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Compile Data Set for Download or QSAR

Found 6476 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146708
PNG
(US8957073, 4.42)
Show SMILES CC1(C)CC(=CCO1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H24N4O/c1-23(2)13-17(9-12-28-23)21-22(25-11-10-24-21)18-14-27(15-18)20-8-7-16-5-3-4-6-19(16)26-20/h3-11,18H,12-15H2,1-2H3
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US Patent
n/an/a 0.00100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146707
PNG
(US8957073, 4.41)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1C1=CCOCC1
Show InChI InChI=1S/C21H20N4O/c1-2-4-18-15(3-1)5-6-19(24-18)25-13-17(14-25)21-20(22-9-10-23-21)16-7-11-26-12-8-16/h1-7,9-10,17H,8,11-14H2
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US Patent
n/an/a 0.00110n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00120n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00120n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47147
PNG
(US8957073, 4.28 | US8957073, 4.44)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16F4N4/c24-18-10-15(9-17(11-18)23(25,26)27)21-22(29-8-7-28-21)16-12-31(13-16)20-6-5-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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n/an/a 0.00122n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146672
PNG
(US8957073, 4.6)
Show SMILES COc1ccc(c(OC)n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H21N5O2/c1-29-20-10-8-17(23(27-20)30-2)22-21(24-11-12-25-22)16-13-28(14-16)19-9-7-15-5-3-4-6-18(15)26-19/h3-12,16H,13-14H2,1-2H3
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n/an/a 0.00135n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146689
PNG
(US8957073, 4.23)
Show SMILES Oc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H17ClN4O/c23-17-11-15(5-7-19(17)28)21-22(25-10-9-24-21)16-12-27(13-16)20-8-6-14-3-1-2-4-18(14)26-20/h1-11,16,28H,12-13H2
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n/an/a 0.00230n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146687
PNG
(US8957073, 4.21)
Show SMILES Cc1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00230n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146667
PNG
(US8957073, 4.1)
Show SMILES COc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-22-17(6-4-10-25-22)21-20(23-11-12-24-21)16-13-27(14-16)19-9-8-15-5-2-3-7-18(15)26-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00234n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146677
PNG
(US8957073, 4.11)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H20N4O2S/c1-30(28,29)19-9-6-17(7-10-19)22-23(25-13-12-24-22)18-14-27(15-18)21-11-8-16-4-2-3-5-20(16)26-21/h2-13,18H,14-15H2,1H3
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n/an/a 0.00262n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146678
PNG
(US8957073, 4.12)
Show SMILES Nc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2,(H2,22,25)
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n/an/a 0.00278n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146668
PNG
(US8957073, 4.2)
Show SMILES Cc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-6-7-17(12-25-15)21-22(24-11-10-23-21)18-13-27(14-18)20-9-8-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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n/an/a 0.00279n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50397973
PNG
(CHEMBL2180441)
Show SMILES Cc1nc2ccc(cc2nc1\C=C\c1nc(N[C@@H]2CCS(=O)(=O)C2)cc(n1)N1CCCC1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N6O2S/c1-15-18(30-20-12-16(24(25,26)27)4-5-19(20)28-15)6-7-21-31-22(29-17-8-11-36(34,35)14-17)13-23(32-21)33-9-2-3-10-33/h4-7,12-13,17H,2-3,8-11,14H2,1H3,(H,29,31,32)/b7-6+/t17-/m1/s1
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Article
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n/an/a 0.00330n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146695
PNG
(US8957073, 4.29)
Show SMILES COc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4O/c1-16-13-18(7-9-21(16)29-2)23-24(26-12-11-25-23)19-14-28(15-19)22-10-8-17-5-3-4-6-20(17)27-22/h3-13,19H,14-15H2,1-2H3
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n/an/a 0.00350n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146679
PNG
(US8957073, 4.13)
Show SMILES Nc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13,22H2
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n/an/a 0.00376n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146698
PNG
(US8957073, 4.32)
Show SMILES Fc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16ClFN4/c23-17-11-15(5-7-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00410n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146670
PNG
(US8957073, 4.4)
Show SMILES Fc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2
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n/an/a 0.00418n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146688
PNG
(US8957073, 4.22)
Show SMILES Cc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00420n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144388
PNG
(US8969376, 1.002 (3/2 HCl))
Show SMILES CN(C1CCOCC1)c1cc(nc2cc(nn12)-c1nc2ccccc2nc1C)N1CCCC1
Show InChI InChI=1S/C25H29N7O/c1-17-25(27-20-8-4-3-7-19(20)26-17)21-15-23-28-22(31-11-5-6-12-31)16-24(32(23)29-21)30(2)18-9-13-33-14-10-18/h3-4,7-8,15-16,18H,5-6,9-14H2,1-2H3
PDB

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n/an/a 0.00450n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146697
PNG
(US8957073, 4.31)
Show SMILES Cc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00510n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146701
PNG
(US8957073, 4.35)
Show SMILES Cc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4/c1-16-7-8-19(13-17(16)2)23-24(26-12-11-25-23)20-14-28(15-20)22-10-9-18-5-3-4-6-21(18)27-22/h3-13,20H,14-15H2,1-2H3
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n/an/a 0.00550n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146691
PNG
(US8957073, 4.25)
Show SMILES CCOc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21FN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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n/an/a 0.00620n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146704
PNG
(US8957073, 4.38)
Show SMILES Cc1cc(ccc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00640n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146669
PNG
(US8957073, 4.3)
Show SMILES Cc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-18(6-4-10-23-15)22-21(24-11-12-25-22)17-13-27(14-17)20-9-8-16-5-2-3-7-19(16)26-20/h2-12,17H,13-14H2,1H3
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n/an/a 0.00648n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146702
PNG
(US8957073, 4.36)
Show SMILES Cc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00670n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144415
PNG
(US8969376, 1.152)
Show SMILES Cc1ccc2nc(C)c(nc2c1)-c1cc2nc(cc(N(C3CC3)C3CCOCC3)n2n1)N1CCC[C@H]1CO
Show InChI InChI=1/C29H35N7O2/c1-18-5-8-23-24(14-18)31-29(19(2)30-23)25-15-27-32-26(34-11-3-4-22(34)17-37)16-28(36(27)33-25)35(20-6-7-20)21-9-12-38-13-10-21/h5,8,14-16,20-22,37H,3-4,6-7,9-13,17H2,1-2H3/t22-/s2
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n/an/a 0.00680n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146709
PNG
(US8957073, 4.43)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cn[nH]c1
Show InChI InChI=1S/C19H16N6/c1-2-4-16-13(3-1)5-6-17(24-16)25-11-15(12-25)19-18(20-7-8-21-19)14-9-22-23-10-14/h1-10,15H,11-12H2,(H,22,23)
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n/an/a 0.00700n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146703
PNG
(US8957073, 4.37)
Show SMILES Cc1cc(Cl)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00720n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146676
PNG
(US8957073, 4.10)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cccnc1
Show InChI InChI=1S/C21H17N5/c1-2-6-18-15(4-1)7-8-19(25-18)26-13-17(14-26)21-20(23-10-11-24-21)16-5-3-9-22-12-16/h1-12,17H,13-14H2
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n/an/a 0.00787n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146674
PNG
(US8957073, 4.8)
Show SMILES COc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-9-7-16(12-25-20)21-22(24-11-10-23-21)17-13-27(14-17)19-8-6-15-4-2-3-5-18(15)26-19/h2-12,17H,13-14H2,1H3
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n/an/a 0.00787n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146700
PNG
(US8957073, 4.34)
Show SMILES Clc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16Cl2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00840n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144408
PNG
(US8969376, 1.112)
Show SMILES Cc1ccc2nc(C)c(nc2c1)-c1cc2nc(cc(N[C@@H]3CCS(=O)(=O)C3)n2n1)N1CCCC1
Show InChI InChI=1/C24H27N7O2S/c1-15-5-6-18-19(11-15)27-24(16(2)25-18)20-12-22-28-21(30-8-3-4-9-30)13-23(31(22)29-20)26-17-7-10-34(32,33)14-17/h5-6,11-13,17,26H,3-4,7-10,14H2,1-2H3/t17-/s2
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n/an/a 0.00850n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146706
PNG
(US8957073, 4.40)
Show SMILES FC(F)(F)c1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16ClF3N4/c24-18-7-5-15(11-17(18)23(25,26)27)21-22(29-10-9-28-21)16-12-31(13-16)20-8-6-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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n/an/a 0.00910n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146699
PNG
(US8957073, 4.33)
Show SMILES Fc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16F2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00990n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146692
PNG
(US8957073, 4.26)
Show SMILES CCOc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21ClN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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n/an/a 0.0106n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146696
PNG
(US8957073, 4.30)
Show SMILES CC(C)Oc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23FN4O/c1-16(2)31-21-12-18(11-20(26)13-21)24-25(28-10-9-27-24)19-14-30(15-19)23-8-7-17-5-3-4-6-22(17)29-23/h3-13,16,19H,14-15H2,1-2H3
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n/an/a 0.0110n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146675
PNG
(US8957073, 4.9)
Show SMILES Cc1cc(cnc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H18FN5/c1-14-10-16(11-26-22(14)23)20-21(25-9-8-24-20)17-12-28(13-17)19-7-6-15-4-2-3-5-18(15)27-19/h2-11,17H,12-13H2,1H3
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n/an/a 0.0122n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47147
PNG
(US8957073, 4.28 | US8957073, 4.44)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16F4N4/c24-18-10-15(9-17(11-18)23(25,26)27)21-22(29-8-7-28-21)16-12-31(13-16)20-6-5-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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n/an/a 0.0122n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146673
PNG
(US8957073, 4.7)
Show SMILES Fc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13H2
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n/an/a 0.0123n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146671
PNG
(US8957073, 4.5)
Show SMILES FC(F)(F)c1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16F3N5/c23-22(24,25)18-7-5-15(11-28-18)20-21(27-10-9-26-20)16-12-30(13-16)19-8-6-14-3-1-2-4-17(14)29-19/h1-11,16H,12-13H2
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n/an/a 0.0142n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146690
PNG
(US8957073, 4.24)
Show SMILES COc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H19F3N4O/c1-32-19-11-16(10-18(12-19)24(25,26)27)22-23(29-9-8-28-22)17-13-31(14-17)21-7-6-15-4-2-3-5-20(15)30-21/h2-12,17H,13-14H2,1H3
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n/an/a 0.0149n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146685
PNG
(US8957073, 4.19)
Show SMILES Cc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-10-17(12-23-11-15)21-22(25-9-8-24-21)18-13-27(14-18)20-7-6-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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US Patent
n/an/a 0.0163n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146693
PNG
(US8957073, 4.27)
Show SMILES CCCOc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23ClN4O/c1-2-13-31-22-9-7-18(14-20(22)26)24-25(28-12-11-27-24)19-15-30(16-19)23-10-8-17-5-3-4-6-21(17)29-23/h3-12,14,19H,2,13,15-16H2,1H3
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US Patent
n/an/a 0.0171n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144399
PNG
(US8969376, 1.050)
Show SMILES COCCN(CCCO)c1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Show InChI InChI=1S/C26H33N7O2/c1-18-7-8-20-21(15-18)28-26(19(2)27-20)22-16-24-29-23(31-9-4-5-10-31)17-25(33(24)30-22)32(11-6-13-34)12-14-35-3/h7-8,15-17,34H,4-6,9-14H2,1-3H3
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US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124548
PNG
(US8759532, 226)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@@H]2CCC(=O)C2)cc1
Show InChI InChI=1S/C24H19N3O3/c28-17-10-7-16(14-17)19-4-3-13-25-24(19)30-18-11-8-15(9-12-18)22(29)23-26-20-5-1-2-6-21(20)27-23/h1-6,8-9,11-13,16H,7,10,14H2,(H,26,27)/t16-/m1/s1
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US Patent
n/an/a 0.0210n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146682
PNG
(US8957073, 4.16)
Show SMILES CN(C)c1ncc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H21N7/c1-28(2)22-25-11-16(12-26-22)20-21(24-10-9-23-20)17-13-29(14-17)19-8-7-15-5-3-4-6-18(15)27-19/h3-12,17H,13-14H2,1-2H3
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US Patent
n/an/a 0.0228n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124500
PNG
(US8759532, 176 | US8759532, 223)
Show SMILES CC(=O)N1CCC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,19H,5-6,15-16H2,1H3,(H,28,29)/t19-/m0/s1
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US Patent
n/an/a 0.0240n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146686
PNG
(US8957073, 4.20)
Show SMILES COc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-18-10-16(11-23-12-18)21-22(25-9-8-24-21)17-13-27(14-17)20-7-6-15-4-2-3-5-19(15)26-20/h2-12,17H,13-14H2,1H3
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US Patent
n/an/a 0.0247n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146683
PNG
(US8957073, 4.17)
Show SMILES Cc1ccncc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-8-9-23-12-18(15)22-21(24-10-11-25-22)17-13-27(14-17)20-7-6-16-4-2-3-5-19(16)26-20/h2-12,17H,13-14H2,1H3
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US Patent
n/an/a 0.0263n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124523
PNG
(US8759532, 201)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCC(=O)CC2)cc1
Show InChI InChI=1S/C25H21N3O3/c29-18-11-7-16(8-12-18)20-4-3-15-26-25(20)31-19-13-9-17(10-14-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-10,13-16H,7-8,11-12H2,(H,27,28)
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US Patent
n/an/a 0.0285n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)

More data for this
Ligand-Target Pair
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