-5,7-10,13,25H,6,11-12,14-15H2
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72n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359528
PNG
(CHEMBL1927149)
Show SMILES Clc1ccccc1CN1CCCn2c(C1)c1c(cc2=O)[nH]n(-c2ccccc2Cl)c1=O
Show InChI InChI=1S/C23H20Cl2N4O2/c24-16-7-2-1-6-15(16)13-27-10-5-11-28-20(14-27)22-18(12-21(28)30)26-29(23(22)31)19-9-4-3-8-17(19)25/h1-4,6-9,12,26H,5,10-11,13-14H2
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76n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330744
PNG
(4-((2-chlorobenzyloxy)methyl)-2-(2-chlorophenyl)-5...)
Show SMILES Cn1c(COCc2ccccc2Cl)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O
Show InChI InChI=1S/C21H17Cl2N3O3/c1-25-18(12-29-11-13-6-2-3-7-14(13)22)20-16(10-19(25)27)24-26(21(20)28)17-9-5-4-8-15(17)23/h2-10,24H,11-12H2,1H3
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82n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359525
PNG
(CHEMBL1927146)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCNCc3c2c1=O
Show InChI InChI=1S/C16H15ClN4O2/c17-10-4-1-2-5-12(10)21-16(23)15-11(19-21)8-14(22)20-7-3-6-18-9-13(15)20/h1-2,4-5,8,18-19H,3,6-7,9H2
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87n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359520
PNG
(CHEMBL1927158)
Show SMILES COc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccn4)Cc3c2c1=O
Show InChI InChI=1S/C23H23N5O3/c1-31-20-9-3-2-8-18(20)28-23(30)22-17(25-28)13-21(29)27-12-6-11-26(15-19(22)27)14-16-7-4-5-10-24-16/h2-5,7-10,13,25H,6,11-12,14-15H2,1H3
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93n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359518
PNG
(CHEMBL1927156)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4cccnc4)Cc3c2c1=O
Show InChI InChI=1S/C22H20ClN5O2/c23-16-6-1-2-7-18(16)28-22(30)21-17(25-28)11-20(29)27-10-4-9-26(14-19(21)27)13-15-5-3-8-24-12-15/h1-3,5-8,11-12,25H,4,9-10,13-14H2
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94n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330743
PNG
(4-(benzyloxymethyl)-2-(2-chlorophenyl)-5-(pyrazin-...)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n(Cc3cnccn3)c(COCc3ccccc3)c2c1=O
Show InChI InChI=1S/C25H20ClN5O3/c26-19-8-4-5-9-21(19)31-25(33)24-20(29-31)12-23(32)30(14-18-13-27-10-11-28-18)22(24)16-34-15-17-6-2-1-3-7-17/h1-13,29H,14-16H2
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95n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359529
PNG
(CHEMBL1927150)
Show SMILES Clc1cccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C23H20Cl2N4O2/c24-16-6-3-5-15(11-16)13-27-9-4-10-28-20(14-27)22-18(12-21(28)30)26-29(23(22)31)19-8-2-1-7-17(19)25/h1-3,5-8,11-12,26H,4,9-10,13-14H2
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101n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359530
PNG
(CHEMBL1927151)
Show SMILES Clc1ccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3Cl)c2=O)cc1
Show InChI InChI=1S/C23H20Cl2N4O2/c24-16-8-6-15(7-9-16)13-27-10-3-11-28-20(14-27)22-18(12-21(28)30)26-29(23(22)31)19-5-2-1-4-17(19)25/h1-2,4-9,12,26H,3,10-11,13-14H2
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103n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359524
PNG
(CHEMBL1927145)
Show SMILES CC(C)(C)OC(=O)N1CCCn2c(C1)c1c(cc2=O)[nH]n(-c2ccccc2Cl)c1=O
Show InChI InChI=1S/C21H23ClN4O4/c1-21(2,3)30-20(29)24-9-6-10-25-16(12-24)18-14(11-17(25)27)23-26(19(18)28)15-8-5-4-7-13(15)22/h4-5,7-8,11,23H,6,9-10,12H2,1-3H3
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103n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359531
PNG
(CHEMBL1927152)
Show SMILES COc1ccccc1CN1CCCn2c(C1)c1c(cc2=O)[nH]n(-c2ccccc2Cl)c1=O
Show InChI InChI=1S/C24H23ClN4O3/c1-32-21-10-5-2-7-16(21)14-27-11-6-12-28-20(15-27)23-18(13-22(28)30)26-29(24(23)31)19-9-4-3-8-17(19)25/h2-5,7-10,13,26H,6,11-12,14-15H2,1H3
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111n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359534
PNG
(CHEMBL1927155)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccoc4)Cc3c2c1=O
Show InChI InChI=1S/C21H19ClN4O3/c22-15-4-1-2-5-17(15)26-21(28)20-16(23-26)10-19(27)25-8-3-7-24(12-18(20)25)11-14-6-9-29-13-14/h1-2,4-6,9-10,13,23H,3,7-8,11-12H2
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111n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359532
PNG
(CHEMBL1927153)
Show SMILES COc1cccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C24H23ClN4O3/c1-32-17-7-4-6-16(12-17)14-27-10-5-11-28-21(15-27)23-19(13-22(28)30)26-29(24(23)31)20-9-3-2-8-18(20)25/h2-4,6-9,12-13,26H,5,10-11,14-15H2,1H3
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112n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330745
PNG
(2-(2-chlorophenyl)-4-((4-fluorophenoxy)methyl)-5-m...)
Show SMILES Cn1c(COc2ccc(F)cc2)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O
Show InChI InChI=1S/C20H15ClFN3O3/c1-24-17(11-28-13-8-6-12(22)7-9-13)19-15(10-18(24)26)23-25(20(19)27)16-5-3-2-4-14(16)21/h2-10,23H,11H2,1H3
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114n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330738
PNG
(2-(2-chloro-4-fluorophenyl)-5-(2-(pyridin-2-yl)eth...)
Show SMILES Fc1ccc(c(Cl)c1)-n1[nH]c2cc(=O)n(CCc3ccccn3)c(CN3CCCC3)c2c1=O
Show InChI InChI=1S/C24H23ClFN5O2/c25-18-13-16(26)6-7-20(18)31-24(33)23-19(28-31)14-22(32)30(12-8-17-5-1-2-9-27-17)21(23)15-29-10-3-4-11-29/h1-2,5-7,9,13-14,28H,3-4,8,10-12,15H2
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114n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359533
PNG
(CHEMBL1927154)
Show SMILES COc1ccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3Cl)c2=O)cc1
Show InChI InChI=1S/C24H23ClN4O3/c1-32-17-9-7-16(8-10-17)14-27-11-4-12-28-21(15-27)23-19(13-22(28)30)26-29(24(23)31)20-6-3-2-5-18(20)25/h2-3,5-10,13,26H,4,11-12,14-15H2,1H3
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116n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330746
PNG
(2-(2-chlorophenyl)-4-(2-fluorophenyl)-5-methyl-1H-...)
Show SMILES Cn1c(-c2ccccc2F)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O
Show InChI InChI=1S/C19H13ClFN3O2/c1-23-16(25)10-14-17(18(23)11-6-2-4-8-13(11)21)19(26)24(22-14)15-9-5-3-7-12(15)20/h2-10,22H,1H3
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128n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359521
PNG
(CHEMBL1927159)
Show SMILES COc1cccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3OC)c2=O)c1
Show InChI InChI=1S/C25H26N4O4/c1-32-18-8-5-7-17(13-18)15-27-11-6-12-28-21(16-27)24-19(14-23(28)30)26-29(25(24)31)20-9-3-4-10-22(20)33-2/h3-5,7-10,13-14,26H,6,11-12,15-16H2,1-2H3
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131n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359526
PNG
(CHEMBL1926690)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCN(Cc4ccccc4)Cc3c2c1=O
Show InChI InChI=1S/C22H19ClN4O2/c23-16-8-4-5-9-18(16)27-22(29)21-17(24-27)12-20(28)26-11-10-25(14-19(21)26)13-15-6-2-1-3-7-15/h1-9,12,24H,10-11,13-14H2
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142n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359527
PNG
(CHEMBL1927148)
Show SMILES COc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccc4)Cc3c2c1=O
Show InChI InChI=1S/C24H24N4O3/c1-31-21-11-6-5-10-19(21)28-24(30)23-18(25-28)14-22(29)27-13-7-12-26(16-20(23)27)15-17-8-3-2-4-9-17/h2-6,8-11,14,25H,7,12-13,15-16H2,1H3
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144n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
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