BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 219 hits Enz. Inhib. hit(s) with Target = 'Papain'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Papain


(Carica papaya)
BDBM50157741
PNG
(CHEMBL374508 | E-64 | E64)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCN=C(N)N
Show InChI InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



University of Lisbon

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by spectrofluorometry


Bioorg Med Chem 19: 7635-42 (2011)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50157741
PNG
(CHEMBL374508 | E-64 | E64)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCN=C(N)N
Show InChI InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50094931
PNG
(CHEMBL430641 | Oxirane-2,3-dicarboxylic acid monoe...)
Show SMILES CCOC(=O)C1OC1C(O)=O
Show InChI InChI=1S/C6H8O5/c1-2-10-6(9)4-3(11-4)5(7)8/h3-4H,2H2,1H3,(H,7,8)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 10.5n/an/an/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
The compound was evaluated for inhibition of papain.


Bioorg Med Chem Lett 10: 2647-51 (2000)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50303441
PNG
(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Show SMILES CCNc1nc(nc2n(cnc12)-c1cc(F)cc(F)c1)C#N
Show InChI InChI=1S/C14H10F2N6/c1-2-18-13-12-14(21-11(6-17)20-13)22(7-19-12)10-4-8(15)3-9(16)5-10/h3-5,7H,2H2,1H3,(H,18,20,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 33.1n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of papaya papain


J Med Chem 53: 52-60 (2010)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50303420
PNG
(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Show SMILES CCn1cnc2c(Nc3cc(F)cc(F)c3)nc(nc12)C#N
Show InChI InChI=1S/C14H10F2N6/c1-2-22-7-18-12-13(20-11(6-17)21-14(12)22)19-10-4-8(15)3-9(16)5-10/h3-5,7H,2H2,1H3,(H,19,20,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 44.7n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of papaya papain


J Med Chem 53: 52-60 (2010)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50157741
PNG
(CHEMBL374508 | E-64 | E64)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCN=C(N)N
Show InChI InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Federal University of Alfenas

Curated by ChEMBL


Assay Description
Inhibition of Carica papaya papain by spectrofluorimetry


Eur J Med Chem 44: 1230-9 (2009)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50366497
PNG
(CHEMBL1790164)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C29H40N6O5/c1-3-20(2)25(27(38)33-23(18-36)17-21-11-6-4-7-12-21)35-26(37)24(15-10-16-32-28(30)31)34-29(39)40-19-22-13-8-5-9-14-22/h4-9,11-14,18,20,23-25H,3,10,15-17,19H2,1-2H3,(H,33,38)(H,34,39)(H,35,37)(H4,30,31,32)/t20-,23-,24-,25-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 70n/an/an/an/an/an/a



Institute for Drug Research

Curated by ChEMBL


Assay Description
Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substrates


Bioorg Med Chem Lett 8: 1477-82 (1999)

Checked by Author
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50070495
PNG
(CHEMBL290218 | [(S)-1-((S)-1-Formyl-4-guanidino-bu...)
Show SMILES CC(C)COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C=O
Show InChI InChI=1S/C20H31N5O4/c1-14(2)13-29-20(28)25-17(11-15-7-4-3-5-8-15)18(27)24-16(12-26)9-6-10-23-19(21)22/h3-5,7-8,12,14,16-17H,6,9-11,13H2,1-2H3,(H,24,27)(H,25,28)(H4,21,22,23)/t16-,17-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 130n/an/an/an/an/an/a



Institute for Drug Research

Curated by ChEMBL


Assay Description
Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substrates


Bioorg Med Chem Lett 8: 1477-82 (1999)

Checked by Author
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50094933
PNG
((S)-Thiirane-2-carboxylic acid methyl ester | CHEM...)
Show SMILES COC(=O)[C@H]1CS1
Show InChI InChI=1S/C4H6O2S/c1-6-4(5)3-2-7-3/h3H,2H2,1H3/t3-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 200n/an/an/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
The compound was evaluated for inhibition of papain.


Bioorg Med Chem Lett 10: 2647-51 (2000)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50094934
PNG
(CHEMBL329821 | Oxirane-2,3-dicarboxylic acid dieth...)
Show SMILES CCOC(=O)C1OC1C(=O)OCC
Show InChI InChI=1S/C8H12O5/c1-3-11-7(9)5-6(13-5)8(10)12-4-2/h5-6H,3-4H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 207n/an/an/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
The compound was evaluated for inhibition of papain.


Bioorg Med Chem Lett 10: 2647-51 (2000)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20120
PNG
((2S)-N-(cyanomethyl)-3-phenyl-2-[(4-phenylphenyl)f...)
Show SMILES O=C(NCC#N)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H21N3O2/c25-15-16-26-24(29)22(17-18-7-3-1-4-8-18)27-23(28)21-13-11-20(12-14-21)19-9-5-2-6-10-19/h1-14,22H,16-17H2,(H,26,29)(H,27,28)/t22-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50095489
PNG
(CHEMBL275080 | N-(1-Cyano-pyrrolidin-3-yl)-benzene...)
Show SMILES O=S(=O)(NC1CCN(C1)C#N)c1ccccc1
Show InChI InChI=1S/C11H13N3O2S/c12-9-14-7-6-10(8-14)13-17(15,16)11-4-2-1-3-5-11/h1-5,10,13H,6-8H2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 230n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity tested against papain at a pH 5.5


J Med Chem 44: 94-104 (2001)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048077
PNG
(CHEMBL3357470)
Show SMILES [N-]=[N+]=NCc1ccc(cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N
Show InChI InChI=1/C19H18N6O2/c20-10-11-22-19(27)17(12-14-4-2-1-3-5-14)24-18(26)16-8-6-15(7-9-16)13-23-25-21/h1-9,17H,11-13H2,(H,22,27)(H,24,26)/t17-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 270n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048079
PNG
(CHEMBL3357955)
Show SMILES Oc1ccc(C[C@H](NC(=O)c2ccc(CN=[N+]=[N-])cc2)C(=O)NCC#N)cc1
Show InChI InChI=1/C19H18N6O3/c20-9-10-22-19(28)17(11-13-3-7-16(26)8-4-13)24-18(27)15-5-1-14(2-6-15)12-23-25-21/h1-8,17,26H,10-12H2,(H,22,28)(H,24,27)/t17-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048070
PNG
(CHEMBL3357964)
Show SMILES NCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCc3nnn(Cc4ccc(cc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC#N)c3CC[C@H]12
Show InChI InChI=1/C36H46N8O6/c37-14-16-39-35(46)32(22-25-4-2-1-3-5-25)41-34(45)27-8-6-26(7-9-27)23-44-33-13-11-29-28(10-12-31(33)42-43-44)30(29)24-50-36(47)40-17-19-49-21-20-48-18-15-38/h1-9,28-30,32H,10-13,15-24,38H2,(H,39,46)(H,40,47)(H,41,45)/t28-,29+,30-,32+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20119
PNG
((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Show SMILES O=C(NCC#N)[C@H](Cc1ccccc1)NC(=O)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c19-11-12-20-18(23)16(13-14-7-3-1-4-8-14)21-17(22)15-9-5-2-6-10-15/h1-10,16H,12-13H2,(H,20,23)(H,21,22)/t16-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50303417
PNG
(4-(Cyclopentylamino)-6-(3,5-difluorophenylamino)-1...)
Show SMILES Fc1cc(F)cc(Nc2nc(NC3CCCC3)nc(n2)C#N)c1
Show InChI InChI=1S/C15H14F2N6/c16-9-5-10(17)7-12(6-9)20-15-22-13(8-18)21-14(23-15)19-11-3-1-2-4-11/h5-7,11H,1-4H2,(H2,19,20,21,22,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 389n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of papaya papain


J Med Chem 53: 52-60 (2010)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50303410
PNG
(4-(3-chlorophenylamino)-6-(cyclopentylamino)-1,3,5...)
Show SMILES Clc1cccc(Nc2nc(NC3CCCC3)nc(n2)C#N)c1
Show InChI InChI=1S/C15H15ClN6/c16-10-4-3-7-12(8-10)19-15-21-13(9-17)20-14(22-15)18-11-5-1-2-6-11/h3-4,7-8,11H,1-2,5-6H2,(H2,18,19,20,21,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 513n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of papaya papain


J Med Chem 53: 52-60 (2010)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50094932
PNG
((S)-Thiirane-2-carboxylic acid ethyl ester | CHEMB...)
Show SMILES CCOC(=O)[C@H]1CS1
Show InChI InChI=1S/C5H8O2S/c1-2-7-5(6)4-3-8-4/h4H,2-3H2,1H3/t4-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 570n/an/an/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
The compound was evaluated for inhibition of papain.


Bioorg Med Chem Lett 10: 2647-51 (2000)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048080
PNG
(CHEMBL3357956)
Show SMILES [N-]=[N+]=NCc1ccc(cc1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCC#N
Show InChI InChI=1/C20H20N6O2/c21-12-13-23-20(28)18(11-8-15-4-2-1-3-5-15)25-19(27)17-9-6-16(7-10-17)14-24-26-22/h1-7,9-10,18H,8,11,13-14H2,(H,23,28)(H,25,27)/t18-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 710n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048081
PNG
(CHEMBL3357957)
Show SMILES Oc1ccc(CC[C@H](NC(=O)c2ccc(CN=[N+]=[N-])cc2)C(=O)NCC#N)cc1
Show InChI InChI=1/C20H20N6O3/c21-11-12-23-20(29)18(10-5-14-3-8-17(27)9-4-14)25-19(28)16-6-1-15(2-7-16)13-24-26-22/h1-4,6-9,18,27H,5,10,12-13H2,(H,23,29)(H,25,28)/t18-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 980n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048082
PNG
(CHEMBL3357958)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(cc1)-c1ccc(CN=[N+]=[N-])cc1)C(=O)NCC#N
Show InChI InChI=1/C22H24N6O2/c1-15(2)13-20(22(30)25-12-11-23)27-21(29)19-9-7-18(8-10-19)17-5-3-16(4-6-17)14-26-28-24/h3-10,15,20H,12-14H2,1-2H3,(H,25,30)(H,27,29)/t20-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.58E+3n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50378032
PNG
(CHEMBL452483 | Guttiferone A)
Show SMILES CC(C)=CCC[C@]1(C)[C@@H](CC=C(C)C)C[C@@]2(CC=C(C)C)C(=O)C(C(=O)c3ccc(O)c(O)c3)C(=O)[C@]1(CC=C(C)C)C2=O
Show InChI InChI=1S/C38H50O6/c1-23(2)11-10-18-36(9)28(14-12-24(3)4)22-37(19-16-25(5)6)33(42)31(32(41)27-13-15-29(39)30(40)21-27)34(43)38(36,35(37)44)20-17-26(7)8/h11-13,15-17,21,28,31,39-40H,10,14,18-20,22H2,1-9H3/t28-,31?,36+,37-,38+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



Federal University of Alfenas

Curated by ChEMBL


Assay Description
Inhibition of Carica papaya papain by spectrofluorimetry


Eur J Med Chem 44: 1230-9 (2009)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048072
PNG
(CHEMBL3357962)
Show SMILES CC(C)C[C@H](NC(=O)CN=[N+]=[N-])C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N
Show InChI InChI=1/C19H25N7O3/c1-13(2)10-15(24-17(27)12-23-26-21)19(29)25-16(18(28)22-9-8-20)11-14-6-4-3-5-7-14/h3-7,13,15-16H,9-12H2,1-2H3,(H,22,28)(H,24,27)(H,25,29)/t15-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.25E+3n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048074
PNG
(CHEMBL3357468)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(CN=[N+]=[N-])cc1)C(=O)NCC#N
Show InChI InChI=1/C16H20N6O2/c1-11(2)9-14(16(24)19-8-7-17)21-15(23)13-5-3-12(4-6-13)10-20-22-18/h3-6,11,14H,8-10H2,1-2H3,(H,19,24)(H,21,23)/t14-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.27E+3n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048068
PNG
(CHEMBL3357961)
Show SMILES CC(C)C[C@H](NC(=O)CN=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)NCC#N
Show InChI InChI=1/C16H27N7O3/c1-10(2)7-12(15(25)19-6-5-17)22-16(26)13(8-11(3)4)21-14(24)9-20-23-18/h10-13H,6-9H2,1-4H3,(H,19,25)(H,21,24)(H,22,26)/t12-,13-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.71E+3n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048073
PNG
(CHEMBL3357963)
Show SMILES [N-]=[N+]=NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N
Show InChI InChI=1/C22H23N7O3/c23-11-12-25-21(31)18(13-16-7-3-1-4-8-16)28-22(32)19(27-20(30)15-26-29-24)14-17-9-5-2-6-10-17/h1-10,18-19H,12-15H2,(H,25,31)(H,27,30)(H,28,32)/t18-,19-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 3.97E+3n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048071
PNG
(CHEMBL3357965)
Show SMILES NCCOCCOCCNC(=O)CCCC(=O)N1Cc2ccccc2-c2c(nnn2Cc2ccc(cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC#N)-c2ccccc12
Show InChI InChI=1/C45H49N9O6/c46-21-23-49-45(58)38(29-32-9-2-1-3-10-32)50-44(57)34-19-17-33(18-20-34)30-54-43-36-12-5-4-11-35(36)31-53(39-14-7-6-13-37(39)42(43)51-52-54)41(56)16-8-15-40(55)48-24-26-60-28-27-59-25-22-47/h1-7,9-14,17-20,38H,8,15-16,22-31,47H2,(H,48,55)(H,49,58)(H,50,57)/t38-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 5.98E+3n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048075
PNG
(CHEMBL3357469)
Show SMILES CCCC[C@H](NC(=O)c1ccc(CN=[N+]=[N-])cc1)C(=O)NCC#N
Show InChI InChI=1/C16H20N6O2/c1-2-3-4-14(16(24)19-10-9-17)21-15(23)13-7-5-12(6-8-13)11-20-22-18/h5-8,14H,2-4,10-11H2,1H3,(H,19,24)(H,21,23)/t14-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 7.10E+3n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50366496
PNG
(CHEMBL1790166)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C29H40N6O5/c1-3-20(2)25(27(38)33-23(18-36)17-21-11-6-4-7-12-21)35-26(37)24(15-10-16-32-28(30)31)34-29(39)40-19-22-13-8-5-9-14-22/h4-9,11-14,18,20,23-25H,3,10,15-17,19H2,1-2H3,(H,33,38)(H,34,39)(H,35,37)(H4,30,31,32)/t20-,23+,24-,25-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 8.50E+3n/an/an/an/an/an/a



Institute for Drug Research

Curated by ChEMBL


Assay Description
Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substrates


Bioorg Med Chem Lett 8: 1477-82 (1999)

Checked by Author
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441683
PNG
(CHEMBL2435695)
Show SMILES COc1c(NCCCNc2ccnc3cc(Cl)ccc23)c(=O)c1=O
Show InChI InChI=1S/C17H16ClN3O3/c1-24-17-14(15(22)16(17)23)21-7-2-6-19-12-5-8-20-13-9-10(18)3-4-11(12)13/h3-5,8-9,21H,2,6-7H2,1H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441684
PNG
(CHEMBL2435694)
Show SMILES COc1c(NCCNc2ccnc3cc(Cl)ccc23)c(=O)c1=O
Show InChI InChI=1S/C16H14ClN3O3/c1-23-16-13(14(21)15(16)22)20-7-6-19-11-4-5-18-12-8-9(17)2-3-10(11)12/h2-5,8,20H,6-7H2,1H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50302107
PNG
(CHEMBL567893 | Grassystatin A)
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](OC(=O)[C@@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)[C@@H](C)O
Show InChI InChI=1S/C58H95N9O16/c1-30(2)25-38(43(69)29-45(71)64-46(36(12)68)52(74)60-35(11)54(76)66(15)42(27-37-21-18-17-19-22-37)55(77)67-24-20-23-41(67)56(78)81-16)61-51(73)40(28-44(59)70)62-50(72)39(26-31(3)4)63-53(75)48(33(7)8)82-58(80)49(34(9)10)83-57(79)47(32(5)6)65(13)14/h17-19,21-22,30-36,38-43,46-49,68-69H,20,23-29H2,1-16H3,(H2,59,70)(H,60,74)(H,61,73)(H,62,72)(H,63,75)(H,64,71)/t35-,36+,38-,39-,40-,41-,42+,43-,46-,47-,48+,49-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of papaya papain after 10 to 15 mins by fluorescence assay


J Med Chem 52: 5732-47 (2009)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441675
PNG
(CHEMBL2435705)
Show SMILES CCCCOc1c(NCCCC(C)Nc2cc(OC)cc3cccnc23)c(=O)c1=O
Show InChI InChI=1S/C23H29N3O4/c1-4-5-12-30-23-20(21(27)22(23)28)25-10-6-8-15(2)26-18-14-17(29-3)13-16-9-7-11-24-19(16)18/h7,9,11,13-15,25-26H,4-6,8,10,12H2,1-3H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441676
PNG
(CHEMBL2435704)
Show SMILES Clc1ccc2c(NCCNC(=O)[C@H](Cc3ccccc3)Nc3c(N[C@@H](Cc4ccccc4)C(=O)NCCNc4ccnc5cc(Cl)ccc45)c(=O)c3=O)ccnc2c1
Show InChI InChI=1S/C44H40Cl2N8O4/c45-29-11-13-31-33(15-17-47-35(31)25-29)49-19-21-51-43(57)37(23-27-7-3-1-4-8-27)53-39-40(42(56)41(39)55)54-38(24-28-9-5-2-6-10-28)44(58)52-22-20-50-34-16-18-48-36-26-30(46)12-14-32(34)36/h1-18,25-26,37-38,53-54H,19-24H2,(H,47,49)(H,48,50)(H,51,57)(H,52,58)/t37-,38-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441677
PNG
(CHEMBL2435702)
Show SMILES Clc1ccc2c(NCCCCNc3c(NCCCCNc4ccnc5cc(Cl)ccc45)c(=O)c3=O)ccnc2c1
Show InChI InChI=1S/C30H30Cl2N6O2/c31-19-5-7-21-23(9-15-35-25(21)17-19)33-11-1-3-13-37-27-28(30(40)29(27)39)38-14-4-2-12-34-24-10-16-36-26-18-20(32)6-8-22(24)26/h5-10,15-18,37-38H,1-4,11-14H2,(H,33,35)(H,34,36)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441678
PNG
(CHEMBL2435701)
Show SMILES Clc1ccc2c(NCCCNc3c(NCCCNc4ccnc5cc(Cl)ccc45)c(=O)c3=O)ccnc2c1
Show InChI InChI=1S/C28H26Cl2N6O2/c29-17-3-5-19-21(7-13-33-23(19)15-17)31-9-1-11-35-25-26(28(38)27(25)37)36-12-2-10-32-22-8-14-34-24-16-18(30)4-6-20(22)24/h3-8,13-16,35-36H,1-2,9-12H2,(H,31,33)(H,32,34)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441679
PNG
(CHEMBL2435700)
Show SMILES Clc1ccc2c(NCCNc3c(NCCNc4ccnc5cc(Cl)ccc45)c(=O)c3=O)ccnc2c1
Show InChI InChI=1S/C26H22Cl2N6O2/c27-15-1-3-17-19(5-7-29-21(17)13-15)31-9-11-33-23-24(26(36)25(23)35)34-12-10-32-20-6-8-30-22-14-16(28)2-4-18(20)22/h1-8,13-14,33-34H,9-12H2,(H,29,31)(H,30,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441680
PNG
(CHEMBL2435698)
Show SMILES CCCCOc1c(N2CCN(CC2)c2ccnc3cc(Cl)ccc23)c(=O)c1=O
Show InChI InChI=1S/C21H22ClN3O3/c1-2-3-12-28-21-18(19(26)20(21)27)25-10-8-24(9-11-25)17-6-7-23-16-13-14(22)4-5-15(16)17/h4-7,13H,2-3,8-12H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441681
PNG
(CHEMBL2435697)
Show SMILES CCCCOc1c(NCCCNc2ccnc3cc(Cl)ccc23)c(=O)c1=O
Show InChI InChI=1S/C20H22ClN3O3/c1-2-3-11-27-20-17(18(25)19(20)26)24-9-4-8-22-15-7-10-23-16-12-13(21)5-6-14(15)16/h5-7,10,12,24H,2-4,8-9,11H2,1H3,(H,22,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50441682
PNG
(CHEMBL2435696)
Show SMILES CCCCOc1c(NCCNc2ccnc3cc(Cl)ccc23)c(=O)c1=O
Show InChI InChI=1S/C19H20ClN3O3/c1-2-3-10-26-19-16(17(24)18(19)25)23-9-8-22-14-6-7-21-15-11-12(20)4-5-13(14)15/h4-7,11,23H,2-3,8-10H2,1H3,(H,21,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Lisbon. Av. Prof. Gama Pinto

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis


Eur J Med Chem 69: 365-72 (2013)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50055218
PNG
(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Show SMILES NC(=O)c1ccc2N(Cc3ccc4ccccc4c3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C20H14N2O3/c21-19(24)15-7-8-17-16(10-15)18(23)20(25)22(17)11-12-5-6-13-3-1-2-4-14(13)9-12/h1-10H,11H2,(H2,21,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of papain


J Med Chem 49: 3440-3 (2006)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50070503
PNG
(CHEMBL286910 | [(S)-1-((R)-1-Formyl-4-guanidino-bu...)
Show SMILES CC(C)COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(N)=N)C=O
Show InChI InChI=1S/C20H31N5O4/c1-14(2)13-29-20(28)25-17(11-15-7-4-3-5-8-15)18(27)24-16(12-26)9-6-10-23-19(21)22/h3-5,7-8,12,14,16-17H,6,9-11,13H2,1-2H3,(H,24,27)(H,25,28)(H4,21,22,23)/t16-,17+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.25E+4n/an/an/an/an/an/a



Institute for Drug Research

Curated by ChEMBL


Assay Description
Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substrates


Bioorg Med Chem Lett 8: 1477-82 (1999)

Checked by Author
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50048083
PNG
(CHEMBL3357959)
Show SMILES [N-]=[N+]=NCc1ccc(cc1)-c1ccc(cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N
Show InChI InChI=1/C25H22N6O2/c26-14-15-28-25(33)23(16-18-4-2-1-3-5-18)30-24(32)22-12-10-21(11-13-22)20-8-6-19(7-9-20)17-29-31-27/h1-13,23H,15-17H2,(H,28,33)(H,30,32)/t23-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.39E+4n/an/an/an/an/an/a



Radboud University Nijmegen

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry


Bioorg Med Chem 22: 5593-603 (2014)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50107004
PNG
(CHEMBL421215 | Chrysene-1,4-dione)
Show SMILES O=C1C=CC(=O)c2c1ccc1c2ccc2ccccc12
Show InChI InChI=1S/C18H10O2/c19-16-9-10-17(20)18-14-6-5-11-3-1-2-4-12(11)13(14)7-8-15(16)18/h1-10H
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against papain using HPLC assay


Bioorg Med Chem Lett 11: 3143-6 (2001)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50249351
PNG
(CHEMBL470519 | epiclusianone)
Show SMILES CC(C)=CC[C@H]1C[C@@]2(CC=C(C)C)C(=O)C(C(=O)c3ccccc3)C(=O)[C@](C=C(C)C)(C2=O)C1(C)C
Show InChI InChI=1S/C32H40O4/c1-20(2)14-15-24-19-31(17-16-21(3)4)27(34)25(26(33)23-12-10-9-11-13-23)28(35)32(29(31)36,18-22(5)6)30(24,7)8/h9-14,16,18,24-25H,15,17,19H2,1-8H3/t24-,25?,31-,32+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.95E+4n/an/an/an/an/an/a



Federal University of Alfenas

Curated by ChEMBL


Assay Description
Inhibition of Carica papaya papain by spectrofluorimetry


Eur J Med Chem 44: 1230-9 (2009)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50107000
PNG
(6-Acetyl-5-hydroxy-2-methoxy-7-methyl-[1,4]naphtho...)
Show SMILES COC1=CC(=O)c2c(O)c(C(C)=O)c(C)cc2C1=O
Show InChI InChI=1S/C14H12O5/c1-6-4-8-12(14(18)11(6)7(2)15)9(16)5-10(19-3)13(8)17/h4-5,18H,1-3H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 2.30E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against papain using HPLC assay


Bioorg Med Chem Lett 11: 3143-6 (2001)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM24776
PNG
(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Show SMILES O=C1C=CC(=O)c2ccccc12
Show InChI InChI=1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 2.90E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against papain using HPLC assay


Bioorg Med Chem Lett 11: 3143-6 (2001)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50364000
PNG
(CHEMBL1950253)
Show SMILES CCOP(=O)(CC=C(NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)c1ccccc1)OCC
Show InChI InChI=1S/C30H35N2O6P/c1-3-37-39(35,38-4-2)21-20-27(26-18-12-7-13-19-26)31-29(33)28(22-24-14-8-5-9-15-24)32-30(34)36-23-25-16-10-6-11-17-25/h5-20,28H,3-4,21-23H2,1-2H3,(H,31,33)(H,32,34)/t28-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



National Chemical Laboratory (CSIR-NCL)

Curated by ChEMBL


Assay Description
Inhibition of papaya papain using BAPNA as substrate assessed as p-nitroaniline release by spectrophotometric analysis


Bioorg Med Chem 19: 7129-35 (2011)

More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM50107007
PNG
(Acetic acid 2-acetyl-6-methoxy-3-methyl-5,8-dioxo-...)
Show SMILES COC1=CC(=O)c2c(OC(C)=O)c(C(C)=O)c(C)cc2C1=O
Show InChI InChI=1S/C16H14O6/c1-7-5-10-14(11(19)6-12(21-4)15(10)20)16(22-9(3)18)13(7)8(2)17/h5-6H,1-4H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against papain using HPLC assay


Bioorg Med Chem Lett 11: 3143-6 (2001)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 219 total )  |  Next  |  Last  >>
Jump to: