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Compile Data Set for Download or QSAR

Found 264 hits Enz. Inhib. hit(s) with Target = 'PI3K p110 beta/p85 alpha'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM4622
PNG
(3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | An...)
Show SMILES COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC
Show InChI InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)
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Article
PubMed
n/an/a 2n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PI3K


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178430
PNG
(US9120812, 215)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N(C)CCN(C)C)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C35H46N8O5/c1-8-42-22-35(3,4)48-30-28(32(42)45)29(38-33(39-30)43-19-20-47-21-23(43)2)24-9-13-26(14-10-24)36-34(46)37-27-15-11-25(12-16-27)31(44)41(7)18-17-40(5)6/h9-16,23H,8,17-22H2,1-7H3,(H2,36,37,46)/t23-/s2
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n/an/a 37n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178238
PNG
(US9120812, 23)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N4CCC(CC4)N(C)C)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C37H48N8O5/c1-7-43-23-37(3,4)50-32-30(34(43)47)31(40-35(41-32)45-20-21-49-22-24(45)2)25-8-12-27(13-9-25)38-36(48)39-28-14-10-26(11-15-28)33(46)44-18-16-29(17-19-44)42(5)6/h8-15,24,29H,7,16-23H2,1-6H3,(H2,38,39,48)/t24-/s2
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n/an/a 79n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178392
PNG
(US9120812, 177)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N4CCC(CC4)N(C)C)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1/C38H48N8O5/c1-6-44-23-38(2,3)51-33-31(35(44)48)32(41-36(42-33)46-21-29-15-16-30(22-46)50-29)24-7-11-26(12-8-24)39-37(49)40-27-13-9-25(10-14-27)34(47)45-19-17-28(18-20-45)43(4)5/h7-14,28-30H,6,15-23H2,1-5H3,(H2,39,40,49)
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n/an/a 87n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178434
PNG
(US9120812, 219)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)NCC(C)(C)O)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C34H43N7O6/c1-7-40-20-34(5,6)47-29-26(30(40)43)27(38-31(39-29)41-16-17-46-18-21(41)2)22-8-12-24(13-9-22)36-32(44)37-25-14-10-23(11-15-25)28(42)35-19-33(3,4)45/h8-15,21,45H,7,16-20H2,1-6H3,(H,35,42)(H2,36,37,44)/t21-/s2
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n/an/a 98n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178391
PNG
(US9120812, 176)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N(C)CCN(C)C)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1/C36H46N8O5/c1-7-43-22-36(2,3)49-31-29(33(43)46)30(39-34(40-31)44-20-27-16-17-28(21-44)48-27)23-8-12-25(13-9-23)37-35(47)38-26-14-10-24(11-15-26)32(45)42(6)19-18-41(4)5/h8-15,27-28H,7,16-22H2,1-6H3,(H2,37,38,47)
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n/an/a 100n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178446
PNG
(US9120812, 231)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C28H32FN7O4/c1-5-35-16-28(3,4)40-24-22(25(35)37)23(33-26(34-24)36-12-13-39-15-17(36)2)18-6-7-21(20(29)14-18)32-27(38)31-19-8-10-30-11-9-19/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,30,31,32,38)/t17-/s2
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n/an/a 103n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178397
PNG
(US9120812, 182)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cn(C)cn4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C27H33FN8O4/c1-6-35-14-27(3,4)40-23-21(24(35)37)22(32-25(33-23)36-9-10-39-13-16(36)2)17-7-8-19(18(28)11-17)30-26(38)31-20-12-34(5)15-29-20/h7-8,11-12,15-16H,6,9-10,13-14H2,1-5H3,(H2,30,31,38)/t16-/s2
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n/an/a 159n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178414
PNG
(US9120812, 199)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccnc(C)c4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C29H34FN7O4/c1-6-36-16-29(4,5)41-25-23(26(36)38)24(34-27(35-25)37-11-12-40-15-18(37)3)19-7-8-22(21(30)14-19)33-28(39)32-20-9-10-31-17(2)13-20/h7-10,13-14,18H,6,11-12,15-16H2,1-5H3,(H2,31,32,33,39)/t18-/s2
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n/an/a 174n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178471
PNG
(US9120812, 256)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCOCC4(C)C)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C34H43FN8O5/c1-7-41-19-34(5,6)48-29-27(30(41)44)28(39-31(40-29)42-12-14-46-18-21(42)2)22-8-10-25(24(35)16-22)38-32(45)37-23-9-11-26(36-17-23)43-13-15-47-20-33(43,3)4/h8-11,16-17,21H,7,12-15,18-20H2,1-6H3,(H2,37,38,45)/t21-/s2
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n/an/a 199n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178417
PNG
(US9120812, 202)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C29H33FN6O4/c1-5-35-17-29(3,4)40-25-23(26(35)37)24(33-27(34-25)36-14-15-39-16-18(36)2)19-10-12-20(13-11-19)31-28(38)32-22-9-7-6-8-21(22)30/h6-13,18H,5,14-17H2,1-4H3,(H2,31,32,38)/t18-/s2
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n/an/a 213n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178386
PNG
(US9120812, 171)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCN(C)CC4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C33H42FN9O4/c1-6-41-20-33(3,4)47-29-27(30(41)44)28(38-31(39-29)43-15-16-46-19-21(43)2)22-7-9-25(24(34)17-22)37-32(45)36-23-8-10-26(35-18-23)42-13-11-40(5)12-14-42/h7-10,17-18,21H,6,11-16,19-20H2,1-5H3,(H2,36,37,45)/t21-/s2
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n/an/a 308n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178376
PNG
(US9120812, 161)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C29H34FN7O4/c1-6-36-16-29(4,5)41-25-23(26(36)38)24(34-27(35-25)37-11-12-40-15-18(37)3)19-8-10-22(21(30)13-19)33-28(39)32-20-9-7-17(2)31-14-20/h7-10,13-14,18H,6,11-12,15-16H2,1-5H3,(H2,32,33,39)/t18-/s2
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n/an/a 321n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178389
PNG
(US9120812, 174)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCN(C)CC4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C33H43N9O4/c1-6-40-21-33(3,4)46-29-27(30(40)43)28(37-31(38-29)42-17-18-45-20-22(42)2)23-7-9-24(10-8-23)35-32(44)36-25-11-12-26(34-19-25)41-15-13-39(5)14-16-41/h7-12,19,22H,6,13-18,20-21H2,1-5H3,(H2,35,36,44)/t22-/s2
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n/an/a 326n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178436
PNG
(US9120812, 221)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccn4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C28H33N7O4/c1-5-34-17-28(3,4)39-24-22(25(34)36)23(32-26(33-24)35-14-15-38-16-18(35)2)19-9-11-20(12-10-19)30-27(37)31-21-8-6-7-13-29-21/h6-13,18H,5,14-17H2,1-4H3,(H2,29,30,31,37)/t18-/s2
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n/an/a 372n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178419
PNG
(US9120812, 204)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccc(OC(F)F)c4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C30H34F2N6O5/c1-5-37-17-30(3,4)43-25-23(26(37)39)24(35-28(36-25)38-13-14-41-16-18(38)2)19-9-11-20(12-10-19)33-29(40)34-21-7-6-8-22(15-21)42-27(31)32/h6-12,15,18,27H,5,13-14,16-17H2,1-4H3,(H2,33,34,40)/t18-/s2
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n/an/a 468n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178402
PNG
(US9120812, 187)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCOCC4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C32H39FN8O5/c1-5-39-19-32(3,4)46-28-26(29(39)42)27(37-30(38-28)41-12-15-45-18-20(41)2)21-6-8-24(23(33)16-21)36-31(43)35-22-7-9-25(34-17-22)40-10-13-44-14-11-40/h6-9,16-17,20H,5,10-15,18-19H2,1-4H3,(H2,35,36,43)/t20-/s2
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n/an/a 472n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178284
PNG
(US9120812, 69)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1/C28H31N7O4/c1-28(2)16-34(3)25(36)22-23(32-26(33-24(22)39-28)35-14-20-8-9-21(15-35)38-20)17-4-6-18(7-5-17)30-27(37)31-19-10-12-29-13-11-19/h4-7,10-13,20-21H,8-9,14-16H2,1-3H3,(H2,29,30,31,37)
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n/an/a 472n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178442
PNG
(US9120812, 227)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)N4CCOCC4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C33H40FN7O5/c1-5-39-20-33(3,4)46-29-27(30(39)42)28(37-31(38-29)41-14-17-45-19-21(41)2)22-6-11-26(25(34)18-22)36-32(43)35-23-7-9-24(10-8-23)40-12-15-44-16-13-40/h6-11,18,21H,5,12-17,19-20H2,1-4H3,(H2,35,36,43)/t21-/s2
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n/an/a 484n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178217
PNG
(US9120812, 2)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NC)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C24H31FN6O4/c1-6-30-13-24(3,4)35-20-18(21(30)32)19(28-22(29-20)31-9-10-34-12-14(31)2)15-7-8-17(16(25)11-15)27-23(33)26-5/h7-8,11,14H,6,9-10,12-13H2,1-5H3,(H2,26,27,33)/t14-/s2
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n/an/a 547n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178374
PNG
(US9120812, 159)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C26H30FN7O5/c1-5-33-14-26(3,4)39-22-20(23(33)35)21(30-24(31-22)34-9-11-37-13-15(34)2)16-6-7-18(17(27)12-16)28-25(36)29-19-8-10-38-32-19/h6-8,10,12,15H,5,9,11,13-14H2,1-4H3,(H2,28,29,32,36)/t15-/s2
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n/an/a 561n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178406
PNG
(US9120812, 191)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C29H32F2N6O4/c1-5-36-16-29(3,4)41-25-23(26(36)38)24(34-27(35-25)37-12-13-40-15-17(37)2)18-6-9-20(10-7-18)32-28(39)33-22-11-8-19(30)14-21(22)31/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,32,33,39)/t17-/s2
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n/an/a 570n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178356
PNG
(US9120812, 141)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)nc4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C29H34FN7O5/c1-6-36-16-29(3,4)42-25-23(26(36)38)24(34-27(35-25)37-11-12-41-15-17(37)2)18-7-9-21(20(30)13-18)33-28(39)32-19-8-10-22(40-5)31-14-19/h7-10,13-14,17H,6,11-12,15-16H2,1-5H3,(H2,32,33,39)/t17-/s2
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n/an/a 598n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178395
PNG
(US9120812, 180)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C27H33N7O6/c1-17-15-38-14-11-34(17)25-30-22(18-5-7-19(8-6-18)28-26(36)29-20-9-12-39-32-20)21-23(31-25)40-27(2,3)16-33(24(21)35)10-13-37-4/h5-9,12,17H,10-11,13-16H2,1-4H3,(H2,28,29,32,36)/t17-/s2
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n/an/a 604n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178227
PNG
(US9120812, 12)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3F)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C28H32FN7O4/c1-5-35-16-28(3,4)40-24-22(25(35)37)23(33-26(34-24)36-12-13-39-15-17(36)2)20-7-6-19(14-21(20)29)32-27(38)31-18-8-10-30-11-9-18/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,30,31,32,38)/t17-/s2
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n/an/a 640n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178416
PNG
(US9120812, 201)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnn(C)c4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C28H36N8O5/c1-18-16-40-13-11-36(18)26-32-23(22-24(33-26)41-28(2,3)17-35(25(22)37)10-12-39-5)19-6-8-20(9-7-19)30-27(38)31-21-14-29-34(4)15-21/h6-9,14-15,18H,10-13,16-17H2,1-5H3,(H2,30,31,38)/t18-/s2
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n/an/a 813n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178385
PNG
(US9120812, 170)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4nnc(C)o4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C26H31FN8O5/c1-6-34-13-26(4,5)40-21-19(22(34)36)20(29-23(30-21)35-9-10-38-12-14(35)2)16-7-8-18(17(27)11-16)28-24(37)31-25-33-32-15(3)39-25/h7-8,11,14H,6,9-10,12-13H2,1-5H3,(H2,28,31,33,37)/t14-/s2
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n/an/a 824n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178405
PNG
(US9120812, 190)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)NCC(C)(C)O)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1/C35H43N7O6/c1-6-41-20-35(4,5)48-30-27(31(41)44)28(39-32(40-30)42-17-25-15-16-26(18-42)47-25)21-7-11-23(12-8-21)37-33(45)38-24-13-9-22(10-14-24)29(43)36-19-34(2,3)46/h7-14,25-26,46H,6,15-20H2,1-5H3,(H,36,43)(H2,37,38,45)
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n/an/a 927n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178428
PNG
(US9120812, 213)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cc(OC)ccc4F)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C30H35FN6O5/c1-6-36-17-30(3,4)42-26-24(27(36)38)25(34-28(35-26)37-13-14-41-16-18(37)2)19-7-9-20(10-8-19)32-29(39)33-23-15-21(40-5)11-12-22(23)31/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H2,32,33,39)/t18-/s2
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n/an/a 991n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM117067
PNG
(US8664230, 3)
Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncnc(OC3CCOCC3)c2n1
Show InChI InChI=1S/C23H18ClF2N5O4S/c24-22-19(31-36(32,33)20-4-1-14(25)10-16(20)26)9-13(11-27-22)17-2-3-18-21(30-17)23(29-12-28-18)35-15-5-7-34-8-6-15/h1-4,9-12,15,31H,5-8H2
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n/an/a<1.00E+3n/an/an/an/an/an/a



The Asan Foundation

US Patent


Assay Description
The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas...


US Patent US8664230 (2014)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM117068
PNG
(US8664230, 4)
Show SMILES CN1CCC(CC1)Oc1ncnc2ccc(nc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2F)c1
Show InChI InChI=1S/C24H21ClF2N6O3S/c1-33-8-6-16(7-9-33)36-24-22-19(29-13-30-24)4-3-18(31-22)14-10-20(23(25)28-12-14)32-37(34,35)21-5-2-15(26)11-17(21)27/h2-5,10-13,16,32H,6-9H2,1H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



The Asan Foundation

US Patent


Assay Description
The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas...


US Patent US8664230 (2014)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178433
PNG
(US9120812, 218)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cn4)N4CCN(C)CC4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C33H43N9O4/c1-6-40-21-33(3,4)46-29-27(30(40)43)28(37-31(38-29)42-17-18-45-20-22(42)2)23-7-9-24(10-8-23)35-32(44)36-26-12-11-25(19-34-26)41-15-13-39(5)14-16-41/h7-12,19,22H,6,13-18,20-21H2,1-5H3,(H2,34,35,36,44)/t22-/s2
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n/an/a 1.06E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178313
PNG
(US9120812, 98)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(nc2OC(C)(C)CN(CC)C(=O)c12)N1CCOC[C@@H]1C
Show InChI InChI=1/C25H34N6O4/c1-6-26-24(33)27-18-10-8-17(9-11-18)20-19-21(35-25(4,5)15-30(7-2)22(19)32)29-23(28-20)31-12-13-34-14-16(31)3/h8-11,16H,6-7,12-15H2,1-5H3,(H2,26,27,33)/t16-/s2
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n/an/a 1.14E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178371
PNG
(US9120812, 156)
Show SMILES C[C@H]1COCCN1c1nc2OC(C)(C)CN(C3CCOCC3)C(=O)c2c(n1)-c1ccc(NC(=O)Nc2ccon2)c(F)c1
Show InChI InChI=1/C29H34FN7O6/c1-17-15-41-13-9-36(17)27-33-24(18-4-5-21(20(30)14-18)31-28(39)32-22-8-12-42-35-22)23-25(34-27)43-29(2,3)16-37(26(23)38)19-6-10-40-11-7-19/h4-5,8,12,14,17,19H,6-7,9-11,13,15-16H2,1-3H3,(H2,31,32,35,39)/t17-/s2
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n/an/a 1.14E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178409
PNG
(US9120812, 194)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cn(C)cn4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1/C28H33FN8O4/c1-5-36-14-28(2,3)41-24-22(25(36)38)23(33-26(34-24)37-11-17-7-8-18(12-37)40-17)16-6-9-20(19(29)10-16)31-27(39)32-21-13-35(4)15-30-21/h6,9-10,13,15,17-18H,5,7-8,11-12,14H2,1-4H3,(H2,31,32,39)
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n/an/a 1.23E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178423
PNG
(US9120812, 208)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cc(OC)c(F)cc4F)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C30H34F2N6O5/c1-6-37-16-30(3,4)43-26-24(27(37)39)25(35-28(36-26)38-11-12-42-15-17(38)2)18-7-9-19(10-8-18)33-29(40)34-22-14-23(41-5)21(32)13-20(22)31/h7-10,13-14,17H,6,11-12,15-16H2,1-5H3,(H2,33,34,40)/t17-/s2
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US Patent
n/an/a 1.24E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178407
PNG
(US9120812, 192)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccn4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C28H32FN7O4/c1-5-35-16-28(3,4)40-24-22(25(35)37)23(33-26(34-24)36-12-13-39-15-17(36)2)18-9-10-20(19(29)14-18)31-27(38)32-21-8-6-7-11-30-21/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,30,31,32,38)/t17-/s2
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US Patent
n/an/a 1.31E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178440
PNG
(US9120812, 225)
Show SMILES CNC(=O)Nc1ccc(cc1F)-c1nc(nc2OC(C)(C)CN(CCOC)C(=O)c12)N1CCOC[C@@H]1C
Show InChI InChI=1/C25H33FN6O5/c1-15-13-36-11-9-32(15)23-29-20(16-6-7-18(17(26)12-16)28-24(34)27-4)19-21(30-23)37-25(2,3)14-31(22(19)33)8-10-35-5/h6-7,12,15H,8-11,13-14H2,1-5H3,(H2,27,28,34)/t15-/s2
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US Patent
n/an/a 1.36E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178283
PNG
(US9120812, 68)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)c2C1=O)N1C2CCC1COC2
Show InChI InChI=1/C28H31N7O4/c1-28(2)16-34(3)25(36)22-23(32-26(33-24(22)39-28)35-20-8-9-21(35)15-38-14-20)17-4-6-18(7-5-17)30-27(37)31-19-10-12-29-13-11-19/h4-7,10-13,20-21H,8-9,14-16H2,1-3H3,(H2,29,30,31,37)
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n/an/a 1.36E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178467
PNG
(US9120812, 252)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4C[C@@H]5C[C@H]4CO5)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C33H39FN8O5/c1-5-40-18-33(3,4)47-29-27(30(40)43)28(38-31(39-29)41-10-11-45-16-19(41)2)20-6-8-25(24(34)12-20)37-32(44)36-21-7-9-26(35-14-21)42-15-23-13-22(42)17-46-23/h6-9,12,14,19,22-23H,5,10-11,13,15-18H2,1-4H3,(H2,36,37,44)/t19-,22-,23-/s2
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US Patent
n/an/a 1.36E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178383
PNG
(US9120812, 168 | US9120812, 169)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C29H35N7O4/c1-6-35-17-29(4,5)40-25-23(26(35)37)24(33-27(34-25)36-13-14-39-16-19(36)3)20-8-10-21(11-9-20)31-28(38)32-22-12-7-18(2)15-30-22/h7-12,15,19H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t19-/s2
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US Patent
n/an/a 1.39E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PI3K


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178311
PNG
(US9120812, 96)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(nc2OC(C)(C)CN(CC)C(=O)c12)N1CCOCC1
Show InChI InChI=1S/C24H32N6O4/c1-5-25-23(32)26-17-9-7-16(8-10-17)19-18-20(28-22(27-19)30-11-13-33-14-12-30)34-24(3,4)15-29(6-2)21(18)31/h7-10H,5-6,11-15H2,1-4H3,(H2,25,26,32)
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US Patent
n/an/a 1.44E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178383
PNG
(US9120812, 168 | US9120812, 169)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C29H35N7O4/c1-6-35-17-29(4,5)40-25-23(26(35)37)24(33-27(34-25)36-13-14-39-16-19(36)3)20-8-10-21(11-9-20)31-28(38)32-22-12-7-18(2)15-30-22/h7-12,15,19H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t19-/s2
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US Patent
n/an/a 1.45E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178298
PNG
(US9120812, 83)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1/C28H30FN7O4/c1-28(2)15-35(3)25(37)22-23(33-26(34-24(22)40-28)36-13-18-5-6-19(14-36)39-18)16-4-7-21(20(29)12-16)32-27(38)31-17-8-10-30-11-9-17/h4,7-12,18-19H,5-6,13-15H2,1-3H3,(H2,30,31,32,38)
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US Patent
n/an/a 1.46E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178427
PNG
(US9120812, 212)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccc(OC(C)F)c4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C31H36F2N6O5/c1-6-38-17-31(4,5)44-27-25(28(38)40)26(36-29(37-27)39-12-13-42-16-18(39)2)20-10-11-24(23(33)14-20)35-30(41)34-21-8-7-9-22(15-21)43-19(3)32/h7-11,14-15,18-19H,6,12-13,16-17H2,1-5H3,(H2,34,35,41)/t18-,19?/s2
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US Patent
n/an/a 1.54E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178388
PNG
(US9120812, 173)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C29H35N7O5/c1-6-35-17-29(3,4)41-25-23(26(35)37)24(33-27(34-25)36-13-14-40-16-18(36)2)19-7-9-20(10-8-19)31-28(38)32-22-12-11-21(39-5)15-30-22/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t18-/s2
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US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178267
PNG
(US9120812, 52)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1CC2CC11CC1O2
Show InChI InChI=1/C29H30FN7O4/c1-4-36-15-28(2,3)41-24-22(25(36)38)23(34-26(35-24)37-14-18-12-29(37)13-21(29)40-18)16-5-6-20(19(30)11-16)33-27(39)32-17-7-9-31-10-8-17/h5-11,18,21H,4,12-15H2,1-3H3,(H2,31,32,33,39)
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US Patent
n/an/a 1.71E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178431
PNG
(US9120812, 216)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccc(OC(F)F)c4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1/C31H36F2N6O6/c1-19-17-43-15-13-39(19)29-36-25(24-26(37-29)45-31(2,3)18-38(27(24)40)12-14-42-4)20-8-10-21(11-9-20)34-30(41)35-22-6-5-7-23(16-22)44-28(32)33/h5-11,16,19,28H,12-15,17-18H2,1-4H3,(H2,34,35,41)/t19-/s2
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US Patent
n/an/a 1.83E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
PI3K p110 beta/p85 alpha


(Homo sapiens (human))
BDBM178435
PNG
(US9120812, 220)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccc(OC(C)F)c4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1/C33H38F2N6O6/c1-19(34)45-22-7-5-6-21(15-22)36-32(43)37-26-11-8-20(14-25(26)35)28-27-29(47-33(2,3)18-40(30(27)42)12-13-44-4)39-31(38-28)41-16-23-9-10-24(17-41)46-23/h5-8,11,14-15,19,23-24H,9-10,12-13,16-18H2,1-4H3,(H2,36,37,43)
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n/an/a 1.86E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)

More data for this
Ligand-Target Pair
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