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Compile Data Set for Download or QSAR

Found 48 hits Enz. Inhib. hit(s) with Target = 'Natural resistance-associated macrophage protein 2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361134
PNG
(CHEMBL1933609)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C15H12N4O3/c1-10-14(11-5-7-12(8-6-11)19(21)22)15(20)18(17-10)13-4-2-3-9-16-13/h2-9,17H,1H3
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n/an/a 60n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361105
PNG
(CHEMBL1933782)
Show SMILES Cc1ccc2nc(sc2c1)-n1[nH]c2CCc3ccccc3-c2c1=O
Show InChI InChI=1S/C19H15N3OS/c1-11-6-8-14-16(10-11)24-19(20-14)22-18(23)17-13-5-3-2-4-12(13)7-9-15(17)21-22/h2-6,8,10,21H,7,9H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361135
PNG
(CHEMBL1933610)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H12F3N3O/c1-10-14(11-5-7-12(8-6-11)16(17,18)19)15(23)22(21-10)13-4-2-3-9-20-13/h2-9,21H,1H3
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361122
PNG
(CHEMBL1933598)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C17H13F3N4O2/c1-10-14(16(26)24(23-10)13-7-2-3-8-21-13)15(25)22-12-6-4-5-11(9-12)17(18,19)20/h2-9,23H,1H3,(H,22,25)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361123
PNG
(CHEMBL1933599)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C16H13N5O4/c1-10-14(16(23)20(19-10)13-4-2-3-9-17-13)15(22)18-11-5-7-12(8-6-11)21(24)25/h2-9,19H,1H3,(H,18,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361114
PNG
(CHEMBL1933791)
Show SMILES COc1ccc(cc1)-c1ccc2-c3c(CCc2c1)[nH]n(-c1ccccn1)c3=O
Show InChI InChI=1S/C23H19N3O2/c1-28-18-9-5-15(6-10-18)16-7-11-19-17(14-16)8-12-20-22(19)23(27)26(25-20)21-4-2-3-13-24-21/h2-7,9-11,13-14,25H,8,12H2,1H3
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361115
PNG
(CHEMBL1933792)
Show SMILES O=c1c-2c(CCc3cc(ccc-23)-c2ccccc2)[nH]n1-c1ccccn1
Show InChI InChI=1S/C22H17N3O/c26-22-21-18-11-9-16(15-6-2-1-3-7-15)14-17(18)10-12-19(21)24-25(22)20-8-4-5-13-23-20/h1-9,11,13-14,24H,10,12H2
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n/an/a 260n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361124
PNG
(CHEMBL1933600)
Show SMILES COc1ccc(NC(=O)c2c(C)[nH]n(-c3ccccn3)c2=O)cc1F
Show InChI InChI=1S/C17H15FN4O3/c1-10-15(17(24)22(21-10)14-5-3-4-8-19-14)16(23)20-11-6-7-13(25-2)12(18)9-11/h3-9,21H,1-2H3,(H,20,23)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361116
PNG
(CHEMBL1933793)
Show SMILES Cc1ccc(cc1)-c1ccc2-c3c(CCc2c1)[nH]n(-c1ccccn1)c3=O
Show InChI InChI=1S/C23H19N3O/c1-15-5-7-16(8-6-15)17-9-11-19-18(14-17)10-12-20-22(19)23(27)26(25-20)21-4-2-3-13-24-21/h2-9,11,13-14,25H,10,12H2,1H3
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361125
PNG
(CHEMBL1933601)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H13F3N4O2/c1-10-14(16(26)24(23-10)13-4-2-3-9-21-13)15(25)22-12-7-5-11(6-8-12)17(18,19)20/h2-9,23H,1H3,(H,22,25)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361117
PNG
(CHEMBL1933794)
Show SMILES Brc1ccc2-c3c(CCc2c1)[nH]n(-c1ccccn1)c3=O
Show InChI InChI=1S/C16H12BrN3O/c17-11-5-6-12-10(9-11)4-7-13-15(12)16(21)20(19-13)14-3-1-2-8-18-14/h1-3,5-6,8-9,19H,4,7H2
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361136
PNG
(CHEMBL1933611)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H12F3N3O/c1-10-14(11-5-4-6-12(9-11)16(17,18)19)15(23)22(21-10)13-7-2-3-8-20-13/h2-9,21H,1H3
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361106
PNG
(CHEMBL1933783)
Show SMILES COc1ccc2nc(sc2c1)-n1[nH]c2CCc3ccccc3-c2c1=O
Show InChI InChI=1S/C19H15N3O2S/c1-24-12-7-9-14-16(10-12)25-19(20-14)22-18(23)17-13-5-3-2-4-11(13)6-8-15(17)21-22/h2-5,7,9-10,21H,6,8H2,1H3
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361137
PNG
(CHEMBL1933612)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1-c1ccc(cc1)C#N
Show InChI InChI=1S/C16H12N4O/c1-11-15(13-7-5-12(10-17)6-8-13)16(21)20(19-11)14-4-2-3-9-18-14/h2-9,19H,1H3
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361144
PNG
(CHEMBL1933773)
Show SMILES Cc1[nH]n(-c2nc3ccc(F)cc3s2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C17H12FN3OS/c1-10-15(11-5-3-2-4-6-11)16(22)21(20-10)17-19-13-8-7-12(18)9-14(13)23-17/h2-9,20H,1H3
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361107
PNG
(CHEMBL1933784)
Show SMILES Fc1ccc2nc(sc2c1)-n1[nH]c2CCc3ccccc3-c2c1=O
Show InChI InChI=1S/C18H12FN3OS/c19-11-6-8-13-15(9-11)24-18(20-13)22-17(23)16-12-4-2-1-3-10(12)5-7-14(16)21-22/h1-4,6,8-9,21H,5,7H2
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361126
PNG
(CHEMBL1933602)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C17H16N4O2/c1-11-6-5-7-13(10-11)19-16(22)15-12(2)20-21(17(15)23)14-8-3-4-9-18-14/h3-10,20H,1-2H3,(H,19,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361145
PNG
(CHEMBL1933774)
Show SMILES Cc1[nH]n(-c2nc3ccccc3s2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C17H13N3OS/c1-11-15(12-7-3-2-4-8-12)16(21)20(19-11)17-18-13-9-5-6-10-14(13)22-17/h2-10,19H,1H3
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361118
PNG
(CHEMBL1933795)
Show SMILES O=c1c-2c(CCc3cc(ccc-23)C#N)[nH]n1-c1ccccn1
Show InChI InChI=1S/C17H12N4O/c18-10-11-4-6-13-12(9-11)5-7-14-16(13)17(22)21(20-14)15-3-1-2-8-19-15/h1-4,6,8-9,20H,5,7H2
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361146
PNG
(CHEMBL1933775)
Show SMILES Cc1[nH]n(-c2nc3ccccc3[nH]2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C17H14N4O/c1-11-15(12-7-3-2-4-8-12)16(22)21(20-11)17-18-13-9-5-6-10-14(13)19-17/h2-10,20H,1H3,(H,18,19)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361108
PNG
(CHEMBL1933785)
Show SMILES OC(=O)c1ccc2nc(sc2c1)-n1[nH]c2CCc3ccccc3-c2c1=O
Show InChI InChI=1S/C19H13N3O3S/c23-17-16-12-4-2-1-3-10(12)5-8-14(16)21-22(17)19-20-13-7-6-11(18(24)25)9-15(13)26-19/h1-4,6-7,9,21H,5,8H2,(H,24,25)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361127
PNG
(CHEMBL1933603)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H14N4O2/c1-11-14(15(21)18-12-7-3-2-4-8-12)16(22)20(19-11)13-9-5-6-10-17-13/h2-10,19H,1H3,(H,18,21)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361128
PNG
(CHEMBL1933604)
Show SMILES COc1cccc(NC(=O)c2c(C)[nH]n(-c3ccccn3)c2=O)c1
Show InChI InChI=1S/C17H16N4O3/c1-11-15(16(22)19-12-6-5-7-13(10-12)24-2)17(23)21(20-11)14-8-3-4-9-18-14/h3-10,20H,1-2H3,(H,19,22)
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Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361129
PNG
(CHEMBL1933605)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1ccc(C)cc1
Show InChI InChI=1S/C17H16N4O2/c1-11-6-8-13(9-7-11)19-16(22)15-12(2)20-21(17(15)23)14-5-3-4-10-18-14/h3-10,20H,1-2H3,(H,19,22)
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n/an/a 690n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361130
PNG
(CHEMBL1933606)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C16H13N5O4/c1-10-14(16(23)20(19-10)13-8-4-5-9-17-13)15(22)18-11-6-2-3-7-12(11)21(24)25/h2-9,19H,1H3,(H,18,22)
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n/an/a 710n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361109
PNG
(CHEMBL1933786)
Show SMILES O=c1c-2c(CCc3ccccc-23)[nH]n1-c1nc2ccccc2s1
Show InChI InChI=1S/C18H13N3OS/c22-17-16-12-6-2-1-5-11(12)9-10-14(16)20-21(17)18-19-13-7-3-4-8-15(13)23-18/h1-8,20H,9-10H2
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n/an/a 720n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361138
PNG
(CHEMBL1933613)
Show SMILES CCOC(=O)c1ccc(cc1)-c1c(C)[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C18H17N3O3/c1-3-24-18(23)14-9-7-13(8-10-14)16-12(2)20-21(17(16)22)15-6-4-5-11-19-15/h4-11,20H,3H2,1-2H3
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n/an/a 770n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361110
PNG
(CHEMBL1933787)
Show SMILES O=c1c-2c(CCc3ccccc-23)[nH]n1-c1ccccn1
Show InChI InChI=1S/C16H13N3O/c20-16-15-12-6-2-1-5-11(12)8-9-13(15)18-19(16)14-7-3-4-10-17-14/h1-7,10,18H,8-9H2
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n/an/a 830n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361139
PNG
(CHEMBL1933614)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1-c1ccc(F)cc1
Show InChI InChI=1S/C15H12FN3O/c1-10-14(11-5-7-12(16)8-6-11)15(20)19(18-10)13-4-2-3-9-17-13/h2-9,18H,1H3
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n/an/a 910n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361131
PNG
(CHEMBL1933607)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1ccccc1C(F)(F)F
Show InChI InChI=1S/C17H13F3N4O2/c1-10-14(16(26)24(23-10)13-8-4-5-9-21-13)15(25)22-12-7-3-2-6-11(12)17(18,19)20/h2-9,23H,1H3,(H,22,25)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361099
PNG
(CHEMBL1933776)
Show SMILES COc1ccc2nc(sc2c1)-n1[nH]c(C)c(-c2ccccc2)c1=O
Show InChI InChI=1S/C18H15N3O2S/c1-11-16(12-6-4-3-5-7-12)17(22)21(20-11)18-19-14-9-8-13(23-2)10-15(14)24-18/h3-10,20H,1-2H3
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n/an/a 1.04E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361132
PNG
(CHEMBL1933608)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1ccc2OCOc2c1
Show InChI InChI=1S/C17H14N4O4/c1-10-15(17(23)21(20-10)14-4-2-3-7-18-14)16(22)19-11-5-6-12-13(8-11)25-9-24-12/h2-8,20H,9H2,1H3,(H,19,22)
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n/an/a 1.22E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361121
PNG
(CHEMBL1933597)
Show SMILES CCN(CC)c1ccc(C=c2c(=C)[nH]n(-c3ccccn3)c2=O)cc1
Show InChI InChI=1S/C20H22N4O/c1-4-23(5-2)17-11-9-16(10-12-17)14-18-15(3)22-24(20(18)25)19-8-6-7-13-21-19/h6-14,22H,3-5H2,1-2H3
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n/an/a 1.53E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361140
PNG
(CHEMBL1933615)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C15H13N3O/c1-11-14(12-7-3-2-4-8-12)15(19)18(17-11)13-9-5-6-10-16-13/h2-10,17H,1H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361111
PNG
(CHEMBL1933788)
Show SMILES O=c1c-2c(CCc3ccccc-23)[nH]n1-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N4O/c23-17-16-12-6-2-1-5-11(12)9-10-15(16)21-22(17)18-19-13-7-3-4-8-14(13)20-18/h1-8,21H,9-10H2,(H,19,20)
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n/an/a 1.76E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361100
PNG
(CHEMBL1933777)
Show SMILES Cc1[nH]n(-c2nccs2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C13H11N3OS/c1-9-11(10-5-3-2-4-6-10)12(17)16(15-9)13-14-7-8-18-13/h2-8,15H,1H3
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n/an/a 2.19E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM54072
PNG
(3-[(4Z)-4-[4-(diethylamino)benzylidene]-5-keto-3-m...)
Show SMILES CCN(CC)c1ccc(C=c2c(=C)[nH]n(-c3nnc(C)c(=O)[nH]3)c2=O)cc1
Show InChI InChI=1S/C19H22N6O2/c1-5-24(6-2)15-9-7-14(8-10-15)11-16-12(3)23-25(18(16)27)19-20-17(26)13(4)21-22-19/h7-11,23H,3,5-6H2,1-2,4H3,(H,20,22,26)
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n/an/a 2.57E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361119
PNG
(CHEMBL1933796)
Show SMILES COc1ccc2-c3c(CCc2c1)[nH]n(-c1ccccn1)c3=O
Show InChI InChI=1S/C17H15N3O2/c1-22-12-6-7-13-11(10-12)5-8-14-16(13)17(21)20(19-14)15-4-2-3-9-18-15/h2-4,6-7,9-10,19H,5,8H2,1H3
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n/an/a 2.77E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361141
PNG
(CHEMBL1933770)
Show SMILES COc1ccc(cc1)-c1c(C)[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C16H15N3O2/c1-11-15(12-6-8-13(21-2)9-7-12)16(20)19(18-11)14-5-3-4-10-17-14/h3-10,18H,1-2H3
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n/an/a 2.82E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361133
PNG
(CHEMBL1537201)
Show SMILES Cc1[nH]n(-c2ccccc2)c(=O)c1C(=O)Nc1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-12-15(16(21)18-13-8-4-2-5-9-13)17(22)20(19-12)14-10-6-3-7-11-14/h2-11,19H,1H3,(H,18,21)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361104
PNG
(CHEMBL1933781)
Show SMILES Cc1[nH]n(N2CC=c3ccccc3=C2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C19H17N3O/c1-14-18(16-8-3-2-4-9-16)19(23)22(20-14)21-12-11-15-7-5-6-10-17(15)13-21/h2-11,13,20H,12H2,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361112
PNG
(CHEMBL1933789)
Show SMILES [O-][n+]1ccccc1-n1[nH]c2CCc3ccccc3-c2c1=O
Show InChI InChI=1S/C16H13N3O2/c20-16-15-12-6-2-1-5-11(12)8-9-13(15)17-19(16)14-7-3-4-10-18(14)21/h1-7,10,17H,8-9H2
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n/an/a>5.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361102
PNG
(CHEMBL1933779)
Show SMILES Cc1[nH]n(-c2ncccn2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C14H12N4O/c1-10-12(11-6-3-2-4-7-11)13(19)18(17-10)14-15-8-5-9-16-14/h2-9,17H,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361103
PNG
(CHEMBL1933780)
Show SMILES Cc1[nH]n(-c2cc(O)cnn2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C14H12N4O2/c1-9-13(10-5-3-2-4-6-10)14(20)18(17-9)12-7-11(19)8-15-16-12/h2-8,17H,1H3,(H,16,19)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361143
PNG
(CHEMBL1933772)
Show SMILES CCN(CC)c1ccc(cc1)-c1c(C)[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C19H22N4O/c1-4-22(5-2)16-11-9-15(10-12-16)18-14(3)21-23(19(18)24)17-8-6-7-13-20-17/h6-13,21H,4-5H2,1-3H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361101
PNG
(CHEMBL1933778)
Show SMILES Cc1[nH]n(Cc2ccccn2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C16H15N3O/c1-12-15(13-7-3-2-4-8-13)16(20)19(18-12)11-14-9-5-6-10-17-14/h2-10,18H,11H2,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361113
PNG
(CHEMBL1933790)
Show SMILES Cc1cccc2sc(nc12)-n1[nH]c2CCc3ccccc3-c2c1=O
Show InChI InChI=1S/C19H15N3OS/c1-11-5-4-8-15-17(11)20-19(24-15)22-18(23)16-13-7-3-2-6-12(13)9-10-14(16)21-22/h2-8,21H,9-10H2,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair
Natural resistance-associated macrophage protein 2


(Homo sapiens)
BDBM50361142
PNG
(CHEMBL1933771)
Show SMILES Cc1[nH]n(-c2ccccn2)c(=O)c1-c1ccc(N)cc1
Show InChI InChI=1S/C15H14N4O/c1-10-14(11-5-7-12(16)8-6-11)15(20)19(18-10)13-4-2-3-9-17-13/h2-9,18H,16H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method


Citation and Details
More data for this
Ligand-Target Pair