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Found 2372 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144388
PNG
(US8969376, 1.002 (3/2 HCl))
Show SMILES CN(C1CCOCC1)c1cc(nc2cc(nn12)-c1nc2ccccc2nc1C)N1CCCC1
Show InChI InChI=1S/C25H29N7O/c1-17-25(27-20-8-4-3-7-19(20)26-17)21-15-23-28-22(31-11-5-6-12-31)16-24(32(23)29-21)30(2)18-9-13-33-14-10-18/h3-4,7-8,15-16,18H,5-6,9-14H2,1-2H3
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US Patent
n/an/a 0.00450n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144415
PNG
(US8969376, 1.152)
Show SMILES Cc1ccc2nc(C)c(nc2c1)-c1cc2nc(cc(N(C3CC3)C3CCOCC3)n2n1)N1CCC[C@H]1CO
Show InChI InChI=1/C29H35N7O2/c1-18-5-8-23-24(14-18)31-29(19(2)30-23)25-15-27-32-26(34-11-3-4-22(34)17-37)16-28(36(27)33-25)35(20-6-7-20)21-9-12-38-13-10-21/h5,8,14-16,20-22,37H,3-4,6-7,9-13,17H2,1-2H3/t22-/s2
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US Patent
n/an/a 0.00680n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144408
PNG
(US8969376, 1.112)
Show SMILES Cc1ccc2nc(C)c(nc2c1)-c1cc2nc(cc(N[C@@H]3CCS(=O)(=O)C3)n2n1)N1CCCC1
Show InChI InChI=1/C24H27N7O2S/c1-15-5-6-18-19(11-15)27-24(16(2)25-18)20-12-22-28-21(30-8-3-4-9-30)13-23(31(22)29-20)26-17-7-10-34(32,33)14-17/h5-6,11-13,17,26H,3-4,7-10,14H2,1-2H3/t17-/s2
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n/an/a 0.00850n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144399
PNG
(US8969376, 1.050)
Show SMILES COCCN(CCCO)c1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Show InChI InChI=1S/C26H33N7O2/c1-18-7-8-20-21(15-18)28-26(19(2)27-20)22-16-24-29-23(31-9-4-5-10-31)17-25(33(24)30-22)32(11-6-13-34)12-14-35-3/h7-8,15-17,34H,4-6,9-14H2,1-3H3
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US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144405
PNG
(US8969376, 1.097)
Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(N[C@H]3CCCC[C@@H]3O)n2n1)N1CCCC1
Show InChI InChI=1/C25H28FN7O/c1-15-25(29-19-12-16(26)8-9-17(19)27-15)20-13-23-30-22(32-10-4-5-11-32)14-24(33(23)31-20)28-18-6-2-3-7-21(18)34/h8-9,12-14,18,21,28,34H,2-7,10-11H2,1H3/t18-,21-/s2
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n/an/a 0.0350n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115431
PNG
(US8637500, 301 | US8637500, 454 | US8637500, 455)
Show SMILES CC(=O)N1CCCC(C1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C24H26N4O2/c1-17-7-12-23(26-15-17)27-20-8-10-21(11-9-20)30-24-22(6-3-13-25-24)19-5-4-14-28(16-19)18(2)29/h3,6-13,15,19H,4-5,14,16H2,1-2H3,(H,26,27)
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n/an/a 0.0400n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144409
PNG
(US8969376, 1.114)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Show InChI InChI=1S/C27H32N8O/c1-17-6-7-21-22(14-17)30-27(18(2)28-21)23-15-25-31-24(34-10-4-5-11-34)16-26(35(25)32-23)29-20-8-12-33(13-9-20)19(3)36/h6-7,14-16,20,29H,4-5,8-13H2,1-3H3
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n/an/a 0.0440n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144398
PNG
(US8969376, 1.047)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1cc(nc2cc(nn12)-c1nc2cc(ccc2nc1C)C(F)(F)F)N1CCCC1
Show InChI InChI=1/C27H30F3N7O/c1-16-26(33-21-13-17(27(28,29)30)5-10-20(21)31-16)22-14-24-34-23(36-11-3-4-12-36)15-25(37(24)35-22)32-18-6-8-19(38-2)9-7-18/h5,10,13-15,18-19,32H,3-4,6-9,11-12H2,1-2H3/t18-,19-
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n/an/a 0.0450n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115430
PNG
(US8637500, 299)
Show SMILES CN(C)C(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C24H28N6O2/c1-17-4-9-21(27-16-17)28-19-5-7-20(8-6-19)32-23-22(25-12-13-26-23)18-10-14-30(15-11-18)24(31)29(2)3/h4-9,12-13,16,18H,10-11,14-15H2,1-3H3,(H,27,28)
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n/an/a 0.0450n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144397
PNG
(US8969376, 1.031)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NCCC#N)n2n1)N1CCCC1
Show InChI InChI=1S/C22H22N8/c1-15-22(26-17-8-3-2-7-16(17)25-15)18-13-21-27-20(29-11-4-5-12-29)14-19(30(21)28-18)24-10-6-9-23/h2-3,7-8,13-14,24H,4-6,10-12H2,1H3
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n/an/a 0.0520n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115427
PNG
(US8637500, 296)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C25H29N5O2/c1-17(2)25(31)30-14-10-19(11-15-30)23-24(27-13-12-26-23)32-21-7-5-20(6-8-21)29-22-9-4-18(3)16-28-22/h4-9,12-13,16-17,19H,10-11,14-15H2,1-3H3,(H,28,29)
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115428
PNG
(US8637500, 297)
Show SMILES CCOC(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C24H27N5O3/c1-3-31-24(30)29-14-10-18(11-15-29)22-23(26-13-12-25-22)32-20-7-5-19(6-8-20)28-21-9-4-17(2)16-27-21/h4-9,12-13,16,18H,3,10-11,14-15H2,1-2H3,(H,27,28)
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n/an/a 0.0560n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142557
PNG
(US8933224, 150)
Show SMILES CCn1c(nc2CCN(Cc2c1=O)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1
Show InChI InChI=1/C22H27N7O2/c1-3-28-20(14-4-5-14)26-17-6-8-27(10-16(17)22(28)30)21-19-18(15-7-9-31-11-15)25-13(2)29(19)24-12-23-21/h12,14-15H,3-11H2,1-2H3/t15-/s2
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n/an/a 0.0697n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142550
PNG
(US8933224, 143 | US8933224, 144)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(C3CC3)n(C)c(=O)c2C1
Show InChI InChI=1/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29)26(2)19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/s2
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n/an/a 0.0837n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142481
PNG
(US8933224, 74)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2ccc(nc2C1)C1CC1
Show InChI InChI=1/C21H24N6O/c1-13-24-19(16-7-9-28-11-16)20-21(22-12-23-27(13)20)26-8-6-15-4-5-17(14-2-3-14)25-18(15)10-26/h4-5,12,14,16H,2-3,6-11H2,1H3/t16-/s2
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n/an/a 0.0896n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144394
PNG
(US8969376, 1.013)
Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(N[C@H]3CC[C@](C)(O)CC3)n2n1)N1CC[C@@H](F)C1
Show InChI InChI=1/C26H29F2N7O/c1-15-25(31-20-11-16(27)3-4-19(20)29-15)21-12-23-32-22(34-10-7-17(28)14-34)13-24(35(23)33-21)30-18-5-8-26(2,36)9-6-18/h3-4,11-13,17-18,30,36H,5-10,14H2,1-2H3/t17-,18-,26-/s2
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144390
PNG
(US8969376, 1.006)
Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1
Show InChI InChI=1/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/s2
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n/an/a 0.0900n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142544
PNG
(US8933224, 137)
Show SMILES CCc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1
Show InChI InChI=1/C22H27N7O/c1-3-17-16-10-28(8-6-18(16)27-21(26-17)14-4-5-14)22-20-19(15-7-9-30-11-15)25-13(2)29(20)24-12-23-22/h12,14-15H,3-11H2,1-2H3/t15-/s2
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n/an/a 0.0950n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115424
PNG
(US8637500, 293)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C26H30N4O2/c1-18(2)26(31)30-15-12-20(13-16-30)23-5-4-14-27-25(23)32-22-9-7-21(8-10-22)29-24-11-6-19(3)17-28-24/h4-11,14,17-18,20H,12-13,15-16H2,1-3H3,(H,28,29)
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Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142536
PNG
(US8933224, 129)
Show SMILES CCn1c(C)nc2CCN(Cc2c1=O)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1/C20H25N7O2/c1-4-26-12(2)23-16-5-7-25(9-15(16)20(26)28)19-18-17(14-6-8-29-10-14)24-13(3)27(18)22-11-21-19/h11,14H,4-10H2,1-3H3/t14-/s2
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n/an/a 0.0998n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142459
PNG
(US8933224, 52)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(nc(O)c2C1)C1CC1
Show InChI InChI=1/C20H23N7O2/c1-11-23-16(13-5-7-29-9-13)17-19(21-10-22-27(11)17)26-6-4-15-14(8-26)20(28)25-18(24-15)12-2-3-12/h10,12-13H,2-9H2,1H3,(H,24,25,28)/t13-/s2
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n/an/a 0.101n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142451
PNG
(US8933224, 44)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nn(C)c(C3CC3)c2C1
Show InChI InChI=1/C20H25N7O/c1-12-23-17(14-6-8-28-10-14)19-20(21-11-22-27(12)19)26-7-5-16-15(9-26)18(13-3-4-13)25(2)24-16/h11,13-14H,3-10H2,1-2H3/t14-/s2
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n/an/a 0.102n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142550
PNG
(US8933224, 143 | US8933224, 144)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(C3CC3)n(C)c(=O)c2C1
Show InChI InChI=1/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29)26(2)19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/s2
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n/an/a 0.106n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144387
PNG
(US8969376, 1.001 (HCl))
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NC3CCOCC3)n2n1)N1CCCC1
Show InChI InChI=1S/C24H27N7O/c1-16-24(27-19-7-3-2-6-18(19)25-16)20-14-22-28-21(30-10-4-5-11-30)15-23(31(22)29-20)26-17-8-12-32-13-9-17/h2-3,6-7,14-15,17,26H,4-5,8-13H2,1H3
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n/an/a 0.110n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142442
PNG
(US8933224, 35)
Show SMILES CCOc1nc(C)nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1/C20H25N7O2/c1-4-29-20-15-9-26(7-5-16(15)23-12(2)24-20)19-18-17(14-6-8-28-10-14)25-13(3)27(18)22-11-21-19/h11,14H,4-10H2,1-3H3/t14-/s2
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n/an/a 0.123n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142555
PNG
(US8933224, 148)
Show SMILES CCOc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1
Show InChI InChI=1/C22H27N7O2/c1-3-31-22-16-10-28(8-6-17(16)26-20(27-22)14-4-5-14)21-19-18(15-7-9-30-11-15)25-13(2)29(19)24-12-23-21/h12,14-15H,3-11H2,1-2H3/t15-/s2
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n/an/a 0.125n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144396
PNG
(US8969376, 1.027)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NC[C@H](O)C(F)(F)F)n2n1)N1CCCC1
Show InChI InChI=1/C22H22F3N7O/c1-13-21(28-15-7-3-2-6-14(15)27-13)16-10-20-29-19(31-8-4-5-9-31)11-18(32(20)30-16)26-12-17(33)22(23,24)25/h2-3,6-7,10-11,17,26,33H,4-5,8-9,12H2,1H3/t17-/s2
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n/an/a 0.130n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142559
PNG
(US8933224, 152)
Show SMILES CNc1ccc2CN(CCc2n1)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1/C19H23N7O/c1-12-23-17(14-6-8-27-10-14)18-19(21-11-22-26(12)18)25-7-5-15-13(9-25)3-4-16(20-2)24-15/h3-4,11,14H,5-10H2,1-2H3,(H,20,24)/t14-/s2
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n/an/a<0.130n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115425
PNG
(US8637500, 294)
Show SMILES COCC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C25H28N4O3/c1-18-5-10-23(27-16-18)28-20-6-8-21(9-7-20)32-25-22(4-3-13-26-25)19-11-14-29(15-12-19)24(30)17-31-2/h3-10,13,16,19H,11-12,14-15,17H2,1-2H3,(H,27,28)
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n/an/a 0.132n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142493
PNG
(US8933224, 86)
Show SMILES CC(C)c1nn(C)c2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1/C20H27N7O/c1-12(2)17-15-9-26(7-5-16(15)25(4)24-17)20-19-18(14-6-8-28-10-14)23-13(3)27(19)22-11-21-20/h11-12,14H,5-10H2,1-4H3/t14-/s2
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n/an/a 0.132n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142446
PNG
(US8933224, 173 | US8933224, 39)
Show SMILES COc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1
Show InChI InChI=1/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29-2)26-19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/s2
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n/an/a 0.136n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142548
PNG
(US8933224, 141)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(nc(OC(F)F)c2C1)C1CC1
Show InChI InChI=1/C21H23F2N7O2/c1-11-26-16(13-5-7-31-9-13)17-19(24-10-25-30(11)17)29-6-4-15-14(8-29)20(32-21(22)23)28-18(27-15)12-2-3-12/h10,12-13,21H,2-9H2,1H3/t13-/s2
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n/an/a 0.142n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142561
PNG
(US8933224, 154)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(ccc2C1)C1CC1
Show InChI InChI=1/C21H24N6O/c1-13-24-19(16-7-9-28-11-16)20-21(22-12-23-27(13)20)26-8-6-18-15(10-26)4-5-17(25-18)14-2-3-14/h4-5,12,14,16H,2-3,6-11H2,1H3/t16-/s2
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n/an/a 0.144n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142425
PNG
(US8933224, 18)
Show SMILES CCc1nn(C)c2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1/C19H25N7O/c1-4-15-14-9-25(7-5-16(14)24(3)23-15)19-18-17(13-6-8-27-10-13)22-12(2)26(18)21-11-20-19/h11,13H,4-10H2,1-3H3/t13-/s2
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n/an/a 0.147n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142519
PNG
(US8933224, 112)
Show SMILES CCc1c2CN(CCc2nn1C)c1ncnn2c(C)nc(-c3ccccc3F)c12
Show InChI InChI=1S/C21H22FN7/c1-4-18-15-11-28(10-9-17(15)26-27(18)3)21-20-19(14-7-5-6-8-16(14)22)25-13(2)29(20)24-12-23-21/h5-8,12H,4,9-11H2,1-3H3
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n/an/a 0.147n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144410
PNG
(US8969376, 1.123)
Show SMILES CCCN1CCC(CC1)Nc1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Show InChI InChI=1S/C28H36N8/c1-4-11-34-14-9-21(10-15-34)30-27-18-25(35-12-5-6-13-35)32-26-17-24(33-36(26)27)28-20(3)29-22-8-7-19(2)16-23(22)31-28/h7-8,16-18,21,30H,4-6,9-15H2,1-3H3
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n/an/a 0.150n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142568
PNG
(US8933224, 161)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2cc(ncc2C1)C1CC1
Show InChI InChI=1/C21H24N6O/c1-13-25-19(16-5-7-28-11-16)20-21(23-12-24-27(13)20)26-6-4-15-8-18(14-2-3-14)22-9-17(15)10-26/h8-9,12,14,16H,2-7,10-11H2,1H3/t16-/s2
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n/an/a 0.163n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144411
PNG
(US8969376, 1.126)
Show SMILES CN(C)CCNc1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Show InChI InChI=1S/C24H30N8/c1-16-7-8-18-19(13-16)27-24(17(2)26-18)20-14-23-28-22(31-10-5-6-11-31)15-21(32(23)29-20)25-9-12-30(3)4/h7-8,13-15,25H,5-6,9-12H2,1-4H3
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n/an/a 0.170n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115429
PNG
(US8637500, 298)
Show SMILES Cc1ccc(Nc2ccc(Oc3nccnc3C3CCN(CC3)C(=O)C3CC3)cc2)nc1
Show InChI InChI=1S/C25H27N5O2/c1-17-2-9-22(28-16-17)29-20-5-7-21(8-6-20)32-24-23(26-12-13-27-24)18-10-14-30(15-11-18)25(31)19-3-4-19/h2,5-9,12-13,16,18-19H,3-4,10-11,14-15H2,1H3,(H,28,29)
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n/an/a 0.171n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142562
PNG
(US8933224, 155)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2cccc(C)c2C1
Show InChI InChI=1/C20H23N5O/c1-13-4-3-5-15-6-8-24(10-17(13)15)20-19-18(16-7-9-26-11-16)23-14(2)25(19)22-12-21-20/h3-5,12,16H,6-11H2,1-2H3/t16-/s2
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n/an/a 0.171n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142593
PNG
(US8933224, 11)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nn(cc2C1)C1CC1
Show InChI InChI=1S/C19H23N7O/c1-12-22-17(13-5-7-27-10-13)18-19(20-11-21-26(12)18)24-6-4-16-14(8-24)9-25(23-16)15-2-3-15/h9,11,13,15H,2-8,10H2,1H3/t13-/m1/s1
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US Patent
n/an/a 0.174n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142444
PNG
(US8933224, 132 | US8933224, 37)
Show SMILES COc1nc(C)nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1/C19H23N7O2/c1-11-22-15-4-6-25(8-14(15)19(23-11)27-3)18-17-16(13-5-7-28-9-13)24-12(2)26(17)21-10-20-18/h10,13H,4-9H2,1-3H3/t13-/s2
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n/an/a 0.174n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142448
PNG
(US8933224, 41)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(nc(C)c2C1)C1CC1
Show InChI InChI=1/C21H25N7O/c1-12-16-9-27(7-5-17(16)26-20(24-12)14-3-4-14)21-19-18(15-6-8-29-10-15)25-13(2)28(19)23-11-22-21/h11,14-15H,3-10H2,1-2H3/t15-/s2
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n/an/a<0.175n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142444
PNG
(US8933224, 132 | US8933224, 37)
Show SMILES COc1nc(C)nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1/C19H23N7O2/c1-11-22-15-4-6-25(8-14(15)19(23-11)27-3)18-17-16(13-5-7-28-9-13)24-12(2)26(17)21-10-20-18/h10,13H,4-9H2,1-3H3/t13-/s2
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n/an/a 0.177n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144404
PNG
(US8969376, 1.085)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1cc(nc2cc(nn12)-c1nc2ccccc2nc1C(F)(F)F)N1CC[C@@H](F)C1
Show InChI InChI=1/C26H27F4N7O/c1-25(38)9-6-16(7-10-25)31-22-13-20(36-11-8-15(27)14-36)34-21-12-19(35-37(21)22)23-24(26(28,29)30)33-18-5-3-2-4-17(18)32-23/h2-5,12-13,15-16,31,38H,6-11,14H2,1H3/t15-,16-,25-/s2
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n/an/a 0.180n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM31592
PNG
(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3
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n/an/a 0.180n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of rat PDE10A


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115422
PNG
(US8637500, 291)
Show SMILES Cc1ccc(Nc2ccc(Oc3ncccc3C3CCN(CC3)S(C)(=O)=O)cc2)nc1
Show InChI InChI=1S/C23H26N4O3S/c1-17-5-10-22(25-16-17)26-19-6-8-20(9-7-19)30-23-21(4-3-13-24-23)18-11-14-27(15-12-18)31(2,28)29/h3-10,13,16,18H,11-12,14-15H2,1-2H3,(H,25,26)
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n/an/a 0.189n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142446
PNG
(US8933224, 173 | US8933224, 39)
Show SMILES COc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1
Show InChI InChI=1/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29-2)26-19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/s2
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n/an/a 0.193n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142594
PNG
(US8933224, 12)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2c(C1)c(nn2C)C1CC1
Show InChI InChI=1S/C20H25N7O/c1-12-23-18(14-6-8-28-10-14)19-20(21-11-22-27(12)19)26-7-5-16-15(9-26)17(13-3-4-13)24-25(16)2/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1
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n/an/a 0.194n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142564
PNG
(US8933224, 157)
Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2ccc(nc2C1)C(F)(F)F
Show InChI InChI=1/C19H19F3N6O/c1-11-25-16(13-5-7-29-9-13)17-18(23-10-24-28(11)17)27-6-4-12-2-3-15(19(20,21)22)26-14(12)8-27/h2-3,10,13H,4-9H2,1H3/t13-/s2
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n/an/a 0.196n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
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