BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'PI3K-alpha/ DNA-PK'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PI3K-alpha/ DNA-PK


(Homo sapiens (human)-Homo sapiens (Human))
BDBM36408
PNG
(1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3...)
Show SMILES COc1ccc(cc1OC)-c1nn(C2CCC2)c2ncnc(N)c12
Show InChI InChI=1S/C17H19N5O2/c1-23-12-7-6-10(8-13(12)24-2)15-14-16(18)19-9-20-17(14)22(21-15)11-4-3-5-11/h6-9,11H,3-5H2,1-2H3,(H2,18,19,20)
KEGG

DrugBank
GoogleScholar
AffyNet 
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 47n/an/an/an/an/an/a



University of California, San Francisco



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


Citation and Details
More data for this
Ligand-Target Pair
PI3K-alpha/ DNA-PK


(Homo sapiens (human)-Homo sapiens (Human))
BDBM36410
PNG
(1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...)
Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1
Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)
KEGG

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 6.30E+3n/an/an/an/an/an/a



University of California, San Francisco



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


Citation and Details
More data for this
Ligand-Target Pair