BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 303 hits Enz. Inhib. hit(s) with Target = 'Nischarin'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Imidazoline I1


(RAT)
BDBM50016897
PNG
(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Show SMILES Clc1cccc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 366n/an/an/an/an/an/a



Gda£?sk University of Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50016897
PNG
(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Show SMILES Clc1cccc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 366n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50270556
PNG
(1-[(Imidazolidin-2-yl)imino]-7-methylindazole hydr...)
Show SMILES Cc1cccc2cnn(N=C3NCCN3)c12
Show InChI InChI=1S/C11H13N5/c1-8-3-2-4-9-7-14-16(10(8)9)15-11-12-5-6-13-11/h2-4,7H,5-6H2,1H3,(H2,12,13,15)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 387n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50256481
PNG
(([4(5)S]-4(5)-(2-aminoethyl)imidazoline) dihydrobr...)
Show SMILES NCC[C@H]1CNC(N)=N1
Show InChI InChI=1S/C5H12N4/c6-2-1-4-3-8-5(7)9-4/h4H,1-3,6H2,(H3,7,8,9)/t4-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 477n/an/an/an/an/an/a



Gda£?sk University of Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360020
PNG
(CHEMBL1928335)
Show SMILES Cc1cc2nn(CC3=NCCN3)nc2cc1C
Show InChI InChI=1S/C12H15N5/c1-8-5-10-11(6-9(8)2)16-17(15-10)7-12-13-3-4-14-12/h5-6H,3-4,7H2,1-2H3,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 646n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360002
PNG
(CHEMBL1928323)
Show SMILES Clc1cccc2cnn(CC3=NCCN3)c12
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-2-8-6-15-16(11(8)9)7-10-13-4-5-14-10/h1-3,6H,4-5,7H2,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 856n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334557
PNG
(CHEMBL1644513 | [4(5)S]-4(5)-(2-Aminoethyl)-2-(2-e...)
Show SMILES CCC1(Cc2ccccc2O1)C1=NC[C@H](CCN)N1
Show InChI InChI=1S/C15H21N3O/c1-2-15(14-17-10-12(18-14)7-8-16)9-11-5-3-4-6-13(11)19-15/h3-6,12H,2,7-10,16H2,1H3,(H,17,18)/t12-,15?/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.01E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334550
PNG
(CHEMBL1644506 | [4(5)R]-4(5)-(2-Aminoethyl)-2-[(3-...)
Show SMILES NCC[C@@H]1CN=C(Nc2cccc(c2)C(F)(F)F)N1
Show InChI InChI=1S/C12H15F3N4/c13-12(14,15)8-2-1-3-9(6-8)18-11-17-7-10(19-11)4-5-16/h1-3,6,10H,4-5,7,16H2,(H2,17,18,19)/t10-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.25E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334549
PNG
(CHEMBL1644505 | [4(5)S]-4(5)-(2-Aminoethyl)-2-[(3-...)
Show SMILES NCC[C@H]1CN=C(Nc2cccc(c2)C(F)(F)F)N1
Show InChI InChI=1S/C12H15F3N4/c13-12(14,15)8-2-1-3-9(6-8)18-11-17-7-10(19-11)4-5-16/h1-3,6,10H,4-5,7,16H2,(H2,17,18,19)/t10-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.31E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334547
PNG
(CHEMBL1644496 | [4(5)S]-4(5)-(2-Aminoethyl)-2-[(2,...)
Show SMILES NCC[C@H]1CN=C(Nc2ccc(Cl)cc2Cl)N1
Show InChI InChI=1S/C11H14Cl2N4/c12-7-1-2-10(9(13)5-7)17-11-15-6-8(16-11)3-4-14/h1-2,5,8H,3-4,6,14H2,(H2,15,16,17)/t8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.48E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334195
PNG
(4-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1cccc2n[nH]c(N=C3NCCN3)c12
Show InChI InChI=1S/C10H10ClN5/c11-6-2-1-3-7-8(6)9(16-15-7)14-10-12-4-5-13-10/h1-3H,4-5H2,(H3,12,13,14,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.84E+3n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334203
PNG
(6-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1ccc2c(N=C3NCCN3)[nH]nc2c1
Show InChI InChI=1S/C10H10ClN5/c11-6-1-2-7-8(5-6)15-16-9(7)14-10-12-3-4-13-10/h1-2,5H,3-4H2,(H3,12,13,14,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.01E+3n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334560
PNG
(CHEMBL1644516 | [4(5)R]-4(5)-(2-Aminoethyl)-2-(2,3...)
Show SMILES NCC[C@@H]1CN=C(N1)C1COc2ccccc2O1
Show InChI InChI=1S/C13H17N3O2/c14-6-5-9-7-15-13(16-9)12-8-17-10-3-1-2-4-11(10)18-12/h1-4,9,12H,5-8,14H2,(H,15,16)/t9-,12?/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.65E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334552
PNG
(CHEMBL1644508 | [4(5)R]-4(5)-(2-Aminoethyl)-2-[(2,...)
Show SMILES NCC[C@@H]1CN=C(Nc2c(Cl)cccc2Cl)N1
Show InChI InChI=1S/C11H14Cl2N4/c12-8-2-1-3-9(13)10(8)17-11-15-6-7(16-11)4-5-14/h1-3,7H,4-6,14H2,(H2,15,16,17)/t7-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.72E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50272774
PNG
(2-(2-(thiophen-2-yl)ethyl)-4,5-dihydro-1H-imidazol...)
Show SMILES C(Cc1cccs1)C1=NCCN1
Show InChI InChI=1S/C9H12N2S/c1-2-8(12-7-1)3-4-9-10-5-6-11-9/h1-2,7H,3-6H2,(H,10,11)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 2.88E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334194
PNG
(3-[(Imidazolidin-2-yl)imino]indazole hydrochloride...)
Show SMILES C1CNC(N1)=Nc1[nH]nc2ccccc12
Show InChI InChI=1S/C10H11N5/c1-2-4-8-7(3-1)9(15-14-8)13-10-11-5-6-12-10/h1-4H,5-6H2,(H3,11,12,13,14,15)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.22E+3n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50272777
PNG
(2-(2-Cyclohexyl-ethyl)-4,5-dihydro-1H-imidazole | ...)
Show SMILES C(CC1=NCCN1)C1CCCCC1
Show InChI InChI=1S/C11H20N2/c1-2-4-10(5-3-1)6-7-11-12-8-9-13-11/h10H,1-9H2,(H,12,13)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.57E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334539
PNG
((S)-4-(2-aminoethyl)-N-(2-bromophenyl)-4,5-dihydro...)
Show SMILES NCC[C@H]1CN=C(Nc2ccccc2Br)N1
Show InChI InChI=1S/C11H15BrN4/c12-9-3-1-2-4-10(9)16-11-14-7-8(15-11)5-6-13/h1-4,8H,5-7,13H2,(H2,14,15,16)/t8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.70E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50272779
PNG
(2-[2-(3-Nitro-biphenyl-2-yl)-ethyl]-4,5-dihydro-1H...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccccc1CCC1=NCCN1
Show InChI InChI=1S/C17H17N3O2/c21-20(22)15-6-3-5-14(12-15)16-7-2-1-4-13(16)8-9-17-18-10-11-19-17/h1-7,12H,8-11H2,(H,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334197
PNG
(7-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1cccc2c(N=C3NCCN3)[nH]nc12
Show InChI InChI=1S/C10H10ClN5/c11-7-3-1-2-6-8(7)15-16-9(6)14-10-12-4-5-13-10/h1-3H,4-5H2,(H3,12,13,14,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.01E+3n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50272781
PNG
(2-[2-(2-Chloro-phenyl)-ethyl]-4,5-dihydro-1H-imida...)
Show SMILES Clc1ccccc1CCC1=NCCN1
Show InChI InChI=1S/C11H13ClN2/c12-10-4-2-1-3-9(10)5-6-11-13-7-8-14-11/h1-4H,5-8H2,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 4.26E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334559
PNG
(CHEMBL1644515 | [4(5)S]-4(5)-(2-Aminoethyl)-2-(2,3...)
Show SMILES NCC[C@H]1CN=C(N1)C1COc2ccccc2O1
Show InChI InChI=1S/C13H17N3O2/c14-6-5-9-7-15-13(16-9)12-8-17-10-3-1-2-4-11(10)18-12/h1-4,9,12H,5-8,14H2,(H,15,16)/t9-,12?/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.11E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360005
PNG
(CHEMBL1928319)
Show SMILES Clc1cccc2n(CC3=NCCN3)ncc12
Show InChI InChI=1S/C11H11ClN4/c12-9-2-1-3-10-8(9)6-15-16(10)7-11-13-4-5-14-11/h1-3,6H,4-5,7H2,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.15E+3n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334548
PNG
(CHEMBL1644504 | [4(5)R]-4(5)-(2-Aminoethyl)-2-[(2,...)
Show SMILES NCC[C@@H]1CN=C(Nc2ccc(Cl)cc2Cl)N1
Show InChI InChI=1S/C11H14Cl2N4/c12-7-1-2-10(9(13)5-7)17-11-15-6-8(16-11)3-4-14/h1-2,5,8H,3-4,6,14H2,(H2,15,16,17)/t8-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6.33E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline receptor 1 (I1R)


(Homo sapiens (Human))
BDBM50086502
PNG
(2-BFi | 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...)
Show SMILES C1CN=C(N1)c1cc2ccccc2o1
Show InChI InChI=1S/C11H10N2O/c1-2-4-9-8(3-1)7-10(14-9)11-12-5-6-13-11/h1-4,7H,5-6H2,(H,12,13)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 6.40E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Inhibition of 3 nM [3H]-clonidine binding to rat kidney membrane imidazoline receptor I-1 in presence of rauwolscine


Bioorg Med Chem Lett 10: 605-7 (2000)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50272811
PNG
(2-[2-(2-Thiophen-3-yl-phenyl)-ethyl]-4,5-dihydro-1...)
Show SMILES C(Cc1ccccc1-c1ccsc1)C1=NCCN1
Show InChI InChI=1S/C15H16N2S/c1-2-4-14(13-7-10-18-11-13)12(3-1)5-6-15-16-8-9-17-15/h1-4,7,10-11H,5-6,8-9H2,(H,16,17)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 6.89E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50272810
PNG
(2-(2-(4,5-dihydro-1H-imidazol-2-yl)ethyl)phenol | ...)
Show SMILES Oc1ccccc1CCC1=NCCN1
Show InChI InChI=1S/C11H14N2O/c14-10-4-2-1-3-9(10)5-6-11-12-7-8-13-11/h1-4,14H,5-8H2,(H,12,13)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 7.30E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50272780
PNG
(2-(2-o-Tolyl-ethyl)-4,5-dihydro-1H-imidazole | CHE...)
Show SMILES Cc1ccccc1CCC1=NCCN1
Show InChI InChI=1S/C12H16N2/c1-10-4-2-3-5-11(10)6-7-12-13-8-9-14-12/h2-5H,6-9H2,1H3,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 7.36E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334205
PNG
(4-Bromo-3-[(imidazolidin-2-yl)imino]indazole hydro...)
Show SMILES Brc1cccc2n[nH]c(N=C3NCCN3)c12
Show InChI InChI=1S/C10H10BrN5/c11-6-2-1-3-7-8(6)9(16-15-7)14-10-12-4-5-13-10/h1-3H,4-5H2,(H3,12,13,14,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.56E+3n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334551
PNG
(CHEMBL1644507 | [4(5)S]-4(5)-(2-Aminoethyl)-2-[(2,...)
Show SMILES NCC[C@H]1CN=C(Nc2c(Cl)cccc2Cl)N1
Show InChI InChI=1S/C11H14Cl2N4/c12-8-2-1-3-9(13)10(8)17-11-15-6-7(16-11)4-5-14/h1-3,7H,4-6,14H2,(H2,15,16,17)/t7-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.75E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334545
PNG
(CHEMBL1644503 | [4(5)S]-4(5)-(2-Aminoethyl)-2-[(6-...)
Show SMILES Cc1cccc(NC2=NC[C@H](CCN)N2)n1
Show InChI InChI=1S/C11H17N5/c1-8-3-2-4-10(14-8)16-11-13-7-9(15-11)5-6-12/h2-4,9H,5-7,12H2,1H3,(H2,13,14,15,16)/t9-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.78E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline receptor 1 (I1R)


(Homo sapiens (Human))
BDBM50086503
PNG
(2-(5-Thiocyanato-benzofuran-2-yl)-4,5-dihydro-1H-i...)
Show SMILES N#CSc1ccc2oc(cc2c1)C1=NCCN1
Show InChI InChI=1S/C12H9N3OS/c13-7-17-9-1-2-10-8(5-9)6-11(16-10)12-14-3-4-15-12/h1-2,5-6H,3-4H2,(H,14,15)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 8.10E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Inhibition of 3 nM [3H]-clonidine binding to rat kidney membrane imidazoline receptor I-1 in presence of rauwolscine


Bioorg Med Chem Lett 10: 605-7 (2000)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334546
PNG
(CHEMBL1644497 | [4(5)R]-4(5)-(2-Aminoethyl)-2-[(6-...)
Show SMILES Cc1cccc(NC2=NC[C@@H](CCN)N2)n1
Show InChI InChI=1S/C11H17N5/c1-8-3-2-4-10(14-8)16-11-13-7-9(15-11)5-6-12/h2-4,9H,5-7,12H2,1H3,(H2,13,14,15,16)/t9-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.51E+3n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360010
PNG
(CHEMBL1928326)
Show SMILES Cc1nc2ccccc2n1CC1=NCCN1
Show InChI InChI=1S/C12H14N4/c1-9-15-10-4-2-3-5-11(10)16(9)8-12-13-6-7-14-12/h2-5H,6-8H2,1H3,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 9.39E+3n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334561
PNG
(CHEMBL1644517 | [4(5)S]-4(5)-(2-Aminoethyl)-2-[(N-...)
Show SMILES NCC[C@H]1CN=C(CN(Cc2ccccc2)c2ccccc2)N1
Show InChI InChI=1S/C19H24N4/c20-12-11-17-13-21-19(22-17)15-23(18-9-5-2-6-10-18)14-16-7-3-1-4-8-16/h1-10,17H,11-15,20H2,(H,21,22)/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.16E+4n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360004
PNG
(CHEMBL1928318)
Show SMILES Cc1cccc2n(CC3=NCCN3)ncc12
Show InChI InChI=1S/C12H14N4/c1-9-3-2-4-11-10(9)7-15-16(11)8-12-13-5-6-14-12/h2-4,7H,5-6,8H2,1H3,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.29E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50270560
PNG
(2-[(Imidazolidin-2-yl)imino]-5-methylindazole hydr...)
Show SMILES Cc1ccc2nn(cc2c1)N=C1NCCN1
Show InChI InChI=1S/C11H13N5/c1-8-2-3-10-9(6-8)7-16(14-10)15-11-12-4-5-13-11/h2-3,6-7H,4-5H2,1H3,(H2,12,13,15)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.34E+4n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50271295
PNG
(1-[(Imidazolidin-2-yl)imino]-4-methoxyindazole hyd...)
Show SMILES COc1cccc2n(N=C3NCCN3)ncc12
Show InChI InChI=1S/C11H13N5O/c1-17-10-4-2-3-9-8(10)7-14-16(9)15-11-12-5-6-13-11/h2-4,7H,5-6H2,1H3,(H2,12,13,15)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.35E+4n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360008
PNG
(CHEMBL1928324)
Show SMILES Fc1cccc2cnn(CC3=NCCN3)c12
Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-8-6-15-16(11(8)9)7-10-13-4-5-14-10/h1-3,6H,4-5,7H2,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.64E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50256484
PNG
((R)-2-(4,5-dihydro-1H-imidazol-5-yl)ethanamine dih...)
Show SMILES NCC[C@@H]1CNC=N1
Show InChI InChI=1S/C5H11N3/c6-2-1-5-3-7-4-8-5/h4-5H,1-3,6H2,(H,7,8)/t5-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.65E+4n/an/an/an/an/an/a



Gda£?sk University of Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334204
PNG
(3-[(Imidazolidin-2-yl)imino]-6-methylindazole hydr...)
Show SMILES Cc1ccc2c(N=C3NCCN3)[nH]nc2c1
Show InChI InChI=1S/C11H13N5/c1-7-2-3-8-9(6-7)15-16-10(8)14-11-12-4-5-13-11/h2-3,6H,4-5H2,1H3,(H3,12,13,14,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.66E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360018
PNG
(CHEMBL1928334)
Show SMILES Cc1cc2nnn(CC3=NCCN3)c2cc1C
Show InChI InChI=1S/C12H15N5/c1-8-5-10-11(6-9(8)2)17(16-15-10)7-12-13-3-4-14-12/h5-6H,3-4,7H2,1-2H3,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.68E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50271297
PNG
(5-Chloro-1-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1ccc2n(N=C3NCCN3)ncc2c1
Show InChI InChI=1S/C10H10ClN5/c11-8-1-2-9-7(5-8)6-14-16(9)15-10-12-3-4-13-10/h1-2,5-6H,3-4H2,(H2,12,13,15)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334564
PNG
(CHEMBL1644520 | [4(5)S]-4(5)-(2-Aminoethyl)-2-[(E)...)
Show SMILES NCC[C@H]1CN=C(N1)C=Cc1ccccc1
Show InChI InChI=1S/C13H17N3/c14-9-8-12-10-15-13(16-12)7-6-11-4-2-1-3-5-11/h1-7,12H,8-10,14H2,(H,15,16)/t12-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.72E+4n/an/an/an/an/an/a



Gdansk University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat imidazoline I1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360000
PNG
(CHEMBL1928316)
Show SMILES C(C1=NCCN1)n1ncc2ccccc12
Show InChI InChI=1S/C11H12N4/c1-2-4-10-9(3-1)7-14-15(10)8-11-12-5-6-13-11/h1-4,7H,5-6,8H2,(H,12,13)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.94E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50270562
PNG
(2-[(Imidazolidin-2-yl)imino]-6-methylindazole hydr...)
Show SMILES Cc1ccc2cn(N=C3NCCN3)nc2c1
Show InChI InChI=1S/C11H13N5/c1-8-2-3-9-7-16(14-10(9)6-8)15-11-12-4-5-13-11/h2-3,6-7H,4-5H2,1H3,(H2,12,13,15)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.97E+4n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50271296
PNG
(1-[(Imidazolidin-2-yl)imino]-5-methylindazole hydr...)
Show SMILES Cc1ccc2n(N=C3NCCN3)ncc2c1
Show InChI InChI=1S/C11H13N5/c1-8-2-3-10-9(6-8)7-14-16(10)15-11-12-4-5-13-11/h2-3,6-7H,4-5H2,1H3,(H2,12,13,15)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.03E+4n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360013
PNG
(CHEMBL1928329)
Show SMILES C(c1nc2ccccc2n1CC1=NCCN1)c1ccccc1
Show InChI InChI=1S/C18H18N4/c1-2-6-14(7-3-1)12-18-21-15-8-4-5-9-16(15)22(18)13-17-19-10-11-20-17/h1-9H,10-13H2,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334208
PNG
(3-[(Imidazolidin-2-yl)imino]-5-methylindazole hydr...)
Show SMILES Cc1ccc2n[nH]c(N=C3NCCN3)c2c1
Show InChI InChI=1S/C11H13N5/c1-7-2-3-9-8(6-7)10(16-15-9)14-11-12-4-5-13-11/h2-3,6H,4-5H2,1H3,(H3,12,13,14,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.12E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50360003
PNG
(CHEMBL1928317)
Show SMILES Cc1nn(CC2=NCCN2)c2ccccc12
Show InChI InChI=1S/C12H14N4/c1-9-10-4-2-3-5-11(10)16(15-9)8-12-13-6-7-14-12/h2-5H,6-8H2,1H3,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.13E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membranes after 45 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 303 total )  |  Next  |  Last  >>
Jump to: