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Compile Data Set for Download or QSAR

Found 252 hits Enz. Inhib. hit(s) with Target = 'Perforin-1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Perforin-1


(Homo sapiens)
BDBM50137357
PNG
(CHEMBL3754633)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C19H13NO3S/c20-18(21)12-3-1-11(2-4-12)16-7-8-17(24-16)13-5-6-15-14(9-13)10-23-19(15)22/h1-9H,10H2,(H2,20,21)
NCI pathway
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n/an/a 180n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...


Bioorg Med Chem Lett 26: 355-60 (2016)

More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361411
PNG
(CHEMBL1934375)
Show SMILES O=C1NC(=S)NC1=Cc1csc(n1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C15H9N3O3S2/c19-12-11(17-15(22)18-12)4-9-6-23-13(16-9)7-1-2-10-8(3-7)5-21-14(10)20/h1-4,6H,5H2,(H2,17,18,19,22)
NCI pathway
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n/an/a 340n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361419
PNG
(CHEMBL1934383)
Show SMILES O=C1NC(=S)NC1=Cc1cc2ccc(cc2[nH]1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C20H13N3O3S/c24-18-17(22-20(27)23-18)8-14-6-12-2-1-11(7-16(12)21-14)10-3-4-15-13(5-10)9-26-19(15)25/h1-8,21H,9H2,(H2,22,23,24,27)
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n/an/a 360n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361417
PNG
(CHEMBL1934381)
Show SMILES O=C1NC(=S)NC1=Cc1cc2ccc(cc2s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C20H12N2O3S2/c23-18-16(21-20(26)22-18)8-14-6-12-2-1-11(7-17(12)27-14)10-3-4-15-13(5-10)9-25-19(15)24/h1-8H,9H2,(H2,21,22,23,26)
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n/an/a 360n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361406
PNG
(CHEMBL1934370)
Show SMILES O=C1NC(=S)NC1=Cc1ccc(cn1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C17H11N3O3S/c21-15-14(19-17(24)20-15)6-12-3-1-10(7-18-12)9-2-4-13-11(5-9)8-23-16(13)22/h1-7H,8H2,(H2,19,20,21,24)
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n/an/a 370n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361433
PNG
(CHEMBL1934397)
Show SMILES O=C1OCc2cc(ccc12)-c1ccc(C=C2C(=O)NC(=S)NC2=O)s1
Show InChI InChI=1S/C17H10N2O4S2/c20-14-12(15(21)19-17(24)18-14)6-10-2-4-13(25-10)8-1-3-11-9(5-8)7-23-16(11)22/h1-6H,7H2,(H2,18,19,20,21,24)
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n/an/a 400n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445263
PNG
(CHEMBL3103651)
Show SMILES O=C1NC(=O)\C(N1)=C/c1ccc(s1)-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C16H11N3O3S/c20-14-11-3-1-8(5-9(11)7-17-14)13-4-2-10(23-13)6-12-15(21)19-16(22)18-12/h1-6H,7H2,(H,17,20)(H2,18,19,21,22)/b12-6+
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n/an/a 400n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361422
PNG
(CHEMBL1934386)
Show SMILES O=C1NC(=S)NC1=Cc1ccc2cc(ccc2n1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C21H13N3O3S/c25-19-18(23-21(28)24-19)9-15-4-1-13-7-12(3-6-17(13)22-15)11-2-5-16-14(8-11)10-27-20(16)26/h1-9H,10H2,(H2,23,24,25,28)
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n/an/a 470n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361416
PNG
(CHEMBL1934380)
Show SMILES O=C1NC(=S)NC1=Cc1cc2cc(ccc2s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C20H12N2O3S2/c23-18-16(21-20(26)22-18)8-14-7-12-5-11(2-4-17(12)27-14)10-1-3-15-13(6-10)9-25-19(15)24/h1-8H,9H2,(H2,21,22,23,26)
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n/an/a 490n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361418
PNG
(CHEMBL1934382)
Show SMILES O=C1NC(=S)NC1=Cc1cc2cc(ccc2o1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C20H12N2O4S/c23-18-16(21-20(27)22-18)8-14-7-12-5-11(2-4-17(12)26-14)10-1-3-15-13(6-10)9-25-19(15)24/h1-8H,9H2,(H2,21,22,23,27)
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n/an/a 510n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445286
PNG
(CHEMBL3103907)
Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C17H13N3O2S2/c1-20-8-10-6-9(2-4-12(10)16(20)22)14-5-3-11(24-14)7-13-15(21)19-17(23)18-13/h2-7H,8H2,1H3,(H2,18,19,21,23)/b13-7+
NCI pathway
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n/an/a 510n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445279
PNG
(CHEMBL3103914)
Show SMILES OCCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C19H17N3O3S2/c23-7-1-6-22-10-12-8-11(2-4-14(12)18(22)25)16-5-3-13(27-16)9-15-17(24)21-19(26)20-15/h2-5,8-9,23H,1,6-7,10H2,(H2,20,21,24,26)/b15-9+
NCI pathway
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n/an/a 530n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445276
PNG
(CHEMBL3103917)
Show SMILES CCOC(=O)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C19H15N3O4S2/c1-2-26-19(25)22-9-11-7-10(3-5-13(11)17(22)24)15-6-4-12(28-15)8-14-16(23)21-18(27)20-14/h3-8H,2,9H2,1H3,(H2,20,21,23,27)/b14-8+
NCI pathway
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n/an/a 550n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445285
PNG
(CHEMBL3103908)
Show SMILES CCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C18H15N3O2S2/c1-2-21-9-11-7-10(3-5-13(11)17(21)23)15-6-4-12(25-15)8-14-16(22)20-18(24)19-14/h3-8H,2,9H2,1H3,(H2,19,20,22,24)/b14-8+
NCI pathway
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n/an/a 600n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445259
PNG
(CHEMBL3103655)
Show SMILES O=C1NC(=S)N\C1=C\c1ccc(cn1)-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C17H12N4O2S/c22-15-13-4-2-9(5-11(13)8-19-15)10-1-3-12(18-7-10)6-14-16(23)21-17(24)20-14/h1-7H,8H2,(H,19,22)(H2,20,21,23,24)/b14-6+
NCI pathway
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n/an/a 630n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445267
PNG
(CHEMBL3103647)
Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2CCNC(=O)c2c1
Show InChI InChI=1S/C17H13N3O2S2/c21-15-12-7-10(2-1-9(12)5-6-18-15)14-4-3-11(24-14)8-13-16(22)20-17(23)19-13/h1-4,7-8H,5-6H2,(H,18,21)(H2,19,20,22,23)/b13-8+
NCI pathway
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n/an/a 640n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50137379
PNG
(CHEMBL3754407)
Show SMILES NC(=O)c1ccc(cc1O)-c1ccc(s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C19H13NO4S/c20-18(22)14-4-2-11(8-15(14)21)17-6-5-16(25-17)10-1-3-13-12(7-10)9-24-19(13)23/h1-8,21H,9H2,(H2,20,22)
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n/an/a 670n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...


Bioorg Med Chem Lett 26: 355-60 (2016)

More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361400
PNG
(CHEMBL1934364)
Show SMILES O=C1NC(=S)NC1=Cc1ccc(s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C16H10N2O3S2/c19-14-12(17-16(22)18-14)6-10-2-4-13(23-10)8-1-3-11-9(5-8)7-21-15(11)20/h1-6H,7H2,(H2,17,18,19,22)
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n/an/a 780n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445280
PNG
(CHEMBL3103913)
Show SMILES OCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C18H15N3O3S2/c22-6-5-21-9-11-7-10(1-3-13(11)17(21)24)15-4-2-12(26-15)8-14-16(23)20-18(25)19-14/h1-4,7-8,22H,5-6,9H2,(H2,19,20,23,25)/b14-8+
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n/an/a 780n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445303
PNG
(CHEMBL3102870)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C15H11N3O2S2/c16-13(19)9-3-1-2-8(6-9)12-5-4-10(22-12)7-11-14(20)18-15(21)17-11/h1-7H,(H2,16,19)(H2,17,18,20,21)/b11-7+
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n/an/a 790n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361432
PNG
(CHEMBL1934396)
Show SMILES O=C1OCc2cc(ccc12)-c1ccc(C=C2C(=O)NC(=O)NC2=O)s1
Show InChI InChI=1S/C17H10N2O5S/c20-14-12(15(21)19-17(23)18-14)6-10-2-4-13(25-10)8-1-3-11-9(5-8)7-24-16(11)22/h1-6H,7H2,(H2,18,19,20,21,23)
NCI pathway
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n/an/a 800n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361420
PNG
(CHEMBL1934384)
Show SMILES O=C1NC(=S)NC1=Cc1cc2cc(ccc2[nH]1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C20H13N3O3S/c24-18-17(22-20(27)23-18)8-14-7-12-5-11(2-4-16(12)21-14)10-1-3-15-13(6-10)9-26-19(15)25/h1-8,21H,9H2,(H2,22,23,24,27)
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n/an/a 820n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50137451
PNG
(CHEMBL3753587)
Show SMILES OCc1ccc(cc1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C19H14O3S/c20-10-12-1-3-13(4-2-12)17-7-8-18(23-17)14-5-6-16-15(9-14)11-22-19(16)21/h1-9,20H,10-11H2
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n/an/a 900n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...


Bioorg Med Chem Lett 26: 355-60 (2016)

More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50137456
PNG
(CHEMBL3753271)
Show SMILES NC(=O)c1ccc(cn1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C18H12N2O3S/c19-17(21)14-4-2-11(8-20-14)16-6-5-15(24-16)10-1-3-13-12(7-10)9-23-18(13)22/h1-8H,9H2,(H2,19,21)
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n/an/a 920n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...


Bioorg Med Chem Lett 26: 355-60 (2016)

More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445277
PNG
(CHEMBL3103916)
Show SMILES CC(=O)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C18H13N3O3S2/c1-9(22)21-8-11-6-10(2-4-13(11)17(21)24)15-5-3-12(26-15)7-14-16(23)20-18(25)19-14/h2-7H,8H2,1H3,(H2,19,20,23,25)/b14-7+
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n/an/a 930n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50275059
PNG
((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc2ccccc12
Show InChI InChI=1S/C17H11NO2S2/c1-9-6-12-13(20-17(19)15(12)16(21)18-9)7-10-8-22-14-5-3-2-4-11(10)14/h2-8H,1H3,(H,18,21)/b13-7-
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n/an/a 970n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50275059
PNG
((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc2ccccc12
Show InChI InChI=1S/C17H11NO2S2/c1-9-6-12-13(20-17(19)15(12)16(21)18-9)7-10-8-22-14-5-3-2-4-11(10)14/h2-8H,1H3,(H,18,21)/b13-7-
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n/an/a 970n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50347203
PNG
(CHEMBL1795754)
Show SMILES CNC(=O)c1ccc(cc1)-c1c(C#N)c(N)n2c3ccccc3nc2c1C#N
Show InChI InChI=1S/C21H14N6O/c1-25-21(28)13-8-6-12(7-9-13)18-14(10-22)19(24)27-17-5-3-2-4-16(17)26-20(27)15(18)11-23/h2-9H,24H2,1H3,(H,25,28)
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n/an/a 1.04E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361401
PNG
(CHEMBL1934365)
Show SMILES O=C1NC(=S)NC1=Cc1cc(cs1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C16H10N2O3S2/c19-14-13(17-16(22)18-14)5-11-4-10(7-23-11)8-1-2-12-9(3-8)6-21-15(12)20/h1-5,7H,6H2,(H2,17,18,19,22)
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n/an/a 1.05E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50137455
PNG
(CHEMBL3752189)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C19H15NO4S2/c1-26(22,23)20-15-5-2-12(3-6-15)17-8-9-18(25-17)13-4-7-16-14(10-13)11-24-19(16)21/h2-10,20H,11H2,1H3
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n/an/a 1.09E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...


Bioorg Med Chem Lett 26: 355-60 (2016)

More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361431
PNG
(CHEMBL1934395)
Show SMILES O=C1NC(=O)\C(S1)=C/c1ccc(s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C16H9NO4S2/c18-14-13(23-16(20)17-14)6-10-2-4-12(22-10)8-1-3-11-9(5-8)7-21-15(11)19/h1-6H,7H2,(H,17,18,20)/b13-6+
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n/an/a 1.12E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445268
PNG
(CHEMBL3103646)
Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C17H13N3O2S2/c21-15-12-3-1-10(7-9(12)5-6-18-15)14-4-2-11(24-14)8-13-16(22)20-17(23)19-13/h1-4,7-8H,5-6H2,(H,18,21)(H2,19,20,22,23)/b13-8+
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n/an/a 1.14E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445307
PNG
(CHEMBL3104019)
Show SMILES CSc1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C15H12N2OS3/c1-20-10-4-2-9(3-5-10)13-7-6-11(21-13)8-12-14(18)17-15(19)16-12/h2-8H,1H3,(H2,16,17,18,19)/b12-8+
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n/an/a 1.15E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445281
PNG
(CHEMBL3103912)
Show SMILES CC(=O)OCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C20H17N3O4S2/c1-11(24)27-7-6-23-10-13-8-12(2-4-15(13)19(23)26)17-5-3-14(29-17)9-16-18(25)22-20(28)21-16/h2-5,8-9H,6-7,10H2,1H3,(H2,21,22,25,28)/b16-9+
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n/an/a 1.17E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445283
PNG
(CHEMBL3103910)
Show SMILES CCCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C20H19N3O2S2/c1-2-3-8-23-11-13-9-12(4-6-15(13)19(23)25)17-7-5-14(27-17)10-16-18(24)22-20(26)21-16/h4-7,9-10H,2-3,8,11H2,1H3,(H2,21,22,24,26)/b16-10+
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n/an/a 1.18E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361429
PNG
(CHEMBL1934393)
Show SMILES O=C1NC(=O)\C(N1)=C/c1ccc(s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C16H10N2O4S/c19-14-12(17-16(21)18-14)6-10-2-4-13(23-10)8-1-3-11-9(5-8)7-22-15(11)20/h1-6H,7H2,(H2,17,18,19,21)/b12-6+
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n/an/a 1.19E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50137447
PNG
(CHEMBL3752776)
Show SMILES NC(=O)c1ccc(cc1N)-c1ccc(s1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C19H14N2O3S/c20-15-8-11(2-4-14(15)18(21)22)17-6-5-16(25-17)10-1-3-13-12(7-10)9-24-19(13)23/h1-8H,9,20H2,(H2,21,22)
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...


Bioorg Med Chem Lett 26: 355-60 (2016)

More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445278
PNG
(CHEMBL3103915)
Show SMILES OCC(O)CN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C19H17N3O4S2/c23-9-12(24)8-22-7-11-5-10(1-3-14(11)18(22)26)16-4-2-13(28-16)6-15-17(25)21-19(27)20-15/h1-6,12,23-24H,7-9H2,(H2,20,21,25,27)/b15-6+
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n/an/a 1.26E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50275013
PNG
((Z)-1-((1H-Indol-2-yl)methylene)-6-methyl-4-thioxo...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H12N2O2S/c1-9-6-12-14(21-17(20)15(12)16(22)18-9)8-11-7-10-4-2-3-5-13(10)19-11/h2-8,19H,1H3,(H,18,22)/b14-8-
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361412
PNG
(CHEMBL1934376)
Show SMILES O=C1NC(=S)NC1=Cc1cc(no1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C15H9N3O4S/c19-13-12(16-15(23)17-13)5-9-4-11(18-22-9)7-1-2-10-8(3-7)6-21-14(10)20/h1-5H,6H2,(H2,16,17,19,23)
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445270
PNG
(CHEMBL3103644)
Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2CNC(=O)c2c1
Show InChI InChI=1S/C16H11N3O2S2/c20-14-11-5-8(1-2-9(11)7-17-14)13-4-3-10(23-13)6-12-15(21)19-16(22)18-12/h1-6H,7H2,(H,17,20)(H2,18,19,21,22)/b12-6+
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n/an/a 1.38E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361410
PNG
(CHEMBL1934374)
Show SMILES O=C1NC(=S)NC1=Cc1nc(cs1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C15H9N3O3S2/c19-13-10(17-15(22)18-13)4-12-16-11(6-23-12)7-1-2-9-8(3-7)5-21-14(9)20/h1-4,6H,5H2,(H2,17,18,19,22)
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n/an/a 1.41E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50361414
PNG
(CHEMBL1934378)
Show SMILES O=C1NC(=S)NC1=Cc1cc(ns1)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C15H9N3O3S2/c19-13-12(16-15(22)17-13)5-9-4-11(18-23-9)7-1-2-10-8(3-7)6-21-14(10)20/h1-5H,6H2,(H2,16,17,19,22)
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n/an/a 1.44E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445255
PNG
(CHEMBL3103900)
Show SMILES O=C1NC(=S)N\C1=C\c1cc2cc(ccc2[nH]1)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C21H16N4O2S/c26-19-16-3-1-11(7-13(16)5-6-22-19)12-2-4-17-14(8-12)9-15(23-17)10-18-20(27)25-21(28)24-18/h1-4,7-10,23H,5-6H2,(H,22,26)(H2,24,25,27,28)/b18-10+
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n/an/a 1.45E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445284
PNG
(CHEMBL3103909)
Show SMILES CCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C19H17N3O2S2/c1-2-7-22-10-12-8-11(3-5-14(12)18(22)24)16-6-4-13(26-16)9-15-17(23)21-19(25)20-15/h3-6,8-9H,2,7,10H2,1H3,(H2,20,21,23,25)/b15-9+
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n/an/a 1.52E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445302
PNG
(CHEMBL3104023)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C15H11N3O2S2/c16-13(19)9-3-1-8(2-4-9)12-6-5-10(22-12)7-11-14(20)18-15(21)17-11/h1-7H,(H2,16,19)(H2,17,18,20,21)/b11-7+
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n/an/a 1.56E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


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More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445258
PNG
(CHEMBL3103897)
Show SMILES O=C1NC(=S)N\C1=C\c1cc2ccc(cc2[nH]1)-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C20H14N4O2S/c25-18-15-4-3-10(5-13(15)9-21-18)11-1-2-12-6-14(22-16(12)7-11)8-17-19(26)24-20(27)23-17/h1-8,22H,9H2,(H,21,25)(H2,23,24,26,27)/b17-8+
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n/an/a 1.58E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445304
PNG
(CHEMBL3104022)
Show SMILES COC(=O)c1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Show InChI InChI=1S/C16H12N2O3S2/c1-21-15(20)10-4-2-9(3-5-10)13-7-6-11(23-13)8-12-14(19)18-16(22)17-12/h2-8H,1H3,(H2,17,18,19,22)/b12-8+
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n/an/a 1.62E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445256
PNG
(CHEMBL3103899)
Show SMILES O=C1NC(=S)N\C1=C\c1cc2ccc(cc2[nH]1)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C21H16N4O2S/c26-19-16-4-3-11(7-13(16)5-6-22-19)12-1-2-14-8-15(23-17(14)9-12)10-18-20(27)25-21(28)24-18/h1-4,7-10,23H,5-6H2,(H,22,26)(H2,24,25,27,28)/b18-10+
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n/an/a 1.66E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens)
BDBM50445306
PNG
(CHEMBL3104020)
Show SMILES CC(=O)c1ccc(cc1)-c1ccc(C=C2NC(=S)NC2=O)s1
Show InChI InChI=1S/C16H12N2O2S2/c1-9(19)10-2-4-11(5-3-10)14-7-6-12(22-14)8-13-15(20)18-16(21)17-13/h2-8H,1H3,(H2,17,18,20,21)
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Article
PubMed
n/an/a 1.67E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...


Citation and Details
More data for this
Ligand-Target Pair
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