Compile Data Set for Download or QSAR

Found 200 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase Type 3 (PDE3B)'   

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15311 ((5R)-5-methyl-6-{4-[(2-{[3-(3-nitrophenyl)phenyl]m...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)-c3cccc(c3)[N+]([O-])=O)C(=O)CCC2)cc1 Show InChI InChI=1S/C30H28N4O4/c1-19-15-29(36)32-33-30(19)21-11-13-24(14-12-21)31-27-9-4-10-28(35)26(27)17-20-5-2-6-22(16-20)23-7-3-8-25(18-23)34(37)38/h2-3,5-8,11-14,16,18-19,31H,4,9-10,15,17H2,1H3,(H,32,36)/t19-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15310 ((5R)-5-methyl-6-{4-[(3-oxo-2-{[3-(thiophen-3-yl)ph...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)-c3ccsc3)C(=O)CCC2)cc1 Show InChI InChI=1S/C28H27N3O2S/c1-18-14-27(33)30-31-28(18)20-8-10-23(11-9-20)29-25-6-3-7-26(32)24(25)16-19-4-2-5-21(15-19)22-12-13-34-17-22/h2,4-5,8-13,15,17-18,29H,3,6-7,14,16H2,1H3,(H,30,33)/t18-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.0680	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15337 ((5R)-6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1 Show InChI InChI=1S/C24H24IN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)/t15-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars AffyNet	PDB PubMed	n/a	n/a	0.110	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15304 ((5R)-6-[4-({2-[(2-methoxyphenyl)methyl]-3-oxocyclo...) Show SMILES COc1ccccc1CC1=C(CCCC1=O)Nc1ccc(cc1)C1=NNC(=O)C[C@H]1C Show InChI InChI=1S/C25H27N3O3/c1-16-14-24(30)27-28-25(16)17-10-12-19(13-11-17)26-21-7-5-8-22(29)20(21)15-18-6-3-4-9-23(18)31-2/h3-4,6,9-13,16,26H,5,7-8,14-15H2,1-2H3,(H,27,30)/t16-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15329 (3-[4-({2-[(2,6-dichlorophenyl)methyl]-3-oxocyclohe...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3c(Cl)cccc3Cl)C(=O)CCC2)cc1F Show InChI InChI=1S/C24H22Cl2FN3O2/c1-24(2)22(29-30-23(24)32)14-10-9-13(11-19(14)27)28-20-7-4-8-21(31)16(20)12-15-17(25)5-3-6-18(15)26/h3,5-6,9-11,28H,4,7-8,12H2,1-2H3,(H,30,32)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15302 ((5R)-6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1 Show InChI InChI=1S/C24H25N3O2/c1-16-14-23(29)26-27-24(16)18-10-12-19(13-11-18)25-21-8-5-9-22(28)20(21)15-17-6-3-2-4-7-17/h2-4,6-7,10-13,16,25H,5,8-9,14-15H2,1H3,(H,26,29)/t16-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.190	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15318 (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-f...) Show SMILES CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F Show InChI InChI=1S/C24H24FN3O2/c1-15-12-23(30)27-28-24(15)18-11-10-17(14-20(18)25)26-21-8-5-9-22(29)19(21)13-16-6-3-2-4-7-16/h2-4,6-7,10-11,14-15,26H,5,8-9,12-13H2,1H3,(H,27,30)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15319 (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-3-f...) Show SMILES CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)c(F)c1 Show InChI InChI=1S/C24H24FN3O2/c1-15-12-23(30)27-28-24(15)17-10-11-21(19(25)14-17)26-20-8-5-9-22(29)18(20)13-16-6-3-2-4-7-16/h2-4,6-7,10-11,14-15,26H,5,8-9,12-13H2,1H3,(H,27,30)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15337 ((5R)-6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1 Show InChI InChI=1S/C24H24IN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)/t15-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars AffyNet	PDB Article PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Biochemistry 43: 6091-100 (2004)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15307 ((5R)-6-[4-({2-[(3-bromophenyl)methyl]-3-oxocyclohe...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(Br)c3)C(=O)CCC2)cc1 Show InChI InChI=1S/C24H24BrN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)/t15-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15335 (3-[(2-{[4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyraz...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)C#N)C(=O)CCC2)c(F)c1F Show InChI InChI=1S/C25H22F2N4O2/c1-25(2)23(30-31-24(25)33)16-9-10-19(22(27)21(16)26)29-18-7-4-8-20(32)17(18)12-14-5-3-6-15(11-14)13-28/h3,5-6,9-11,29H,4,7-8,12H2,1-2H3,(H,31,33)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15305 ((5R)-5-methyl-6-{4-[(3-oxo-2-{[2-(trifluoromethyl)...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3C(F)(F)F)C(=O)CCC2)cc1 Show InChI InChI=1S/C25H24F3N3O2/c1-15-13-23(33)30-31-24(15)16-9-11-18(12-10-16)29-21-7-4-8-22(32)19(21)14-17-5-2-3-6-20(17)25(26,27)28/h2-3,5-6,9-12,15,29H,4,7-8,13-14H2,1H3,(H,30,33)/t15-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15328 (3-[4-({2-[(2-chlorophenyl)methyl]-3-oxocyclohex-1-...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3Cl)C(=O)CCC2)cc1F Show InChI InChI=1S/C24H23ClFN3O2/c1-24(2)22(28-29-23(24)31)16-11-10-15(13-19(16)26)27-20-8-5-9-21(30)17(20)12-14-6-3-4-7-18(14)25/h3-4,6-7,10-11,13,27H,5,8-9,12H2,1-2H3,(H,29,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15316 (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-3-m...) Show SMILES CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)c(C)c1 Show InChI InChI=1S/C25H27N3O2/c1-16-13-19(25-17(2)14-24(30)27-28-25)11-12-21(16)26-22-9-6-10-23(29)20(22)15-18-7-4-3-5-8-18/h3-5,7-8,11-13,17,26H,6,9-10,14-15H2,1-2H3,(H,27,30)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.610	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15321 (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2,5...) Show SMILES CC1CC(=O)NN=C1c1cc(F)c(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F Show InChI InChI=1S/C24H23F2N3O2/c1-14-10-23(31)28-29-24(14)16-12-19(26)21(13-18(16)25)27-20-8-5-9-22(30)17(20)11-15-6-3-2-4-7-15/h2-4,6-7,12-14,27H,5,8-11H2,1H3,(H,28,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15312 ((5R)-6-[4-({2-[(4-methoxyphenyl)methyl]-3-oxocyclo...) Show SMILES COc1ccc(CC2=C(CCCC2=O)Nc2ccc(cc2)C2=NNC(=O)C[C@H]2C)cc1 Show InChI InChI=1S/C25H27N3O3/c1-16-14-24(30)27-28-25(16)18-8-10-19(11-9-18)26-22-4-3-5-23(29)21(22)15-17-6-12-20(31-2)13-7-17/h6-13,16,26H,3-5,14-15H2,1-2H3,(H,27,30)/t16-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15306 ((5R)-6-[4-({2-[(3-fluorophenyl)methyl]-3-oxocycloh...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(F)c3)C(=O)CCC2)cc1 Show InChI InChI=1S/C24H24FN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)/t15-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15309 ((5R)-5-methyl-6-[4-({2-[(3-nitrophenyl)methyl]-3-o...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)[N+]([O-])=O)C(=O)CCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c1-15-12-23(30)26-27-24(15)17-8-10-18(11-9-17)25-21-6-3-7-22(29)20(21)14-16-4-2-5-19(13-16)28(31)32/h2,4-5,8-11,13,15,25H,3,6-7,12,14H2,1H3,(H,26,30)/t15-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	0.940	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human))	BDBM50129817 (CHEMBL3628685) Show SMILES COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OC3CCCC3)c2)cc1 Show InChI InChI=1S/C21H23F2NO4/c1-26-16-9-6-14(7-10-16)13-24-20(25)15-8-11-18(28-21(22)23)19(12-15)27-17-4-2-3-5-17/h6-12,17,21H,2-5,13H2,1H3,(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	>1	n/a	n/a	n/a	n/a	n/a	n/a
Southern Medical University Curated by ChEMBL					Assay Description Inhibition of human PDE3B using AM-Cyclic-3',5'-AMP after 60 mins by fluorescence polarization assay				Bioorg Med Chem 23: 7332-9 (2015)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15301 (benzyl N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyri...) Show SMILES CC1CC(=O)NN=C1c1ccc(NC(=O)OCc2ccccc2)cc1 Show InChI InChI=1S/C19H19N3O3/c1-13-11-17(23)21-22-18(13)15-7-9-16(10-8-15)20-19(24)25-12-14-5-3-2-4-6-14/h2-10,13H,11-12H2,1H3,(H,20,24)(H,21,23)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars AffyNet	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15330 (3-[2-fluoro-4-({2-[(2-fluorophenyl)methyl]-3-oxocy...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3F)C(=O)CCC2)cc1F Show InChI InChI=1S/C24H23F2N3O2/c1-24(2)22(28-29-23(24)31)16-11-10-15(13-19(16)26)27-20-8-5-9-21(30)17(20)12-14-6-3-4-7-18(14)25/h3-4,6-7,10-11,13,27H,5,8-9,12H2,1-2H3,(H,29,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15325 (3-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-f...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F Show InChI InChI=1S/C24H24FN3O2/c1-24(2)22(27-28-23(24)30)17-12-11-16(14-19(17)25)26-20-9-6-10-21(29)18(20)13-15-7-4-3-5-8-15/h3-5,7-8,11-12,14,26H,6,9-10,13H2,1-2H3,(H,28,30)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15314 (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-m...) Show SMILES CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1C Show InChI InChI=1S/C25H27N3O2/c1-16-13-19(11-12-20(16)25-17(2)14-24(30)27-28-25)26-22-9-6-10-23(29)21(22)15-18-7-4-3-5-8-18/h3-5,7-8,11-13,17,26H,6,9-10,14-15H2,1-2H3,(H,27,30)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15332 (3-[2-fluoro-4-({2-[(4-fluorophenyl)methyl]-3-oxocy...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccc(F)cc3)C(=O)CCC2)cc1F Show InChI InChI=1S/C24H23F2N3O2/c1-24(2)22(28-29-23(24)31)17-11-10-16(13-19(17)26)27-20-4-3-5-21(30)18(20)12-14-6-8-15(25)9-7-14/h6-11,13,27H,3-5,12H2,1-2H3,(H,29,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15326 (3-[(2-{[4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyraz...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)C#N)C(=O)CCC2)cc1F Show InChI InChI=1S/C25H23FN4O2/c1-25(2)23(29-30-24(25)32)18-10-9-17(13-20(18)26)28-21-7-4-8-22(31)19(21)12-15-5-3-6-16(11-15)14-27/h3,5-6,9-11,13,28H,4,7-8,12H2,1-2H3,(H,30,32)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15327 (3-[2-fluoro-4-({2-[(3-nitrophenyl)methyl]-3-oxocyc...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)[N+]([O-])=O)C(=O)CCC2)cc1F Show InChI InChI=1S/C24H23FN4O4/c1-24(2)22(27-28-23(24)31)17-10-9-15(13-19(17)25)26-20-7-4-8-21(30)18(20)12-14-5-3-6-16(11-14)29(32)33/h3,5-6,9-11,13,26H,4,7-8,12H2,1-2H3,(H,28,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15320 (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-c...) Show SMILES CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1Cl Show InChI InChI=1S/C24H24ClN3O2/c1-15-12-23(30)27-28-24(15)18-11-10-17(14-20(18)25)26-21-8-5-9-22(29)19(21)13-16-6-3-2-4-7-16/h2-4,6-7,10-11,14-15,26H,5,8-9,12-13H2,1H3,(H,27,30)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15323 (3-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-m...) Show SMILES Cc1cc(NC2=C(Cc3ccccc3)C(=O)CCC2)ccc1C1=NNC(=O)C1(C)C Show InChI InChI=1S/C25H27N3O2/c1-16-14-18(12-13-19(16)23-25(2,3)24(30)28-27-23)26-21-10-7-11-22(29)20(21)15-17-8-5-4-6-9-17/h4-6,8-9,12-14,26H,7,10-11,15H2,1-3H3,(H,28,30)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15299 (N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC(=O)c2ccccc2C(F)(F)F)cc1 Show InChI InChI=1S/C19H16F3N3O2/c1-11-10-16(26)24-25-17(11)12-6-8-13(9-7-12)23-18(27)14-4-2-3-5-15(14)19(20,21)22/h2-9,11H,10H2,1H3,(H,23,27)(H,24,26)/t11-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15315 (N-{4-[(4S)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...) Show SMILES C[C@H]1CC(=O)NN=C1c1ccc(NC(=O)c2ccccc2)cc1 Show InChI InChI=1S/C18H17N3O2/c1-12-11-16(22)20-21-17(12)13-7-9-15(10-8-13)19-18(23)14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H,19,23)(H,20,22)/t12-/m0/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15313 ((5R)-5-methyl-6-[4-({2-[(4-nitrophenyl)methyl]-3-o...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccc(cc3)[N+]([O-])=O)C(=O)CCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c1-15-13-23(30)26-27-24(15)17-7-9-18(10-8-17)25-21-3-2-4-22(29)20(21)14-16-5-11-19(12-6-16)28(31)32/h5-12,15,25H,2-4,13-14H2,1H3,(H,26,30)/t15-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15331 (3-[2-fluoro-4-({2-[(3-fluorophenyl)methyl]-3-oxocy...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3cccc(F)c3)C(=O)CCC2)cc1F Show InChI InChI=1S/C24H23F2N3O2/c1-24(2)22(28-29-23(24)31)17-10-9-16(13-19(17)26)27-20-7-4-8-21(30)18(20)12-14-5-3-6-15(25)11-14/h3,5-6,9-11,13,27H,4,7-8,12H2,1-2H3,(H,29,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15334 (3-[2-chloro-4-({2-[(2-chlorophenyl)methyl]-3-oxocy...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3Cl)C(=O)CCC2)cc1Cl Show InChI InChI=1S/C24H23Cl2N3O2/c1-24(2)22(28-29-23(24)31)16-11-10-15(13-19(16)26)27-20-8-5-9-21(30)17(20)12-14-6-3-4-7-18(14)25/h3-4,6-7,10-11,13,27H,5,8-9,12H2,1-2H3,(H,29,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15300 (dihydropyridazinone 6c | ethyl N-{4-[(4R)-4-methyl...) Show SMILES CCOC(=O)Nc1ccc(cc1)C1=NNC(=O)C[C@H]1C Show InChI InChI=1S/C14H17N3O3/c1-3-20-14(19)15-11-6-4-10(5-7-11)13-9(2)8-12(18)16-17-13/h4-7,9H,3,8H2,1-2H3,(H,15,19)(H,16,18)/t9-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15303 ((5R)-5-methyl-6-{4-[(2-methyl-3-oxocyclohex-1-en-1...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(C)C(=O)CCC2)cc1 Show InChI InChI=1S/C18H21N3O2/c1-11-10-17(23)20-21-18(11)13-6-8-14(9-7-13)19-15-4-3-5-16(22)12(15)2/h6-9,11,19H,3-5,10H2,1-2H3,(H,20,23)/t11-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	8.80	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15322 (3-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]phen...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1 Show InChI InChI=1S/C24H25N3O2/c1-24(2)22(26-27-23(24)29)17-11-13-18(14-12-17)25-20-9-6-10-21(28)19(20)15-16-7-4-3-5-8-16/h3-5,7-8,11-14,25H,6,9-10,15H2,1-2H3,(H,27,29)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15324 (3-[(2-{[4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyraz...) Show SMILES Cc1cc(NC2=C(Cc3cccc(c3)C#N)C(=O)CCC2)ccc1C1=NNC(=O)C1(C)C Show InChI InChI=1S/C26H26N4O2/c1-16-12-19(10-11-20(16)24-26(2,3)25(32)30-29-24)28-22-8-5-9-23(31)21(22)14-17-6-4-7-18(13-17)15-27/h4,6-7,10-13,28H,5,8-9,14H2,1-3H3,(H,30,32)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15297 (CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...) Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1 Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet	PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15317 (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-e...) Show SMILES CCc1cc(NC2=C(Cc3ccccc3)C(=O)CCC2)ccc1C1=NNC(=O)CC1C Show InChI InChI=1S/C26H29N3O2/c1-3-19-16-20(12-13-21(19)26-17(2)14-25(31)28-29-26)27-23-10-7-11-24(30)22(23)15-18-8-5-4-6-9-18/h4-6,8-9,12-13,16-17,27H,3,7,10-11,14-15H2,1-2H3,(H,28,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15333 (3-[2-chloro-4-({2-[(3-nitrophenyl)methyl]-3-oxocyc...) Show SMILES CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)[N+]([O-])=O)C(=O)CCC2)cc1Cl Show InChI InChI=1S/C24H23ClN4O4/c1-24(2)22(27-28-23(24)31)17-10-9-15(13-19(17)25)26-20-7-4-8-21(30)18(20)12-14-5-3-6-16(11-14)29(32)33/h3,5-6,9-11,13,26H,4,7-8,12H2,1-2H3,(H,28,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15298 (N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C13H15N3O2/c1-8-7-12(18)15-16-13(8)10-3-5-11(6-4-10)14-9(2)17/h3-6,8H,7H2,1-2H3,(H,14,17)(H,15,18)/t8-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars AffyNet	PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human))	BDBM15297 (CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...) Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1 Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet	Article PubMed	n/a	n/a	69.1	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3B				Bioorg Med Chem Lett 21: 1617-20 (2011)
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human))	BDBM50338586 (CHEMBL1683806 | N'-(1-(3,3-dimethyl-2-oxoindolin-5...) Show SMILES CC(=NNS(=O)(=O)c1ccc(C)cc1)c1ccc2NC(=O)C(C)(C)c2c1 Show InChI InChI=1S/C19H21N3O3S/c1-12-5-8-15(9-6-12)26(24,25)22-21-13(2)14-7-10-17-16(11-14)19(3,4)18(23)20-17/h5-11,22H,1-4H3,(H,20,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	88.4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3B				Bioorg Med Chem Lett 21: 1617-20 (2011)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15336 (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...) Show SMILES CC(C)Cn1c2nc[nH]c2c(=O)n(C)c1=O Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars AffyNet	Article PubMed	n/a	n/a	242	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Biochemistry 43: 6091-100 (2004)
					More data for this Ligand-Target Pair				3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Bioorg Med Chem Lett 13: 3983-7 (2003)
					More data for this Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human))	BDBM14776 (2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...) Show SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...				Structure 12: 2233-47 (2004)
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human))	BDBM50308950 (6-({3-[(4-Hydroxypiperidino)carbonyl]benzyl}oxy)-4...) Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(O)CC3)cc12 Show InChI InChI=1S/C23H24N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13,18,26H,7-10,14H2,1H3,(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
Islamic Azad University Curated by ChEMBL					Assay Description Inhibition of human PDE3B by fluorescence microplate reader				Bioorg Med Chem 18: 855-62 (2010)
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE3b				Bioorg Med Chem Lett 19: 2537-41 (2009)
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human))	BDBM14754 (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	Article PubMed	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011)
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human))	BDBM50308948 (4-Methyl-6-(3-[(4-oxopiperidino)carbonyl]benzyloxy...) Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(=O)CC3)cc12 Show InChI InChI=1S/C23H22N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13H,7-10,14H2,1H3,(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Islamic Azad University Curated by ChEMBL					Assay Description Inhibition of human PDE3B by fluorescence microplate reader				Bioorg Med Chem 18: 855-62 (2010)
					More data for this Ligand-Target Pair

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