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Compile Data Set for Download or QSAR

Found 199 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 11A'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50129817
PNG
(CHEMBL3628685)
Show SMILES COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OC3CCCC3)c2)cc1
Show InChI InChI=1S/C21H23F2NO4/c1-26-16-9-6-14(7-10-16)13-24-20(25)15-8-11-18(28-21(22)23)19(12-15)27-17-4-2-3-5-17/h6-12,17,21H,2-5,13H2,1H3,(H,24,25)
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n/an/a>1n/an/an/an/an/an/a



Southern Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PDE11A using AM-Cyclic-3',5'-AMP after 60 mins by fluorescence polarization assay


Bioorg Med Chem 23: 7332-9 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126452
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-pyri...)
Show SMILES O=C1CN([C@@H]2CCN(CCc3ccccn3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C32H31N5O4/c38-29-18-36(22-11-14-35(17-22)13-10-21-5-3-4-12-33-21)32(39)26-16-24-23-6-1-2-7-25(23)34-30(24)31(37(26)29)20-8-9-27-28(15-20)41-19-40-27/h1-9,12,15,22,26,31,34H,10-11,13-14,16-19H2/t22-,26-,31-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126462
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-{(R)-1-[2-(1-m...)
Show SMILES Cn1ccnc1CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C31H32N6O4/c1-34-13-10-32-27(34)9-12-35-11-8-20(16-35)36-17-28(38)37-24(31(36)39)15-22-21-4-2-3-5-23(21)33-29(22)30(37)19-6-7-25-26(14-19)41-18-40-25/h2-7,10,13-14,20,24,30,33H,8-9,11-12,15-18H2,1H3/t20-,24-,30-/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126455
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-pyri...)
Show SMILES O=C1CN([C@@H]2CCN(CCc3cccnc3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C32H31N5O4/c38-29-18-36(22-10-13-35(17-22)12-9-20-4-3-11-33-16-20)32(39)26-15-24-23-5-1-2-6-25(23)34-30(24)31(37(26)29)21-7-8-27-28(14-21)41-19-40-27/h1-8,11,14,16,22,26,31,34H,9-10,12-13,15,17-19H2/t22-,26-,31-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126467
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-{(R)-1-[2-(1H-...)
Show SMILES O=C1CN([C@@H]2CCN(CCc3ncc[nH]3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C30H30N6O4/c37-27-16-35(19-7-11-34(15-19)12-8-26-31-9-10-32-26)30(38)23-14-21-20-3-1-2-4-22(20)33-28(21)29(36(23)27)18-5-6-24-25(13-18)40-17-39-24/h1-6,9-10,13,19,23,29,33H,7-8,11-12,14-17H2,(H,31,32)/t19-,23-,29-/m1/s1
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n/an/a 3.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126464
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-pyra...)
Show SMILES O=C1CN([C@@H]2CCN(CCc3cnccn3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C31H30N6O4/c38-28-17-36(21-8-12-35(16-21)11-7-20-15-32-9-10-33-20)31(39)25-14-23-22-3-1-2-4-24(22)34-29(23)30(37(25)28)19-5-6-26-27(13-19)41-18-40-26/h1-6,9-10,13,15,21,25,30,34H,7-8,11-12,14,16-18H2/t21-,25-,30-/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126453
PNG
(3-[(R)-3-((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-1,4-di...)
Show SMILES CCNC(=O)CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C30H33N5O5/c1-2-31-26(36)10-12-33-11-9-19(15-33)34-16-27(37)35-23(30(34)38)14-21-20-5-3-4-6-22(20)32-28(21)29(35)18-7-8-24-25(13-18)40-17-39-24/h3-8,13,19,23,29,32H,2,9-12,14-17H2,1H3,(H,31,36)/t19-,23-,29-/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126456
PNG
((6R,12aR)-2-[(R)-1-(3-Azetidin-1-yl-3-oxo-propyl)-...)
Show SMILES O=C(CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O)N1CCC1
Show InChI InChI=1S/C31H33N5O5/c37-27(34-10-3-11-34)9-13-33-12-8-20(16-33)35-17-28(38)36-24(31(35)39)15-22-21-4-1-2-5-23(21)32-29(22)30(36)19-6-7-25-26(14-19)41-18-40-25/h1-2,4-7,14,20,24,30,32H,3,8-13,15-18H2/t20-,24-,30-/m1/s1
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n/an/a 4.70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126449
PNG
(3-[(R)-3-((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-1,4-di...)
Show SMILES CN(C)C(=O)CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C30H33N5O5/c1-32(2)26(36)10-12-33-11-9-19(15-33)34-16-27(37)35-23(30(34)38)14-21-20-5-3-4-6-22(20)31-28(21)29(35)18-7-8-24-25(13-18)40-17-39-24/h3-8,13,19,23,29,31H,9-12,14-17H2,1-2H3/t19-,23-,29-/m1/s1
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n/an/a 4.70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126458
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-benzyl-...)
Show SMILES O=C1CN([C@@H]2CCN(Cc3ccccc3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C32H30N4O4/c37-29-18-35(22-12-13-34(17-22)16-20-6-2-1-3-7-20)32(38)26-15-24-23-8-4-5-9-25(23)33-30(24)31(36(26)29)21-10-11-27-28(14-21)40-19-39-27/h1-11,14,22,26,31,33H,12-13,15-19H2/t22-,26-,31-/m1/s1
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n/an/a 5.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126463
PNG
((6R,12aR)-2-((R)-1-Benzyl-pyrrolidin-3-yl)-6-p-tol...)
Show SMILES Cc1ccc(cc1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(CC2=O)[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C32H32N4O2/c1-21-11-13-23(14-12-21)31-30-26(25-9-5-6-10-27(25)33-30)17-28-32(38)35(20-29(37)36(28)31)24-15-16-34(19-24)18-22-7-3-2-4-8-22/h2-14,24,28,31,33H,15-20H2,1H3/t24-,28-,31-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126451
PNG
((6R,12aR)-2-((R)-1-Benzyl-pyrrolidin-3-yl)-6-(4-me...)
Show SMILES COc1ccc(cc1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(CC2=O)[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C32H32N4O3/c1-39-24-13-11-22(12-14-24)31-30-26(25-9-5-6-10-27(25)33-30)17-28-32(38)35(20-29(37)36(28)31)23-15-16-34(19-23)18-21-7-3-2-4-8-21/h2-14,23,28,31,33H,15-20H2,1H3/t23-,28-,31-/m1/s1
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n/an/a 6.70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 11 (PDE11A)


(Homo sapiens (human))
BDBM14777
PNG
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Show SMILES CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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n/an/a 10n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50335827
PNG
((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Show SMILES CCN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(Cl)cc2Cl)C1=O
Show InChI InChI=1S/C22H19Cl2N3O2/c1-2-26-11-19(28)27-18(22(26)29)10-15-13-5-3-4-6-17(13)25-20(15)21(27)14-8-7-12(23)9-16(14)24/h3-9,18,21,25H,2,10-11H2,1H3/t18-,21-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE11A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126457
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(3-meth...)
Show SMILES COCCCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C29H32N4O5/c1-36-12-4-10-31-11-9-19(15-31)32-16-26(34)33-23(29(32)35)14-21-20-5-2-3-6-22(20)30-27(21)28(33)18-7-8-24-25(13-18)38-17-37-24/h2-3,5-8,13,19,23,28,30H,4,9-12,14-17H2,1H3/t19-,23-,28-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126468
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-hexyl-p...)
Show SMILES CCCCCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C30H34N4O4/c1-2-3-6-12-32-13-11-20(16-32)33-17-27(35)34-24(30(33)36)15-22-21-7-4-5-8-23(21)31-28(22)29(34)19-9-10-25-26(14-19)38-18-37-25/h4-5,7-10,14,20,24,29,31H,2-3,6,11-13,15-18H2,1H3/t20-,24-,29-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM14777
PNG
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Show SMILES CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 11


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM14777
PNG
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Show SMILES CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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n/an/a 37n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126471
PNG
((6R,12aR)-2-((R)-1-Benzyl-pyrrolidin-3-yl)-6-(6-ox...)
Show SMILES O=C1CN([C@@H]2CCN(Cc3ccccc3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc(=O)[nH]c1
Show InChI InChI=1S/C30H29N5O3/c36-26-11-10-20(15-31-26)29-28-23(22-8-4-5-9-24(22)32-28)14-25-30(38)34(18-27(37)35(25)29)21-12-13-33(17-21)16-19-6-2-1-3-7-19/h1-11,15,21,25,29,32H,12-14,16-18H2,(H,31,36)/t21-,25-,29-/m1/s1
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n/an/a 39n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126466
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-cycl...)
Show SMILES O=C1CN([C@@H]2CCN(CCC3CC3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C30H32N4O4/c35-27-16-33(20-10-12-32(15-20)11-9-18-5-6-18)30(36)24-14-22-21-3-1-2-4-23(21)31-28(22)29(34(24)27)19-7-8-25-26(13-19)38-17-37-25/h1-4,7-8,13,18,20,24,29,31H,5-6,9-12,14-17H2/t20-,24-,29-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126461
PNG
((6R,12aR)-2-((R)-1-Benzyl-pyrrolidin-3-yl)-6-(3-me...)
Show SMILES COc1cccc(c1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(CC2=O)[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C32H32N4O3/c1-39-24-11-7-10-22(16-24)31-30-26(25-12-5-6-13-27(25)33-30)17-28-32(38)35(20-29(37)36(28)31)23-14-15-34(19-23)18-21-8-3-2-4-9-21/h2-13,16,23,28,31,33H,14-15,17-20H2,1H3/t23-,28-,31-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126459
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(3-dime...)
Show SMILES CN(C)CC(=O)CN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C30H33N5O5/c1-32(2)14-20(36)15-33-10-9-19(13-33)34-16-27(37)35-24(30(34)38)12-22-21-5-3-4-6-23(21)31-28(22)29(35)18-7-8-25-26(11-18)40-17-39-25/h3-8,11,19,24,29,31H,9-10,12-17H2,1-2H3/t19-,24-,29-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126470
PNG
(3-[(R)-3-((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-1,4-di...)
Show SMILES NC(=O)CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C28H29N5O5/c29-24(34)8-10-31-9-7-17(13-31)32-14-25(35)33-21(28(32)36)12-19-18-3-1-2-4-20(18)30-26(19)27(33)16-5-6-22-23(11-16)38-15-37-22/h1-6,11,17,21,27,30H,7-10,12-15H2,(H2,29,34)/t17-,21-,27-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM14777
PNG
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Show SMILES CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE11A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM189300
PNG
(US9173884, BC11-8 )
Show SMILES CCCSc1nnc2n(-c3ccccc3)c(=O)c3c(C)c(C)sc3n12
Show InChI InChI=1S/C18H18N4OS2/c1-4-10-24-18-20-19-17-21(13-8-6-5-7-9-13)15(23)14-11(2)12(3)25-16(14)22(17)18/h5-9H,4,10H2,1-3H3
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US Patent
n/an/a 50n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126460
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-(2-dimethylami...)
Show SMILES CN(C)CCN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C25H26N4O4/c1-27(2)9-10-28-13-22(30)29-19(25(28)31)12-17-16-5-3-4-6-18(16)26-23(17)24(29)15-7-8-20-21(11-15)33-14-32-20/h3-8,11,19,24,26H,9-10,12-14H2,1-2H3/t19-,24-/m1/s1
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n/an/a 53n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50300953
PNG
(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H31N5O4/c1-3-11-33-12-10-29-21-13-19(16-4-9-22(32-2)26-14-16)25-15-20(21)28-23(24(29)31)27-17-5-7-18(30)8-6-17/h4,9,13-15,17-18,30H,3,5-8,10-12H2,1-2H3,(H,27,28)/t17-,18-
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n/an/a 64n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE11


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a 69n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE11A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a 69n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE11A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126472
PNG
((6R,12aR)-2-((R)-1-Benzyl-pyrrolidin-3-yl)-6-(4-me...)
Show SMILES COc1ccc(cc1C)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(CC2=O)[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C33H34N4O3/c1-21-16-23(12-13-29(21)40-2)32-31-26(25-10-6-7-11-27(25)34-31)17-28-33(39)36(20-30(38)37(28)32)24-14-15-35(19-24)18-22-8-4-3-5-9-22/h3-13,16,24,28,32,34H,14-15,17-20H2,1-2H3/t24-,28-,32-/m1/s1
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n/an/a 71n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126447
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((S)-1-benzyl-...)
Show SMILES O=C1CN([C@H]2CCN(Cc3ccccc3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C32H30N4O4/c37-29-18-35(22-12-13-34(17-22)16-20-6-2-1-3-7-20)32(38)26-15-24-23-8-4-5-9-25(23)33-30(24)31(36(26)29)21-10-11-27-28(14-21)40-19-39-27/h1-11,14,22,26,31,33H,12-13,15-19H2/t22-,26+,31+/m0/s1
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n/an/a 85n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50335827
PNG
((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Show SMILES CCN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(Cl)cc2Cl)C1=O
Show InChI InChI=1S/C22H19Cl2N3O2/c1-2-26-11-19(28)27-18(22(26)29)10-15-13-5-3-4-6-17(13)25-20(15)21(27)14-8-7-12(23)9-16(14)24/h3-9,18,21,25H,2,10-11H2,1H3/t18-,21-/m1/s1
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n/an/a 104n/an/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE11A-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM60812
PNG
(BDBM86641 | US9173884, BC11-28)
Show SMILES Cc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H19FN4/c1-17-7-5-6-10-22(17)29-24-23-21(18-8-3-2-4-9-18)15-30(25(23)28-16-27-24)20-13-11-19(26)12-14-20/h2-16H,1H3,(H,27,28,29)
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n/an/a 110n/an/an/an/an/an/a



Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM60812
PNG
(BDBM86641 | US9173884, BC11-28)
Show SMILES Cc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H19FN4/c1-17-7-5-6-10-22(17)29-24-23-21(18-8-3-2-4-9-18)15-30(25(23)28-16-27-24)20-13-11-19(26)12-14-20/h2-16H,1H3,(H,27,28,29)
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US Patent
n/an/a 110n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM60812
PNG
(BDBM86641 | US9173884, BC11-28)
Show SMILES Cc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H19FN4/c1-17-7-5-6-10-22(17)29-24-23-21(18-8-3-2-4-9-18)15-30(25(23)28-16-27-24)20-13-11-19(26)12-14-20/h2-16H,1H3,(H,27,28,29)
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n/an/a 110n/an/an/an/an/an/a



Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50126448
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-but-3-e...)
Show SMILES C=CCCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C29H30N4O4/c1-2-3-11-31-12-10-19(15-31)32-16-26(34)33-23(29(32)35)14-21-20-6-4-5-7-22(20)30-27(21)28(33)18-8-9-24-25(13-18)37-17-36-24/h2,4-9,13,19,23,28,30H,1,3,10-12,14-17H2/t19-,23-,28-/m1/s1
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n/an/a 118n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression


Bioorg Med Chem Lett 13: 1425-8 (2003)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM14776
PNG
(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)
Show SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)
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n/an/a 130n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 11


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50219274
PNG
(8-[5-aminomethyl-2-(8-methoxy-2-trifluoromethyl-qu...)
Show SMILES COc1ccc(-c2nc(C(=O)N3CCC4(CC3)N(CNC4=O)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C29H27F3N6O4/c1-41-20-9-7-19(18-8-10-22(29(30,31)32)35-23(18)20)25-36-24(21(15-33)42-25)26(39)37-13-11-28(12-14-37)27(40)34-16-38(28)17-5-3-2-4-6-17/h2-10H,11-16,33H2,1H3,(H,34,40)
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n/an/a 130n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PDE11


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50344902
PNG
(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Show SMILES CCN1C2=NC3(CCc4ccccc34)CN2c2c(nc(Cc3ccccc3)n2Cc2ccccc2)C1=O
Show InChI InChI=1S/C31H29N5O/c1-2-34-29(37)27-28(36-21-31(33-30(34)36)18-17-24-15-9-10-16-25(24)31)35(20-23-13-7-4-8-14-23)26(32-27)19-22-11-5-3-6-12-22/h3-16H,2,17-21H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PDE11


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM189297
PNG
(US9173884, BC11-4)
Show SMILES Cn1c(NC(=O)c2ccccc2NC(=O)c2ccccc2)nc2ccccc12
Show InChI InChI=1S/C22H18N4O2/c1-26-19-14-8-7-13-18(19)24-22(26)25-21(28)16-11-5-6-12-17(16)23-20(27)15-9-3-2-4-10-15/h2-14H,1H3,(H,23,27)(H,24,25,28)
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n/an/a 150n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM86639
PNG
(BC11-15 | US9173884, BC11-15)
Show SMILES CCN(CC)C(=O)c1cc(nc2n(nc(C)c12)-c1ccccc1C)-c1cccs1
Show InChI InChI=1S/C23H24N4OS/c1-5-26(6-2)23(28)17-14-18(20-12-9-13-29-20)24-22-21(17)16(4)25-27(22)19-11-8-7-10-15(19)3/h7-14H,5-6H2,1-4H3
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n/an/a 180n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM86639
PNG
(BC11-15 | US9173884, BC11-15)
Show SMILES CCN(CC)C(=O)c1cc(nc2n(nc(C)c12)-c1ccccc1C)-c1cccs1
Show InChI InChI=1S/C23H24N4OS/c1-5-26(6-2)23(28)17-14-18(20-12-9-13-29-20)24-22-21(17)16(4)25-27(22)19-11-8-7-10-15(19)3/h7-14H,5-6H2,1-4H3
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n/an/a 180n/an/an/an/an/an/a



Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM189316
PNG
(US9173884, BC11-28-6)
Show SMILES Cc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C25H20N4/c1-18-10-8-9-15-22(18)28-24-23-21(19-11-4-2-5-12-19)16-29(25(23)27-17-26-24)20-13-6-3-7-14-20/h2-17H,1H3,(H,26,27,28)
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n/an/a<200n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM189317
PNG
(US9173884, BC11-28-7)
Show SMILES COc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H19FN4O/c1-31-22-10-6-5-9-21(22)29-24-23-20(17-7-3-2-4-8-17)15-30(25(23)28-16-27-24)19-13-11-18(26)12-14-19/h2-16H,1H3,(H,27,28,29)
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n/an/a<200n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM189315
PNG
(US9173884, BC11-28-5)
Show SMILES N(c1ccccc1)c1ncnc2n(cc(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C24H18N4/c1-4-10-18(11-5-1)21-16-28(20-14-8-3-9-15-20)24-22(21)23(25-17-26-24)27-19-12-6-2-7-13-19/h1-17H,(H,25,26,27)
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n/an/a<200n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 11 (PDE11A)


(Homo sapiens (human))
BDBM14776
PNG
(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)
Show SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)
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n/an/a 240n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM86642
PNG
(BC11-38 | US9173884, BC11-38)
Show SMILES CCCSc1nc2CCSc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3
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n/an/a 280n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM86642
PNG
(BC11-38 | US9173884, BC11-38)
Show SMILES CCCSc1nc2CCSc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3
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n/an/a 280n/an/an/an/an/an/a



Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM14777
PNG
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Show SMILES CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Chong Kun Dang Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE11


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM14777
PNG
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Show SMILES CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE11A-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
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