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Compile Data Set for Download or QSAR

Found 328 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 3'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50129817
PNG
(CHEMBL3628685)
Show SMILES COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OC3CCCC3)c2)cc1
Show InChI InChI=1S/C21H23F2NO4/c1-26-16-9-6-14(7-10-16)13-24-20(25)15-8-11-18(28-21(22)23)19(12-15)27-17-4-2-3-5-17/h6-12,17,21H,2-5,13H2,1H3,(H,24,25)
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n/an/a>1n/an/an/an/an/an/a



Southern Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using AM-Cyclic-3',5'-AMP after 60 mins by fluorescence polarization assay


Bioorg Med Chem 23: 7332-9 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203459
PNG
(US9242982, 1k)
Show SMILES Cn1c2[nH]c(=O)c(Cc3ccc(Br)cc3)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14BrN3O3/c1-19-13-12(15(22)20(2)16(19)23)8-10(14(21)18-13)7-9-3-5-11(17)6-4-9/h3-6,8H,7H2,1-2H3,(H,18,21)
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US Patent
n/an/a 4.80n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203457
PNG
(US9242982, 1i)
Show SMILES Cn1c2[nH]c(=O)c(Cc3ccccc3Br)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14BrN3O3/c1-19-13-11(15(22)20(2)16(19)23)8-10(14(21)18-13)7-9-5-3-4-6-12(9)17/h3-6,8H,7H2,1-2H3,(H,18,21)
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US Patent
n/an/a 6.60n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205353
PNG
(US9249139, 1j)
Show SMILES CCOC(=O)c1cc(Cc2cccc(Br)c2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18BrNO3/c1-2-23-18(22)15-11-13(9-12-5-3-6-14(19)10-12)17(21)20-8-4-7-16(15)20/h3,5-6,10-11H,2,4,7-9H2,1H3
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n/an/a 11.3n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203455
PNG
(US9242982, 1g)
Show SMILES Cn1c2[nH]c(=O)c(Cc3ccc(Cl)cc3)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14ClN3O3/c1-19-13-12(15(22)20(2)16(19)23)8-10(14(21)18-13)7-9-3-5-11(17)6-4-9/h3-6,8H,7H2,1-2H3,(H,18,21)
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n/an/a 12.5n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205346
PNG
(US9249139, 1c)
Show SMILES CCOC(=O)c1cc(Cc2cccc(F)c2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18FNO3/c1-2-23-18(22)15-11-13(9-12-5-3-6-14(19)10-12)17(21)20-8-4-7-16(15)20/h3,5-6,10-11H,2,4,7-9H2,1H3
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n/an/a 13.5n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203451
PNG
(US9242982, 1c)
Show SMILES Cn1c2[nH]c(=O)c(Cc3cccc(F)c3)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14FN3O3/c1-19-13-12(15(22)20(2)16(19)23)8-10(14(21)18-13)6-9-4-3-5-11(17)7-9/h3-5,7-8H,6H2,1-2H3,(H,18,21)
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n/an/a 32.3n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074896
PNG
(2-[4-(6-Ethoxy-2,3-bis-hydroxymethyl-7-methoxy-nap...)
Show SMILES CCOc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C33H28N4O5/c1-3-42-29-14-22-13-23(18-38)27(19-39)31(26(22)16-28(29)41-2)20-10-12-35-30(15-20)37-33(40)25-9-5-4-8-24(25)32(36-37)21-7-6-11-34-17-21/h4-17,38-39H,3,18-19H2,1-2H3
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n/an/a 34n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50026877
PNG
(CHEMBL12346)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3c4ccccc4c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C32H26N2O5/c1-38-28-14-20-13-21(17-35)26(18-36)31(25(20)16-29(28)39-2)19-11-12-33-30(15-19)34-27-10-6-5-8-23(27)22-7-3-4-9-24(22)32(34)37/h3-16,35-36H,17-18H2,1-2H3
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n/an/a 41n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203450
PNG
(US9242982, 1b)
Show SMILES Cn1c2[nH]c(=O)c(Cc3ccccc3F)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14FN3O3/c1-19-13-11(15(22)20(2)16(19)23)8-10(14(21)18-13)7-9-5-3-4-6-12(9)17/h3-6,8H,7H2,1-2H3,(H,18,21)
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US Patent
n/an/a 48.8n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205354
PNG
(US9249139, 1k)
Show SMILES CCOC(=O)c1cc(Cc2ccc(Br)cc2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18BrNO3/c1-2-23-18(22)15-11-13(10-12-5-7-14(19)8-6-12)17(21)20-9-3-4-16(15)20/h5-8,11H,2-4,9-10H2,1H3
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n/an/a 67.3n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM15297
PNG
(CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
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n/an/a 69.1n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3B


Bioorg Med Chem Lett 21: 1617-20 (2011)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074898
PNG
(2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...)
Show SMILES COc1cc2cc(CO)cc(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C31H24N4O4/c1-38-27-14-22-12-19(18-36)13-25(26(22)16-28(27)39-2)20-9-11-33-29(15-20)35-31(37)24-8-4-3-7-23(24)30(34-35)21-6-5-10-32-17-21/h3-17,36H,18H2,1-2H3
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n/an/a 81n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50338586
PNG
(CHEMBL1683806 | N'-(1-(3,3-dimethyl-2-oxoindolin-5...)
Show SMILES CC(=NNS(=O)(=O)c1ccc(C)cc1)c1ccc2NC(=O)C(C)(C)c2c1
Show InChI InChI=1S/C19H21N3O3S/c1-12-5-8-15(9-6-12)26(24,25)22-21-13(2)14-7-10-17-16(11-14)19(3,4)18(23)20-17/h5-11,22H,1-4H3,(H,20,23)
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n/an/a 88.4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3B


Bioorg Med Chem Lett 21: 1617-20 (2011)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074886
PNG
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4ccncc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C32H26N4O5/c1-40-27-14-21-13-22(17-37)26(18-38)30(25(21)16-28(27)41-2)20-9-12-34-29(15-20)36-32(39)24-6-4-3-5-23(24)31(35-36)19-7-10-33-11-8-19/h3-16,37-38H,17-18H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205350
PNG
(US9249139, 1g)
Show SMILES CCOC(=O)c1cc(Cc2ccc(Cl)cc2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18ClNO3/c1-2-23-18(22)15-11-13(10-12-5-7-14(19)8-6-12)17(21)20-9-3-4-16(15)20/h5-8,11H,2-4,9-10H2,1H3
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n/an/a 108n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205348
PNG
(US9249139, 1e)
Show SMILES CCOC(=O)c1cc(Cc2ccccc2Cl)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18ClNO3/c1-2-23-18(22)14-11-13(10-12-6-3-4-7-15(12)19)17(21)20-9-5-8-16(14)20/h3-4,6-7,11H,2,5,8-10H2,1H3
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n/an/a 129n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074894
PNG
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4ccccn4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C32H26N4O5/c1-40-27-14-20-13-21(17-37)25(18-38)30(24(20)16-28(27)41-2)19-10-12-34-29(15-19)36-32(39)23-8-4-3-7-22(23)31(35-36)26-9-5-6-11-33-26/h3-16,37-38H,17-18H2,1-2H3
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n/an/a 170n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074884
PNG
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ncc4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C27H23N3O5/c1-34-23-10-18-9-19(14-31)22(15-32)26(21(18)12-24(23)35-2)16-7-8-28-25(11-16)30-27(33)20-6-4-3-5-17(20)13-29-30/h3-13,31-32H,14-15H2,1-2H3
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n/an/a 250n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074901
PNG
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C32H26N4O5/c1-40-27-13-21-12-22(17-37)26(18-38)30(25(21)15-28(27)41-2)19-9-11-34-29(14-19)36-32(39)24-8-4-3-7-23(24)31(35-36)20-6-5-10-33-16-20/h3-16,37-38H,17-18H2,1-2H3
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n/an/a 290n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50075710
PNG
(3-Carbamoyl-6,7-dimethoxy-1-(3,4,5-trimethoxy-phen...)
Show SMILES COC(=O)c1c(cc2cc(OC)c(OC)cc2c1-c1cc(OC)c(OC)c(OC)c1)C(N)=O
Show InChI InChI=1S/C24H25NO8/c1-28-16-8-12-7-15(23(25)26)21(24(27)33-6)20(14(12)11-17(16)29-2)13-9-18(30-3)22(32-5)19(10-13)31-4/h7-11H,1-6H3,(H2,25,26)
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n/an/a 320n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 3 (PDE 3) isolated from cardiac ventricle


J Med Chem 42: 1293-305 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50052090
PNG
(6,7-Dimethoxy-9-(3,4,5-trimethoxy-phenyl)-3H-napht...)
Show SMILES COc1cc(cc(OC)c1OC)-c1c2C(=O)OCc2cc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22O7/c1-25-16-7-12-6-14-11-30-23(24)21(14)20(15(12)10-17(16)26-2)13-8-18(27-3)22(29-5)19(9-13)28-4/h6-10H,11H2,1-5H3
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n/an/a 320n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 3 (PDE 3) isolated from cardiac ventricle


J Med Chem 42: 1293-305 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074889
PNG
(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3c4ccccc4ccc3=O)c2cc1OC
Show InChI InChI=1S/C28H24N2O5/c1-34-24-12-19-11-20(15-31)22(16-32)28(21(19)14-25(24)35-2)18-9-10-29-26(13-18)30-23-6-4-3-5-17(23)7-8-27(30)33/h3-14,31-32H,15-16H2,1-2H3
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n/an/a 330n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074887
PNG
(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccc(=O)c4ccccc34)c2cc1OC
Show InChI InChI=1S/C28H24N2O5/c1-34-25-12-18-11-19(15-31)22(16-32)28(21(18)14-26(25)35-2)17-7-9-29-27(13-17)30-10-8-24(33)20-5-3-4-6-23(20)30/h3-14,31-32H,15-16H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205344
PNG
(US9249139, 1a)
Show SMILES CCOC(=O)c1cc(Cc2ccccc2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H19NO3/c1-2-22-18(21)15-12-14(11-13-7-4-3-5-8-13)17(20)19-10-6-9-16(15)19/h3-5,7-8,12H,2,6,9-11H2,1H3
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US Patent
n/an/a 435n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074897
PNG
(2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-nap...)
Show SMILES CCOc1cc2c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c(CO)c(CO)cc2cc1OC
Show InChI InChI=1S/C33H28N4O5/c1-3-42-29-16-26-22(14-28(29)41-2)13-23(18-38)27(19-39)31(26)20-10-12-35-30(15-20)37-33(40)25-9-5-4-8-24(25)32(36-37)21-7-6-11-34-17-21/h4-17,38-39H,3,18-19H2,1-2H3
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n/an/a 490n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205351
PNG
(US9249139, 1h)
Show SMILES CCOC(=O)c1cc(Cc2ccc(Cl)cc2Cl)c(=O)n2CCCc12
Show InChI InChI=1S/C18H17Cl2NO3/c1-2-24-18(23)14-9-12(17(22)21-7-3-4-16(14)21)8-11-5-6-13(19)10-15(11)20/h5-6,9-10H,2-4,7-8H2,1H3
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n/an/a 577n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50163876
PNG
(2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...)
Show SMILES CCOC(=O)c1sc(Nc2nc(NCc3ccc(OC)c(OC)c3)c3n(CC)cnc3n2)nc1C
Show InChI InChI=1S/C23H27N7O4S/c1-6-30-12-25-20-17(30)19(24-11-14-8-9-15(32-4)16(10-14)33-5)27-22(28-20)29-23-26-13(3)18(35-23)21(31)34-7-2/h8-10,12H,6-7,11H2,1-5H3,(H2,24,26,27,28,29)
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n/an/a 580n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3


Bioorg Med Chem Lett 15: 1829-33 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50093082
PNG
(CHEMBL3586573)
Show SMILES CCN1C(=O)CNc2ncc(nc12)-c1ccc(nc1C)-c1nc[nH]n1
Show InChI InChI=1S/C16H16N8O/c1-3-24-13(25)7-18-15-16(24)22-12(6-17-15)10-4-5-11(21-9(10)2)14-19-8-20-23-14/h4-6,8H,3,7H2,1-2H3,(H,17,18)(H,19,20,23)
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n/an/a 630n/an/an/an/an/an/a



Celgene Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDE3 (unknown origin)


J Med Chem 58: 5599-608 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50026876
PNG
(CHEMBL543965)
Show SMILES Cl.COc1cc2c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c(CO)c(CO)cc2cc1OC1CCCC1
Show InChI InChI=1S/C36H32N4O5.ClH/c1-44-31-18-29-24(16-32(31)45-26-8-2-3-9-26)15-25(20-41)30(21-42)34(29)22-12-14-38-33(17-22)40-36(43)28-11-5-4-10-27(28)35(39-40)23-7-6-13-37-19-23;/h4-7,10-19,26,41-42H,2-3,8-9,20-21H2,1H3;1H
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n/an/a 690n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50026880
PNG
(CHEMBL543017)
Show SMILES Cl.COc1cc2ccc(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C31H24N4O4.ClH/c1-38-26-14-19-9-10-22(18-36)29(25(19)16-27(26)39-2)20-11-13-33-28(15-20)35-31(37)24-8-4-3-7-23(24)30(34-35)21-6-5-12-32-17-21;/h3-17,36H,18H2,1-2H3;1H
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n/an/a 700n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50075695
PNG
(6,7-Dimethoxy-4-(3,4,5-trimethoxy-phenyl)-3H-napht...)
Show SMILES COc1cc(cc(OC)c1OC)-c1c2COC(=O)c2cc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22O7/c1-25-17-7-12-6-15-16(11-30-23(15)24)21(14(12)10-18(17)26-2)13-8-19(27-3)22(29-5)20(9-13)28-4/h6-10H,11H2,1-5H3
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n/an/a 840n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 3 (PDE 3) isolated from cardiac ventricle


J Med Chem 42: 1293-305 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50052098
PNG
(CHEMBL285361 | [3-Hydroxymethyl-6,7-dimethoxy-1-(3...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3cc(OC)c(OC)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C23H26O7/c1-26-18-7-13-6-15(11-24)17(12-25)22(16(13)10-19(18)27-2)14-8-20(28-3)23(30-5)21(9-14)29-4/h6-10,24-25H,11-12H2,1-5H3
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n/an/a 880n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 3 (PDE 3) isolated from cardiac ventricle


J Med Chem 42: 1293-305 (1999)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308950
PNG
(6-({3-[(4-Hydroxypiperidino)carbonyl]benzyl}oxy)-4...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(O)CC3)cc12
Show InChI InChI=1S/C23H24N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13,18,26H,7-10,14H2,1H3,(H,24,27)
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n/an/a 910n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50259148
PNG
((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O
Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3b


Bioorg Med Chem Lett 19: 2537-41 (2009)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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n/an/a 1.03E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Eur J Med Chem 46: 3986-95 (2011)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308948
PNG
(4-Methyl-6-(3-[(4-oxopiperidino)carbonyl]benzyloxy...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(=O)CC3)cc12
Show InChI InChI=1S/C23H22N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13H,7-10,14H2,1H3,(H,24,27)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308954
PNG
(4-Methyl-6-{[3-(tetrahydro-1H-1-pyrrolylcarbonyl)-...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCCC3)cc12
Show InChI InChI=1S/C22H22N2O3/c1-15-11-21(25)23-20-8-7-18(13-19(15)20)27-14-16-5-4-6-17(12-16)22(26)24-9-2-3-10-24/h4-8,11-13H,2-3,9-10,14H2,1H3,(H,23,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50351908
PNG
(CHEMBL1821774)
Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1F
Show InChI InChI=1S/C20H19F2NO3/c1-24-18-4-3-13(9-16(18)22)10-17-15-12-19(25-2)20(26-8-6-21)11-14(15)5-7-23-17/h3-5,7,9,11-12H,6,8,10H2,1-2H3
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n/an/a 1.25E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Eur J Med Chem 46: 3986-95 (2011)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308949
PNG
(1-(3-{[(4-Methyl-2-oxo-1,2-dihydro-6-quinolinyl)ox...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(CC3)C(O)=O)cc12
Show InChI InChI=1S/C24H24N2O5/c1-15-11-22(27)25-21-6-5-19(13-20(15)21)31-14-16-3-2-4-18(12-16)23(28)26-9-7-17(8-10-26)24(29)30/h2-6,11-13,17H,7-10,14H2,1H3,(H,25,27)(H,29,30)
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n/an/a 1.28E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50170480
PNG
(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Show SMILES CCc1cc(C(C)=O)c(O)cc1OCc1cccc(n1)C(=O)Nc1nc(CC(=O)NO)cs1
Show InChI InChI=1S/C22H22N4O6S/c1-3-13-7-16(12(2)27)18(28)9-19(13)32-10-14-5-4-6-17(23-14)21(30)25-22-24-15(11-33-22)8-20(29)26-31/h4-7,9,11,28,31H,3,8,10H2,1-2H3,(H,26,29)(H,24,25,30)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Sumitomo Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory concentration against Phosphodiesterase type 3


Bioorg Med Chem Lett 15: 4085-90 (2005)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308953
PNG
(4-Methyl-6-{[3-(morpholinocarbonyl)benzyl]oxy}-1,2...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCOCC3)cc12
Show InChI InChI=1S/C22H22N2O4/c1-15-11-21(25)23-20-6-5-18(13-19(15)20)28-14-16-3-2-4-17(12-16)22(26)24-7-9-27-10-8-24/h2-6,11-13H,7-10,14H2,1H3,(H,23,25)
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n/an/a 1.54E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205347
PNG
(US9249139, 1d)
Show SMILES CCOC(=O)c1cc(Cc2ccc(F)cc2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18FNO3/c1-2-23-18(22)15-11-13(10-12-5-7-14(19)8-6-12)17(21)20-9-3-4-16(15)20/h5-8,11H,2-4,9-10H2,1H3
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US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308952
PNG
(4-Methyl-6-({3-[(4-methylpiperidino)carbonyl]-benz...)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C24H26N2O3/c1-16-8-10-26(11-9-16)24(28)19-5-3-4-18(13-19)15-29-20-6-7-22-21(14-20)17(2)12-23(27)25-22/h3-7,12-14,16H,8-11,15H2,1-2H3,(H,25,27)
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n/an/a 1.61E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50351895
PNG
(CHEMBL1821775)
Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1C
Show InChI InChI=1S/C21H22FNO3/c1-14-10-15(4-5-19(14)24-2)11-18-17-13-20(25-3)21(26-9-7-22)12-16(17)6-8-23-18/h4-6,8,10,12-13H,7,9,11H2,1-3H3
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n/an/a 1.67E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Eur J Med Chem 46: 3986-95 (2011)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308951
PNG
(4-Methyl-6-{[3-(piperidinocarbonyl)benzyl]oxy}-1,2...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCCCC3)cc12
Show InChI InChI=1S/C23H24N2O3/c1-16-12-22(26)24-21-9-8-19(14-20(16)21)28-15-17-6-5-7-18(13-17)23(27)25-10-3-2-4-11-25/h5-9,12-14H,2-4,10-11,15H2,1H3,(H,24,26)
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n/an/a 1.73E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074893
PNG
(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)
Show SMILES CCOc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OCC
Show InChI InChI=1S/C34H30N4O5/c1-3-42-29-15-23-14-24(19-39)28(20-40)32(27(23)17-30(29)43-4-2)21-11-13-36-31(16-21)38-34(41)26-10-6-5-9-25(26)33(37-38)22-8-7-12-35-18-22/h5-18,39-40H,3-4,19-20H2,1-2H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308946
PNG
(4-Methyl-6-({3-[(4-ethylpiperazino)carbonyl]-benzy...)
Show SMILES CCN1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C24H27N3O3/c1-3-26-9-11-27(12-10-26)24(29)19-6-4-5-18(14-19)16-30-20-7-8-22-21(15-20)17(2)13-23(28)25-22/h4-8,13-15H,3,9-12,16H2,1-2H3,(H,25,28)
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n/an/a 1.93E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074890
PNG
(4'-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccccc3=O)c2cc1OC
Show InChI InChI=1S/C24H22N2O5/c1-30-20-10-16-9-17(13-27)19(14-28)24(18(16)12-21(20)31-2)15-6-7-25-22(11-15)26-8-4-3-5-23(26)29/h3-12,27-28H,13-14H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50296256
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCN2CCOCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-11-33-14-10-30-21-15-19(18-4-5-22(32-2)27-16-18)26-17-20(21)28-23(24(30)31)25-6-7-29-8-12-34-13-9-29/h4-5,15-17H,3,6-14H2,1-2H3,(H,25,28)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem Lett 19: 5209-13 (2009)

More data for this
Ligand-Target Pair
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