BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1619 hits Enz. Inhib. hit(s) with Target = 'Neuropeptide Y receptor type 5'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141347
PNG
(US8916594, I-024)
Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccccc1
Show InChI InChI=1/C18H26N4O3S/c1-13(2)26(23,24)19-12-14-8-10-16(11-9-14)20-18-21-17(22-25-18)15-6-4-3-5-7-15/h3-7,13-14,16,19H,8-12H2,1-2H3,(H,20,21,22)/t14-,16-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.130n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390219
PNG
(CHEMBL2070148)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(F)c(c1)-c1ccccc1
Show InChI InChI=1S/C21H17FN2O2S/c1-2-27(25,26)16-9-11-19-20(13-16)24-21(23-19)15-8-10-18(22)17(12-15)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.160n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390216
PNG
(CHEMBL2070151)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(Cl)c(c1)-c1ccccc1
Show InChI InChI=1S/C21H17ClN2O2S/c1-2-27(25,26)16-9-11-19-20(13-16)24-21(23-19)15-8-10-18(22)17(12-15)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.160n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141350
PNG
(US8916594, I-034)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccc(F)cc1F
Show InChI InChI=1/C17H22F2N4O3S/c1-2-27(24,25)20-10-11-3-6-13(7-4-11)21-17-22-16(23-26-17)14-8-5-12(18)9-15(14)19/h5,8-9,11,13,20H,2-4,6-7,10H2,1H3,(H,21,22,23)/t11-,13-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.180n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141345
PNG
(US8916594, I-018)
Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cccc(F)c1
Show InChI InChI=1/C18H25FN4O3S/c1-12(2)27(24,25)20-11-13-6-8-16(9-7-13)21-18-22-17(23-26-18)14-4-3-5-15(19)10-14/h3-5,10,12-13,16,20H,6-9,11H2,1-2H3,(H,21,22,23)/t13-,16-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390213
PNG
(CHEMBL2069316)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(C)c(c1)-c1ccccc1
Show InChI InChI=1S/C22H20N2O2S/c1-3-27(25,26)18-11-12-20-21(14-18)24-22(23-20)17-10-9-15(2)19(13-17)16-7-5-4-6-8-16/h4-14H,3H2,1-2H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258001
PNG
(CHEMBL492370 | N-(3,4-dichlorophenyl)-1-(methylsul...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(Cl)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C20H21Cl2N3O3S/c1-29(27,28)25-13-20(15-4-2-3-5-18(15)25)8-10-24(11-9-20)19(26)23-14-6-7-16(21)17(22)12-14/h2-7,12H,8-11,13H2,1H3,(H,23,26)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093652
PNG
(2-Methyl-6-pentyl-4-piperidin-1-yl-5H-pyrrolo[3,2-...)
Show SMILES CCCCCc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C17H26N4/c1-3-4-6-9-14-12-15-16(20-14)17(19-13(2)18-15)21-10-7-5-8-11-21/h12,20H,3-11H2,1-2H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394224
PNG
(CHEMBL2159167)
Show SMILES FC(F)(F)CS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C19H18F3N3O3S/c20-19(21,22)12-29(26,27)14-6-7-15-16(10-14)24-18(23-15)25-8-9-28-17(11-25)13-4-2-1-3-5-13/h1-7,10,17H,8-9,11-12H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.210n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141349
PNG
(US8916594, I-029)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccc(F)c(F)c1
Show InChI InChI=1/C17H22F2N4O3S/c1-2-27(24,25)20-10-11-3-6-13(7-4-11)21-17-22-16(23-26-17)12-5-8-14(18)15(19)9-12/h5,8-9,11,13,20H,2-4,6-7,10H2,1H3,(H,21,22,23)/t11-,13-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.220n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141344
PNG
(US8916594, I-017)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cccc(F)c1
Show InChI InChI=1/C17H23FN4O3S/c1-2-26(23,24)19-11-12-6-8-15(9-7-12)20-17-21-16(22-25-17)13-4-3-5-14(18)10-13/h3-5,10,12,15,19H,2,6-9,11H2,1H3,(H,20,21,22)/t12-,15-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.220n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50111656
PNG
(1-[2-(5-Chloro-2-oxo-benzothiazol-3-yl)-acetyl]-pi...)
Show SMILES Clc1ccc2sc(=O)n(CC(=O)N3CCC(CC3)C(=O)Nc3ccc(Cl)c4ccccc34)c2c1
Show InChI InChI=1S/C25H21Cl2N3O3S/c26-16-5-8-22-21(13-16)30(25(33)34-22)14-23(31)29-11-9-15(10-12-29)24(32)28-20-7-6-19(27)17-3-1-2-4-18(17)20/h1-8,13,15H,9-12,14H2,(H,28,32)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.230n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Tested for the inhibition of [125I]-PYY binding to HEK 293 cells stably expressed with human neuropeptide NPY Y5 receptor


Bioorg Med Chem Lett 12: 1171-5 (2002)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141351
PNG
(US8916594, I-053)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cc(F)cc(F)c1
Show InChI InChI=1/C17H22F2N4O3S/c1-2-27(24,25)20-10-11-3-5-15(6-4-11)21-17-22-16(23-26-17)12-7-13(18)9-14(19)8-12/h7-9,11,15,20H,2-6,10H2,1H3,(H,21,22,23)/t11-,15-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.230n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118179
PNG
(US8653125, Ia-40)
Show SMILES Clc1ccc(cc1Cl)-c1c[nH]c(n1)[C@@H]1CC[C@@H](CC1)NC(=O)c1ccon1
Show InChI InChI=1S/C19H18Cl2N4O2/c20-14-6-3-12(9-15(14)21)17-10-22-18(24-17)11-1-4-13(5-2-11)23-19(26)16-7-8-27-25-16/h3,6-11,13H,1-2,4-5H2,(H,22,24)(H,23,26)/t11-,13+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.260n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394211
PNG
(CHEMBL2159165)
Show SMILES CC(C)CS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C21H25N3O3S/c1-15(2)14-28(25,26)17-8-9-18-19(12-17)23-21(22-18)24-10-11-27-20(13-24)16-6-4-3-5-7-16/h3-9,12,15,20H,10-11,13-14H2,1-2H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.280n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394221
PNG
(CHEMBL2159158)
Show SMILES CCCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCCC(C1)c1ccccc1
Show InChI InChI=1S/C21H25N3O2S/c1-2-13-27(25,26)18-10-11-19-20(14-18)23-21(22-19)24-12-6-9-17(15-24)16-7-4-3-5-8-16/h3-5,7-8,10-11,14,17H,2,6,9,12-13,15H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.290n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390228
PNG
(CHEMBL2070161)
Show SMILES FC(F)(F)CS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(=O)n(c1)-c1ccccc1
Show InChI InChI=1S/C20H14F3N3O3S/c21-20(22,23)12-30(28,29)15-7-8-16-17(10-15)25-19(24-16)13-6-9-18(27)26(11-13)14-4-2-1-3-5-14/h1-11H,12H2,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.290n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093646
PNG
(6-Benzofuran-2-yl-2-methyl-4-piperidin-1-yl-5H-pyr...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc2ccccc2o1
Show InChI InChI=1S/C20H20N4O/c1-13-21-16-12-15(18-11-14-7-3-4-8-17(14)25-18)23-19(16)20(22-13)24-9-5-2-6-10-24/h3-4,7-8,11-12,23H,2,5-6,9-10H2,1H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093664
PNG
(6-(4-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-5-7-14(19)8-6-13)22-17(16)18(21-12)23-9-3-2-4-10-23/h5-8,11,22H,2-4,9-10H2,1H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093696
PNG
(6-(3-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-6-5-7-14(19)10-13)22-17(16)18(21-12)23-8-3-2-4-9-23/h5-7,10-11,22H,2-4,8-9H2,1H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390232
PNG
(CHEMBL2070157)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccnc(c1)-c1ccccc1
Show InChI InChI=1S/C20H17N3O2S/c1-2-26(24,25)16-8-9-17-19(13-16)23-20(22-17)15-10-11-21-18(12-15)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.310n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141342
PNG
(US8916594, I-006)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccc(F)cc1
Show InChI InChI=1/C17H23FN4O3S/c1-2-26(23,24)19-11-12-3-9-15(10-4-12)20-17-21-16(22-25-17)13-5-7-14(18)8-6-13/h5-8,12,15,19H,2-4,9-11H2,1H3,(H,20,21,22)/t12-,15-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.320n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141343
PNG
(US8916594, I-011)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccccc1
Show InChI InChI=1/C17H24N4O3S/c1-2-25(22,23)18-12-13-8-10-15(11-9-13)19-17-20-16(21-24-17)14-6-4-3-5-7-14/h3-7,13,15,18H,2,8-12H2,1H3,(H,19,20,21)/t13-,15-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.340n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093675
PNG
(6-(3,5-Difluoro-phenyl)-2-methyl-4-piperidin-1-yl-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H18F2N4/c1-11-21-16-10-15(12-7-13(19)9-14(20)8-12)23-17(16)18(22-11)24-5-3-2-4-6-24/h7-10,23H,2-6H2,1H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093691
PNG
(4-(3,6-Dihydro-2H-pyridin-1-yl)-2-methyl-6-phenyl-...)
Show SMILES Cc1nc(N2CCC=CC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H18N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h2-6,8-9,12,21H,7,10-11H2,1H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118190
PNG
(US8653125, Ic-16)
Show SMILES CC(C)n1c2ccc(NC(=O)[C@@H]3CC[C@@H](CC3)Oc3cc(ccn3)C(F)(F)F)cc2oc1=O
Show InChI InChI=1S/C23H24F3N3O4/c1-13(2)29-18-8-5-16(12-19(18)33-22(29)31)28-21(30)14-3-6-17(7-4-14)32-20-11-15(9-10-27-20)23(24,25)26/h5,8-14,17H,3-4,6-7H2,1-2H3,(H,28,30)/t14-,17+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.410n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394214
PNG
(CHEMBL2159162)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C19H21N3O3S/c1-2-26(23,24)15-8-9-16-17(12-15)21-19(20-16)22-10-11-25-18(13-22)14-6-4-3-5-7-14/h3-9,12,18H,2,10-11,13H2,1H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.430n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY-Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394214
PNG
(CHEMBL2159162)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C19H21N3O3S/c1-2-26(23,24)15-8-9-16-17(12-15)21-19(20-16)22-10-11-25-18(13-22)14-6-4-3-5-7-14/h3-9,12,18H,2,10-11,13H2,1H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.430n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390225
PNG
(CHEMBL2070140)
Show SMILES CCCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C22H20N2O2S/c1-2-13-27(25,26)19-11-12-20-21(15-19)24-22(23-20)18-10-6-9-17(14-18)16-7-4-3-5-8-16/h3-12,14-15H,2,13H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.430n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390222
PNG
(CHEMBL2070137)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H18N2O2S/c1-2-26(24,25)18-11-12-19-20(14-18)23-21(22-19)17-10-6-9-16(13-17)15-7-4-3-5-8-15/h3-14H,2H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.460n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50073048
PNG
(2-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperi...)
Show SMILES O=C(CN1CCC(CC1)n1c2ccccc2[nH]c1=O)Nc1ccc2C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C27H24N4O3/c32-25(28-17-9-10-21-22(15-17)19-5-1-2-6-20(19)26(21)33)16-30-13-11-18(12-14-30)31-24-8-4-3-7-23(24)29-27(31)34/h1-10,15,18H,11-14,16H2,(H,28,32)(H,29,34)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
PubMed
n/an/a 0.470n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound against human Neuropeptide Y receptor type 5 in HEK 293 cell line by using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50073048
PNG
(2-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperi...)
Show SMILES O=C(CN1CCC(CC1)n1c2ccccc2[nH]c1=O)Nc1ccc2C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C27H24N4O3/c32-25(28-17-9-10-21-22(15-17)19-5-1-2-6-20(19)26(21)33)16-30-13-11-18(12-14-30)31-24-8-4-3-7-23(24)29-27(31)34/h1-10,15,18H,11-14,16H2,(H,28,32)(H,29,34)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 0.470n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for the binding affinity against Neuropeptide Y receptor type 5 in rat


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141357
PNG
(US8916594, I-138)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C1(F)CCCC1
Show InChI InChI=1/C16H27FN4O3S/c1-2-25(22,23)18-11-12-5-7-13(8-6-12)19-15-20-14(21-24-15)16(17)9-3-4-10-16/h12-13,18H,2-11H2,1H3,(H,19,20,21)/t12-,13-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.5n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101571
PNG
(1-Methyl-1-(1-methyl-2-pyridin-4-yl-ethyl)-3-(4-ph...)
Show SMILES CC(Cc1ccncc1)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C22H23N3O2/c1-17(16-18-12-14-23-15-13-18)25(2)22(26)24-19-8-10-21(11-9-19)27-20-6-4-3-5-7-20/h3-15,17H,16H2,1-2H3,(H,24,26)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093647
PNG
(2-Methyl-6-(5-methyl-furan-2-yl)-4-piperidin-1-yl-...)
Show SMILES Cc1ccc(o1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C17H20N4O/c1-11-6-7-15(22-11)13-10-14-16(20-13)17(19-12(2)18-14)21-8-4-3-5-9-21/h6-7,10,20H,3-5,8-9H2,1-2H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093697
PNG
(2-Methyl-4-piperidin-1-yl-6-p-tolyl-5H-pyrrolo[3,2...)
Show SMILES Cc1ccc(cc1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C19H22N4/c1-13-6-8-15(9-7-13)16-12-17-18(22-16)19(21-14(2)20-17)23-10-4-3-5-11-23/h6-9,12,22H,3-5,10-11H2,1-2H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390220
PNG
(CHEMBL2070147)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cc(ccc1F)-c1ccccc1
Show InChI InChI=1S/C21H17FN2O2S/c1-2-27(25,26)16-9-11-19-20(13-16)24-21(23-19)17-12-15(8-10-18(17)22)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.540n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110571
PNG
(CHEMBL167991 | FR-230481 | Naphthalene-1-sulfonic ...)
Show SMILES COc1ccc2CCCC(O)(CNCC3CCN(CCNS(=O)(=O)c4cccc5ccccc45)CC3)c2c1
Show InChI InChI=1S/C30H39N3O4S/c1-37-26-12-11-25-8-5-15-30(34,28(25)20-26)22-31-21-23-13-17-33(18-14-23)19-16-32-38(35,36)29-10-4-7-24-6-2-3-9-27(24)29/h2-4,6-7,9-12,20,23,31-32,34H,5,8,13-19,21-22H2,1H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.540n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390234
PNG
(CHEMBL2070155)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cc(ccn1)-c1ccccc1
Show InChI InChI=1S/C20H17N3O2S/c1-2-26(24,25)16-8-9-17-18(13-16)23-20(22-17)19-12-15(10-11-21-19)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.550n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118188
PNG
(US8653125, Ic-13)
Show SMILES CC(C)n1c2ccc(NC(=O)[C@@H]3CC[C@@H](CC3)Oc3cc(Cl)ccc3C#N)cc2oc1=O
Show InChI InChI=1S/C24H24ClN3O4/c1-14(2)28-20-10-7-18(12-22(20)32-24(28)30)27-23(29)15-4-8-19(9-5-15)31-21-11-17(25)6-3-16(21)13-26/h3,6-7,10-12,14-15,19H,4-5,8-9H2,1-2H3,(H,27,29)/t15-,19+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.560n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258232
PNG
(1-(Methylsulfonyl)-N-(5-phenylpyrimidin-2-yl)-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ncc(cn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(20-9-5-6-10-21(20)29)11-13-28(14-12-24)23(30)27-22-25-15-19(16-26-22)18-7-3-2-4-8-18/h2-10,15-16H,11-14,17H2,1H3,(H,25,26,27,30)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.570n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258232
PNG
(1-(Methylsulfonyl)-N-(5-phenylpyrimidin-2-yl)-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ncc(cn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(20-9-5-6-10-21(20)29)11-13-28(14-12-24)23(30)27-22-25-15-19(16-26-22)18-7-3-2-4-8-18/h2-10,15-16H,11-14,17H2,1H3,(H,25,26,27,30)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.570n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118192
PNG
(US8653125, Id-8)
Show SMILES Fc1ccccc1-n1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)N2c3ccccc3OS2(=O)=O)n1
Show InChI InChI=1S/C22H21FN4O4S/c23-17-5-1-2-6-18(17)26-14-13-21(25-26)24-22(28)15-9-11-16(12-10-15)27-19-7-3-4-8-20(19)31-32(27,29)30/h1-8,13-16H,9-12H2,(H,24,25,28)/t15-,16+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.580n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50111645
PNG
(1-[2-(5-Chloro-2-oxo-benzothiazol-3-yl)-acetyl]-pi...)
Show SMILES Fc1ccc(NC(=O)C2CCN(CC2)C(=O)Cn2c3cc(Cl)ccc3sc2=O)cc1C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N3O3S/c23-13-1-4-18-17(9-13)30(21(33)34-18)11-19(31)29-7-5-12(6-8-29)20(32)28-14-2-3-16(24)15(10-14)22(25,26)27/h1-4,9-10,12H,5-8,11H2,(H,28,32)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.590n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with Human NPY-Y5 cDNA (compound prepared by manual s...


Bioorg Med Chem Lett 12: 1171-5 (2002)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50111644
PNG
(1-[2-(5-Chloro-2-oxo-benzothiazol-3-yl)-acetyl]-pi...)
Show SMILES CC(=O)c1cccc(NC(=O)C2CCN(CC2)C(=O)Cn2c3cc(Cl)ccc3sc2=O)c1
Show InChI InChI=1S/C23H22ClN3O4S/c1-14(28)16-3-2-4-18(11-16)25-22(30)15-7-9-26(10-8-15)21(29)13-27-19-12-17(24)5-6-20(19)32-23(27)31/h2-6,11-12,15H,7-10,13H2,1H3,(H,25,30)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.590n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with Human NPY-Y5 cDNA (compound prepared by manual s...


Bioorg Med Chem Lett 12: 1171-5 (2002)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50089055
PNG
(CHEMBL273811 | N*2*-(4-Ethanesulfonylmethyl-phenyl...)
Show SMILES CCS(=O)(=O)Cc1ccc(Nc2nc(Nc3ccccc3)c3ccccc3n2)cc1
Show InChI InChI=1S/C23H22N4O2S/c1-2-30(28,29)16-17-12-14-19(15-13-17)25-23-26-21-11-7-6-10-20(21)22(27-23)24-18-8-4-3-5-9-18/h3-15H,2,16H2,1H3,(H2,24,25,26,27)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Antagonistic activity against neuropeptide Y receptor type 5 subtype stably expressed in LM(tk-)cells


Bioorg Med Chem Lett 10: 1175-9 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394218
PNG
(CHEMBL2159156)
Show SMILES CCCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C20H23N3O3S/c1-2-12-27(24,25)16-8-9-17-18(13-16)22-20(21-17)23-10-11-26-19(14-23)15-6-4-3-5-7-15/h3-9,13,19H,2,10-12,14H2,1H3,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50354066
PNG
(CHEMBL1836324)
Show SMILES CCS(=O)(=O)NCCCCCNc1nc-2c(CCSc3ccccc-23)s1
Show InChI InChI=1S/C18H25N3O2S3/c1-2-26(22,23)20-12-7-3-6-11-19-18-21-17-14-8-4-5-9-15(14)24-13-10-16(17)25-18/h4-5,8-9,20H,2-3,6-7,10-13H2,1H3,(H,19,21)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141361
PNG
(US8916594, I-147)
Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C1(C)CC(F)(F)C1
Show InChI InChI=1/C17H28F2N4O3S/c1-11(2)27(24,25)20-8-12-4-6-13(7-5-12)21-15-22-14(23-26-15)16(3)9-17(18,19)10-16/h11-13,20H,4-10H2,1-3H3,(H,21,22,23)/t12-,13-
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.610n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50301643
PNG
(CHEMBL570633 | trans-3'-oxo-N-(5-phenylpyrimidin-2...)
Show SMILES O=C(Nc1ncc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21
Show InChI InChI=1S/C24H21N3O3/c28-21(27-23-25-14-18(15-26-23)16-6-2-1-3-7-16)17-10-12-24(13-11-17)20-9-5-4-8-19(20)22(29)30-24/h1-9,14-15,17H,10-13H2,(H,25,26,27,28)/t17-,24-
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.640n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk cells


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1619 total )  |  Next  |  Last  >>
Jump to: