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Compile Data Set for Download or QSAR

Found 99 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 8A'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50129817
PNG
(CHEMBL3628685)
Show SMILES COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OC3CCCC3)c2)cc1
Show InChI InChI=1S/C21H23F2NO4/c1-26-16-9-6-14(7-10-16)13-24-20(25)15-8-11-18(28-21(22)23)19(12-15)27-17-4-2-3-5-17/h6-12,17,21H,2-5,13H2,1H3,(H,24,25)
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n/an/a>1n/an/an/an/an/an/a



Southern Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PDE8A1 using AM-Cyclic-3',5'-AMP after 60 mins by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50344017
PNG
(1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)
Show SMILES Cc1oc(nc1CN1CCCC(C1)C(=O)NCc1cccc(C)n1)-c1ccccc1
Show InChI InChI=1S/C24H28N4O2/c1-17-8-6-12-21(26-17)14-25-23(29)20-11-7-13-28(15-20)16-22-18(2)30-24(27-22)19-9-4-3-5-10-19/h3-6,8-10,12,20H,7,11,13-16H2,1-2H3,(H,25,29)
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50344016
PNG
(2-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)
Show SMILES Cc1oc(nc1CN1CC(C(=O)NCc2cccc(C)n2)c2ccccc2C1)-c1ccccc1
Show InChI InChI=1S/C28H28N4O2/c1-19-9-8-13-23(30-19)15-29-27(33)25-17-32(16-22-12-6-7-14-24(22)25)18-26-20(2)34-28(31-26)21-10-4-3-5-11-21/h3-14,25H,15-18H2,1-2H3,(H,29,33)
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50344018
PNG
(CHEMBL1779984 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1
Show InChI InChI=1S/C26H32N4O2/c1-4-20-13-22(25(31)27-14-23-12-8-9-18(2)28-23)16-30(15-20)17-24-19(3)32-26(29-24)21-10-6-5-7-11-21/h5-12,20,22H,4,13-17H2,1-3H3,(H,27,31)/t20-,22-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50390334
PNG
(CHEMBL2070735)
Show SMILES Cc1nc(N)c2nnn(C[C@H]3CN(Cc4nccs4)CCO3)c2n1
Show InChI InChI=1S/C14H18N8OS/c1-9-17-13(15)12-14(18-9)22(20-19-12)7-10-6-21(3-4-23-10)8-11-16-2-5-24-11/h2,5,10H,3-4,6-8H2,1H3,(H2,15,17,18)/t10-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM135584
PNG
(US8846654, 294)
Show SMILES FCC(CF)Oc1ccc2n(C3CCN(CC3)C=O)c(=O)n(Cc3ccc(-c4ccccc4)c(c3)C#N)c(=O)c2c1
Show InChI InChI=1S/C31H28F2N4O4/c32-16-26(17-33)41-25-7-9-29-28(15-25)30(39)36(31(40)37(29)24-10-12-35(20-38)13-11-24)19-21-6-8-27(23(14-21)18-34)22-4-2-1-3-5-22/h1-9,14-15,20,24,26H,10-13,16-17,19H2
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US Patent
n/an/a 15n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...


US Patent US8846654 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM135577
PNG
(US8846654, 11)
Show SMILES COc1ccc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OC(CF)CF)cc3c2=O)cc1OC
Show InChI InChI=1S/C26H29F2N3O6/c1-35-23-6-3-17(11-24(23)36-2)15-30-25(33)21-12-19(37-20(13-27)14-28)4-5-22(21)31(26(30)34)18-7-9-29(16-32)10-8-18/h3-6,11-12,16,18,20H,7-10,13-15H2,1-2H3
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US Patent
n/an/a 140n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...


US Patent US8846654 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM135583
PNG
(US8846654, 251)
Show SMILES COc1cc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OC(CF)CF)cc3c2=O)ccc1OCC(=O)N1CCCCC1
Show InChI InChI=1S/C32H38F2N4O7/c1-43-29-15-22(5-8-28(29)44-20-30(40)36-11-3-2-4-12-36)19-37-31(41)26-16-24(45-25(17-33)18-34)6-7-27(26)38(32(37)42)23-9-13-35(21-39)14-10-23/h5-8,15-16,21,23,25H,2-4,9-14,17-20H2,1H3
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n/an/a 390n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...


US Patent US8846654 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357870
PNG
(CHEMBL1916130)
Show SMILES COc1cc(cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n21)C(F)(F)F
Show InChI InChI=1S/C20H17F3N4O/c1-10-9-24-6-5-14(10)19-26-12(3)18-11(2)25-17-15(27(18)19)7-13(20(21,22)23)8-16(17)28-4/h5-9H,1-4H3
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n/an/a>500n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM23620
PNG
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO
Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
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n/an/a 500n/an/an/an/a7.524



University of North Carolina



Assay Description
Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50259148
PNG
((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O
Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE8a


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357871
PNG
(CHEMBL1916131)
Show SMILES COc1cc(Cl)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1
Show InChI InChI=1S/C19H17ClN4O/c1-10-9-21-6-5-14(10)19-23-12(3)18-11(2)22-17-15(20)7-13(25-4)8-16(17)24(18)19/h5-9H,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357872
PNG
(CHEMBL1916132)
Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(Cl)cc(cc21)C(F)(F)F
Show InChI InChI=1S/C19H14ClF3N4/c1-9-8-24-5-4-13(9)18-26-11(3)17-10(2)25-16-14(20)6-12(19(21,22)23)7-15(16)27(17)18/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357825
PNG
(CHEMBL1915891)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4cc(Cl)ccc4Cl)n3c2n1
Show InChI InChI=1S/C18H14Cl2N4O/c1-9-16-10(2)22-17(12-8-11(19)4-5-13(12)20)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50356427
PNG
(CHEMBL1911559)
Show SMILES Fc1cccc(Cl)c1Cn1cc(C(=O)Nc2ccc(cc2)N2CCOCC2)c(=O)c2[nH]c(=O)ccc12
Show InChI InChI=1S/C26H22ClFN4O4/c27-20-2-1-3-21(28)18(20)14-32-15-19(25(34)24-22(32)8-9-23(33)30-24)26(35)29-16-4-6-17(7-5-16)31-10-12-36-13-11-31/h1-9,15H,10-14H2,(H,29,35)(H,30,33)
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n/an/a>1.00E+3n/an/an/an/an/an/a



biocrea GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357234
PNG
(CHEMBL1916475)
Show SMILES CCCOCCn1c2cc(nnc2c(NC2CCC(O)CC2)nc1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C23H30N6O4/c1-3-11-33-12-10-29-19-13-18(15-4-9-20(32-2)24-14-15)27-28-21(19)22(26-23(29)31)25-16-5-7-17(30)8-6-16/h4,9,13-14,16-17,30H,3,5-8,10-12H2,1-2H3,(H,25,26,31)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50300953
PNG
(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H31N5O4/c1-3-11-33-12-10-29-21-13-19(16-4-9-22(32-2)26-14-16)25-15-20(21)28-23(24(29)31)27-17-5-7-18(30)8-6-17/h4,9,13-15,17-18,30H,3,5-8,10-12H2,1-2H3,(H,27,28)/t17-,18-
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50296256
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCN2CCOCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-11-33-14-10-30-21-15-19(18-4-5-22(32-2)27-16-18)26-17-20(21)28-23(24(30)31)25-6-7-29-8-12-34-13-9-29/h4-5,15-17H,3,6-14H2,1-2H3,(H,25,28)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM123687
PNG
(US8741907, 3 | US9067945, 2)
Show SMILES CCC(CC)n1ncc2c1nc(CC1CCCCC1)[nH]c2=O
Show InChI InChI=1S/C17H26N4O/c1-3-13(4-2)21-16-14(11-18-21)17(22)20-15(19-16)10-12-8-6-5-7-9-12/h11-13H,3-10H2,1-2H3,(H,19,20,22)
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US Patent
n/an/a>4.00E+3n/an/an/an/an/an/a



Boehringer Ingehleim International GmbH

US Patent


Assay Description
The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20...


US Patent US9067945 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM123687
PNG
(US8741907, 3 | US9067945, 2)
Show SMILES CCC(CC)n1ncc2c1nc(CC1CCCCC1)[nH]c2=O
Show InChI InChI=1S/C17H26N4O/c1-3-13(4-2)21-16-14(11-18-21)17(22)20-15(19-16)10-12-8-6-5-7-9-12/h11-13H,3-10H2,1-2H3,(H,19,20,22)
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US Patent
n/an/a>4.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. 2 uL portions of the diluted substa...


US Patent US8741907 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357849
PNG
(CHEMBL1916108)
Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F
Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50356428
PNG
(CHEMBL1911572)
Show SMILES CCN(CC)c1ccc(NC(=O)c2cn(Cc3c(F)cccc3Cl)c3ccc(=O)[nH]c3c2=O)cc1
Show InChI InChI=1S/C26H24ClFN4O3/c1-3-31(4-2)17-10-8-16(9-11-17)29-26(35)19-15-32(14-18-20(27)6-5-7-21(18)28)22-12-13-23(33)30-24(22)25(19)34/h5-13,15H,3-4,14H2,1-2H3,(H,29,35)(H,30,33)
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n/an/a>5.00E+3n/an/an/an/an/an/a



biocrea GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM14773
PNG
(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1(CCC(CC1)C(O)=O)C#N
Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)
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n/an/a 7.00E+3n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50399909
PNG
(CHEMBL2180945)
Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE8A1 at 1 uM by [3H]cGMP based tritium scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE8A1 at 1 uM by [3H]cGMP based tritium scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357865
PNG
(CHEMBL1916125)
Show SMILES COc1cc(OC)c2nc(C)c3c(C)nc(-c4cccnc4C)n3c2c1
Show InChI InChI=1S/C20H20N4O2/c1-11-15(7-6-8-21-11)20-23-13(3)19-12(2)22-18-16(24(19)20)9-14(25-4)10-17(18)26-5/h6-10H,1-5H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357864
PNG
(CHEMBL1916124)
Show SMILES COc1cc(OC)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1
Show InChI InChI=1S/C20H20N4O2/c1-11-10-21-7-6-15(11)20-23-13(3)19-12(2)22-18-16(24(19)20)8-14(25-4)9-17(18)26-5/h6-10H,1-5H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357863
PNG
(CHEMBL1916123)
Show SMILES COc1cc(OC)c2nc(C)c3c(C)nc(-c4cnccc4C)n3c2c1
Show InChI InChI=1S/C20H20N4O2/c1-11-6-7-21-10-15(11)20-23-13(3)19-12(2)22-18-16(24(19)20)8-14(25-4)9-17(18)26-5/h6-10H,1-5H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357854
PNG
(CHEMBL1916114)
Show SMILES COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n21
Show InChI InChI=1S/C19H17FN4O/c1-10-14(6-5-7-21-10)19-23-12(3)18-11(2)22-17-15(24(18)19)8-13(20)9-16(17)25-4/h5-9H,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357803
PNG
(CHEMBL1916113)
Show SMILES COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n21
Show InChI InChI=1S/C19H17FN4O/c1-10-9-21-6-5-14(10)19-23-12(3)18-11(2)22-17-15(24(18)19)7-13(20)8-16(17)25-4/h5-9H,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357847
PNG
(CHEMBL1916106)
Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(OC(F)(F)F)cc21
Show InChI InChI=1S/C19H15F3N4O/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(27-19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357832
PNG
(CHEMBL1916091)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4cnccc4C)n3c2n1
Show InChI InChI=1S/C18H17N5O/c1-10-7-8-19-9-13(10)17-21-12(3)16-11(2)20-14-5-6-15(24-4)22-18(14)23(16)17/h5-9H,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357828
PNG
(CHEMBL1915912)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4sc(C)nc4C)n3c2n1
Show InChI InChI=1S/C17H17N5OS/c1-8-14-9(2)20-17(15-10(3)18-11(4)24-15)22(14)16-12(19-8)6-7-13(21-16)23-5/h6-7H,1-5H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357820
PNG
(CHEMBL1915910)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1
Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8A


(Homo sapiens (human))
BDBM50067186
PNG
(CHEMBL3401745)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)NCCCCCCO
Show InChI InChI=1S/C23H33N5O5S/c1-4-10-18-20-21(28(3)27-18)23(30)26-22(25-20)17-15-16(11-12-19(17)33-5-2)34(31,32)24-13-8-6-7-9-14-29/h11-12,15,24,29H,4-10,13-14H2,1-3H3,(H,25,26,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



CSIR-Indian Institute of Integrative Medicine

Curated by ChEMBL


Assay Description
Inhibition of PDE4A1 (unknown origin) using fluorescently labeled cAMP substrate by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357806
PNG
(CHEMBL1915896)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4cccc(c4)C(N)=O)n3c2n1
Show InChI InChI=1S/C19H17N5O2/c1-10-16-11(2)22-18(13-6-4-5-12(9-13)17(20)25)24(16)19-14(21-10)7-8-15(23-19)26-3/h4-9H,1-3H3,(H2,20,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357822
PNG
(CHEMBL1915888)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1
Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50259108
PNG
((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...)
Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O
Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE8a


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50259057
PNG
(3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...)
Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O
Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE8a


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50357816
PNG
(CHEMBL1915906)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4sccc4C)n3c2n1
Show InChI InChI=1S/C17H16N4OS/c1-9-7-8-23-15(9)17-19-11(3)14-10(2)18-12-5-6-13(22-4)20-16(12)21(14)17/h5-8H,1-4H3
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50176521
PNG
(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)
Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12
Show InChI InChI=1S/C14H10N4O3S/c1-18-9-4-7-2-3-21-10(7)5-8(9)11(13(18)20)12(19)16-14-17-15-6-22-14/h2-6,11H,1H3,(H,16,17,19)
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n/an/a>1.60E+4n/an/an/an/an/an/a



Pfizer, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE8A by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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Pfizer, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50176377
PNG
((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Show SMILES C[C@@H](NC(=O)c1cccnc1Oc1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C18H15FN2O2S/c1-12(16-5-3-11-24-16)21-17(22)15-4-2-10-20-18(15)23-14-8-6-13(19)7-9-14/h2-12H,1H3,(H,21,22)/t12-/m1/s1
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Pfizer, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM28393
PNG
((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Show SMILES CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N5O/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17)/t10-,11+/m0/s1
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n/an/a>1.60E+4n/an/an/an/an/an/a



Pfizer, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE8A by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM98891
PNG
(US8497265, 217 | US8497265, 239)
Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assay


Citation and Details
More data for this
Ligand-Target Pair
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