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Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with Target = 'Peptidase 1 (Der p 1)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031689
PNG
(CHEMBL3360298)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccnc2ccccc12)C(C)(C)C)C(=O)C(=O)NCC(=O)N1CCN(CC1)C(C)C
Show InChI InChI=1/C34H49N7O6/c1-20(2)27(28(43)32(46)36-19-26(42)41-17-15-40(16-18-41)21(3)4)38-30(44)22(5)37-33(47)29(34(6,7)8)39-31(45)24-13-14-35-25-12-10-9-11-23(24)25/h9-14,20-22,27,29H,15-19H2,1-8H3,(H,36,46)(H,37,47)(H,38,44)(H,39,45)/t22-,27-,29+/s2
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n/an/a 3n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031688
PNG
(CHEMBL3360299)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N1Cc2ccccc2C1=O)C(C)(C)C)C(=O)C(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1/C30H39N5O7S/c1-17(2)23(24(36)27(38)32-15-19-11-13-21(14-12-19)43(31,41)42)34-26(37)18(3)33-28(39)25(30(4,5)6)35-16-20-9-7-8-10-22(20)29(35)40/h7-14,17-18,23,25H,15-16H2,1-6H3,(H,32,38)(H,33,39)(H,34,37)(H2,31,41,42)/t18-,23-,25+/s2
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n/an/a 3n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031695
PNG
(CHEMBL3360292)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCC(=O)N1CCN(CC1)C(C)C
Show InChI InChI=1/C34H46N6O6/c1-22(2)29(30(42)34(46)35-21-28(41)40-18-16-39(17-19-40)23(3)4)38-31(43)24(5)36-33(45)27(20-25-12-8-6-9-13-25)37-32(44)26-14-10-7-11-15-26/h6-15,22-24,27,29H,16-21H2,1-5H3,(H,35,46)(H,36,45)(H,37,44)(H,38,43)/t24-,27-,29-/s2
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n/an/a 4n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031687
PNG
(CHEMBL3360300)
Show SMILES CNC(=O)c1ccc(CNC(=O)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N2Cc3ccccc3C2=O)C(C)(C)C)C(C)C)cc1
Show InChI InChI=1/C32H41N5O6/c1-18(2)24(25(38)29(41)34-16-20-12-14-21(15-13-20)28(40)33-7)36-27(39)19(3)35-30(42)26(32(4,5)6)37-17-22-10-8-9-11-23(22)31(37)43/h8-15,18-19,24,26H,16-17H2,1-7H3,(H,33,40)(H,34,41)(H,35,42)(H,36,39)/t19-,24-,26+/s2
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n/an/a 4n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031685
PNG
(CHEMBL3360301)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N1Cc2ccccc2C1=O)C(C)(C)C)C(=O)C(=O)NCc1ccc(CN(C)C)cc1
Show InChI InChI=1/C33H45N5O5/c1-20(2)26(27(39)30(41)34-17-22-13-15-23(16-14-22)18-37(7)8)36-29(40)21(3)35-31(42)28(33(4,5)6)38-19-24-11-9-10-12-25(24)32(38)43/h9-16,20-21,26,28H,17-19H2,1-8H3,(H,34,41)(H,35,42)(H,36,40)/t21-,26-,28+/s2
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n/an/a 4n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031684
PNG
(CHEMBL3360302)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1cccc2ccccc12)C(C)(C)C)C(=O)C(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1/C33H41N5O7S/c1-19(2)26(27(39)31(42)35-18-21-14-16-23(17-15-21)46(34,44)45)37-29(40)20(3)36-32(43)28(33(4,5)6)38-30(41)25-13-9-11-22-10-7-8-12-24(22)25/h7-17,19-20,26,28H,18H2,1-6H3,(H,35,42)(H,36,43)(H,37,40)(H,38,41)(H2,34,44,45)/t20-,26-,28+/s2
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n/an/a 4n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031690
PNG
(CHEMBL3360297)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C12CC3CC(CC(C3)C1)C2)C(=O)C(=O)NCC(=O)N1CCN(C)CC1
Show InChI InChI=1/C35H50N6O6/c1-21(2)28(29(43)33(46)36-20-27(42)41-12-10-40(4)11-13-41)38-31(44)22(3)37-34(47)30(39-32(45)26-8-6-5-7-9-26)35-17-23-14-24(18-35)16-25(15-23)19-35/h5-9,21-25,28,30H,10-20H2,1-4H3,(H,36,46)(H,37,47)(H,38,44)(H,39,45)/t22-,23?,24?,25?,28-,30+,35?/s2
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n/an/a 5n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031635
PNG
(CHEMBL3359786)
Show SMILES [O-]C=O.CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C1CC[N+](C)(C)CC1)C(C)(C)C)C(=O)C(=O)NCc1ccccc1
Show InChI InChI=1/C30H47N5O5/c1-19(2)23(24(36)28(39)31-18-21-12-10-9-11-13-21)33-26(37)20(3)32-29(40)25(30(4,5)6)34-27(38)22-14-16-35(7,8)17-15-22/h9-13,19-20,22-23,25H,14-18H2,1-8H3,(H3-,31,32,33,34,37,38,39,40)/p+1/t20-,23-,25+/s2
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n/an/a 6n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031632
PNG
(CHEMBL3359790)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(N)=O
Show InChI InChI=1/C22H32N4O5/c1-12(2)15(16(27)18(23)28)25-19(29)13(3)24-21(31)17(22(4,5)6)26-20(30)14-10-8-7-9-11-14/h7-13,15,17H,1-6H3,(H2,23,28)(H,24,31)(H,25,29)(H,26,30)/t13-,15-,17+/s2
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n/an/a 6n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031713
PNG
(CHEMBL3360282)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1/C29H39N5O7S/c1-17(2)22(23(35)27(38)31-16-19-12-14-21(15-13-19)42(30,40)41)33-25(36)18(3)32-28(39)24(29(4,5)6)34-26(37)20-10-8-7-9-11-20/h7-15,17-18,22,24H,16H2,1-6H3,(H,31,38)(H,32,39)(H,33,36)(H,34,37)(H2,30,40,41)/t18-,22-,24+/s2
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n/an/a 6n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031693
PNG
(CHEMBL3360294)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCC(=O)N1CCc2ccccc2C1
Show InChI InChI=1/C33H43N5O6/c1-20(2)26(27(40)31(43)34-18-25(39)38-17-16-22-12-10-11-15-24(22)19-38)36-29(41)21(3)35-32(44)28(33(4,5)6)37-30(42)23-13-8-7-9-14-23/h7-15,20-21,26,28H,16-19H2,1-6H3,(H,34,43)(H,35,44)(H,36,41)(H,37,42)/t21-,26-,28+/s2
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n/an/a 6n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM103023
PNG
(US8541363, PVA-039)
Show SMILES CCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccncc1)C(C)(C)C)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1S/C28H43N5O5/c1-6-7-13-21(22(34)26(37)31-20-11-9-8-10-12-20)32-24(35)18(2)30-27(38)23(28(3,4)5)33-25(36)19-14-16-29-17-15-19/h14-18,20-21,23H,6-13H2,1-5H3,(H,30,38)(H,31,37)(H,32,35)(H,33,36)/t18-,21-,23+/m0/s1
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US Patent
n/an/a 6.30n/an/an/an/an/an/a



St George's Hosptial Medical School; The University of Manchester

US Patent


Assay Description
The fluorogenic substrate used for measuring Der p 1 proteolytic activity was 2-aminobenzoylvalylalanylnorleucylseryl-(3-nitro)tyrosinyl aspartamide....


US Patent US8541363 (2013)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031668
PNG
(CHEMBL3359782)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N1Cc2ccccc2C1=O)C(C)(C)C)C(=O)C(=O)NCc1ccccc1
Show InChI InChI=1/C30H38N4O5/c1-18(2)23(24(35)27(37)31-16-20-12-8-7-9-13-20)33-26(36)19(3)32-28(38)25(30(4,5)6)34-17-21-14-10-11-15-22(21)29(34)39/h7-15,18-19,23,25H,16-17H2,1-6H3,(H,31,37)(H,32,38)(H,33,36)/t19-,23-,25+/s2
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n/an/a 7n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM103022
PNG
(US8541363, PVA-037)
Show SMILES CCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1S/C29H44N4O5/c1-6-7-18-22(23(34)27(37)31-21-16-12-9-13-17-21)32-25(35)19(2)30-28(38)24(29(3,4)5)33-26(36)20-14-10-8-11-15-20/h8,10-11,14-15,19,21-22,24H,6-7,9,12-13,16-18H2,1-5H3,(H,30,38)(H,31,37)(H,32,35)(H,33,36)/t19-,22-,24+/m0/s1
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US Patent
n/an/a 7.85n/an/an/an/an/an/a



St George's Hosptial Medical School; The University of Manchester

US Patent


Assay Description
The fluorogenic substrate used for measuring Der p 1 proteolytic activity was 2-aminobenzoylvalylalanylnorleucylseryl-(3-nitro)tyrosinyl aspartamide....


US Patent US8541363 (2013)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031711
PNG
(CHEMBL3360284)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCc1ccc(CN(C)C)cc1
Show InChI InChI=1/C32H45N5O5/c1-20(2)25(26(38)30(41)33-18-22-14-16-23(17-15-22)19-37(7)8)35-28(39)21(3)34-31(42)27(32(4,5)6)36-29(40)24-12-10-9-11-13-24/h9-17,20-21,25,27H,18-19H2,1-8H3,(H,33,41)(H,34,42)(H,35,39)(H,36,40)/t21-,25-,27+/s2
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n/an/a 8n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031719
PNG
(CHEMBL3359772)
Show SMILES CCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1/C32H42N4O5/c1-3-4-20-26(28(37)32(41)34-25-18-12-7-13-19-25)35-29(38)22(2)33-31(40)27(21-23-14-8-5-9-15-23)36-30(39)24-16-10-6-11-17-24/h5-6,8-11,14-17,22,25-27H,3-4,7,12-13,18-21H2,1-2H3,(H,33,40)(H,34,41)(H,35,38)(H,36,39)/t22-,26-,27-/s2
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n/an/a 8n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031697
PNG
(CHEMBL3360290)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCC(=O)N1CCOCC1
Show InChI InChI=1/C31H39N5O7/c1-20(2)26(27(38)31(42)32-19-25(37)36-14-16-43-17-15-36)35-28(39)21(3)33-30(41)24(18-22-10-6-4-7-11-22)34-29(40)23-12-8-5-9-13-23/h4-13,20-21,24,26H,14-19H2,1-3H3,(H,32,42)(H,33,41)(H,34,40)(H,35,39)/t21-,24-,26-/s2
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n/an/a 9n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031714
PNG
(CHEMBL3360281)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCc1ccccc1
Show InChI InChI=1/C29H38N4O5/c1-18(2)22(23(34)27(37)30-17-20-13-9-7-10-14-20)32-25(35)19(3)31-28(38)24(29(4,5)6)33-26(36)21-15-11-8-12-16-21/h7-16,18-19,22,24H,17H2,1-6H3,(H,30,37)(H,31,38)(H,32,35)(H,33,36)/t19-,22-,24+/s2
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n/an/a 9n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031694
PNG
(CHEMBL3360293)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)N[C@@H](C)C(=O)N1CCN(C)CC1
Show InChI InChI=1/C33H44N6O6/c1-21(2)27(28(40)32(44)35-23(4)33(45)39-18-16-38(5)17-19-39)37-29(41)22(3)34-31(43)26(20-24-12-8-6-9-13-24)36-30(42)25-14-10-7-11-15-25/h6-15,21-23,26-27H,16-20H2,1-5H3,(H,34,43)(H,35,44)(H,36,42)(H,37,41)/t22-,23-,26-,27-/s2
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n/an/a 10n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031700
PNG
(CHEMBL3360287)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCc1cn[nH]c1
Show InChI InChI=1/C26H36N6O5/c1-15(2)19(20(33)24(36)27-12-17-13-28-29-14-17)31-22(34)16(3)30-25(37)21(26(4,5)6)32-23(35)18-10-8-7-9-11-18/h7-11,13-16,19,21H,12H2,1-6H3,(H,27,36)(H,28,29)(H,30,37)(H,31,34)(H,32,35)/t16-,19-,21+/s2
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n/an/a 11n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031682
PNG
(CHEMBL3359775)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCc1ccccc1
Show InChI InChI=1/C32H36N4O5/c1-21(2)27(28(37)32(41)33-20-24-15-9-5-10-16-24)36-29(38)22(3)34-31(40)26(19-23-13-7-4-8-14-23)35-30(39)25-17-11-6-12-18-25/h4-18,21-22,26-27H,19-20H2,1-3H3,(H,33,41)(H,34,40)(H,35,39)(H,36,38)/t22-,26-,27-/s2
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n/an/a 12n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031673
PNG
(CHEMBL3359780)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccnc2ccccc12)C(C)(C)C)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1/C31H43N5O5/c1-18(2)24(25(37)29(40)34-20-12-8-7-9-13-20)35-27(38)19(3)33-30(41)26(31(4,5)6)36-28(39)22-16-17-32-23-15-11-10-14-21(22)23/h10-11,14-20,24,26H,7-9,12-13H2,1-6H3,(H,33,41)(H,34,40)(H,35,38)(H,36,39)/t19-,24-,26+/s2
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n/an/a 13n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM103021
PNG
(US8541363, PVA-038)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccncc1)C(C)(C)C)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1S/C27H41N5O5/c1-16(2)20(21(33)25(36)30-19-10-8-7-9-11-19)31-23(34)17(3)29-26(37)22(27(4,5)6)32-24(35)18-12-14-28-15-13-18/h12-17,19-20,22H,7-11H2,1-6H3,(H,29,37)(H,30,36)(H,31,34)(H,32,35)/t17-,20-,22+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM103021
PNG
(US8541363, PVA-038)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccncc1)C(C)(C)C)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1S/C27H41N5O5/c1-16(2)20(21(33)25(36)30-19-10-8-7-9-11-19)31-23(34)17(3)29-26(37)22(27(4,5)6)32-24(35)18-12-14-28-15-13-18/h12-17,19-20,22H,7-11H2,1-6H3,(H,29,37)(H,30,36)(H,31,34)(H,32,35)/t17-,20-,22+/m0/s1
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US Patent
n/an/a 13.3n/an/an/an/an/an/a



St George's Hosptial Medical School; The University of Manchester

US Patent


Assay Description
The fluorogenic substrate used for measuring Der p 1 proteolytic activity was 2-aminobenzoylvalylalanylnorleucylseryl-(3-nitro)tyrosinyl aspartamide....


US Patent US8541363 (2013)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031699
PNG
(CHEMBL3360288)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCC(=O)N1CCN(C)CC1
Show InChI InChI=1/C32H42N6O6/c1-21(2)27(28(40)32(44)33-20-26(39)38-17-15-37(4)16-18-38)36-29(41)22(3)34-31(43)25(19-23-11-7-5-8-12-23)35-30(42)24-13-9-6-10-14-24/h5-14,21-22,25,27H,15-20H2,1-4H3,(H,33,44)(H,34,43)(H,35,42)(H,36,41)/t22-,25-,27-/s2
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n/an/a 14n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031698
PNG
(CHEMBL3360289)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCC(=O)N1CCCCC1
Show InChI InChI=1/C32H41N5O6/c1-21(2)27(28(39)32(43)33-20-26(38)37-17-11-6-12-18-37)36-29(40)22(3)34-31(42)25(19-23-13-7-4-8-14-23)35-30(41)24-15-9-5-10-16-24/h4-5,7-10,13-16,21-22,25,27H,6,11-12,17-20H2,1-3H3,(H,33,43)(H,34,42)(H,35,41)(H,36,40)/t22-,25-,27-/s2
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n/an/a 14n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031696
PNG
(CHEMBL3360291)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCC(=O)N1CCN(C)CC1
Show InChI InChI=1/C29H44N6O6/c1-18(2)22(23(37)27(40)30-17-21(36)35-15-13-34(7)14-16-35)32-25(38)19(3)31-28(41)24(29(4,5)6)33-26(39)20-11-9-8-10-12-20/h8-12,18-19,22,24H,13-17H2,1-7H3,(H,30,40)(H,31,41)(H,32,38)(H,33,39)/t19-,22-,24+/s2
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n/an/a 14n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM103020
PNG
(US8541363, PVA-026)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1S/C28H42N4O5/c1-17(2)21(22(33)26(36)30-20-15-11-8-12-16-20)31-24(34)18(3)29-27(37)23(28(4,5)6)32-25(35)19-13-9-7-10-14-19/h7,9-10,13-14,17-18,20-21,23H,8,11-12,15-16H2,1-6H3,(H,29,37)(H,30,36)(H,31,34)(H,32,35)/t18-,21-,23+/m0/s1
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US Patent
n/an/a 14n/an/an/an/an/an/a



St George's Hosptial Medical School; The University of Manchester

US Patent


Assay Description
The fluorogenic substrate used for measuring Der p 1 proteolytic activity was 2-aminobenzoylvalylalanylnorleucylseryl-(3-nitro)tyrosinyl aspartamide....


US Patent US8541363 (2013)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM103020
PNG
(US8541363, PVA-026)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1S/C28H42N4O5/c1-17(2)21(22(33)26(36)30-20-15-11-8-12-16-20)31-24(34)18(3)29-27(37)23(28(4,5)6)32-25(35)19-13-9-7-10-14-19/h7,9-10,13-14,17-18,20-21,23H,8,11-12,15-16H2,1-6H3,(H,29,37)(H,30,36)(H,31,34)(H,32,35)/t18-,21-,23+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031633
PNG
(CHEMBL3359789)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NC1CC1
Show InChI InChI=1/C25H36N4O5/c1-14(2)18(19(30)23(33)27-17-12-13-17)28-21(31)15(3)26-24(34)20(25(4,5)6)29-22(32)16-10-8-7-9-11-16/h7-11,14-15,17-18,20H,12-13H2,1-6H3,(H,26,34)(H,27,33)(H,28,31)(H,29,32)/t15-,18-,20+/s2
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n/an/a 17n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031719
PNG
(CHEMBL3359772)
Show SMILES CCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1/C32H42N4O5/c1-3-4-20-26(28(37)32(41)34-25-18-12-7-13-19-25)35-29(38)22(2)33-31(40)27(21-23-14-8-5-9-15-23)36-30(39)24-16-10-6-11-17-24/h5-6,8-11,14-17,22,25-27H,3-4,7,12-13,18-21H2,1-2H3,(H,33,40)(H,34,41)(H,35,38)(H,36,39)/t22-,26-,27-/s2
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n/an/a 17n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Reversible inhibition of house dust mite Derp-1


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031692
PNG
(CHEMBL3360295)
Show SMILES [O-]C=O.CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCC(=O)N1CC[N+](C)(C)CC1
Show InChI InChI=1/C33H44N6O6.CH2O2/c1-22(2)28(29(41)33(45)34-21-27(40)38-16-18-39(4,5)19-17-38)37-30(42)23(3)35-32(44)26(20-24-12-8-6-9-13-24)36-31(43)25-14-10-7-11-15-25;2-1-3/h6-15,22-23,26,28H,16-21H2,1-5H3,(H3-,34,35,36,37,42,43,44,45);1H,(H,2,3)/t23-,26-,28-;/s2
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n/an/a 17n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031710
PNG
(CHEMBL3360285)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1/C30H40N4O5/c1-18(2)23(24(35)28(38)31-19(3)21-14-10-8-11-15-21)33-26(36)20(4)32-29(39)25(30(5,6)7)34-27(37)22-16-12-9-13-17-22/h8-20,23,25H,1-7H3,(H,31,38)(H,32,39)(H,33,36)(H,34,37)/t19-,20+,23+,25-/s2
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n/an/a 17n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031683
PNG
(CHEMBL3359773)
Show SMILES CC(C)C(NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1/C31H40N4O5/c1-20(2)26(27(36)31(40)33-24-17-11-6-12-18-24)35-28(37)21(3)32-30(39)25(19-22-13-7-4-8-14-22)34-29(38)23-15-9-5-10-16-23/h4-5,7-10,13-16,20-21,24-26H,6,11-12,17-19H2,1-3H3,(H,32,39)(H,33,40)(H,34,38)(H,35,37)/t21-,25-,26?/s2
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n/an/a 18n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031670
PNG
(CHEMBL3359781)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccnc2ccccc12)C(C)(C)C)C(=O)C(=O)NCc1ccccc1
Show InChI InChI=1/C32H39N5O5/c1-19(2)25(26(38)30(41)34-18-21-12-8-7-9-13-21)36-28(39)20(3)35-31(42)27(32(4,5)6)37-29(40)23-16-17-33-24-15-11-10-14-22(23)24/h7-17,19-20,25,27H,18H2,1-6H3,(H,34,41)(H,35,42)(H,36,39)(H,37,40)/t20-,25-,27+/s2
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n/an/a 18n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031678
PNG
(CHEMBL3359779)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1cccc2ccccc12)C(C)(C)C)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1/C32H44N4O5/c1-19(2)25(26(37)30(40)34-22-15-8-7-9-16-22)35-28(38)20(3)33-31(41)27(32(4,5)6)36-29(39)24-18-12-14-21-13-10-11-17-23(21)24/h10-14,17-20,22,25,27H,7-9,15-16H2,1-6H3,(H,33,41)(H,34,40)(H,35,38)(H,36,39)/t20-,25-,27+/s2
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n/an/a 20n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031691
PNG
(CHEMBL3360296)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2ccccc12)C(=O)C(=O)NCC(=O)N1CCN(C)CC1
Show InChI InChI=1/C36H44N6O6/c1-23(2)31(32(44)36(48)37-22-30(43)42-19-17-41(4)18-20-42)40-33(45)24(3)38-35(47)29(21-25-11-6-5-7-12-25)39-34(46)28-16-10-14-26-13-8-9-15-27(26)28/h5-16,23-24,29,31H,17-22H2,1-4H3,(H,37,48)(H,38,47)(H,39,46)(H,40,45)/t24-,29-,31-/s2
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n/an/a 20n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031715
PNG
(CHEMBL3359791)
Show SMILES CNC(=O)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(C)C
Show InChI InChI=1/C23H34N4O5/c1-13(2)16(17(28)21(31)24-7)26-19(29)14(3)25-22(32)18(23(4,5)6)27-20(30)15-11-9-8-10-12-15/h8-14,16,18H,1-7H3,(H,24,31)(H,25,32)(H,26,29)(H,27,30)/t14-,16-,18+/s2
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n/an/a 24n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031681
PNG
(CHEMBL3359777)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)c1ccccc1)C(=O)C(=O)NCc1ccccc1
Show InChI InChI=1/C34H40N4O5/c1-22(2)27(28(39)32(42)35-21-24-15-9-6-10-16-24)37-30(40)23(3)36-33(43)29(34(4,5)26-19-13-8-14-20-26)38-31(41)25-17-11-7-12-18-25/h6-20,22-23,27,29H,21H2,1-5H3,(H,35,42)(H,36,43)(H,37,40)(H,38,41)/t23-,27-,29+/s2
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n/an/a 42n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031712
PNG
(CHEMBL3360283)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C30H37F3N4O5/c1-17(2)22(23(38)27(41)34-16-19-12-14-21(15-13-19)30(31,32)33)36-25(39)18(3)35-28(42)24(29(4,5)6)37-26(40)20-10-8-7-9-11-20/h7-15,17-18,22,24H,16H2,1-6H3,(H,34,41)(H,35,42)(H,36,39)(H,37,40)/t18-,22-,24+/s2
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n/an/a 47n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031634
PNG
(CHEMBL3359787)
Show SMILES CC(C)C(NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NC1CCOCC1
Show InChI InChI=1/C30H38N4O6/c1-19(2)25(26(35)30(39)32-23-14-16-40-17-15-23)34-27(36)20(3)31-29(38)24(18-21-10-6-4-7-11-21)33-28(37)22-12-8-5-9-13-22/h4-13,19-20,23-25H,14-18H2,1-3H3,(H,31,38)(H,32,39)(H,33,37)(H,34,36)/t20-,24-,25?/s2
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n/an/a 55n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031722
PNG
(CHEMBL3359770)
Show SMILES CCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)CN1CCCC1
Show InChI InChI=1/C30H40N4O4/c1-3-4-17-25(27(35)21-34-18-11-12-19-34)32-28(36)22(2)31-30(38)26(20-23-13-7-5-8-14-23)33-29(37)24-15-9-6-10-16-24/h5-10,13-16,22,25-26H,3-4,11-12,17-21H2,1-2H3,(H,31,38)(H,32,36)(H,33,37)/t22-,25-,26-/s2
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n/an/a 65n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Reversible inhibition of house dust mite Derp-1


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031717
PNG
(CHEMBL3359784)
Show SMILES CC(C)C(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1c(C)n[nH]c1C)C(C)(C)C)C(=O)C(=O)NCc1ccccc1
Show InChI InChI=1/C28H40N6O5/c1-15(2)21(22(35)26(38)29-14-19-12-10-9-11-13-19)31-24(36)18(5)30-27(39)23(28(6,7)8)32-25(37)20-16(3)33-34-17(20)4/h9-13,15,18,21,23H,14H2,1-8H3,(H,29,38)(H,30,39)(H,31,36)(H,32,37)(H,33,34)/t18-,21?,23+/s2
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n/an/a 67n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031716
PNG
(CHEMBL3359788)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NC1CCN(C)CC1
Show InChI InChI=1/C31H41N5O5/c1-20(2)26(27(37)31(41)33-24-15-17-36(4)18-16-24)35-28(38)21(3)32-30(40)25(19-22-11-7-5-8-12-22)34-29(39)23-13-9-6-10-14-23/h5-14,20-21,24-26H,15-19H2,1-4H3,(H,32,40)(H,33,41)(H,34,39)(H,35,38)/t21-,25-,26-/s2
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n/an/a 115n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031701
PNG
(CHEMBL3360286)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1/C30H40N4O5/c1-18(2)23(24(35)28(38)31-19(3)21-14-10-8-11-15-21)33-26(36)20(4)32-29(39)25(30(5,6)7)34-27(37)22-16-12-9-13-17-22/h8-20,23,25H,1-7H3,(H,31,38)(H,32,39)(H,33,36)(H,34,37)/t19-,20-,23-,25+/s2
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n/an/a 117n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031680
PNG
(CHEMBL3359778)
Show SMILES CCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)C(=O)NC1CCCCC1
Show InChI InChI=1/C33H44N4O5/c1-4-14-26(31(40)37-28(22(2)3)29(38)33(42)34-25-19-12-7-13-20-25)35-32(41)27(21-23-15-8-5-9-16-23)36-30(39)24-17-10-6-11-18-24/h5-6,8-11,15-18,22,25-28H,4,7,12-14,19-21H2,1-3H3,(H,34,42)(H,35,41)(H,36,39)(H,37,40)/t26-,27-,28-/s2
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n/an/a 164n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031663
PNG
(CHEMBL3359785)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C1CCN(C)CC1)C(C)(C)C)C(=O)C(=O)NCc1ccccc1
Show InChI InChI=1/C29H45N5O5/c1-18(2)22(23(35)27(38)30-17-20-11-9-8-10-12-20)32-25(36)19(3)31-28(39)24(29(4,5)6)33-26(37)21-13-15-34(7)16-14-21/h8-12,18-19,21-22,24H,13-17H2,1-7H3,(H,30,38)(H,31,39)(H,32,36)(H,33,37)/t19-,22-,24+/s2
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n/an/a 192n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031721
PNG
(CHEMBL3359771)
Show SMILES CCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)N1CCCC1
Show InChI InChI=1/C30H38N4O5/c1-3-4-17-24(26(35)30(39)34-18-11-12-19-34)32-27(36)21(2)31-29(38)25(20-22-13-7-5-8-14-22)33-28(37)23-15-9-6-10-16-23/h5-10,13-16,21,24-25H,3-4,11-12,17-20H2,1-2H3,(H,31,38)(H,32,36)(H,33,37)/t21-,24-,25-/s2
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n/an/a 997n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Reversible inhibition of house dust mite Derp-1


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair
Peptidase 1 (Der p 1)


(Dermatophagoides pteronyssinus (European house dus...)
BDBM50031718
PNG
(CHEMBL3359774)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)N[C@H](C(=O)C(=O)NC1CCCCC1)C(C)(C)C
Show InChI InChI=1/C32H42N4O5/c1-21(28(38)36-27(32(2,3)4)26(37)31(41)34-24-18-12-7-13-19-24)33-30(40)25(20-22-14-8-5-9-15-22)35-29(39)23-16-10-6-11-17-23/h5-6,8-11,14-17,21,24-25,27H,7,12-13,18-20H2,1-4H3,(H,33,40)(H,34,41)(H,35,39)(H,36,38)/t21-,25-,27+/s2
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n/an/a 9.17E+3n/an/an/an/an/an/a



Domainex Ltd.

Curated by ChEMBL


Assay Description
Inhibition of house dust mite Derp-1 after 20 mins


J Med Chem 57: 9447-62 (2014)

More data for this
Ligand-Target Pair