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Found 12 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4-kinase type 2-alpha'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50034808
PNG
(CHEMBL3353011)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C[C@@]2(CO)CC[C@@H]1C2
Show InChI InChI=1/C13H17N5O/c14-11-10-12(16-6-15-11)18(7-17-10)9-4-13(5-19)2-1-8(9)3-13/h6-9,19H,1-5H2,(H2,14,15,16)/t8-,9-,13-/s2
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n/an/a 4.89E+4n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibition of human PI4K2alpha expressed in Escherichia coli BL21 after 60 mins by ADP-GloTM Kinase Assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087056
PNG
(CHEMBL3426603)
Show SMILES COc1ccc(cc1OC)-c1c(C)nc2c(N)cc(Cl)nn12
Show InChI InChI=1S/C15H15ClN4O2/c1-8-14(9-4-5-11(21-2)12(6-9)22-3)20-15(18-8)10(17)7-13(16)19-20/h4-7H,17H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087057
PNG
(CHEMBL3426602)
Show SMILES COc1ccc(cc1OC)-c1c(C)nc2c(NCCNC(C)=O)ccnn12
Show InChI InChI=1S/C19H23N5O3/c1-12-18(14-5-6-16(26-3)17(11-14)27-4)24-19(23-12)15(7-8-22-24)21-10-9-20-13(2)25/h5-8,11,21H,9-10H2,1-4H3,(H,20,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087058
PNG
(CHEMBL3426601)
Show SMILES CC(C)NS(=O)(=O)c1cccc(c1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C20H25ClN6O3S/c1-12(2)26-31(29,30)16-7-5-6-15(10-16)19-13(3)24-20-17(11-18(21)25-27(19)20)23-9-8-22-14(4)28/h5-7,10-12,23,26H,8-9H2,1-4H3,(H,22,28)
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087117
PNG
(CHEMBL3426594)
Show SMILES COc1ccc(cc1OC)-c1c(C)nn2c(NCCNC(C)=O)cc(C)nc12
Show InChI InChI=1S/C20H25N5O3/c1-12-10-18(22-9-8-21-14(3)26)25-20(23-12)19(13(2)24-25)15-6-7-16(27-4)17(11-15)28-5/h6-7,10-11,22H,8-9H2,1-5H3,(H,21,26)
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087060
PNG
(CHEMBL3426599)
Show SMILES COc1ccc(cc1OC)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C19H22ClN5O3/c1-11-18(13-5-6-15(27-3)16(9-13)28-4)25-19(23-11)14(10-17(20)24-25)22-8-7-21-12(2)26/h5-6,9-10,22H,7-8H2,1-4H3,(H,21,26)
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087061
PNG
(CHEMBL3426598)
Show SMILES COc1ccc(cc1OC)-c1c(C)nc2c(NCCN3CCOCC3)ccnn12
Show InChI InChI=1S/C21H27N5O3/c1-15-20(16-4-5-18(27-2)19(14-16)28-3)26-21(24-15)17(6-7-23-26)22-8-9-25-10-12-29-13-11-25/h4-7,14,22H,8-13H2,1-3H3
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087062
PNG
(CHEMBL3426597)
Show SMILES COc1ccc(cc1OC)-c1c(C)nn2c(NCCOC(C)=O)cc(C)nc12
Show InChI InChI=1S/C20H24N4O4/c1-12-10-18(21-8-9-28-14(3)25)24-20(22-12)19(13(2)23-24)15-6-7-16(26-4)17(11-15)27-5/h6-7,10-11,21H,8-9H2,1-5H3
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087092
PNG
(CHEMBL3426596)
Show SMILES COc1ccc(cc1OC)-c1c(C)nn2c(NCCNS(C)(=O)=O)cc(C)nc12
Show InChI InChI=1S/C19H25N5O4S/c1-12-10-17(20-8-9-21-29(5,25)26)24-19(22-12)18(13(2)23-24)14-6-7-15(27-3)16(11-14)28-4/h6-7,10-11,20-21H,8-9H2,1-5H3
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087099
PNG
(CHEMBL3426595)
Show SMILES COc1ccc(cc1OC)-c1c(C)nn2c(NCCNC(=O)C(C)C)cc(C)nc12
Show InChI InChI=1S/C22H29N5O3/c1-13(2)22(28)24-10-9-23-19-11-14(3)25-21-20(15(4)26-27(19)21)16-7-8-17(29-5)18(12-16)30-6/h7-8,11-13,23H,9-10H2,1-6H3,(H,24,28)
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50005005
PNG
(CHEMBL2397317)
Show SMILES COc1ccc(cc1OC)-c1c(C)nn2c(NCCN3CCOCC3)cc(C)nc12
Show InChI InChI=1S/C22H29N5O3/c1-15-13-20(23-7-8-26-9-11-30-12-10-26)27-22(24-15)21(16(2)25-27)17-5-6-18(28-3)19(14-17)29-4/h5-6,13-14,23H,7-12H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase type 2-alpha


(Homo sapiens)
BDBM50087059
PNG
(CHEMBL3426600)
Show SMILES CC(=O)NCCNc1cc(Cl)nn2c(c(C)nc12)-c1ccc(F)c(C=O)c1
Show InChI InChI=1S/C18H17ClFN5O2/c1-10-17(12-3-4-14(20)13(7-12)9-26)25-18(23-10)15(8-16(19)24-25)22-6-5-21-11(2)27/h3-4,7-9,22H,5-6H2,1-2H3,(H,21,27)
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI4K2alpha (unknown origin) assessed as hydrolysis of ATP for 60 mins by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair