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Compile Data Set for Download or QSAR

Found 48 hits Enz. Inhib. hit(s) with Target = 'Natural resistance-associated macrophage protein 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387712
PNG
(CHEMBL2058611)
Show SMILES NC(=N)SCc1cc(F)ccc1Sc1ccc(cc1CSC(N)=N)C(F)(F)F
Show InChI InChI=1S/C17H16F4N4S3/c18-12-2-4-14(10(6-12)8-27-16(24)25)28-13-3-1-11(17(19,20)21)5-9(13)7-26-15(22)23/h1-6H,7-8H2,(H3,22,23)(H3,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387759
PNG
(CHEMBL2058620)
Show SMILES NC(=N)SCc1ccccc1Oc1ccccc1CSC(N)=N
Show InChI InChI=1S/C16H18N4OS2/c17-15(18)22-9-11-5-1-3-7-13(11)21-14-8-4-2-6-12(14)10-23-16(19)20/h1-8H,9-10H2,(H3,17,18)(H3,19,20)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387714
PNG
(CHEMBL2058892)
Show SMILES NC(=N)SCc1cccc2c1sc1c(CSC(N)=N)c(Br)ccc21
Show InChI InChI=1S/C16H15BrN4S3/c17-12-5-4-10-9-3-1-2-8(6-22-15(18)19)13(9)24-14(10)11(12)7-23-16(20)21/h1-5H,6-7H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387715
PNG
(CHEMBL2058621)
Show SMILES NC(=N)SCc1cc(F)ccc1Oc1ccc(cc1CSC(N)=N)[N+]([O-])=O
Show InChI InChI=1S/C16H16FN5O3S2/c17-11-1-3-13(9(5-11)7-26-15(18)19)25-14-4-2-12(22(23)24)6-10(14)8-27-16(20)21/h1-6H,7-8H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387716
PNG
(CHEMBL2058622)
Show SMILES NC(=N)SCc1cc(F)ccc1Oc1ccc(F)cc1CSC(N)=N
Show InChI InChI=1S/C16H16F2N4OS2/c17-11-1-3-13(9(5-11)7-24-15(19)20)23-14-4-2-12(18)6-10(14)8-25-16(21)22/h1-6H,7-8H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387717
PNG
(CHEMBL2058623)
Show SMILES NC(=N)SCc1ccc(Cl)cc1Oc1ccc(F)cc1CSC(N)=N
Show InChI InChI=1S/C16H16ClFN4OS2/c17-11-2-1-9(7-24-15(19)20)14(6-11)23-13-4-3-12(18)5-10(13)8-25-16(21)22/h1-6H,7-8H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387718
PNG
(CHEMBL2058624)
Show SMILES NC(=N)SCc1ccc(F)cc1Oc1ccc(F)cc1CSC(N)=N
Show InChI InChI=1S/C16H16F2N4OS2/c17-11-3-4-13(10(5-11)8-25-16(21)22)23-14-6-12(18)2-1-9(14)7-24-15(19)20/h1-6H,7-8H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387719
PNG
(CHEMBL2058625)
Show SMILES NC(=N)SCc1ccccc1Oc1ccc(Cl)cc1CSC(N)=N
Show InChI InChI=1S/C16H17ClN4OS2/c17-12-5-6-14(11(7-12)9-24-16(20)21)22-13-4-2-1-3-10(13)8-23-15(18)19/h1-7H,8-9H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387720
PNG
(CHEMBL2058626)
Show SMILES NC(=N)SCc1cc(Cl)ccc1Oc1ccc(cc1CSC(N)=N)[N+]([O-])=O
Show InChI InChI=1S/C16H16ClN5O3S2/c17-11-1-3-13(9(5-11)7-26-15(18)19)25-14-4-2-12(22(23)24)6-10(14)8-27-16(20)21/h1-6H,7-8H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387721
PNG
(CHEMBL2058627)
Show SMILES NC(=N)SCc1ccccc1Oc1cc(Cl)ccc1CSC(N)=N
Show InChI InChI=1S/C16H17ClN4OS2/c17-12-6-5-11(9-24-16(20)21)14(7-12)22-13-4-2-1-3-10(13)8-23-15(18)19/h1-7H,8-9H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387722
PNG
(CHEMBL2058629)
Show SMILES NC(=N)SCc1ccccc1C(=O)c1ccc(F)cc1CSC(N)=N
Show InChI InChI=1S/C17H17FN4OS2/c18-12-5-6-14(11(7-12)9-25-17(21)22)15(23)13-4-2-1-3-10(13)8-24-16(19)20/h1-7H,8-9H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387723
PNG
(CHEMBL2058630)
Show SMILES NC(=N)SCc1ccccc1C(=O)c1cc(F)ccc1CSC(N)=N
Show InChI InChI=1S/C17H17FN4OS2/c18-12-6-5-11(9-25-17(21)22)14(7-12)15(23)13-4-2-1-3-10(13)8-24-16(19)20/h1-7H,8-9H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387724
PNG
(CHEMBL2058876)
Show SMILES NC(=N)SCc1ccccc1C(=O)c1ccc(Cl)cc1CSC(N)=N
Show InChI InChI=1S/C17H17ClN4OS2/c18-12-5-6-14(11(7-12)9-25-17(21)22)15(23)13-4-2-1-3-10(13)8-24-16(19)20/h1-7H,8-9H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387725
PNG
(CHEMBL2058877)
Show SMILES NC(=N)SCc1ccccc1C(=O)c1cc(Cl)ccc1CSC(N)=N
Show InChI InChI=1S/C17H17ClN4OS2/c18-12-6-5-11(9-25-17(21)22)14(7-12)15(23)13-4-2-1-3-10(13)8-24-16(19)20/h1-7H,8-9H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387726
PNG
(CHEMBL2058878)
Show SMILES NC(=N)SCc1cccc2c1oc1c(CSC(N)=N)cccc21
Show InChI InChI=1S/C16H16N4OS2/c17-15(18)22-7-9-3-1-5-11-12-6-2-4-10(8-23-16(19)20)14(12)21-13(9)11/h1-6H,7-8H2,(H3,17,18)(H3,19,20)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387727
PNG
(CHEMBL2058879)
Show SMILES NC(=N)SCc1cccc2-c3cccc(CSC(N)=N)c3-c12
Show InChI InChI=1S/C16H16N4S2/c17-15(18)21-7-9-3-1-5-11-12-6-2-4-10(8-22-16(19)20)14(12)13(9)11/h1-6H,7-8H2,(H3,17,18)(H3,19,20)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387728
PNG
(CHEMBL2058880)
Show SMILES NC(=N)SCc1cccc2c1sc1c(CSC(N)=N)cccc21
Show InChI InChI=1S/C16H16N4S3/c17-15(18)21-7-9-3-1-5-11-12-6-2-4-10(8-22-16(19)20)14(12)23-13(9)11/h1-6H,7-8H2,(H3,17,18)(H3,19,20)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387729
PNG
(CHEMBL2058881)
Show SMILES NC(=N)SCc1cccc2-c3cccc(CSC(N)=N)c3C(=O)c12
Show InChI InChI=1S/C17H16N4OS2/c18-16(19)23-7-9-3-1-5-11-12-6-2-4-10(8-24-17(20)21)14(12)15(22)13(9)11/h1-6H,7-8H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387730
PNG
(CHEMBL2058882)
Show SMILES NC(=N)SCc1cccc2sc3cccc(CSC(N)=N)c3c12
Show InChI InChI=1S/C16H16N4S3/c17-15(18)21-7-9-3-1-5-11-13(9)14-10(8-22-16(19)20)4-2-6-12(14)23-11/h1-6H,7-8H2,(H3,17,18)(H3,19,20)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387731
PNG
(CHEMBL2058883)
Show SMILES NC(=N)SCc1cccc2C(=O)c3cccc(CSC(N)=N)c3-c12
Show InChI InChI=1S/C17H16N4OS2/c18-16(19)23-7-9-3-1-5-11-13(9)14-10(8-24-17(20)21)4-2-6-12(14)15(11)22/h1-6H,7-8H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387732
PNG
(CHEMBL2058884)
Show SMILES NC(=N)SCc1cccc2Sc3cccc(CSC(N)=N)c3Oc12
Show InChI InChI=1S/C16H16N4OS3/c17-15(18)22-7-9-3-1-5-11-13(9)21-14-10(8-23-16(19)20)4-2-6-12(14)24-11/h1-6H,7-8H2,(H3,17,18)(H3,19,20)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387733
PNG
(CHEMBL2058885)
Show SMILES NC(=N)SCc1cccc2cc3cccc(CSC(N)=N)c3nc12
Show InChI InChI=1S/C17H17N5S2/c18-16(19)23-8-12-5-1-3-10-7-11-4-2-6-13(9-24-17(20)21)15(11)22-14(10)12/h1-7H,8-9H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387734
PNG
(CHEMBL2058886)
Show SMILES NC(=N)SCc1cccc2c1oc1c(CSC(N)=N)cc(F)cc21
Show InChI InChI=1S/C16H15FN4OS2/c17-10-4-9(7-24-16(20)21)14-12(5-10)11-3-1-2-8(13(11)22-14)6-23-15(18)19/h1-5H,6-7H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387735
PNG
(CHEMBL2058887)
Show SMILES NC(=N)SCc1cc(F)cc2c3cc(Cl)cc(CSC(N)=N)c3sc12
Show InChI InChI=1S/C16H14ClFN4S3/c17-9-1-7(5-23-15(19)20)13-11(3-9)12-4-10(18)2-8(14(12)25-13)6-24-16(21)22/h1-4H,5-6H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387736
PNG
(CHEMBL2058888)
Show SMILES NC(=N)SCc1cccc2c1sc1c(CSC(N)=N)cc(F)cc21
Show InChI InChI=1S/C16H15FN4S3/c17-10-4-9(7-23-16(20)21)14-12(5-10)11-3-1-2-8(13(11)24-14)6-22-15(18)19/h1-5H,6-7H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387737
PNG
(CHEMBL2058889)
Show SMILES NC(=N)SCc1c(F)ccc2c1oc1c(CSC(N)=N)c(F)ccc21
Show InChI InChI=1S/C16H14F2N4OS2/c17-11-3-1-7-8-2-4-12(18)10(6-25-16(21)22)14(8)23-13(7)9(11)5-24-15(19)20/h1-4H,5-6H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387738
PNG
(CHEMBL2058890)
Show SMILES NC(=N)SCc1c(Br)ccc2c1oc1c(CSC(N)=N)c(Br)ccc21
Show InChI InChI=1S/C16H14Br2N4OS2/c17-11-3-1-7-8-2-4-12(18)10(6-25-16(21)22)14(8)23-13(7)9(11)5-24-15(19)20/h1-4H,5-6H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387739
PNG
(CHEMBL2058891)
Show SMILES NC(=N)SCc1c(Cl)ccc2c1oc1c(CSC(N)=N)c(Cl)ccc21
Show InChI InChI=1S/C16H14Cl2N4OS2/c17-11-3-1-7-8-2-4-12(18)10(6-25-16(21)22)14(8)23-13(7)9(11)5-24-15(19)20/h1-4H,5-6H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387740
PNG
(CHEMBL2058893)
Show SMILES NC(=N)SCc1c(Br)ccc2c1sc1c(CSC(N)=N)c(Br)ccc21
Show InChI InChI=1S/C16H14Br2N4S3/c17-11-3-1-7-8-2-4-12(18)10(6-24-16(21)22)14(8)25-13(7)9(11)5-23-15(19)20/h1-4H,5-6H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387741
PNG
(CHEMBL2058360)
Show SMILES NC(=N)SCc1ccccc1Sc1ccccc1CSC(N)=N
Show InChI InChI=1S/C16H18N4S3/c17-15(18)21-9-11-5-1-3-7-13(11)23-14-8-4-2-6-12(14)10-22-16(19)20/h1-8H,9-10H2,(H3,17,18)(H3,19,20)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387742
PNG
(CHEMBL2058361)
Show SMILES NC(=N)SCc1cc(F)ccc1Sc1ccc(cc1CSC(N)=N)[N+]([O-])=O
Show InChI InChI=1S/C16H16FN5O2S3/c17-11-1-3-13(9(5-11)7-25-15(18)19)27-14-4-2-12(22(23)24)6-10(14)8-26-16(20)21/h1-6H,7-8H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387743
PNG
(CHEMBL2058362)
Show SMILES NC(=N)SCc1ccccc1Sc1ccc(F)cc1CSC(N)=N
Show InChI InChI=1S/C16H17FN4S3/c17-12-5-6-14(11(7-12)9-23-16(20)21)24-13-4-2-1-3-10(13)8-22-15(18)19/h1-7H,8-9H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387744
PNG
(CHEMBL2058363)
Show SMILES NC(=N)SCc1cc(F)ccc1Sc1ccc(F)cc1CSC(N)=N
Show InChI InChI=1S/C16H16F2N4S3/c17-11-1-3-13(9(5-11)7-23-15(19)20)25-14-4-2-12(18)6-10(14)8-24-16(21)22/h1-6H,7-8H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387745
PNG
(CHEMBL2058364)
Show SMILES CS(=O)(=O)c1ccc(Sc2ccc(F)cc2CSC(N)=N)c(CSC(N)=N)c1
Show InChI InChI=1S/C17H19FN4O2S4/c1-28(23,24)13-3-5-15(11(7-13)9-26-17(21)22)27-14-4-2-12(18)6-10(14)8-25-16(19)20/h2-7H,8-9H2,1H3,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387746
PNG
(CHEMBL2058365)
Show SMILES COc1ccc(Sc2ccc(F)cc2CSC(N)=N)c(CSC(N)=N)c1
Show InChI InChI=1S/C17H19FN4OS3/c1-23-13-3-5-15(11(7-13)9-25-17(21)22)26-14-4-2-12(18)6-10(14)8-24-16(19)20/h2-7H,8-9H2,1H3,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387747
PNG
(CHEMBL2058607)
Show SMILES NC(=N)SCc1ccccc1Sc1cc(F)c(F)cc1CSC(N)=N
Show InChI InChI=1S/C16H16F2N4S3/c17-11-5-10(8-24-16(21)22)14(6-12(11)18)25-13-4-2-1-3-9(13)7-23-15(19)20/h1-6H,7-8H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387748
PNG
(CHEMBL2058608)
Show SMILES Cc1ccc(Sc2ccccc2CSC(N)=N)c(CSC(N)=N)c1
Show InChI InChI=1S/C17H20N4S3/c1-11-6-7-15(13(8-11)10-23-17(20)21)24-14-5-3-2-4-12(14)9-22-16(18)19/h2-8H,9-10H2,1H3,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387749
PNG
(CHEMBL2058609)
Show SMILES NC(=N)SCc1ccccc1Sc1cc(F)ccc1CSC(N)=N
Show InChI InChI=1S/C16H17FN4S3/c17-12-6-5-11(9-23-16(20)21)14(7-12)24-13-4-2-1-3-10(13)8-22-15(18)19/h1-7H,8-9H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387750
PNG
(CHEMBL2058610)
Show SMILES NC(=N)SCc1cc(F)ccc1Sc1cc(F)c(F)cc1CSC(N)=N
Show InChI InChI=1S/C16H15F3N4S3/c17-10-1-2-13(8(3-10)6-24-15(20)21)26-14-5-12(19)11(18)4-9(14)7-25-16(22)23/h1-5H,6-7H2,(H3,20,21)(H3,22,23)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387751
PNG
(CHEMBL2058612)
Show SMILES NC(=N)SCc1ccccc1Sc1ccc(N)cc1CSC(N)=N
Show InChI InChI=1S/C16H19N5S3/c17-12-5-6-14(11(7-12)9-23-16(20)21)24-13-4-2-1-3-10(13)8-22-15(18)19/h1-7H,8-9,17H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387752
PNG
(CHEMBL2058613)
Show SMILES CN(C)S(=O)(=O)c1ccc(Sc2ccc(F)cc2CSC(N)=N)c(CSC(N)=N)c1
Show InChI InChI=1S/C18H22FN5O2S4/c1-24(2)30(25,26)14-4-6-16(12(8-14)10-28-18(22)23)29-15-5-3-13(19)7-11(15)9-27-17(20)21/h3-8H,9-10H2,1-2H3,(H3,20,21)(H3,22,23)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387753
PNG
(CHEMBL2058614)
Show SMILES COc1ccc(Sc2ccccc2CSC(N)=N)c(CSC(N)=N)c1
Show InChI InChI=1S/C17H20N4OS3/c1-22-13-6-7-15(12(8-13)10-24-17(20)21)25-14-5-3-2-4-11(14)9-23-16(18)19/h2-8H,9-10H2,1H3,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387754
PNG
(CHEMBL2058615)
Show SMILES Cc1ccc(CSC(N)=N)c(Sc2ccc(F)cc2CSC(N)=N)c1
Show InChI InChI=1S/C17H19FN4S3/c1-10-2-3-11(8-23-16(19)20)15(6-10)25-14-5-4-13(18)7-12(14)9-24-17(21)22/h2-7H,8-9H2,1H3,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387755
PNG
(CHEMBL2058616)
Show SMILES NC(=N)SCc1cc(Cl)ccc1Sc1ccc(Cl)cc1CSC(N)=N
Show InChI InChI=1S/C16H16Cl2N4S3/c17-11-1-3-13(9(5-11)7-23-15(19)20)25-14-4-2-12(18)6-10(14)8-24-16(21)22/h1-6H,7-8H2,(H3,19,20)(H3,21,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387756
PNG
(CHEMBL2058617)
Show SMILES Cc1cccc(CSC(N)=N)c1Sc1ccccc1CSC(N)=N
Show InChI InChI=1S/C17H20N4S3/c1-11-5-4-7-13(10-23-17(20)21)15(11)24-14-8-3-2-6-12(14)9-22-16(18)19/h2-8H,9-10H2,1H3,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387757
PNG
(CHEMBL2058618)
Show SMILES NC(=N)SCc1cc(F)ccc1Sc1c(CSC(N)=N)cccc1[N+]([O-])=O
Show InChI InChI=1S/C16H16FN5O2S3/c17-11-4-5-13(10(6-11)8-26-16(20)21)27-14-9(7-25-15(18)19)2-1-3-12(14)22(23)24/h1-6H,7-8H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387758
PNG
(CHEMBL2058619)
Show SMILES CN(c1ccccc1CSC(N)=N)c1ccccc1CSC(N)=N
Show InChI InChI=1S/C17H21N5S2/c1-22(14-8-4-2-6-12(14)10-23-16(18)19)15-9-5-3-7-13(15)11-24-17(20)21/h2-9H,10-11H2,1H3,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 1


(Homo sapiens)
BDBM50387713
PNG
(CHEMBL2058628)
Show SMILES NC(=N)SCc1ccccc1C(=O)c1cc(ccc1CSC(N)=N)[N+]([O-])=O
Show InChI InChI=1S/C17H17N5O3S2/c18-16(19)26-8-10-3-1-2-4-13(10)15(23)14-7-12(22(24)25)6-5-11(14)9-27-17(20)21/h1-7H,8-9H2,(H3,18,19)(H3,20,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of NRAMP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair