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Found 10 hits Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50339937
PNG
(1,1',1''-(5,5',5''-(benzene-1,3,5-triyl)tris(penta...)
Show SMILES C(CCc1cc(CCCCC[n+]2cccc(c2)-c2ccccc2)cc(CCCCC[n+]2cccc(c2)-c2ccccc2)c1)CC[n+]1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C54H60N3/c1-10-25-49(26-11-1)52-31-19-37-55(43-52)34-16-4-7-22-46-40-47(23-8-5-17-35-56-38-20-32-53(44-56)50-27-12-2-13-28-50)42-48(41-46)24-9-6-18-36-57-39-21-33-54(45-57)51-29-14-3-15-30-51/h1-3,10-15,19-21,25-33,37-45H,4-9,16-18,22-24,34-36H2/q+3
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Article
PubMed
n/an/a 0.560n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Antagonist activity at alpha9/alpha10 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiolog...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50339933
PNG
(1,1',1'',1'''-(5,5',5'',5'''-(benzene-1,2,4,5-tetr...)
Show SMILES C(CC#Cc1cc(C#CCCC[n+]2cccc(c2)-c2ccccc2)c(cc1C#CCCC[n+]1cccc(c1)-c1ccccc1)C#CCCC[n+]1cccc(c1)-c1ccccc1)C[n+]1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C70H62N4/c1-9-29-59(30-10-1)67-41-25-49-71(55-67)45-21-5-17-37-63-53-65(39-19-7-23-47-73-51-27-43-69(57-73)61-33-13-3-14-34-61)66(40-20-8-24-48-74-52-28-44-70(58-74)62-35-15-4-16-36-62)54-64(63)38-18-6-22-46-72-50-26-42-68(56-72)60-31-11-2-12-32-60/h1-4,9-16,25-36,41-44,49-58H,5-8,21-24,45-48H2/q+4
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PubMed
n/an/a 1.70n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Antagonist activity at alpha9/alpha10 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiolog...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50339936
PNG
(2,2',2''-(5,5',5''-(benzene-1,3,5-triyl)tris(penta...)
Show SMILES C(CCc1cc(CCCCC[n+]2ccc3ccccc3c2)cc(CCCCC[n+]2ccc3ccccc3c2)c1)CC[n+]1ccc2ccccc2c1
Show InChI InChI=1S/C48H54N3/c1(13-28-49-31-25-43-19-7-10-22-46(43)37-49)4-16-40-34-41(17-5-2-14-29-50-32-26-44-20-8-11-23-47(44)38-50)36-42(35-40)18-6-3-15-30-51-33-27-45-21-9-12-24-48(45)39-51/h7-12,19-27,31-39H,1-6,13-18,28-30H2/q+3
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n/an/a 3.70n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Antagonist activity at alpha9/alpha10 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiolog...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50339934
PNG
(1,1'-(3,3'-(biphenyl-4,4'-diyl)bis(propane-3,1-diy...)
Show SMILES Cc1cc[n+](CCCc2ccc(cc2)-c2ccc(CCC[n+]3ccc(C)c(C)c3)cc2)cc1C
Show InChI InChI=1S/C32H38N2/c1-25-17-21-33(23-27(25)3)19-5-7-29-9-13-31(14-10-29)32-15-11-30(12-16-32)8-6-20-34-22-18-26(2)28(4)24-34/h9-18,21-24H,5-8,19-20H2,1-4H3/q+2
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PubMed
n/an/a 4.20n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Antagonist activity at alpha9/alpha10 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiolog...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50339935
PNG
(1,1',1''-(5,5',5''-(benzene-1,3,5-triyl)tris(penta...)
Show SMILES C(CCc1cc(CCCCC[n+]2cccc3ccccc23)cc(CCCCC[n+]2cccc3ccccc23)c1)CC[n+]1cccc2ccccc12
Show InChI InChI=1S/C48H54N3/c1(13-31-49-34-16-25-43-22-7-10-28-46(43)49)4-19-40-37-41(20-5-2-14-32-50-35-17-26-44-23-8-11-29-47(44)50)39-42(38-40)21-6-3-15-33-51-36-18-27-45-24-9-12-30-48(45)51/h7-12,16-18,22-30,34-39H,1-6,13-15,19-21,31-33H2/q+3
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PubMed
n/an/a 4.80n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Antagonist activity at alpha9/alpha10 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiolog...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50445328
PNG
(CHEMBL3104241)
Show SMILES NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCCN=C(N)N)NC2=O)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC1=O
Show InChI InChI=1S/C59H96N26O17S4/c60-22-42(88)74-37-24-103-104-26-39-52(99)77-31(7-2-16-71-57(64)65)45(92)79-34(20-28-11-13-29(87)14-12-28)48(95)76-32(8-3-17-72-58(66)67)46(93)82-38(51(98)75-30(44(61)91)6-1-15-70-56(62)63)25-105-106-27-40(84-50(37)97)53(100)81-36(23-86)49(96)80-35(21-43(89)90)55(102)85-19-5-10-41(85)54(101)78-33(47(94)83-39)9-4-18-73-59(68)69/h11-14,30-41,86-87H,1-10,15-27,60H2,(H2,61,91)(H,74,88)(H,75,98)(H,76,95)(H,77,99)(H,78,101)(H,79,92)(H,80,96)(H,81,100)(H,82,93)(H,83,94)(H,84,97)(H,89,90)(H4,62,63,70)(H4,64,65,71)(H4,66,67,72)(H4,68,69,73)/t30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
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PubMed
n/an/a 5.20n/an/an/an/an/an/a



Hainan University

Curated by ChEMBL


Assay Description
Inhibition of alpha9alpha10 (unknown origin) nAChR


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50339938
PNG
(1,1',1'',1'''-(5,5',5'',5'''-(benzene-1,2,4,5-tetr...)
Show SMILES C(CCc1cc(CCCCC[n+]2cccc(c2)-c2ccccc2)c(CCCCC[n+]2cccc(c2)-c2ccccc2)cc1CCCCC[n+]1cccc(c1)-c1ccccc1)CC[n+]1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C70H78N4/c1-9-29-59(30-10-1)67-41-25-49-71(55-67)45-21-5-17-37-63-53-65(39-19-7-23-47-73-51-27-43-69(57-73)61-33-13-3-14-34-61)66(40-20-8-24-48-74-52-28-44-70(58-74)62-35-15-4-16-36-62)54-64(63)38-18-6-22-46-72-50-26-42-68(56-72)60-31-11-2-12-32-60/h1-4,9-16,25-36,41-44,49-58H,5-8,17-24,37-40,45-48H2/q+4
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PC sid
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Article
PubMed
n/an/a 5.40n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Antagonist activity at alpha9/alpha10 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiolog...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50339931
PNG
(1,1'-(3,3'-(biphenyl-4,4'-diyl)bis(prop-2-yne-3,1-...)
Show SMILES Cc1cc[n+](CC#Cc2ccc(cc2)-c2ccc(cc2)C#CC[n+]2ccc(C)c(C)c2)cc1C
Show InChI InChI=1S/C32H30N2/c1-25-17-21-33(23-27(25)3)19-5-7-29-9-13-31(14-10-29)32-15-11-30(12-16-32)8-6-20-34-22-18-26(2)28(4)24-34/h9-18,21-24H,19-20H2,1-4H3/q+2
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PubMed
n/an/a 16n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Antagonist activity at alpha9/alpha10 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiolog...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50339932
PNG
(1,1',1''-(5,5',5''-(benzene-1,3,5-triyl)tris(pent-...)
Show SMILES C(CC#Cc1cc(cc(c1)C#CCCC[n+]1cccc(c1)-c1ccccc1)C#CCCC[n+]1cccc(c1)-c1ccccc1)C[n+]1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C54H48N3/c1-10-25-49(26-11-1)52-31-19-37-55(43-52)34-16-4-7-22-46-40-47(23-8-5-17-35-56-38-20-32-53(44-56)50-27-12-2-13-28-50)42-48(41-46)24-9-6-18-36-57-39-21-33-54(45-57)51-29-14-3-15-30-51/h1-3,10-15,19-21,25-33,37-45H,4-6,16-18,34-36H2/q+3
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PubMed
n/an/a 670n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Antagonist activity at alpha9/alpha10 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiolog...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit


(Homo sapiens)
BDBM50445329
PNG
(CHEMBL3104242)
Show SMILES C[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)CN)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC1=O)C(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2
Show InChI InChI=1S/C52H78N20O15S4/c1-24-41(78)66-30(15-25-18-61-27-8-3-2-7-26(25)27)44(81)64-28(9-4-12-59-51(55)56)42(79)69-33(40(54)77)20-88-90-23-36-48(85)68-32(19-73)45(82)67-31(16-39(75)76)50(87)72-14-6-11-37(72)49(86)65-29(10-5-13-60-52(57)58)43(80)70-35(46(83)62-24)22-91-89-21-34(47(84)71-36)63-38(74)17-53/h2-3,7-8,18,24,28-37,61,73H,4-6,9-17,19-23,53H2,1H3,(H2,54,77)(H,62,83)(H,63,74)(H,64,81)(H,65,86)(H,66,78)(H,67,82)(H,68,85)(H,69,79)(H,70,80)(H,71,84)(H,75,76)(H4,55,56,59)(H4,57,58,60)/t24-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-/m0/s1
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PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Hainan University

Curated by ChEMBL


Assay Description
Inhibition of human alpha9alpha10 nAChR


Citation and Details
More data for this
Ligand-Target Pair