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Found 181 hits Enz. Inhib. hit(s) with Target = 'Neuropeptide Y receptor type 5 (NPY Y5)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141347
PNG
(US8916594, I-024)
Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccccc1
Show InChI InChI=1/C18H26N4O3S/c1-13(2)26(23,24)19-12-14-8-10-16(11-9-14)20-18-21-17(22-25-18)15-6-4-3-5-7-15/h3-7,13-14,16,19H,8-12H2,1-2H3,(H,20,21,22)/t14-,16-
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US Patent
n/an/a 0.130n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390219
PNG
(CHEMBL2070148)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(F)c(c1)-c1ccccc1
Show InChI InChI=1S/C21H17FN2O2S/c1-2-27(25,26)16-9-11-19-20(13-16)24-21(23-19)15-8-10-18(22)17(12-15)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,23,24)
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n/an/a 0.160n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390216
PNG
(CHEMBL2070151)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(Cl)c(c1)-c1ccccc1
Show InChI InChI=1S/C21H17ClN2O2S/c1-2-27(25,26)16-9-11-19-20(13-16)24-21(23-19)15-8-10-18(22)17(12-15)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,23,24)
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n/an/a 0.160n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141350
PNG
(US8916594, I-034)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccc(F)cc1F
Show InChI InChI=1/C17H22F2N4O3S/c1-2-27(24,25)20-10-11-3-6-13(7-4-11)21-17-22-16(23-26-17)14-8-5-12(18)9-15(14)19/h5,8-9,11,13,20H,2-4,6-7,10H2,1H3,(H,21,22,23)/t11-,13-
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US Patent
n/an/a 0.180n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390213
PNG
(CHEMBL2069316)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(C)c(c1)-c1ccccc1
Show InChI InChI=1S/C22H20N2O2S/c1-3-27(25,26)18-11-12-20-21(14-18)24-22(23-20)17-10-9-15(2)19(13-17)16-7-5-4-6-8-16/h4-14H,3H2,1-2H3,(H,23,24)
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n/an/a 0.200n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141345
PNG
(US8916594, I-018)
Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cccc(F)c1
Show InChI InChI=1/C18H25FN4O3S/c1-12(2)27(24,25)20-11-13-6-8-16(9-7-13)21-18-22-17(23-26-18)14-4-3-5-15(19)10-14/h3-5,10,12-13,16,20H,6-9,11H2,1-2H3,(H,21,22,23)/t13-,16-
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US Patent
n/an/a 0.200n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394224
PNG
(CHEMBL2159167)
Show SMILES FC(F)(F)CS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C19H18F3N3O3S/c20-19(21,22)12-29(26,27)14-6-7-15-16(10-14)24-18(23-15)25-8-9-28-17(11-25)13-4-2-1-3-5-13/h1-7,10,17H,8-9,11-12H2,(H,23,24)
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n/an/a 0.210n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141344
PNG
(US8916594, I-017)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cccc(F)c1
Show InChI InChI=1/C17H23FN4O3S/c1-2-26(23,24)19-11-12-6-8-15(9-7-12)20-17-21-16(22-25-17)13-4-3-5-14(18)10-13/h3-5,10,12,15,19H,2,6-9,11H2,1H3,(H,20,21,22)/t12-,15-
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US Patent
n/an/a 0.220n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141349
PNG
(US8916594, I-029)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccc(F)c(F)c1
Show InChI InChI=1/C17H22F2N4O3S/c1-2-27(24,25)20-10-11-3-6-13(7-4-11)21-17-22-16(23-26-17)12-5-8-14(18)15(19)9-12/h5,8-9,11,13,20H,2-4,6-7,10H2,1H3,(H,21,22,23)/t11-,13-
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US Patent
n/an/a 0.220n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141351
PNG
(US8916594, I-053)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cc(F)cc(F)c1
Show InChI InChI=1/C17H22F2N4O3S/c1-2-27(24,25)20-10-11-3-5-15(6-4-11)21-17-22-16(23-26-17)12-7-13(18)9-14(19)8-12/h7-9,11,15,20H,2-6,10H2,1H3,(H,21,22,23)/t11-,15-
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US Patent
n/an/a 0.230n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118179
PNG
(US8653125, Ia-40)
Show SMILES Clc1ccc(cc1Cl)-c1c[nH]c(n1)[C@@H]1CC[C@@H](CC1)NC(=O)c1ccon1
Show InChI InChI=1S/C19H18Cl2N4O2/c20-14-6-3-12(9-15(14)21)17-10-22-18(24-17)11-1-4-13(5-2-11)23-19(26)16-7-8-27-25-16/h3,6-11,13H,1-2,4-5H2,(H,22,24)(H,23,26)/t11-,13+
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US Patent
n/an/a 0.260n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394211
PNG
(CHEMBL2159165)
Show SMILES CC(C)CS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C21H25N3O3S/c1-15(2)14-28(25,26)17-8-9-18-19(12-17)23-21(22-18)24-10-11-27-20(13-24)16-6-4-3-5-7-16/h3-9,12,15,20H,10-11,13-14H2,1-2H3,(H,22,23)
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n/an/a 0.280n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390228
PNG
(CHEMBL2070161)
Show SMILES FC(F)(F)CS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(=O)n(c1)-c1ccccc1
Show InChI InChI=1S/C20H14F3N3O3S/c21-20(22,23)12-30(28,29)15-7-8-16-17(10-15)25-19(24-16)13-6-9-18(27)26(11-13)14-4-2-1-3-5-14/h1-11H,12H2,(H,24,25)
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n/an/a 0.290n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394221
PNG
(CHEMBL2159158)
Show SMILES CCCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCCC(C1)c1ccccc1
Show InChI InChI=1S/C21H25N3O2S/c1-2-13-27(25,26)18-10-11-19-20(14-18)23-21(22-19)24-12-6-9-17(15-24)16-7-4-3-5-8-16/h3-5,7-8,10-11,14,17H,2,6,9,12-13,15H2,1H3,(H,22,23)
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n/an/a 0.290n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390232
PNG
(CHEMBL2070157)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccnc(c1)-c1ccccc1
Show InChI InChI=1S/C20H17N3O2S/c1-2-26(24,25)16-8-9-17-19(13-16)23-20(22-17)15-10-11-21-18(12-15)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,22,23)
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n/an/a 0.310n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141342
PNG
(US8916594, I-006)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccc(F)cc1
Show InChI InChI=1/C17H23FN4O3S/c1-2-26(23,24)19-11-12-3-9-15(10-4-12)20-17-21-16(22-25-17)13-5-7-14(18)8-6-13/h5-8,12,15,19H,2-4,9-11H2,1H3,(H,20,21,22)/t12-,15-
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US Patent
n/an/a 0.320n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141343
PNG
(US8916594, I-011)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccccc1
Show InChI InChI=1/C17H24N4O3S/c1-2-25(22,23)18-12-13-8-10-15(11-9-13)19-17-20-16(21-24-17)14-6-4-3-5-7-14/h3-7,13,15,18H,2,8-12H2,1H3,(H,19,20,21)/t13-,15-
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n/an/a 0.340n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118190
PNG
(US8653125, Ic-16)
Show SMILES CC(C)n1c2ccc(NC(=O)[C@@H]3CC[C@@H](CC3)Oc3cc(ccn3)C(F)(F)F)cc2oc1=O
Show InChI InChI=1S/C23H24F3N3O4/c1-13(2)29-18-8-5-16(12-19(18)33-22(29)31)28-21(30)14-3-6-17(7-4-14)32-20-11-15(9-10-27-20)23(24,25)26/h5,8-14,17H,3-4,6-7H2,1-2H3,(H,28,30)/t14-,17+
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n/an/a 0.410n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394214
PNG
(CHEMBL2159162)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C19H21N3O3S/c1-2-26(23,24)15-8-9-16-17(12-15)21-19(20-16)22-10-11-25-18(13-22)14-6-4-3-5-7-14/h3-9,12,18H,2,10-11,13H2,1H3,(H,20,21)
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n/an/a 0.430n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390225
PNG
(CHEMBL2070140)
Show SMILES CCCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C22H20N2O2S/c1-2-13-27(25,26)19-11-12-20-21(15-19)24-22(23-20)18-10-6-9-17(14-18)16-7-4-3-5-8-16/h3-12,14-15H,2,13H2,1H3,(H,23,24)
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n/an/a 0.430n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394214
PNG
(CHEMBL2159162)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C19H21N3O3S/c1-2-26(23,24)15-8-9-16-17(12-15)21-19(20-16)22-10-11-25-18(13-22)14-6-4-3-5-7-14/h3-9,12,18H,2,10-11,13H2,1H3,(H,20,21)
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n/an/a 0.430n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY-Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390222
PNG
(CHEMBL2070137)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H18N2O2S/c1-2-26(24,25)18-11-12-19-20(14-18)23-21(22-19)17-10-6-9-16(13-17)15-7-4-3-5-8-15/h3-14H,2H2,1H3,(H,22,23)
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n/an/a 0.460n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141357
PNG
(US8916594, I-138)
Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C1(F)CCCC1
Show InChI InChI=1/C16H27FN4O3S/c1-2-25(22,23)18-11-12-5-7-13(8-6-12)19-15-20-14(21-24-15)16(17)9-3-4-10-16/h12-13,18H,2-11H2,1H3,(H,19,20,21)/t12-,13-
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US Patent
n/an/a 0.5n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390220
PNG
(CHEMBL2070147)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cc(ccc1F)-c1ccccc1
Show InChI InChI=1S/C21H17FN2O2S/c1-2-27(25,26)16-9-11-19-20(13-16)24-21(23-19)17-12-15(8-10-18(17)22)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,23,24)
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n/an/a 0.540n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50390234
PNG
(CHEMBL2070155)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cc(ccn1)-c1ccccc1
Show InChI InChI=1S/C20H17N3O2S/c1-2-26(24,25)16-8-9-17-18(13-16)23-20(22-17)19-12-15(10-11-21-19)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,22,23)
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n/an/a 0.550n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118188
PNG
(US8653125, Ic-13)
Show SMILES CC(C)n1c2ccc(NC(=O)[C@@H]3CC[C@@H](CC3)Oc3cc(Cl)ccc3C#N)cc2oc1=O
Show InChI InChI=1S/C24H24ClN3O4/c1-14(2)28-20-10-7-18(12-22(20)32-24(28)30)27-23(29)15-4-8-19(9-5-15)31-21-11-17(25)6-3-16(21)13-26/h3,6-7,10-12,14-15,19H,4-5,8-9H2,1-2H3,(H,27,29)/t15-,19+
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US Patent
n/an/a 0.560n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118192
PNG
(US8653125, Id-8)
Show SMILES Fc1ccccc1-n1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)N2c3ccccc3OS2(=O)=O)n1
Show InChI InChI=1S/C22H21FN4O4S/c23-17-5-1-2-6-18(17)26-14-13-21(25-26)24-22(28)15-9-11-16(12-10-15)27-19-7-3-4-8-20(19)31-32(27,29)30/h1-8,13-16H,9-12H2,(H,24,25,28)/t15-,16+
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n/an/a 0.580n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394218
PNG
(CHEMBL2159156)
Show SMILES CCCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C20H23N3O3S/c1-2-12-27(24,25)16-8-9-17-18(13-16)22-20(21-17)23-10-11-26-19(14-23)15-6-4-3-5-7-15/h3-9,13,19H,2,10-12,14H2,1H3,(H,21,22)
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n/an/a 0.600n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141361
PNG
(US8916594, I-147)
Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C1(C)CC(F)(F)C1
Show InChI InChI=1/C17H28F2N4O3S/c1-11(2)27(24,25)20-8-12-4-6-13(7-5-12)21-15-22-14(23-26-15)16(3)9-17(18,19)10-16/h11-13,20H,4-10H2,1-3H3,(H,21,22,23)/t12-,13-
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n/an/a 0.610n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118178
PNG
(US8653125, Ia-35)
Show SMILES O=C(Nc1ccc(cc1)-c1ccccc1)[C@@H]1CC[C@@H](CC1)NC(=O)c1ccon1
Show InChI InChI=1S/C23H23N3O3/c27-22(24-19-10-6-17(7-11-19)16-4-2-1-3-5-16)18-8-12-20(13-9-18)25-23(28)21-14-15-29-26-21/h1-7,10-11,14-15,18,20H,8-9,12-13H2,(H,24,27)(H,25,28)/t18-,20+
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n/an/a 0.650n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141364
PNG
(US8916594, I-152)
Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C(F)(F)C(F)(F)F
Show InChI InChI=1/C14H21F5N4O3S/c1-8(2)27(24,25)20-7-9-3-5-10(6-4-9)21-12-22-11(23-26-12)13(15,16)14(17,18)19/h8-10,20H,3-7H2,1-2H3,(H,21,22,23)/t9-,10-
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US Patent
n/an/a 0.650n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118189
PNG
(US8653125, Ic-14)
Show SMILES CC(C)n1c2ccc(NC(=O)[C@@H]3CC[C@@H](CC3)Oc3cc(ccc3C#N)C(F)(F)F)cc2oc1=O
Show InChI InChI=1S/C25H24F3N3O4/c1-14(2)31-20-10-7-18(12-22(20)35-24(31)33)30-23(32)15-4-8-19(9-5-15)34-21-11-17(25(26,27)28)6-3-16(21)13-29/h3,6-7,10-12,14-15,19H,4-5,8-9H2,1-2H3,(H,30,32)/t15-,19+
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n/an/a 0.680n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118191
PNG
(US8653125, Ic-17)
Show SMILES Fc1ccccc1-n1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)Oc2cc(Cl)ccn2)n1
Show InChI InChI=1S/C21H20ClFN4O2/c22-15-9-11-24-20(13-15)29-16-7-5-14(6-8-16)21(28)25-19-10-12-27(26-19)18-4-2-1-3-17(18)23/h1-4,9-14,16H,5-8H2,(H,25,26,28)/t14-,16+
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n/an/a 0.690n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141355
PNG
(US8916594, I-130)
Show SMILES CC(C)(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C(C)(C)c1ccccc1
Show InChI InChI=1/C22H34N4O3S/c1-21(2,3)30(27,28)23-15-16-11-13-18(14-12-16)24-20-25-19(26-29-20)22(4,5)17-9-7-6-8-10-17/h6-10,16,18,23H,11-15H2,1-5H3,(H,24,25,26)/t16-,18-
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n/an/a 0.700n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50168691
PNG
(2-Methoxy-5-methyl-N-{3-[5-(2-methyl-benzoyl)-thia...)
Show SMILES COc1ccc(C)cc1S(=O)(=O)NCCCNc1ncc(s1)C(=O)c1ccccc1C
Show InChI InChI=1S/C22H25N3O4S2/c1-15-9-10-18(29-3)20(13-15)31(27,28)25-12-6-11-23-22-24-14-19(30-22)21(26)17-8-5-4-7-16(17)2/h4-5,7-10,13-14,25H,6,11-12H2,1-3H3,(H,23,24)
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n/an/a 0.710n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibitory concentration against mouse NPY5 receptor at 1 um


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118176
PNG
(US8653125, Ia-30)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)NC(=O)c2ccon2)cc1
Show InChI InChI=1S/C23H22FN3O3/c24-20-4-2-1-3-19(20)15-5-9-17(10-6-15)25-22(28)16-7-11-18(12-8-16)26-23(29)21-13-14-30-27-21/h1-6,9-10,13-14,16,18H,7-8,11-12H2,(H,25,28)(H,26,29)/t16-,18+
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n/an/a 0.710n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394223
PNG
(CHEMBL2159166)
Show SMILES FC(F)(F)S(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C18H16F3N3O3S/c19-18(20,21)28(25,26)13-6-7-14-15(10-13)23-17(22-14)24-8-9-27-16(11-24)12-4-2-1-3-5-12/h1-7,10,16H,8-9,11H2,(H,22,23)
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n/an/a 0.730n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141358
PNG
(US8916594, I-143)
Show SMILES CC(C)(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C1(C)CC(F)(F)C1
Show InChI InChI=1/C18H30F2N4O3S/c1-16(2,3)28(25,26)21-9-12-5-7-13(8-6-12)22-15-23-14(24-27-15)17(4)10-18(19,20)11-17/h12-13,21H,5-11H2,1-4H3,(H,22,23,24)/t12-,13-
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n/an/a 0.800n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141353
PNG
(US8916594, I-099)
Show SMILES CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccc(F)cn1
Show InChI InChI=1/C17H24FN5O3S/c1-11(2)27(24,25)20-9-12-3-6-14(7-4-12)21-17-22-16(23-26-17)15-8-5-13(18)10-19-15/h5,8,10-12,14,20H,3-4,6-7,9H2,1-2H3,(H,21,22,23)/t12-,14-
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n/an/a 0.800n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394228
PNG
(CHEMBL2159171)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C20H23N3O3S/c1-3-27(24,25)16-8-9-17-18(12-16)22-20(21-17)23-10-11-26-19(13-23)15-6-4-14(2)5-7-15/h4-9,12,19H,3,10-11,13H2,1-2H3,(H,21,22)
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n/an/a 0.800n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50168688
PNG
(2-Chloro-N-{3-[5-(2-methyl-benzoyl)-thiazol-2-ylam...)
Show SMILES Cc1ccccc1C(=O)c1cnc(NCCCNS(=O)(=O)c2cc(ccc2Cl)C(F)(F)F)s1
Show InChI InChI=1S/C21H19ClF3N3O3S2/c1-13-5-2-3-6-15(13)19(29)17-12-27-20(32-17)26-9-4-10-28-33(30,31)18-11-14(21(23,24)25)7-8-16(18)22/h2-3,5-8,11-12,28H,4,9-10H2,1H3,(H,26,27)
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n/an/a 0.850n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibitory concentration against mouse NPY5 receptor at 1 um


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394227
PNG
(CHEMBL2159170)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O3S/c1-2-27(24,25)15-7-8-16-17(11-15)22-19(21-16)23-9-10-26-18(12-23)13-3-5-14(20)6-4-13/h3-8,11,18H,2,9-10,12H2,1H3,(H,21,22)
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n/an/a 0.850n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141348
PNG
(US8916594, I-027)
Show SMILES CS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cccc(F)c1
Show InChI InChI=1/C16H21FN4O3S/c1-25(22,23)18-10-11-5-7-14(8-6-11)19-16-20-15(21-24-16)12-3-2-4-13(17)9-12/h2-4,9,11,14,18H,5-8,10H2,1H3,(H,19,20,21)/t11-,14-
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US Patent
n/an/a 0.860n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141354
PNG
(US8916594, I-100)
Show SMILES CC(C)(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1ccc(F)cn1
Show InChI InChI=1/C18H26FN5O3S/c1-18(2,3)28(25,26)21-10-12-4-7-14(8-5-12)22-17-23-16(24-27-17)15-9-6-13(19)11-20-15/h6,9,11-12,14,21H,4-5,7-8,10H2,1-3H3,(H,22,23,24)/t12-,14-
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US Patent
n/an/a 0.900n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141352
PNG
(US8916594, I-081)
Show SMILES CS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cccc(Cl)c1
Show InChI InChI=1/C16H21ClN4O3S/c1-25(22,23)18-10-11-5-7-14(8-6-11)19-16-20-15(21-24-16)12-3-2-4-13(17)9-12/h2-4,9,11,14,18H,5-8,10H2,1H3,(H,19,20,21)/t11-,14-
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n/an/a 0.900n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50168690
PNG
(CHEMBL364386 | Thiophene-2-sulfonic acid {3-[5-(2-...)
Show SMILES Cc1ccccc1C(=O)c1cnc(NCCCNS(=O)(=O)c2cccs2)s1
Show InChI InChI=1S/C18H19N3O3S3/c1-13-6-2-3-7-14(13)17(22)15-12-20-18(26-15)19-9-5-10-21-27(23,24)16-8-4-11-25-16/h2-4,6-8,11-12,21H,5,9-10H2,1H3,(H,19,20)
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n/an/a 1n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibitory concentration against mouse NPY5 receptor at 1 um


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394222
PNG
(CHEMBL2159174)
Show SMILES CCCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCC(C1)c1ccccc1
Show InChI InChI=1S/C20H23N3O2S/c1-2-12-26(24,25)17-8-9-18-19(13-17)22-20(21-18)23-11-10-16(14-23)15-6-4-3-5-7-15/h3-9,13,16H,2,10-12,14H2,1H3,(H,21,22)
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n/an/a 1.01n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM141362
PNG
(US8916594, I-149)
Show SMILES CC(C)(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C(F)(F)C(F)(F)F
Show InChI InChI=1/C15H23F5N4O3S/c1-13(2,3)28(25,26)21-8-9-4-6-10(7-5-9)22-12-23-11(24-27-12)14(16,17)15(18,19)20/h9-10,21H,4-8H2,1-3H3,(H,22,23,24)/t9-,10-
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n/an/a 1.04n/an/an/an/a7.425



Shionogi & Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Bio...


US Patent US8916594 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM50394226
PNG
(CHEMBL2159169)
Show SMILES CCS(=O)(=O)c1ccc2nc([nH]c2c1)N1CCOC(C1)c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3O3S/c1-2-27(24,25)15-7-8-16-17(11-15)22-19(21-16)23-9-10-26-18(12-23)13-3-5-14(20)6-4-13/h3-8,11,18H,2,9-10,12H2,1H3,(H,21,22)
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n/an/a 1.05n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from mouse NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 (NPY Y5)


(Mus musculus (Mouse))
BDBM118187
PNG
(US8653125, Ic-12)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)Oc2cc(Cl)ccc2C#N)cc1
Show InChI InChI=1S/C26H30ClN3O3/c1-17-15-30(16-18(2)32-17)23-9-7-22(8-10-23)29-26(31)19-4-11-24(12-5-19)33-25-13-21(27)6-3-20(25)14-28/h3,6-10,13,17-19,24H,4-5,11-12,15-16H2,1-2H3,(H,29,31)/t17-,18+,19-,24+
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n/an/a 1.10n/an/an/an/an/an/a



Shionogi Co., Ltd.

US Patent


Assay Description
cDNA sequence encoding mouse NPY Y5 receptor (Biochem. Biophys. Acta 1328: 83-89, 1997) was cloned in the expression vector (pME18S, Takebe et al. Mo...


US Patent US8653125 (2014)

More data for this
Ligand-Target Pair
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