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Found 1430 hits Enz. Inhib. hit(s) with Target = 'Peripheral-Type Benzodiazepine Receptor'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50355785
PNG
(CHEMBL1911624)
Show SMILES CCCCN(C)C(=O)Cn1c2nn(-c3ccc(F)cc3)c(=O)c2c(C)c2ccccc12
Show InChI InChI=1S/C24H25FN4O2/c1-4-5-14-27(3)21(30)15-28-20-9-7-6-8-19(20)16(2)22-23(28)26-29(24(22)31)18-12-10-17(25)11-13-18/h6-13H,4-5,14-15H2,1-3H3
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n/an/a 0.130n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50355784
PNG
(CHEMBL1911623)
Show SMILES CN(C(=O)Cn1c2nn(-c3ccccc3)c(=O)c2c(C)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H21ClN4O2/c1-17-21-10-6-7-11-22(21)30(16-23(32)29(2)19-14-12-18(27)13-15-19)25-24(17)26(33)31(28-25)20-8-4-3-5-9-20/h3-15H,16H2,1-2H3
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n/an/a 0.130n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50355781
PNG
(CHEMBL1911620)
Show SMILES CCCCN(C)C(=O)Cn1c2nn(-c3ccccc3)c(=O)c2c(C)c2ccccc12
Show InChI InChI=1S/C24H26N4O2/c1-4-5-15-26(3)21(29)16-27-20-14-10-9-13-19(20)17(2)22-23(27)25-28(24(22)30)18-11-7-6-8-12-18/h6-14H,4-5,15-16H2,1-3H3
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n/an/a 0.140n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50271820
PNG
(1-(2-iodophenyl)-N-methyl-N-(3-fluoropropyl)-3-iso...)
Show SMILES CN(CCCF)C(=O)c1cc2ccccc2c(n1)-c1ccccc1I
Show InChI InChI=1S/C20H18FIN2O/c1-24(12-6-11-21)20(25)18-13-14-7-2-3-8-15(14)19(23-18)16-9-4-5-10-17(16)22/h2-5,7-10,13H,6,11-12H2,1H3
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n/an/a 0.280n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from PBR in rat kidney mitochondrial membrane


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50355786
PNG
(CHEMBL1911625)
Show SMILES CN(C(=O)Cn1c2nn(-c3ccc(F)cc3)c(=O)c2c(C)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H20ClFN4O2/c1-16-21-5-3-4-6-22(21)31(15-23(33)30(2)19-11-7-17(27)8-12-19)25-24(16)26(34)32(29-25)20-13-9-18(28)10-14-20/h3-14H,15H2,1-2H3
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n/an/a 0.280n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50355783
PNG
(CHEMBL1911622)
Show SMILES CCCCN(CCCC)C(=O)Cn1c2nn(-c3ccccc3)c(=O)c2c(C)c2ccccc12
Show InChI InChI=1S/C27H32N4O2/c1-4-6-17-29(18-7-5-2)24(32)19-30-23-16-12-11-15-22(23)20(3)25-26(30)28-31(27(25)33)21-13-9-8-10-14-21/h8-16H,4-7,17-19H2,1-3H3
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n/an/a 0.340n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50131724
PNG
(3-Chloromethyl-4-phenyl-quinoline-2-carboxylic aci...)
Show SMILES CN(Cc1ccccc1)C(=O)c1nc2ccccc2c(-c2ccccc2)c1CCl
Show InChI InChI=1S/C25H21ClN2O/c1-28(17-18-10-4-2-5-11-18)25(29)24-21(16-26)23(19-12-6-3-7-13-19)20-14-8-9-15-22(20)27-24/h2-15H,16-17H2,1H3
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n/an/a 0.450n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibitory activity against specific binding of [3H]-CB 34 to peripheral benzodiazepine receptor in rat cortical membranes was evaluated


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50054126
PNG
((E)-N-(4-chlorophenyl)-2-(2-(4-chlorophenyl)-1-oxo...)
Show SMILES CN(C(=O)\C=C1\N(C(=O)c2cc3ccccc3nc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H17Cl2N3O2/c1-30(19-10-6-17(27)7-11-19)24(32)15-23-25-21(14-16-4-2-3-5-22(16)29-25)26(33)31(23)20-12-8-18(28)9-13-20/h2-15H,1H3/b23-15+
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n/an/a 0.620n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK115 from peripheral benzodiazepine receptor in Sprague-Dawley rat cortical membrane


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50052754
PNG
(CHEMBL115740 | Diethyl-carbamic acid 5-phenyl-6-ox...)
Show SMILES CCN(CC)C(=O)OC1=C(Oc2ccccc2-n2cccc12)c1ccccc1
Show InChI InChI=1S/C23H22N2O3/c1-3-24(4-2)23(26)28-22-19-14-10-16-25(19)18-13-8-9-15-20(18)27-21(22)17-11-6-5-7-12-17/h5-16H,3-4H2,1-2H3
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n/an/a 0.680n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-PK 11195 to peripheral-type benzodiazepine receptor (PBR) from rat cortex homogenate


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50054125
PNG
((E)-2-(2-(4-chlorophenyl)-1,2-dihydro-1-oxo-3H-pyr...)
Show SMILES COc1ccc(cc1)N(C)C(=O)\C=C1\N(C(=O)c2cc3ccccc3nc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H20ClN3O3/c1-30(19-11-13-21(34-2)14-12-19)25(32)16-24-26-22(15-17-5-3-4-6-23(17)29-26)27(33)31(24)20-9-7-18(28)8-10-20/h3-16H,1-2H3/b24-16+
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n/an/a 0.700n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK11195 from rat kidney peripheral benzodiazepine receptor (type 1)


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50122294
PNG
(CHEMBL292092 | N-(5-fluoro-2-phenoxyphenyl)-N-(2-(...)
Show SMILES COc1ccc(OCCF)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1
Show InChI InChI=1S/C24H23F2NO4/c1-17(28)27(16-18-14-21(29-2)9-11-23(18)30-13-12-25)22-15-19(26)8-10-24(22)31-20-6-4-3-5-7-20/h3-11,14-15H,12-13,16H2,1-2H3
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n/an/a 0.770n/an/an/an/an/an/a



National Institute of Radiological Sciences

Curated by ChEMBL


Assay Description
In vitro displacement of [11C]-DAA1106 from PBR (peripheral benzodiazepine receptor) of rat brain


Bioorg Med Chem Lett 13: 201-4 (2002)

More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060126
PNG
(2-[6,8-Dibromo-2-(4-chloro-phenyl)-imidazo[1,2-a]p...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(Br)cc(Br)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22Br2ClN3O/c1-3-9-26(10-4-2)19(28)12-18-20(14-5-7-16(24)8-6-14)25-21-17(23)11-15(22)13-27(18)21/h5-8,11,13H,3-4,9-10,12H2,1-2H3
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n/an/a 0.794n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50355782
PNG
(CHEMBL1911621)
Show SMILES CCN(CC)C(=O)Cn1c2nn(-c3ccccc3)c(=O)c2c(C)c2ccccc12
Show InChI InChI=1S/C23H24N4O2/c1-4-25(5-2)20(28)15-26-19-14-10-9-13-18(19)16(3)21-22(26)24-27(23(21)29)17-11-7-6-8-12-17/h6-14H,4-5,15H2,1-3H3
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n/an/a 0.830n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50054125
PNG
((E)-2-(2-(4-chlorophenyl)-1,2-dihydro-1-oxo-3H-pyr...)
Show SMILES COc1ccc(cc1)N(C)C(=O)\C=C1\N(C(=O)c2cc3ccccc3nc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H20ClN3O3/c1-30(19-11-13-21(34-2)14-12-19)25(32)16-24-26-22(15-17-5-3-4-6-23(17)29-26)27(33)31(24)20-9-7-18(28)8-10-20/h3-16H,1-2H3/b24-16+
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n/an/a 0.900n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK115 from peripheral benzodiazepine receptor in Sprague-Dawley rat cortical membrane


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50052749
PNG
(CHEMBL325025 | Diethyl-carbamic acid 5-p-tolyl-6-o...)
Show SMILES CCN(CC)C(=O)OC1=C(Oc2ccccc2-n2cccc12)c1ccc(C)cc1
Show InChI InChI=1S/C24H24N2O3/c1-4-25(5-2)24(27)29-23-20-10-8-16-26(20)19-9-6-7-11-21(19)28-22(23)18-14-12-17(3)13-15-18/h6-16H,4-5H2,1-3H3
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n/an/a 0.940n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-PK 11195 to peripheral-type benzodiazepine receptor (PBR) from rat cortex homogenate


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060095
PNG
(2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(Cl)cc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22Cl3N3O/c1-3-9-26(10-4-2)19(28)12-18-20(14-5-7-15(22)8-6-14)25-21-17(24)11-16(23)13-27(18)21/h5-8,11,13H,3-4,9-10,12H2,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50054126
PNG
((E)-N-(4-chlorophenyl)-2-(2-(4-chlorophenyl)-1-oxo...)
Show SMILES CN(C(=O)\C=C1\N(C(=O)c2cc3ccccc3nc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H17Cl2N3O2/c1-30(19-10-6-17(27)7-11-19)24(32)15-23-25-21(14-16-4-2-3-5-22(16)29-25)26(33)31(23)20-12-8-18(28)9-13-20/h2-15H,1H3/b23-15+
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n/an/a 1.10n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK11195 from rat kidney peripheral benzodiazepine receptor (type 1)


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 1.30n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50052753
PNG
(CHEMBL325953 | Dimethyl-carbamic acid 7-chloro-5-p...)
Show SMILES CN(C)C(=O)OC1=C(Oc2c(Cl)cccc2-n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H17ClN2O3/c1-23(2)21(25)27-20-17-12-7-13-24(17)16-11-6-10-15(22)19(16)26-18(20)14-8-4-3-5-9-14/h3-13H,1-2H3
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n/an/a 1.30n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-PK 11195 to peripheral-type benzodiazepine receptor (PBR) from rat cortex homogenate


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50122293
PNG
(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Show SMILES COc1ccc(OC)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1
Show InChI InChI=1S/C23H22FNO4/c1-16(26)25(15-17-13-20(27-2)10-12-22(17)28-3)21-14-18(24)9-11-23(21)29-19-7-5-4-6-8-19/h4-14H,15H2,1-3H3
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n/an/a 1.30n/an/an/an/an/an/a



National Institute of Radiological Sciences

Curated by ChEMBL


Assay Description
Displacement of [11C]PK-11195 from PBR in Sprague-Dawley rat brain


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50052747
PNG
(CHEMBL117444 | Dimethyl-carbamic acid 5-p-tolyl-6-...)
Show SMILES CN(C)C(=O)OC1=C(Oc2ccccc2-n2cccc12)c1ccc(C)cc1
Show InChI InChI=1S/C22H20N2O3/c1-15-10-12-16(13-11-15)20-21(27-22(25)23(2)3)18-8-6-14-24(18)17-7-4-5-9-19(17)26-20/h4-14H,1-3H3
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Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-PK 11195 to peripheral-type benzodiazepine receptor (PBR) from rat cortex homogenate


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50271821
PNG
(1-(3-Iodophenyl)-N-methyl-N-(3-fluoropropyl)-3-iso...)
Show SMILES CN(CCCF)C(=O)c1cc2ccccc2c(n1)-c1cccc(I)c1
Show InChI InChI=1S/C20H18FIN2O/c1-24(11-5-10-21)20(25)18-13-14-6-2-3-9-17(14)19(23-18)15-7-4-8-16(22)12-15/h2-4,6-9,12-13H,5,10-11H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from PBR in rat kidney mitochondrial membrane


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM81939
PNG
(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Show SMILES COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Show InChI InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
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n/an/a 1.40n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-PK 11195 binding to peripheral-type benzodiazepine receptor(PBR) in rat cerebral cortex homogenate.


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 1.41n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408734
PNG
(CHEMBL126262)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(C)cccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H26ClN3O/c1-4-12-25(13-5-2)20(27)15-19-21(17-8-10-18(23)11-9-17)24-22-16(3)7-6-14-26(19)22/h6-11,14H,4-5,12-13,15H2,1-3H3
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n/an/a 1.41n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060126
PNG
(2-[6,8-Dibromo-2-(4-chloro-phenyl)-imidazo[1,2-a]p...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(Br)cc(Br)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22Br2ClN3O/c1-3-9-26(10-4-2)19(28)12-18-20(14-5-7-16(24)8-6-14)25-21-17(23)11-15(22)13-27(18)21/h5-8,11,13H,3-4,9-10,12H2,1-2H3
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n/an/a 1.58n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50122293
PNG
(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Show SMILES COc1ccc(OC)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1
Show InChI InChI=1S/C23H22FNO4/c1-16(26)25(15-17-13-20(27-2)10-12-22(17)28-3)21-14-18(24)9-11-23(21)29-19-7-5-4-6-8-19/h4-14H,15H2,1-3H3
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n/an/a 1.60n/an/an/an/an/an/a



National Institute of Radiological Sciences

Curated by ChEMBL


Assay Description
Displacement of [11C]DAA1106 from PBR in Sprague-Dawley rat brain


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 1.60n/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50122293
PNG
(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Show SMILES COc1ccc(OC)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1
Show InChI InChI=1S/C23H22FNO4/c1-16(26)25(15-17-13-20(27-2)10-12-22(17)28-3)21-14-18(24)9-11-23(21)29-19-7-5-4-6-8-19/h4-14H,15H2,1-3H3
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n/an/a 1.60n/an/an/an/an/an/a



National Institute of Radiological Sciences

Curated by ChEMBL


Assay Description
In vitro displacement of [11C]-DAA1106 from PBR (peripheral benzodiazepine receptor) of rat brain


Bioorg Med Chem Lett 13: 201-4 (2002)

More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060115
PNG
(2-(6-Bromo-8-methyl-2-phenyl-imidazo[1,2-a]pyridin...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(C)cc(Br)cn12)-c1ccccc1
Show InChI InChI=1S/C22H26BrN3O/c1-4-11-25(12-5-2)20(27)14-19-21(17-9-7-6-8-10-17)24-22-16(3)13-18(23)15-26(19)22/h6-10,13,15H,4-5,11-12,14H2,1-3H3
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n/an/a 1.62n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50054125
PNG
((E)-2-(2-(4-chlorophenyl)-1,2-dihydro-1-oxo-3H-pyr...)
Show SMILES COc1ccc(cc1)N(C)C(=O)\C=C1\N(C(=O)c2cc3ccccc3nc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H20ClN3O3/c1-30(19-11-13-21(34-2)14-12-19)25(32)16-24-26-22(15-17-5-3-4-6-23(17)29-26)27(33)31(24)20-9-7-18(28)8-10-20/h3-16H,1-2H3/b24-16+
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n/an/a 1.70n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro-5-4864 from rat kidney peripheral benzodiazepine receptor


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50122295
PNG
(CHEMBL63065 | N-(2-Fluoromethoxy-5-methoxy-benzyl)...)
Show SMILES COc1ccc(OCF)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1
Show InChI InChI=1S/C23H21F2NO4/c1-16(27)26(14-17-12-20(28-2)9-11-22(17)29-15-24)21-13-18(25)8-10-23(21)30-19-6-4-3-5-7-19/h3-13H,14-15H2,1-2H3
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n/an/a 1.71n/an/an/an/an/an/a



National Institute of Radiological Sciences

Curated by ChEMBL


Assay Description
In vitro displacement of [11C]-DAA1106 from PBR (peripheral benzodiazepine receptor) of rat brain


Bioorg Med Chem Lett 13: 201-4 (2002)

More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50355767
PNG
(CHEMBL1911606)
Show SMILES CN(C(=O)Cn1n(-c2ccccc2)c(=O)c2c(C)c3ccccc3nc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H21ClN4O2/c1-17-21-10-6-7-11-22(21)28-25-24(17)26(33)31(20-8-4-3-5-9-20)30(25)16-23(32)29(2)19-14-12-18(27)13-15-19/h3-15H,16H2,1-2H3
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n/an/a 1.80n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 1.80n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity against peripheral benzodiazepine receptor( PBR).


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 1.82n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060105
PNG
(2-[8-Chloro-2-(4-chloro-phenyl)-6-trifluoromethyl-...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(Cl)cc(cn12)C(F)(F)F)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22Cl2F3N3O/c1-3-9-29(10-4-2)19(31)12-18-20(14-5-7-16(23)8-6-14)28-21-17(24)11-15(13-30(18)21)22(25,26)27/h5-8,11,13H,3-4,9-10,12H2,1-2H3
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n/an/a 1.82n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50054125
PNG
((E)-2-(2-(4-chlorophenyl)-1,2-dihydro-1-oxo-3H-pyr...)
Show SMILES COc1ccc(cc1)N(C)C(=O)\C=C1\N(C(=O)c2cc3ccccc3nc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H20ClN3O3/c1-30(19-11-13-21(34-2)14-12-19)25(32)16-24-26-22(15-17-5-3-4-6-23(17)29-26)27(33)31(24)20-9-7-18(28)8-10-20/h3-16H,1-2H3/b24-16+
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n/an/a 1.90n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity against peripheral benzodiazepine receptor( PBR).


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 2n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-PK 11195 binding to peripheral-type benzodiazepine receptor(PBR) in rat cerebral cortex homogenate.


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 2n/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from rat peripheral (mitochondrial) benzodiazepine receptor


J Med Chem 37: 4100-8 (1995)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 2n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral (mitochondrial) benzodiazepine receptor


J Med Chem 37: 1427-38 (1994)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 2n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-PK 11195 to peripheral-type benzodiazepine receptor (PBR) from rat cortex homogenate


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50054126
PNG
((E)-N-(4-chlorophenyl)-2-(2-(4-chlorophenyl)-1-oxo...)
Show SMILES CN(C(=O)\C=C1\N(C(=O)c2cc3ccccc3nc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H17Cl2N3O2/c1-30(19-10-6-17(27)7-11-19)24(32)15-23-25-21(14-16-4-2-3-5-22(16)29-25)26(33)31(23)20-12-8-18(28)9-13-20/h2-15H,1H3/b23-15+
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n/an/a 2.10n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro-5-4864 from rat kidney peripheral benzodiazepine receptor


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 2.10n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Displacement of [3H]PK115 from peripheral benzodiazepine receptor in Sprague-Dawley rat cortical membrane


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50059749
PNG
(3-Methyl-4-phenyl-quinoline-2-carboxylic acid benz...)
Show SMILES CN(Cc1ccccc1)C(=O)c1nc2ccccc2c(c1C)-c1ccccc1
Show InChI InChI=1S/C25H22N2O/c1-18-23(20-13-7-4-8-14-20)21-15-9-10-16-22(21)26-24(18)25(28)27(2)17-19-11-5-3-6-12-19/h3-16H,17H2,1-2H3
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n/an/a 2.10n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat.


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50059749
PNG
(3-Methyl-4-phenyl-quinoline-2-carboxylic acid benz...)
Show SMILES CN(Cc1ccccc1)C(=O)c1nc2ccccc2c(c1C)-c1ccccc1
Show InChI InChI=1S/C25H22N2O/c1-18-23(20-13-7-4-8-14-20)21-15-9-10-16-22(21)26-24(18)25(28)27(2)17-19-11-5-3-6-12-19/h3-16H,17H2,1-2H3
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n/an/a 2.10n/an/an/an/an/an/a



Universit£ degli Studi Magna Graecia di Catanzaro

Curated by ChEMBL


Assay Description
Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortex


J Med Chem 44: 1134-50 (2001)

More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50059754
PNG
(3-Methyl-4-phenyl-quinoline-2-carboxylic acid sec-...)
Show SMILES CCC(C)N(C)C(=O)c1nc2ccccc2c(-c2ccccc2)c1C
Show InChI InChI=1S/C22H24N2O/c1-5-15(2)24(4)22(25)21-16(3)20(17-11-7-6-8-12-17)18-13-9-10-14-19(18)23-21/h6-15H,5H2,1-4H3
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Universit£ di Siena

Curated by ChEMBL


Assay Description
In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat.


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50059754
PNG
(3-Methyl-4-phenyl-quinoline-2-carboxylic acid sec-...)
Show SMILES CCC(C)N(C)C(=O)c1nc2ccccc2c(-c2ccccc2)c1C
Show InChI InChI=1S/C22H24N2O/c1-5-15(2)24(4)22(25)21-16(3)20(17-11-7-6-8-12-17)18-13-9-10-14-19(18)23-21/h6-15H,5H2,1-4H3
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n/an/a 2.10n/an/an/an/an/an/a



Universit£ degli Studi Magna Graecia di Catanzaro

Curated by ChEMBL


Assay Description
Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortex


J Med Chem 44: 1134-50 (2001)

More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50059749
PNG
(3-Methyl-4-phenyl-quinoline-2-carboxylic acid benz...)
Show SMILES CN(Cc1ccccc1)C(=O)c1nc2ccccc2c(c1C)-c1ccccc1
Show InChI InChI=1S/C25H22N2O/c1-18-23(20-13-7-4-8-14-20)21-15-9-10-16-22(21)26-24(18)25(28)27(2)17-19-11-5-3-6-12-19/h3-16H,17H2,1-2H3
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n/an/a 2.10n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50059754
PNG
(3-Methyl-4-phenyl-quinoline-2-carboxylic acid sec-...)
Show SMILES CCC(C)N(C)C(=O)c1nc2ccccc2c(-c2ccccc2)c1C
Show InChI InChI=1S/C22H24N2O/c1-5-15(2)24(4)22(25)21-16(3)20(17-11-7-6-8-12-17)18-13-9-10-14-19(18)23-21/h6-15H,5H2,1-4H3
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n/an/a 2.10n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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n/an/a 2.20n/an/an/an/an/an/a



Universit£ degli Studi Magna Graecia di Catanzaro

Curated by ChEMBL


Assay Description
Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortex


J Med Chem 44: 1134-50 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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