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Found 148 hits Enz. Inhib. hit(s) with Target = 'Neutral cholesterol ester hydrolase 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390517
PNG
(CHEMBL2071652)
Show SMILES CN(C)C(=O)Oc1ccc2cc(Br)ccc2c1Br
Show InChI InChI=1S/C13H11Br2NO2/c1-16(2)13(17)18-11-6-3-8-7-9(14)4-5-10(8)12(11)15/h3-7H,1-2H3
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n/an/a 50n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390544
PNG
(CHEMBL2071655)
Show SMILES CN(C)C(=O)Oc1ccc2cc(Br)ccc2c1Cl
Show InChI InChI=1S/C13H11BrClNO2/c1-16(2)13(17)18-11-6-3-8-7-9(14)4-5-10(8)12(11)15/h3-7H,1-2H3
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n/an/a 80n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390508
PNG
(CHEMBL2069333)
Show SMILES CCCCOC[C@H]1CCCC[C@H]1COCCNC(=O)Oc1ccccc1F
Show InChI InChI=1S/C21H32FNO4/c1-2-3-13-25-15-17-8-4-5-9-18(17)16-26-14-12-23-21(24)27-20-11-7-6-10-19(20)22/h6-7,10-11,17-18H,2-5,8-9,12-16H2,1H3,(H,23,24)/t17-,18+/m1/s1
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ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 4 hrs measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390518
PNG
(CHEMBL2071651)
Show SMILES CCCc1ccc2c(Br)c(OC(=O)N(C)C)ccc2c1
Show InChI InChI=1S/C16H18BrNO2/c1-4-5-11-6-8-13-12(10-11)7-9-14(15(13)17)20-16(19)18(2)3/h6-10H,4-5H2,1-3H3
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n/an/a 130n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390515
PNG
(CHEMBL2071654)
Show SMILES CCCc1ccc2c(Cl)c(OC(=O)N(C)C)ccc2c1
Show InChI InChI=1S/C16H18ClNO2/c1-4-5-11-6-8-13-12(10-11)7-9-14(15(13)17)20-16(19)18(2)3/h6-10H,4-5H2,1-3H3
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n/an/a 150n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390519
PNG
(CHEMBL2071650)
Show SMILES CN(C)C(=O)Oc1ccc2cc(ccc2c1Br)C#N
Show InChI InChI=1S/C14H11BrN2O2/c1-17(2)14(18)19-12-6-4-10-7-9(8-16)3-5-11(10)13(12)15/h3-7H,1-2H3
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n/an/a 150n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390516
PNG
(CHEMBL2071653)
Show SMILES CN(C)C(=O)Oc1ccc2cc(ccc2c1Cl)C#N
Show InChI InChI=1S/C14H11ClN2O2/c1-17(2)14(18)19-12-6-4-10-7-9(8-16)3-5-11(10)13(12)15/h3-7H,1-2H3
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n/an/a 150n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390508
PNG
(CHEMBL2069333)
Show SMILES CCCCOC[C@H]1CCCC[C@H]1COCCNC(=O)Oc1ccccc1F
Show InChI InChI=1S/C21H32FNO4/c1-2-3-13-25-15-17-8-4-5-9-18(17)16-26-14-12-23-21(24)27-20-11-7-6-10-19(20)22/h6-7,10-11,17-18H,2-5,8-9,12-16H2,1H3,(H,23,24)/t17-,18+/m1/s1
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ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate after 1 hr by serine hydrolase activity-based probe assa...


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390520
PNG
(CHEMBL2071649)
Show SMILES CN(C)C(=O)Oc1ccc2cc(ccc2c1Br)C(=O)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H24BrN3O3/c1-26(2)24(30)31-21-11-9-17-16-18(8-10-20(17)22(21)25)23(29)28-14-12-27(13-15-28)19-6-4-3-5-7-19/h3-11,16H,12-15H2,1-2H3
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n/an/a 310n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390528
PNG
(CHEMBL2071641)
Show SMILES CN(C)C(=O)Oc1ccc2ccccc2c1I
Show InChI InChI=1S/C13H12INO2/c1-15(2)13(16)17-11-8-7-9-5-3-4-6-10(9)12(11)14/h3-8H,1-2H3
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n/an/a 330n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390513
PNG
(CHEMBL2071656)
Show SMILES Brc1c(OC(=O)N2CCC2)ccc2ccccc12
Show InChI InChI=1S/C14H12BrNO2/c15-13-11-5-2-1-4-10(11)6-7-12(13)18-14(17)16-8-3-9-16/h1-2,4-7H,3,8-9H2
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n/an/a 330n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 4 hrs measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390510
PNG
(CHEMBL2071659)
Show SMILES Brc1c(OC(=O)NCc2ccccc2)ccc2ccccc12
Show InChI InChI=1S/C18H14BrNO2/c19-17-15-9-5-4-8-14(15)10-11-16(17)22-18(21)20-12-13-6-2-1-3-7-13/h1-11H,12H2,(H,20,21)
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n/an/a 710n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 4 hrs measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390529
PNG
(CHEMBL2071640)
Show SMILES CN(C)C(=O)Oc1ccc2ccccc2c1[N+]([O-])=O
Show InChI InChI=1S/C13H12N2O4/c1-14(2)13(16)19-11-8-7-9-5-3-4-6-10(9)12(11)15(17)18/h3-8H,1-2H3
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n/an/a 890n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390541
PNG
(CHEMBL2071629)
Show SMILES CN(C)C(=O)Oc1ccc2cc(Br)ccc2c1
Show InChI InChI=1S/C13H12BrNO2/c1-15(2)13(16)17-12-6-4-9-7-11(14)5-3-10(9)8-12/h3-8H,1-2H3
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n/an/a 920n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390523
PNG
(CHEMBL2071646)
Show SMILES CN(C)C(=O)Oc1ccc2cc(ccc2c1Br)C(=O)NC1CCCCCC1
Show InChI InChI=1S/C21H25BrN2O3/c1-24(2)21(26)27-18-12-10-14-13-15(9-11-17(14)19(18)22)20(25)23-16-7-5-3-4-6-8-16/h9-13,16H,3-8H2,1-2H3,(H,23,25)
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n/an/a 920n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390509
PNG
(CHEMBL2069332)
Show SMILES Brc1c(OC(=O)N2CCCCC2)ccc2ccccc12
Show InChI InChI=1S/C16H16BrNO2/c17-15-13-7-3-2-6-12(13)8-9-14(15)20-16(19)18-10-4-1-5-11-18/h2-3,6-9H,1,4-5,10-11H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 4 hrs measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390530
PNG
(CHEMBL1481956)
Show SMILES CN(C)C(=O)Oc1ccc2ccccc2c1Cl
Show InChI InChI=1S/C13H12ClNO2/c1-15(2)13(16)17-11-8-7-9-5-3-4-6-10(9)12(11)14/h3-8H,1-2H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390514
PNG
(CHEMBL2071626)
Show SMILES CN(C)C(=O)Oc1ccc2ccccc2c1Br
Show InChI InChI=1S/C13H12BrNO2/c1-15(2)13(16)17-11-8-7-9-5-3-4-6-10(9)12(11)14/h3-8H,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390522
PNG
(CHEMBL2071647)
Show SMILES CN(C)C(=O)Oc1ccc2cc(ccc2c1Br)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H17BrN2O3/c1-23(2)20(25)26-17-11-9-13-12-14(8-10-16(13)18(17)21)19(24)22-15-6-4-3-5-7-15/h3-12H,1-2H3,(H,22,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390524
PNG
(CHEMBL2071645)
Show SMILES CN(C)C(=O)Oc1ccc2cc(ccc2c1Br)C(=O)NC1CCCC1
Show InChI InChI=1S/C19H21BrN2O3/c1-22(2)19(24)25-16-10-8-12-11-13(7-9-15(12)17(16)20)18(23)21-14-5-3-4-6-14/h7-11,14H,3-6H2,1-2H3,(H,21,23)
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n/an/a 1.50E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390511
PNG
(CHEMBL2071658)
Show SMILES CC(C)NC(=O)Oc1ccc2ccccc2c1Br
Show InChI InChI=1S/C14H14BrNO2/c1-9(2)16-14(17)18-12-8-7-10-5-3-4-6-11(10)13(12)15/h3-9H,1-2H3,(H,16,17)
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n/an/a 1.50E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 4 hrs measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390514
PNG
(CHEMBL2071626)
Show SMILES CN(C)C(=O)Oc1ccc2ccccc2c1Br
Show InChI InChI=1S/C13H12BrNO2/c1-15(2)13(16)17-11-8-7-9-5-3-4-6-10(9)12(11)14/h3-8H,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 4 hrs measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390526
PNG
(CHEMBL2071643)
Show SMILES CCCCCCCNC(=O)c1ccc2c(Br)c(OC(=O)N(C)C)ccc2c1
Show InChI InChI=1S/C21H27BrN2O3/c1-4-5-6-7-8-13-23-20(25)16-9-11-17-15(14-16)10-12-18(19(17)22)27-21(26)24(2)3/h9-12,14H,4-8,13H2,1-3H3,(H,23,25)
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n/an/a 1.70E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390513
PNG
(CHEMBL2071656)
Show SMILES Brc1c(OC(=O)N2CCC2)ccc2ccccc12
Show InChI InChI=1S/C14H12BrNO2/c15-13-11-5-2-1-4-10(11)6-7-12(13)18-14(17)16-8-3-9-16/h1-2,4-7H,3,8-9H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390512
PNG
(CHEMBL2071657)
Show SMILES CCCCNC(=O)Oc1ccc2ccccc2c1Br
Show InChI InChI=1S/C15H16BrNO2/c1-2-3-10-17-15(18)19-13-9-8-11-6-4-5-7-12(11)14(13)16/h4-9H,2-3,10H2,1H3,(H,17,18)
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n/an/a 2.20E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 4 hrs measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390536
PNG
(CHEMBL2071634)
Show SMILES CCCc1c(OC(=O)N(C)C)ccc2ccccc12
Show InChI InChI=1S/C16H19NO2/c1-4-7-14-13-9-6-5-8-12(13)10-11-15(14)19-16(18)17(2)3/h5-6,8-11H,4,7H2,1-3H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390532
PNG
(CHEMBL2069331)
Show SMILES COC(=O)c1c(OC(=O)N(C)C)ccc2ccccc12
Show InChI InChI=1S/C15H15NO4/c1-16(2)15(18)20-12-9-8-10-6-4-5-7-11(10)13(12)14(17)19-3/h4-9H,1-3H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390508
PNG
(CHEMBL2069333)
Show SMILES CCCCOC[C@H]1CCCC[C@H]1COCCNC(=O)Oc1ccccc1F
Show InChI InChI=1S/C21H32FNO4/c1-2-3-13-25-15-17-8-4-5-9-18(17)16-26-14-12-23-21(24)27-20-11-7-6-10-19(20)22/h6-7,10-11,17-18H,2-5,8-9,12-16H2,1H3,(H,23,24)/t17-,18+/m1/s1
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n/an/a 5.40E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390537
PNG
(CHEMBL2071633)
Show SMILES CCc1c(OC(=O)N(C)C)ccc2ccccc12
Show InChI InChI=1S/C15H17NO2/c1-4-12-13-8-6-5-7-11(13)9-10-14(12)18-15(17)16(2)3/h5-10H,4H2,1-3H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390535
PNG
(CHEMBL2071635)
Show SMILES CCCCc1c(OC(=O)N(C)C)ccc2ccccc12
Show InChI InChI=1S/C17H21NO2/c1-4-5-9-15-14-10-7-6-8-13(14)11-12-16(15)20-17(19)18(2)3/h6-8,10-12H,4-5,9H2,1-3H3
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n/an/a 7.50E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50240877
PNG
(CHEMBL158897 | Quinolyl derivatives | cyclohexanon...)
Show SMILES O=C(NCCCCCCNC(=O)ON=C1CCCCC1)ON=C1CCCCC1
Show InChI InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant KIAA1363 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50247137
PNG
(7-phenyl-1-(4-(trifluoromethyl)oxazol-2-yl)heptan-...)
Show SMILES FC(F)(F)c1coc(n1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H18F3NO2/c18-17(19,20)15-12-23-16(21-15)14(22)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390521
PNG
(CHEMBL2071648)
Show SMILES CN(C)C(=O)Oc1ccc2cc(ccc2c1Br)C(=O)N(C)C
Show InChI InChI=1S/C16H17BrN2O3/c1-18(2)15(20)11-5-7-12-10(9-11)6-8-13(14(12)17)22-16(21)19(3)4/h5-9H,1-4H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390545
PNG
(CHEMBL2071638)
Show SMILES CN(C)C(=O)Oc1ccc2ccccc2c1C(C)=O
Show InChI InChI=1S/C15H15NO3/c1-10(17)14-12-7-5-4-6-11(12)8-9-13(14)19-15(18)16(2)3/h4-9H,1-3H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50204475
PNG
(1-(5-bromooxazol-2-yl)-7-phenylheptan-1-one | CHEM...)
Show SMILES Brc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C16H18BrNO2/c17-15-12-18-16(20-15)14(19)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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n/an/a 1.30E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390525
PNG
(CHEMBL2071644)
Show SMILES CN(C)C(=O)Oc1ccc2cc(ccc2c1Br)C(=O)NC1CC1
Show InChI InChI=1S/C17H17BrN2O3/c1-20(2)17(22)23-14-8-4-10-9-11(3-7-13(10)15(14)18)16(21)19-12-5-6-12/h3-4,7-9,12H,5-6H2,1-2H3,(H,19,21)
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n/an/a 1.70E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50372374
PNG
(CHEMBL258820)
Show SMILES O=C(CCc1ccc(COc2ccccc2)cc1)c1ncc(o1)C#N
Show InChI InChI=1S/C20H16N2O3/c21-12-18-13-22-20(25-18)19(23)11-10-15-6-8-16(9-7-15)14-24-17-4-2-1-3-5-17/h1-9,13H,10-11,14H2
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n/an/a 1.90E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50204493
PNG
(1-(oxazol-2-yl)-7-phenylheptan-1-one | CHEMBL22012...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncco1
Show InChI InChI=1S/C16H19NO2/c18-15(16-17-12-13-19-16)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2
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n/an/a 1.90E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50204493
PNG
(1-(oxazol-2-yl)-7-phenylheptan-1-one | CHEMBL22012...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncco1
Show InChI InChI=1S/C16H19NO2/c18-15(16-17-12-13-19-16)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2
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n/an/a 1.90E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50204493
PNG
(1-(oxazol-2-yl)-7-phenylheptan-1-one | CHEMBL22012...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncco1
Show InChI InChI=1S/C16H19NO2/c18-15(16-17-12-13-19-16)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2
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n/an/a 2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50204493
PNG
(1-(oxazol-2-yl)-7-phenylheptan-1-one | CHEMBL22012...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncco1
Show InChI InChI=1S/C16H19NO2/c18-15(16-17-12-13-19-16)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2
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n/an/a 2.00E+4n/an/an/an/an/an/a



Institute for Chemical Biology

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50372372
PNG
(CHEMBL272038)
Show SMILES O=C(CCc1ccc(Oc2ccccc2)cc1)c1ncc(o1)C#N
Show InChI InChI=1S/C19H14N2O3/c20-12-17-13-21-19(24-17)18(22)11-8-14-6-9-16(10-7-14)23-15-4-2-1-3-5-15/h1-7,9-10,13H,8,11H2
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n/an/a 2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390534
PNG
(CHEMBL2071636)
Show SMILES CC(C)c1c(OC(=O)N(C)C)ccc2ccccc12
Show InChI InChI=1S/C16H19NO2/c1-11(2)15-13-8-6-5-7-12(13)9-10-14(15)19-16(18)17(3)4/h5-11H,1-4H3
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n/an/a 2.10E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390538
PNG
(CHEMBL2071632)
Show SMILES CN(C)C(=O)Oc1ccc2ccccc2c1C
Show InChI InChI=1S/C14H15NO2/c1-10-12-7-5-4-6-11(12)8-9-13(10)17-14(16)15(2)3/h4-9H,1-3H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390539
PNG
(CHEMBL2071631)
Show SMILES CN(C)C(=O)Oc1ccc(C)c(C)c1Br
Show InChI InChI=1S/C11H14BrNO2/c1-7-5-6-9(10(12)8(7)2)15-11(14)13(3)4/h5-6H,1-4H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50262188
PNG
(1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one | CH...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncno1
Show InChI InChI=1S/C15H18N2O2/c18-14(15-16-12-17-19-15)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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n/an/a 2.50E+4n/an/an/an/an/an/a



Institute for Chemical Biology

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390510
PNG
(CHEMBL2071659)
Show SMILES Brc1c(OC(=O)NCc2ccccc2)ccc2ccccc12
Show InChI InChI=1S/C18H14BrNO2/c19-17-15-9-5-4-8-14(15)10-11-16(17)22-18(21)20-12-13-6-2-1-3-7-13/h1-11H,12H2,(H,20,21)
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n/an/a 2.70E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390511
PNG
(CHEMBL2071658)
Show SMILES CC(C)NC(=O)Oc1ccc2ccccc2c1Br
Show InChI InChI=1S/C14H14BrNO2/c1-9(2)16-14(17)18-12-8-7-10-5-3-4-6-11(10)13(12)15/h3-9H,1-2H3,(H,16,17)
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n/an/a 2.80E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50390527
PNG
(CHEMBL2071642)
Show SMILES CNC(=O)c1ccc2c(Br)c(OC(=O)N(C)C)ccc2c1
Show InChI InChI=1S/C15H15BrN2O3/c1-17-14(19)10-4-6-11-9(8-10)5-7-12(13(11)16)21-15(20)18(2)3/h4-8H,1-3H3,(H,17,19)
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n/an/a 2.90E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 20 mins measured after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens)
BDBM50262244
PNG
(1-(1-Methyl-1H-tetrazol-5-yl)-7-phenylheptan-1-one...)
Show SMILES O=C(CCCCCCc1ccccc1)c1nc(no1)-c1ccccn1
Show InChI InChI=1S/C20H21N3O2/c24-18(14-7-2-1-4-10-16-11-5-3-6-12-16)20-22-19(23-25-20)17-13-8-9-15-21-17/h3,5-6,8-9,11-13,15H,1-2,4,7,10,14H2
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antibodypedia
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Institute for Chemical Biology

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
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