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Compile Data Set for Download or QSAR

Found 859 hits Enz. Inhib. hit(s) with Target = 'NF-kappa-beta-inducing kinase (NF-kB)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429614
PNG
(CHEMBL2334589)
Show SMILES COCCOc1cnc(N)nc1-c1c[nH]c2ccc(cc12)C#CC(C)(C)O
Show InChI InChI=1S/C20H22N4O3/c1-20(2,25)7-6-13-4-5-16-14(10-13)15(11-22-16)18-17(27-9-8-26-3)12-23-19(21)24-18/h4-5,10-12,22,25H,8-9H2,1-3H3,(H2,21,23,24)
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n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK in human HT-29 cells assessed as LTalpha/beta2-induced p100 processing to NFkappaB2 preincubated for 30 mins before LTalpha/beta2 s...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429614
PNG
(CHEMBL2334589)
Show SMILES COCCOc1cnc(N)nc1-c1c[nH]c2ccc(cc12)C#CC(C)(C)O
Show InChI InChI=1S/C20H22N4O3/c1-20(2,25)7-6-13-4-5-16-14(10-13)15(11-22-16)18-17(27-9-8-26-3)12-23-19(21)24-18/h4-5,10-12,22,25H,8-9H2,1-3H3,(H2,21,23,24)
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n/an/a 40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429615
PNG
(CHEMBL2334586)
Show SMILES CC(C)(O)C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
Show InChI InChI=1S/C20H20N4O/c1-20(2,25)9-8-12-6-7-15-14(10-12)17-16(23-15)5-3-4-13-11-22-19(21)24-18(13)17/h6-7,10-11,23,25H,3-5H2,1-2H3,(H2,21,22,24)
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n/an/a 41n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429634
PNG
(CHEMBL2334966)
Show SMILES Nc1nccc(n1)-n1ccc2ccc(cc12)C#N
Show InChI InChI=1S/C13H9N5/c14-8-9-1-2-10-4-6-18(11(10)7-9)12-3-5-16-13(15)17-12/h1-7H,(H2,15,16,17)
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n/an/a 63n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429630
PNG
(CHEMBL2334970)
Show SMILES Nc1nccc(n1)-c1c[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C13H9N5/c14-6-8-1-2-11-9(5-8)10(7-17-11)12-3-4-16-13(15)18-12/h1-5,7,17H,(H2,15,16,18)
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n/an/a 63n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429624
PNG
(CHEMBL2334579)
Show SMILES Nc1ncc2CCCc3[nH]c4ccc(Cl)cc4c3-c2n1
Show InChI InChI=1S/C15H13ClN4/c16-9-4-5-11-10(6-9)13-12(19-11)3-1-2-8-7-18-15(17)20-14(8)13/h4-7,19H,1-3H2,(H2,17,18,20)
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429636
PNG
(CHEMBL2334964)
Show SMILES Nc1nccc(n1)-n1ccc2ccc(Cl)cc12
Show InChI InChI=1S/C12H9ClN4/c13-9-2-1-8-4-6-17(10(8)7-9)11-3-5-15-12(14)16-11/h1-7H,(H2,14,15,16)
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n/an/a 76n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429635
PNG
(CHEMBL2334965)
Show SMILES Nc1nccc(n1)-n1ccc2ccc(Br)cc12
Show InChI InChI=1S/C12H9BrN4/c13-9-2-1-8-4-6-17(10(8)7-9)11-3-5-15-12(14)16-11/h1-7H,(H2,14,15,16)
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n/an/a 89n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429616
PNG
(CHEMBL2334583)
Show SMILES Nc1ncc2CCCc3[nH]c4ccc(Br)cc4c3-c2n1
Show InChI InChI=1S/C15H13BrN4/c16-9-4-5-11-10(6-9)13-12(19-11)3-1-2-8-7-18-15(17)20-14(8)13/h4-7,19H,1-3H2,(H2,17,18,20)
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n/an/a 100n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429626
PNG
(CHEMBL2334577)
Show SMILES Cc1cnc(N)nc1-c1c[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C13H11ClN4/c1-7-5-17-13(15)18-12(7)10-6-16-11-3-2-8(14)4-9(10)11/h2-6,16H,1H3,(H2,15,17,18)
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n/an/a 110n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429637
PNG
(CHEMBL2334963)
Show SMILES Nc1nccc(n1)-c1c[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C12H9ClN4/c13-7-1-2-10-8(5-7)9(6-16-10)11-3-4-15-12(14)17-11/h1-6,16H,(H2,14,15,17)
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n/an/a 150n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429615
PNG
(CHEMBL2334586)
Show SMILES CC(C)(O)C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
Show InChI InChI=1S/C20H20N4O/c1-20(2,25)9-8-12-6-7-15-14(10-12)17-16(23-15)5-3-4-13-11-22-19(21)24-18(13)17/h6-7,10-11,23,25H,3-5H2,1-2H3,(H2,21,22,24)
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n/an/a 170n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK in human HT-29 cells assessed as LTalpha/beta2-induced p100 processing to NFkappaB2 preincubated for 30 mins before LTalpha/beta2 s...


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429641
PNG
(CHEMBL2334591)
Show SMILES Nc1nccc(n1)-c1cnc2ccc(Br)cn12
Show InChI InChI=1S/C11H8BrN5/c12-7-1-2-10-15-5-9(17(10)6-7)8-3-4-14-11(13)16-8/h1-6H,(H2,13,14,16)
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n/an/a 190n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429638
PNG
(CHEMBL2334962)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1-c1ccnc(N)n1
Show InChI InChI=1S/C13H11ClN4/c1-7-12(11-4-5-16-13(15)18-11)9-6-8(14)2-3-10(9)17-7/h2-6,17H,1H3,(H2,15,16,18)
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n/an/a 300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429639
PNG
(CHEMBL2334593)
Show SMILES Nc1nccc(n1)-n1cnc2ccc(Cl)cc12
Show InChI InChI=1S/C11H8ClN5/c12-7-1-2-8-9(5-7)17(6-15-8)10-3-4-14-11(13)16-10/h1-6H,(H2,13,14,16)
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n/an/a 310n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50374681
PNG
(CHEMBL257834)
Show SMILES CC(C)(C)CN1CCC(CC1)NC(=O)c1csc(NC(=O)c2ccc3cc4C(=O)NCC5(CCC5)n4c3c2)n1
Show InChI InChI=1S/C29H36N6O3S/c1-28(2,3)17-34-11-7-20(8-12-34)31-25(37)21-15-39-27(32-21)33-24(36)19-6-5-18-13-23-26(38)30-16-29(9-4-10-29)35(23)22(18)14-19/h5-6,13-15,20H,4,7-12,16-17H2,1-3H3,(H,30,38)(H,31,37)(H,32,33,36)
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n/an/a 480n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of NIK


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429633
PNG
(CHEMBL2334967)
Show SMILES Nc1nccc(n1)N1CCc2ccc(Br)cc12
Show InChI InChI=1S/C12H11BrN4/c13-9-2-1-8-4-6-17(10(8)7-9)11-3-5-15-12(14)16-11/h1-3,5,7H,4,6H2,(H2,14,15,16)
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n/an/a 550n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429613
PNG
(CHEMBL2334590)
Show SMILES Cc1nc2ccc(Cl)cn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C12H10ClN5/c1-7-11(9-4-5-15-12(14)17-9)18-6-8(13)2-3-10(18)16-7/h2-6H,1H3,(H2,14,15,17)
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n/an/a 600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429622
PNG
(CHEMBL2334581)
Show SMILES Nc1ncc2CCc3[nH]c4ccc(Cl)cc4c3-c2n1
Show InChI InChI=1S/C14H11ClN4/c15-8-2-4-10-9(5-8)12-11(18-10)3-1-7-6-17-14(16)19-13(7)12/h2,4-6,18H,1,3H2,(H2,16,17,19)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429632
PNG
(CHEMBL2334968)
Show SMILES Nc1nccc(n1)-c1c[nH]c2ccc(F)cc12
Show InChI InChI=1S/C12H9FN4/c13-7-1-2-10-8(5-7)9(6-16-10)11-3-4-15-12(14)17-11/h1-6,16H,(H2,14,15,17)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50059889
PNG
((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Show SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429623
PNG
(CHEMBL2334580)
Show SMILES Nc1ncc2CCc3c(Cl)ccc4[nH]cc(-c2n1)c34
Show InChI InChI=1S/C14H11ClN4/c15-10-3-4-11-12-8(10)2-1-7-5-18-14(16)19-13(7)9(12)6-17-11/h3-6,17H,1-2H2,(H2,16,18,19)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429640
PNG
(CHEMBL2334592)
Show SMILES Cc1nc2ccc(Cl)cc2n1-c1ccnc(N)n1
Show InChI InChI=1S/C12H10ClN5/c1-7-16-9-3-2-8(13)6-10(9)18(7)11-4-5-15-12(14)17-11/h2-6H,1H3,(H2,14,15,17)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429616
PNG
(CHEMBL2334583)
Show SMILES Nc1ncc2CCCc3[nH]c4ccc(Br)cc4c3-c2n1
Show InChI InChI=1S/C15H13BrN4/c16-9-4-5-11-10(6-9)13-12(19-11)3-1-2-8-7-18-15(17)20-14(8)13/h4-7,19H,1-3H2,(H2,17,18,20)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK in human HT-29 cells assessed as LTalpha/beta2-induced p100 processing to NFkappaB2 preincubated for 30 mins before LTalpha/beta2 s...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429617
PNG
(CHEMBL2334588)
Show SMILES CC(O)c1ccc(s1)-c1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
Show InChI InChI=1S/C21H20N4OS/c1-11(26)17-7-8-18(27-17)12-5-6-15-14(9-12)19-16(24-15)4-2-3-13-10-23-21(22)25-20(13)19/h5-11,24,26H,2-4H2,1H3,(H2,22,23,25)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429613
PNG
(CHEMBL2334590)
Show SMILES Cc1nc2ccc(Cl)cn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C12H10ClN5/c1-7-11(9-4-5-15-12(14)17-9)18-6-8(13)2-3-10(18)16-7/h2-6H,1H3,(H2,14,15,17)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK in human HT-29 cells assessed as LTalpha/beta2-induced p100 processing to NFkappaB2 preincubated for 30 mins before LTalpha/beta2 s...


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429621
PNG
(CHEMBL2334582)
Show SMILES Nc1ncc2CCCCc3[nH]c4ccc(Cl)cc4c3-c2n1
Show InChI InChI=1S/C16H15ClN4/c17-10-5-6-12-11(7-10)14-13(20-12)4-2-1-3-9-8-19-16(18)21-15(9)14/h5-8,20H,1-4H2,(H2,18,19,21)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429618
PNG
(CHEMBL2334587)
Show SMILES CC(O)c1ccc(cc1)-c1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
Show InChI InChI=1S/C23H22N4O/c1-13(28)14-5-7-15(8-6-14)16-9-10-19-18(11-16)21-20(26-19)4-2-3-17-12-25-23(24)27-22(17)21/h5-13,26,28H,2-4H2,1H3,(H2,24,25,27)
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n/an/a 2.40E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429631
PNG
(CHEMBL2334969)
Show SMILES COc1ccc2[nH]cc(-c3ccnc(N)n3)c2c1
Show InChI InChI=1S/C13H12N4O/c1-18-8-2-3-11-9(6-8)10(7-16-11)12-4-5-15-13(14)17-12/h2-7,16H,1H3,(H2,14,15,17)
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n/an/a 2.40E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429619
PNG
(CHEMBL2334585)
Show SMILES Cn1cncc1C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
Show InChI InChI=1S/C21H18N6/c1-27-12-23-11-15(27)7-5-13-6-8-17-16(9-13)19-18(25-17)4-2-3-14-10-24-21(22)26-20(14)19/h6,8-12,25H,2-4H2,1H3,(H2,22,24,26)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429620
PNG
(CHEMBL2334584)
Show SMILES Nc1ncc2CCCc3[nH]c4ccc(cc4c3-c2n1)C#Cc1cccnc1
Show InChI InChI=1S/C22H17N5/c23-22-25-13-16-4-1-5-19-20(21(16)27-22)17-11-14(8-9-18(17)26-19)6-7-15-3-2-10-24-12-15/h2-3,8-13,26H,1,4-5H2,(H2,23,25,27)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429625
PNG
(CHEMBL2334578)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1-c1nc(N)ncc1C
Show InChI InChI=1S/C14H13ClN4/c1-7-6-17-14(16)19-13(7)12-8(2)18-11-4-3-9(15)5-10(11)12/h3-6,18H,1-2H3,(H2,16,17,19)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM10844
PNG
(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Show SMILES Nc1nccc(n1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C12H10N4/c13-12-14-6-5-11(16-12)9-7-15-10-4-2-1-3-8(9)10/h1-7,15H,(H2,13,14,16)
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n/an/a 4.10E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429629
PNG
(CHEMBL2334971)
Show SMILES Cc1nc2ccc(C)cn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C13H13N5/c1-8-3-4-11-16-9(2)12(18(11)7-8)10-5-6-15-13(14)17-10/h3-7H,1-2H3,(H2,14,15,17)
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n/an/a 4.20E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50322999
PNG
(4-(ethoxymethylene)isoquinoline-1,3(2H,4H)-dione |...)
Show SMILES CCO\C=C1\C(=O)NC(=O)c2ccccc12
Show InChI InChI=1S/C12H11NO3/c1-2-16-7-10-8-5-3-4-6-9(8)11(14)13-12(10)15/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50322995
PNG
(CHEMBL1210769 | cid_349435 | isoquinoline-1,3(2H,4...)
Show SMILES O=C1Cc2ccccc2C(=O)N1
Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)9(12)10-8/h1-4H,5H2,(H,10,11,12)
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n/an/a 5.10E+4n/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM7641
PNG
(4-{2-methylimidazo[1,2-a]pyridin-3-yl}pyrimidin-2-...)
Show SMILES Cc1nc2ccccn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C12H11N5/c1-8-11(9-5-6-14-12(13)16-9)17-7-3-2-4-10(17)15-8/h2-7H,1H3,(H2,13,14,16)
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n/an/a>8.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429628
PNG
(CHEMBL2334575)
Show SMILES Cc1nc2cc(C)ccn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C13H13N5/c1-8-4-6-18-11(7-8)16-9(2)12(18)10-3-5-15-13(14)17-10/h3-7H,1-2H3,(H2,14,15,17)
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n/an/a>8.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50429627
PNG
(CHEMBL2334576)
Show SMILES Cc1nc2c(C)cccn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C13H13N5/c1-8-4-3-7-18-11(9(2)16-12(8)18)10-5-6-15-13(14)17-10/h3-7H,1-2H3,(H2,14,15,17)
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n/an/a>8.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50322996
PNG
(2,7-naphthyridine-1,3,6,8-tetrone | CHEMBL1210770)
Show SMILES O=C1CC2CC(=O)NC(=O)C2C(=O)N1
Show InChI InChI=1S/C8H8N2O4/c11-4-1-3-2-5(12)10-8(14)6(3)7(13)9-4/h3,6H,1-2H2,(H,9,11,13)(H,10,12,14)
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n/an/a 9.00E+4n/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50322997
PNG
(1,2-dihydroisoquinolin-3(4H)-one | CHEMBL1210771)
Show SMILES O=C1Cc2ccccc2CN1
Show InChI InChI=1S/C9H9NO/c11-9-5-7-3-1-2-4-8(7)6-10-9/h1-4H,5-6H2,(H,10,11)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50323000
PNG
(5,7-dichloroquinazoline-2,4(1H,3H)-dione | CHEMBL1...)
Show SMILES Clc1cc(Cl)c2c(c1)[nH]c(=O)[nH]c2=O
Show InChI InChI=1S/C8H4Cl2N2O2/c9-3-1-4(10)6-5(2-3)11-8(14)12-7(6)13/h1-2H,(H2,11,12,13,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50012070
PNG
(5-Hydroxy-2-methyl-[1,4]naphthoquinone | 5-hydroxy...)
Show SMILES CC1=CC(=O)c2c(O)cccc2C1=O
Show InChI InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM50322998
PNG
(4-(thiophen-2-ylmethylene)isoquinoline-1,3(2H,4H)-...)
Show SMILES O=C1NC(=O)c2ccccc2\C1=C/c1cccs1
Show InChI InChI=1S/C14H9NO2S/c16-13-11-6-2-1-5-10(11)12(14(17)15-13)8-9-4-3-7-18-9/h1-8H,(H,15,16,17)/b12-8+
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158752
PNG
(US9034866, 227)
Show SMILES CN1CCC(O)(C#Cc2ccc3OCCc4sc(nc4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H17N3O4S/c1-22-8-7-19(25,18(22)24)6-4-11-2-3-13-12(10-11)15-14(5-9-26-13)27-17(21-15)16(20)23/h2-3,10,25H,5,7-9H2,1H3,(H2,20,23)
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US Patent
0.0400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158801
PNG
(US9034866, 276)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OCCc4sc(nc4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H17N3O4S/c1-22-8-7-19(25,18(22)24)6-4-11-2-3-13-12(10-11)15-14(5-9-26-13)27-17(21-15)16(20)23/h2-3,10,25H,5,7-9H2,1H3,(H2,20,23)/t19-/s2
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US Patent
0.0550n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159077
PNG
(US9034866, 552)
Show SMILES C[C@H]1COc2ccc(cc2-c2nc(sc12)C(N)=O)C#C[C@]1(O)CCNC1=O
Show InChI InChI=1/C19H17N3O4S/c1-10-9-26-13-3-2-11(4-5-19(25)6-7-21-18(19)24)8-12(13)14-15(10)27-17(22-14)16(20)23/h2-3,8,10,25H,6-7,9H2,1H3,(H2,20,23)(H,21,24)/t10-,19-/s2
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159087
PNG
(US9034866, 562)
Show SMILES C[C@@H]1COc2ccc(cc2-c2nc(sc12)C(N)=O)C#C[C@]1(O)CCNC1=O
Show InChI InChI=1/C19H17N3O4S/c1-10-9-26-13-3-2-11(4-5-19(25)6-7-21-18(19)24)8-12(13)14-15(10)27-17(22-14)16(20)23/h2-3,8,10,25H,6-7,9H2,1H3,(H2,20,23)(H,21,24)/t10-,19+/s2
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158883
PNG
(US9034866, 358)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3c(nc(C(N)=O)c3[C@H](O)c3ccnn3C)-c2c1
Show InChI InChI=1/C27H26N6O4/c1-14-10-21(31-37-14)27(2,36)8-6-15-4-5-18-16-12-17(13-16)33-23(24(34)20-7-9-29-32(20)3)22(25(28)35)30-26(33)19(18)11-15/h4-5,7,9-11,16-17,24,34,36H,12-13H2,1-3H3,(H2,28,35)/t16?,17?,24-,27-/s2
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158884
PNG
(US9034866, 359)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3c(nc(C(N)=O)c3[C@@H](O)c3ccnn3C)-c2c1
Show InChI InChI=1/C27H26N6O4/c1-14-10-21(31-37-14)27(2,36)8-6-15-4-5-18-16-12-17(13-16)33-23(24(34)20-7-9-29-32(20)3)22(25(28)35)30-26(33)19(18)11-15/h4-5,7,9-11,16-17,24,34,36H,12-13H2,1-3H3,(H2,28,35)/t16?,17?,24-,27+/s2
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
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