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Found 21 hits Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor subunit beta-2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006632
PNG
(CHEMBL3235508)
Show SMILES Br.Oc1cc2CCN3CC[C@@H]4CCCC[C@]34c2cc1O
Show InChI InChI=1S/C16H21NO2.BrH/c18-14-9-11-4-7-17-8-5-12-3-1-2-6-16(12,17)13(11)10-15(14)19;/h9-10,12,18-19H,1-8H2;1H/t12-,16-;/m0./s1
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n/an/a 580n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006630
PNG
(CHEMBL3235506)
Show SMILES COc1cc2c(CCN3CC[C@@H]4CCCC[C@]234)cc1O
Show InChI InChI=1S/C17H23NO2/c1-20-16-11-14-12(10-15(16)19)5-8-18-9-6-13-4-2-3-7-17(13,14)18/h10-11,13,19H,2-9H2,1H3/t13-,17-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006638
PNG
(CHEMBL2140445)
Show SMILES CN1CCc2cc3OCOc3cc2C1
Show InChI InChI=1S/C11H13NO2/c1-12-3-2-8-4-10-11(14-7-13-10)5-9(8)6-12/h4-5H,2-3,6-7H2,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006631
PNG
(CHEMBL3235507)
Show SMILES COc1cc2CCN3CC[C@@H]4CCCC[C@]34c2cc1O
Show InChI InChI=1S/C17H23NO2/c1-20-16-10-12-5-8-18-9-6-13-4-2-3-7-17(13,18)14(12)11-15(16)19/h10-11,13,19H,2-9H2,1H3/t13-,17-/m0/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006634
PNG
(CHEMBL3235510)
Show SMILES C1CC2N(C1)CCc1cc3OCOc3cc21
Show InChI InChI=1S/C13H15NO2/c1-2-11-10-7-13-12(15-8-16-13)6-9(10)3-5-14(11)4-1/h6-7,11H,1-5,8H2
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006640
PNG
(CHEMBL593001)
Show SMILES COc1cc2CCN(C)Cc2cc1O
Show InChI InChI=1S/C11H15NO2/c1-12-4-3-8-6-11(14-2)10(13)5-9(8)7-12/h5-6,13H,3-4,7H2,1-2H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006629
PNG
(CHEMBL3235505)
Show SMILES C1Oc2cc3CCN4CC[C@@H]5CCCC[C@]45c3cc2O1
Show InChI InChI=1S/C17H21NO2/c1-2-6-17-13(3-1)5-8-18(17)7-4-12-9-15-16(10-14(12)17)20-11-19-15/h9-10,13H,1-8,11H2/t13-,17-/m0/s1
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n/an/a 9.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50014648
PNG
(6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquino...)
Show SMILES COc1cc2CCN(C)Cc2cc1OC
Show InChI InChI=1S/C12H17NO2/c1-13-5-4-9-6-11(14-2)12(15-3)7-10(9)8-13/h6-7H,4-5,8H2,1-3H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50014647
PNG
(1,2-Dimethyl-1,2,3,4-tetrahydro-isoquinoline-6,7-d...)
Show SMILES CN1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C10H13NO2/c1-11-3-2-7-4-9(12)10(13)5-8(7)6-11/h4-5,12-13H,2-3,6H2,1H3
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006636
PNG
(CHEMBL3235512)
Show SMILES COc1cc2CCN3CCCC3c2cc1O
Show InChI InChI=1S/C13H17NO2/c1-16-13-7-9-4-6-14-5-2-3-11(14)10(9)8-12(13)15/h7-8,11,15H,2-6H2,1H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006633
PNG
(CHEMBL3235509)
Show SMILES COc1cc2CCN3CCCC3c2cc1OC
Show InChI InChI=1S/C14H19NO2/c1-16-13-8-10-5-7-15-6-3-4-12(15)11(10)9-14(13)17-2/h8-9,12H,3-7H2,1-2H3
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006639
PNG
(CHEMBL3235514)
Show SMILES COc1cc2CN(C)CCc2cc1O
Show InChI InChI=1S/C11H15NO2/c1-12-4-3-8-5-10(13)11(14-2)6-9(8)7-12/h5-6,13H,3-4,7H2,1-2H3
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n/an/a 3.30E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006635
PNG
(CHEMBL3235511)
Show SMILES COc1cc2C3CCCN3CCc2cc1O
Show InChI InChI=1S/C13H17NO2/c1-16-13-8-10-9(7-12(13)15)4-6-14-5-2-3-11(10)14/h7-8,11,15H,2-6H2,1H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006637
PNG
(CHEMBL3235513)
Show SMILES Br.Oc1cc2CCN3CCCC3c2cc1O
Show InChI InChI=1S/C12H15NO2.BrH/c14-11-6-8-3-5-13-4-1-2-10(13)9(8)7-12(11)15;/h6-7,10,14-15H,1-5H2;1H
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006641
PNG
(CHEMBL3235515)
Show SMILES CCC1N(C)CCc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C14H21NO2/c1-5-12-11-9-14(17-4)13(16-3)8-10(11)6-7-15(12)2/h8-9,12H,5-7H2,1-4H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006642
PNG
(CHEMBL2385327)
Show SMILES CCCCC1N(C)CCc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C16H25NO2/c1-5-6-7-14-13-11-16(19-4)15(18-3)10-12(13)8-9-17(14)2/h10-11,14H,5-9H2,1-4H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006643
PNG
(CHEMBL3235516)
Show SMILES COc1cc2CCN(C)C(C3CCCCC3)c2cc1OC
Show InChI InChI=1S/C18H27NO2/c1-19-10-9-14-11-16(20-2)17(21-3)12-15(14)18(19)13-7-5-4-6-8-13/h11-13,18H,4-10H2,1-3H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006644
PNG
(CHEMBL3235517)
Show SMILES COc1cc2CCN(C)C(c3ccccc3)c2cc1OC
Show InChI InChI=1S/C18H21NO2/c1-19-10-9-14-11-16(20-2)17(21-3)12-15(14)18(19)13-7-5-4-6-8-13/h4-8,11-12,18H,9-10H2,1-3H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006645
PNG
(CHEMBL3235518)
Show SMILES COc1cccc(c1)C1N(C)CCc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C19H23NO3/c1-20-9-8-13-11-17(22-3)18(23-4)12-16(13)19(20)14-6-5-7-15(10-14)21-2/h5-7,10-12,19H,8-9H2,1-4H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit beta-2


(Mus musculus)
BDBM50006646
PNG
(CHEMBL3235519)
Show SMILES COc1ccc(cc1OC)C1N(C)CCc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C20H25NO4/c1-21-9-8-13-10-18(24-4)19(25-5)12-15(13)20(21)14-6-7-16(22-2)17(11-14)23-3/h6-7,10-12,20H,8-9H2,1-5H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor beta-2 (β2 nAChR)


(Homo sapiens (Human))
BDBM50336020
PNG
(CHEMBL1669092 | N,N,N-trimethyl-1-(4-styrylphenoxy...)
Show SMILES CC(COc1ccc(\C=C/c2ccccc2)cc1)[N+](C)(C)C
Show InChI InChI=1S/C20H26NO/c1-17(21(2,3)4)16-22-20-14-12-19(13-15-20)11-10-18-8-6-5-7-9-18/h5-15,17H,16H2,1-4H3/q+1/b11-10-
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3.90E+4n/an/an/an/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to beta2 nAChR


Citation and Details
More data for this
Ligand-Target Pair