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Found 141 hits Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B (NF-kB)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062648
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H5ClF9N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)
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n/an/a 50n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50196926
PNG
(CHEMBL438139 | Rocaglamide)
Show SMILES COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C
Show InChI InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
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n/an/a 75n/an/an/an/an/an/a



The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062645
PNG
(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Show SMILES CCCCOC(=O)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C18H14ClF6N3O3/c1-2-3-4-31-15(30)9-5-10(17(20,21)22)7-11(6-9)27-14(29)12-8-26-16(19)28-13(12)18(23,24)25/h5-8H,2-4H2,1H3,(H,27,29)
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n/an/a 170n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062658
PNG
(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Show SMILES CCOC(=O)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H10ClF6N3O3/c1-2-29-13(28)7-3-8(15(18,19)20)5-9(4-7)25-12(27)10-6-24-14(17)26-11(10)16(21,22)23/h3-6H,2H2,1H3,(H,25,27)
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n/an/a 280n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062669
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc1
Show InChI InChI=1S/C13H6ClF6N3O/c14-11-21-5-8(9(23-11)13(18,19)20)10(24)22-7-3-1-6(2-4-7)12(15,16)17/h1-5H,(H,22,24)
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n/an/a 380n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062661
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES FC(F)(F)c1nc(Cl)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C12H5Cl3F3N3O/c13-5-1-6(14)3-7(2-5)20-10(22)8-4-19-11(15)21-9(8)12(16,17)18/h1-4H,(H,20,22)
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n/an/a 500n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062653
PNG
(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Show SMILES CCCCCCOC(=O)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C20H18ClF6N3O3/c1-2-3-4-5-6-33-17(32)11-7-12(19(22,23)24)9-13(8-11)29-16(31)14-10-28-18(21)30-15(14)20(25,26)27/h7-10H,2-6H2,1H3,(H,29,31)
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n/an/a 620n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062663
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES FC(F)(F)c1nc(Cl)ncc1C(=O)Nc1cc(Cl)nc(Cl)n1
Show InChI InChI=1S/C10H3Cl3F3N5O/c11-4-1-5(20-9(13)18-4)19-7(22)3-2-17-8(12)21-6(3)10(14,15)16/h1-2H,(H,18,19,20,22)
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n/an/a 800n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062650
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES FC(F)(F)c1nc(Cl)ncc1C(=O)Nc1cc(Cl)c(Cl)c(Cl)c1
Show InChI InChI=1S/C12H4Cl4F3N3O/c13-6-1-4(2-7(14)8(6)15)21-10(23)5-3-20-11(16)22-9(5)12(17,18)19/h1-3H,(H,21,23)
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n/an/a 900n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062672
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES COc1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(OC)c1
Show InChI InChI=1S/C14H11ClF3N3O3/c1-23-8-3-7(4-9(5-8)24-2)20-12(22)10-6-19-13(15)21-11(10)14(16,17)18/h3-6H,1-2H3,(H,20,22)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062656
PNG
(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Show SMILES CCCCCCCCOC(=O)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C22H22ClF6N3O3/c1-2-3-4-5-6-7-8-35-19(34)13-9-14(21(24,25)26)11-15(10-13)31-18(33)16-12-30-20(23)32-17(16)22(27,28)29/h9-12H,2-8H2,1H3,(H,31,33)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062651
PNG
(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(=O)OC1CCCCC1
Show InChI InChI=1S/C20H16ClF6N3O3/c21-18-28-9-14(15(30-18)20(25,26)27)16(31)29-12-7-10(6-11(8-12)19(22,23)24)17(32)33-13-4-2-1-3-5-13/h6-9,13H,1-5H2,(H,29,31)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50196926
PNG
(CHEMBL438139 | Rocaglamide)
Show SMILES COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C
Show InChI InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of p50 after 1 hr by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062652
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES CN(C(=O)c1cnc(Cl)nc1C(F)(F)F)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C13H7Cl3F3N3O/c1-22(8-3-6(14)2-7(15)4-8)11(23)9-5-20-12(16)21-10(9)13(17,18)19/h2-5H,1H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062673
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES Cc1ccc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)s1
Show InChI InChI=1S/C11H7ClF3N3OS/c1-5-2-3-7(20-5)17-9(19)6-4-16-10(12)18-8(6)11(13,14)15/h2-4H,1H3,(H,17,19)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50317859
PNG
(CHEMBL1099162 | artobiloxanthone)
Show SMILES CC(=C)[C@H]1Cc2c(O)c3c(oc2-c2c(O)cc(O)c(O)c12)c1C=CC(C)(C)Oc1cc3=O
Show InChI InChI=1S/C25H22O7/c1-10(2)12-7-13-21(29)20-15(27)9-17-11(5-6-25(3,4)32-17)23(20)31-24(13)19-14(26)8-16(28)22(30)18(12)19/h5-6,8-9,12,26,28-30H,1,7H2,2-4H3/t12-/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50331545
PNG
(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Show SMILES O=c1ccc2ccc3occc3c2o1
Show InChI InChI=1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H
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n/an/a 2.50E+3n/an/an/an/an/an/a



BioPharmaNet

Curated by ChEMBL


Assay Description
Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSA


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062649
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES FC(F)(F)c1nc(Cl)ncc1C(=O)N(Cc1ccccc1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C19H11Cl3F3N3O/c20-12-6-13(21)8-14(7-12)28(10-11-4-2-1-3-5-11)17(29)15-9-26-18(22)27-16(15)19(23,24)25/h1-9H,10H2
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n/an/a 2.70E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50331544
PNG
(7H-furo[3,2-g]chromen-7-one | CHEMBL164660 | Furo[...)
Show SMILES O=c1ccc2cc3ccoc3cc2o1
Show InChI InChI=1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
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n/an/a 3.00E+3n/an/an/an/an/an/a



BioPharmaNet

Curated by ChEMBL


Assay Description
Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSA


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191744
PNG
(US9187397, 3 | US9187397, 31)
Show SMILES O=C(\C=C\c1cccnc1)/C=C/c1cccnc1
Show InChI InChI=1S/C15H12N2O/c18-15(7-5-13-3-1-9-16-11-13)8-6-14-4-2-10-17-12-14/h1-12H/b7-5+,8-6+
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n/an/a 3.40E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
The 293T/NF-κB-luc cells were re-plated 24 hr prior to treatment, into 24-well cell culture plates in media without hygromycin, to prevent it from...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191744
PNG
(US9187397, 3 | US9187397, 31)
Show SMILES O=C(\C=C\c1cccnc1)/C=C/c1cccnc1
Show InChI InChI=1S/C15H12N2O/c18-15(7-5-13-3-1-9-16-11-13)8-6-14-4-2-10-17-12-14/h1-12H/b7-5+,8-6+
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n/an/a 3.40E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
The 293T/NF-κB-luc cells were re-plated 24 hr prior to treatment, into 24-well cell culture plates in media without hygromycin, to prevent it from...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191745
PNG
(US9187397, 29)
Show SMILES O=C(\C=C\c1ccncc1)/C=C/c1ccncc1
Show InChI InChI=1S/C15H12N2O/c18-15(3-1-13-5-9-16-10-6-13)4-2-14-7-11-17-12-8-14/h1-12H/b3-1+,4-2+
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n/an/a 3.50E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
The 293T/NF-κB-luc cells were re-plated 24 hr prior to treatment, into 24-well cell culture plates in media without hygromycin, to prevent it from...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062659
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES Cc1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)on1
Show InChI InChI=1S/C10H6ClF3N4O2/c1-4-2-6(20-18-4)16-8(19)5-3-15-9(11)17-7(5)10(12,13)14/h2-3H,1H3,(H,16,19)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50067033
PNG
((2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyc...)
Show SMILES COc1cc(\C=C2/CCC\C(=C/c3ccc(O)c(OC)c3)C2=O)ccc1O
Show InChI InChI=1S/C22H22O5/c1-26-20-12-14(6-8-18(20)23)10-16-4-3-5-17(22(16)25)11-15-7-9-19(24)21(13-15)27-2/h6-13,23-24H,3-5H2,1-2H3/b16-10+,17-11+
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n/an/a 4.20E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
TRAP Assay: The first procedure called for antioxidant activity to be measured as the ability of the analogs to react with the pre-formed radical mon...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191746
PNG
(US9187397, 20q)
Show SMILES Oc1ccccc1\C=C\C(=O)\C=C\c1ccccc1O
Show InChI InChI=1S/C17H14O3/c18-15(11-9-13-5-1-3-7-16(13)19)12-10-14-6-2-4-8-17(14)20/h1-12,19-20H/b11-9+,12-10+
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n/an/a 4.20E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
The first procedure called for antioxidant activity to be measured as the ability of the analogs to react with the pre-formed radical monocation of 2...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50067033
PNG
((2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyc...)
Show SMILES COc1cc(\C=C2/CCC\C(=C/c3ccc(O)c(OC)c3)C2=O)ccc1O
Show InChI InChI=1S/C22H22O5/c1-26-20-12-14(6-8-18(20)23)10-16-4-3-5-17(22(16)25)11-15-7-9-19(24)21(13-15)27-2/h6-13,23-24H,3-5H2,1-2H3/b16-10+,17-11+
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n/an/a 4.40E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
The 293T/NF-κB-luc cells were re-plated 24 hr prior to treatment, into 24-well cell culture plates in media without hygromycin, to prevent it from...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062671
PNG
(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Show SMILES CCOP(=O)(COC(=O)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F)OCC
Show InChI InChI=1S/C19H17ClF6N3O6P/c1-3-34-36(32,35-4-2)9-33-16(31)10-5-11(18(21,22)23)7-12(6-10)28-15(30)13-8-27-17(20)29-14(13)19(24,25)26/h5-8H,3-4,9H2,1-2H3,(H,28,30)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50331548
PNG
(4-((7-hydroxy-4-oxo-1,2,3,4-tetrahydrocyclopenta[c...)
Show SMILES OC(=O)c1ccc(COc2cc(O)cc3oc(=O)c4CCCc4c23)cc1
Show InChI InChI=1S/C20H16O6/c21-13-8-16(25-10-11-4-6-12(7-5-11)19(22)23)18-14-2-1-3-15(14)20(24)26-17(18)9-13/h4-9,21H,1-3,10H2,(H,22,23)
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n/an/a 5.00E+3n/an/an/an/an/an/a



BioPharmaNet

Curated by ChEMBL


Assay Description
Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSA


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062668
PNG
(2-Piperidin-1-yl-4-trifluoromethyl-pyrimidine-5-ca...)
Show SMILES FC(F)(F)c1nc(ncc1C(=O)Nc1cc(Cl)cc(Cl)c1)N1CCCCC1
Show InChI InChI=1S/C17H15Cl2F3N4O/c18-10-6-11(19)8-12(7-10)24-15(27)13-9-23-16(25-14(13)17(20,21)22)26-4-2-1-3-5-26/h6-9H,1-5H2,(H,24,27)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062674
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES NC(=O)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H7ClF6N4O2/c15-12-23-4-8(9(25-12)14(19,20)21)11(27)24-7-2-5(10(22)26)1-6(3-7)13(16,17)18/h1-4H,(H2,22,26)(H,24,27)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191762
PNG
(US9187397, 5)
Show SMILES FC(F)(F)c1ccccc1\C=C\C(=O)\C=C\c1ccccc1C(F)(F)F
Show InChI InChI=1S/C19H12F6O/c20-18(21,22)16-7-3-1-5-13(16)9-11-15(26)12-10-14-6-2-4-8-17(14)19(23,24)25/h1-12H/b11-9+,12-10+
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n/an/a 5.00E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
The 293T/NF-κB-luc cells were re-plated 24 hr prior to treatment, into 24-well cell culture plates in media without hygromycin, to prevent it from...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191747
PNG
(US9187397, 20ag)
Show SMILES COc1cc(\C=C\C(=O)\C=C\c2ccc(OC(C)=O)c(OC)c2)ccc1OC(C)=O
Show InChI InChI=1S/C23H22O7/c1-15(24)29-20-11-7-17(13-22(20)27-3)5-9-19(26)10-6-18-8-12-21(30-16(2)25)23(14-18)28-4/h5-14H,1-4H3/b9-5+,10-6+
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n/an/a 5.40E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
Anti-oxidant activity was also measured in the Ferric reducing/anti-oxidant power assay (FRAP assay) in which the analogs are reacted with a ferric t...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191748
PNG
(US9187397, 20m)
Show SMILES COc1ccc(OC)c(\C=C\C(=O)\C=C\c2cc(OC)ccc2OC)c1
Show InChI InChI=1S/C21H22O5/c1-23-18-9-11-20(25-3)15(13-18)5-7-17(22)8-6-16-14-19(24-2)10-12-21(16)26-4/h5-14H,1-4H3/b7-5+,8-6+
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n/an/a 6.40E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
The 293T/NF-κB-luc cells were re-plated 24 hr prior to treatment, into 24-well cell culture plates in media without hygromycin, to prevent it from...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191749
PNG
(US9187397, 2 | US9187397, 6a)
Show SMILES COc1cc(\C=C\C(\O)=C(/C)C(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C22H22O6/c1-14(17(23)8-4-15-6-10-19(25)21(12-15)27-2)18(24)9-5-16-7-11-20(26)22(13-16)28-3/h4-13,23,25-26H,1-3H3/b8-4+,9-5+,17-14-
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n/an/a 6.70E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
TRAP Assay: The first procedure called for antioxidant activity to be measured as the ability of the analogs to react with the pre-formed radical mon...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191749
PNG
(US9187397, 2 | US9187397, 6a)
Show SMILES COc1cc(\C=C\C(\O)=C(/C)C(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C22H22O6/c1-14(17(23)8-4-15-6-10-19(25)21(12-15)27-2)18(24)9-5-16-7-11-20(26)22(13-16)28-3/h4-13,23,25-26H,1-3H3/b8-4+,9-5+,17-14-
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n/an/a 6.70E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
The 293T/NF-κB-luc cells were re-plated 24 hr prior to treatment, into 24-well cell culture plates in media without hygromycin, to prevent it from...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50241454
PNG
(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Show SMILES COc1cc2oc3cc(O)c(OC)c(CC=C(C)C)c3c(=O)c2c(O)c1CC=C(C)C
Show InChI InChI=1S/C25H28O6/c1-13(2)7-9-15-18(29-5)12-20-22(23(15)27)24(28)21-16(10-8-14(3)4)25(30-6)17(26)11-19(21)31-20/h7-8,11-12,26-27H,9-10H2,1-6H3
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n/an/a 7.50E+3n/an/an/an/an/an/a



The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of p50 after 1 hr by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191750
PNG
(US9187397, 9a)
Show SMILES COc1cc(\C=C\C(\O)=C(/Cc2ccccc2)C(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C28H26O6/c1-33-27-17-20(10-14-25(27)31)8-12-23(29)22(16-19-6-4-3-5-7-19)24(30)13-9-21-11-15-26(32)28(18-21)34-2/h3-15,17-18,29,31-32H,16H2,1-2H3/b12-8+,13-9+,23-22-
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n/an/a 7.60E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
TRAP Assay: The first procedure called for antioxidant activity to be measured as the ability of the analogs to react with the pre-formed radical mon...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191758
PNG
(US9187397, 1 (curcumin) | US9187397, 3a)
Show SMILES COc1cc(\C=C\C(\O)=C\C(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,22,24-25H,1-2H3/b7-3+,8-4+,16-13-
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n/an/a 8.20E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
TRAP Assay: The first procedure called for antioxidant activity to be measured as the ability of the analogs to react with the pre-formed radical mon...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM191763
PNG
(US9187397, 1 | US9187406, Curcumin | curcumin)
Show SMILES COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(CO)c2)ccc1O
Show InChI InChI=1S/C21H20O6/c1-27-21-11-15(5-9-20(21)26)3-7-18(24)12-17(23)6-2-14-4-8-19(25)16(10-14)13-22/h2-11,22,25-26H,12-13H2,1H3/b6-2+,7-3+
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n/an/a 8.20E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
The 293T/NF-κB-luc cells were re-plated 24 hr prior to treatment, into 24-well cell culture plates in media without hygromycin, to prevent it from...


US Patent US9187397 (2015)

More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062644
PNG
(2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxyli...)
Show SMILES FC(F)(F)c1[nH]c(=O)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C12H6Cl2F3N3O2/c13-5-1-6(14)3-7(2-5)19-10(21)8-4-18-11(22)20-9(8)12(15,16)17/h1-4H,(H,19,21)(H,18,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062654
PNG
(2-Phenylamino-4-trifluoromethyl-pyrimidine-5-carbo...)
Show SMILES FC(F)(F)c1nc(Nc2ccccc2)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H11Cl2F3N4O/c19-10-6-11(20)8-13(7-10)25-16(28)14-9-24-17(27-15(14)18(21,22)23)26-12-4-2-1-3-5-12/h1-9H,(H,25,28)(H,24,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50331546
PNG
(2-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)benzenes...)
Show SMILES Oc1ccc2c(-c3ccccc3S(O)(=O)=O)c3ccc(=O)c(O)c3oc2c1O
Show InChI InChI=1S/C19H12O8S/c20-12-7-5-10-15(9-3-1-2-4-14(9)28(24,25)26)11-6-8-13(21)17(23)19(11)27-18(10)16(12)22/h1-8,20,22-23H,(H,24,25,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



BioPharmaNet

Curated by ChEMBL


Assay Description
Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSA


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50317862
PNG
(CHEMBL1096731 | Cyclorigidol)
Show SMILES CC(C)=CCc1c(O)c(CC=C(C)C)c2oc3-c4cc(O)c(O)cc4OC(C=C(C)C)c3c(=O)c2c1O
Show InChI InChI=1S/C30H32O7/c1-14(2)7-9-17-26(33)18(10-8-15(3)4)29-25(27(17)34)28(35)24-23(11-16(5)6)36-22-13-21(32)20(31)12-19(22)30(24)37-29/h7-8,11-13,23,31-34H,9-10H2,1-6H3
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The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50317861
PNG
(Artoristilbene | CHEMBL1096732)
Show SMILES CC1(C)Oc2cc3Oc4cc(O)ccc4C(=O)Cc3cc2C=C1
Show InChI InChI=1S/C19H16O4/c1-19(2)6-5-11-7-12-8-15(21)14-4-3-13(20)9-18(14)22-16(12)10-17(11)23-19/h3-7,9-10,20H,8H2,1-2H3
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The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50317860
PNG
(Artonin O | CHEMBL1096733)
Show SMILES CC(C)=CCC1C(=O)C(=O)C2=C(C1=O)c1oc3cc(O)c(CC=C(C)C)c(=O)c3c(O)c1C[C@@H]2C(C)=C
Show InChI InChI=1S/C30H30O7/c1-13(2)7-9-16-20(31)12-21-23(25(16)32)27(34)19-11-18(15(5)6)22-24(30(19)37-21)26(33)17(10-8-14(3)4)28(35)29(22)36/h7-8,12,17-18,31,34H,5,9-11H2,1-4,6H3/t17?,18-/m1/s1
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The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50317858
PNG
(CHEMBL1095556 | cycloartobiloxanthone)
Show SMILES CC1(C)Oc2c3[C@@H]1Cc1c(oc4c5C=CC(C)(C)Oc5cc(O)c4c1=O)-c3c(O)cc2O
Show InChI InChI=1S/C25H22O7/c1-24(2)6-5-10-16(31-24)9-14(27)19-20(29)11-7-12-17-18(22(11)30-21(10)19)13(26)8-15(28)23(17)32-25(12,3)4/h5-6,8-9,12,26-28H,7H2,1-4H3/t12-/m0/s1
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The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50085545
PNG
(3-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-5-methoxy-p...)
Show SMILES COc1cc(O)cc(\C=C\c2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C17H18O4/c1-19-15-9-13(8-14(18)11-15)5-4-12-6-7-16(20-2)17(10-12)21-3/h4-11,18H,1-3H3/b5-4+
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The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50317857
PNG
(Artorigidin A | CHEMBL1094756)
Show SMILES CC(C)=CCc1c(O)c(CC=C(C)C)c2oc-3c(C[C@H](C(C)=C)c4c(O)c(O)cc(O)c-34)c(=O)c2c1O
Show InChI InChI=1S/C30H32O7/c1-13(2)7-9-16-25(33)17(10-8-14(3)4)29-24(26(16)34)27(35)19-11-18(15(5)6)22-23(30(19)37-29)20(31)12-21(32)28(22)36/h7-8,12,18,31-34,36H,5,9-11H2,1-4,6H3/t18-/m1/s1
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The Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062657
PNG
(4-Trifluoromethyl-pyrimidine-5-carboxylic acid (3,...)
Show SMILES FC(F)(F)c1ncncc1C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C12H6Cl2F3N3O/c13-6-1-7(14)3-8(2-6)20-11(21)9-4-18-5-19-10(9)12(15,16)17/h1-5H,(H,20,21)
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Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB)


(Homo sapiens (Human))
BDBM50062662
PNG
(2-Cyclohexylamino-4-trifluoromethyl-pyrimidine-5-c...)
Show SMILES FC(F)(F)c1nc(NC2CCCCC2)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H17Cl2F3N4O/c19-10-6-11(20)8-13(7-10)25-16(28)14-9-24-17(27-15(14)18(21,22)23)26-12-4-2-1-3-5-12/h6-9,12H,1-5H2,(H,25,28)(H,24,26,27)
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Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor


Citation and Details
More data for this
Ligand-Target Pair
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