Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15311![]() ((5R)-5-methyl-6-{4-[(2-{[3-(3-nitrophenyl)phenyl]m...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.0490 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15310![]() ((5R)-5-methyl-6-{4-[(3-oxo-2-{[3-(thiophen-3-yl)ph...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15337![]() ((5R)-6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB PubMed | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15304![]() ((5R)-6-[4-({2-[(2-methoxyphenyl)methyl]-3-oxocyclo...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15329![]() (3-[4-({2-[(2,6-dichlorophenyl)methyl]-3-oxocyclohe...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15302![]() ((5R)-6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15318![]() (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-f...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15319![]() (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-3-f...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15337![]() ((5R)-6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars AffyNet ![]() | PDB Article PubMed | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Biochemistry 43: 6091-100 (2004) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15307![]() ((5R)-6-[4-({2-[(3-bromophenyl)methyl]-3-oxocyclohe...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15335![]() (3-[(2-{[4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyraz...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15305![]() ((5R)-5-methyl-6-{4-[(3-oxo-2-{[2-(trifluoromethyl)...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15328![]() (3-[4-({2-[(2-chlorophenyl)methyl]-3-oxocyclohex-1-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15316![]() (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-3-m...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15321![]() (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2,5...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15312![]() ((5R)-6-[4-({2-[(4-methoxyphenyl)methyl]-3-oxocyclo...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15306![]() ((5R)-6-[4-({2-[(3-fluorophenyl)methyl]-3-oxocycloh...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15309![]() ((5R)-5-methyl-6-[4-({2-[(3-nitrophenyl)methyl]-3-o...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human)) | BDBM50129817![]() (CHEMBL3628685) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | >1 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Medical University Curated by ChEMBL | Assay Description Inhibition of human PDE3B using AM-Cyclic-3',5'-AMP after 60 mins by fluorescence polarization assay | Bioorg Med Chem 23: 7332-9 (2015) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15301![]() (benzyl N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyri...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars AffyNet ![]() | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15330![]() (3-[2-fluoro-4-({2-[(2-fluorophenyl)methyl]-3-oxocy...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15325![]() (3-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-f...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15314![]() (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-m...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15332![]() (3-[2-fluoro-4-({2-[(4-fluorophenyl)methyl]-3-oxocy...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15326![]() (3-[(2-{[4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyraz...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15327![]() (3-[2-fluoro-4-({2-[(3-nitrophenyl)methyl]-3-oxocyc...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15320![]() (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-c...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15323![]() (3-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-m...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15299![]() (N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15315![]() (N-{4-[(4S)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15313![]() ((5R)-5-methyl-6-[4-({2-[(4-nitrophenyl)methyl]-3-o...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15331![]() (3-[2-fluoro-4-({2-[(3-fluorophenyl)methyl]-3-oxocy...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15334![]() (3-[2-chloro-4-({2-[(2-chlorophenyl)methyl]-3-oxocy...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15300![]() (dihydropyridazinone 6c | ethyl N-{4-[(4R)-4-methyl...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15303![]() ((5R)-5-methyl-6-{4-[(2-methyl-3-oxocyclohex-1-en-1...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15322![]() (3-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]phen...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15324![]() (3-[(2-{[4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyraz...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15297![]() (CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15317![]() (6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-e...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15333![]() (3-[2-chloro-4-({2-[(3-nitrophenyl)methyl]-3-oxocyc...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15298![]() (N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human)) | BDBM15297![]() (CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | n/a | n/a | 69.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE3B | Bioorg Med Chem Lett 21: 1617-20 (2011) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human)) | BDBM50338586![]() (CHEMBL1683806 | N'-(1-(3,3-dimethyl-2-oxoindolin-5...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem AffyNet ![]() | Article PubMed | n/a | n/a | 88.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE3B | Bioorg Med Chem Lett 21: 1617-20 (2011) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15336![]() (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 242 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Biochemistry 43: 6091-100 (2004) | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM15296![]() (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet ![]() | PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t... | Bioorg Med Chem Lett 13: 3983-7 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 3 (PDE3B) (Homo sapiens (human)) | BDBM14776![]() (2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human)) | BDBM50308950![]() (6-({3-[(4-Hydroxypiperidino)carbonyl]benzyl}oxy)-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Islamic Azad University Curated by ChEMBL | Assay Description Inhibition of human PDE3B by fluorescence microplate reader | Bioorg Med Chem 18: 855-62 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human)) | BDBM50259148![]() ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem AffyNet ![]() | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of PDE3b | Bioorg Med Chem Lett 19: 2537-41 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human)) | BDBM14754![]() (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University Curated by ChEMBL | Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay | Eur J Med Chem 46: 3986-95 (2011) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (human)) | BDBM50308948![]() (4-Methyl-6-(3-[(4-oxopiperidino)carbonyl]benzyloxy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Islamic Azad University Curated by ChEMBL | Assay Description Inhibition of human PDE3B by fluorescence microplate reader | Bioorg Med Chem 18: 855-62 (2010) | |||||||||||
More data for this Ligand-Target Pair |
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