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Found 3 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase Type 5 (PDE5A) Mutant (661-681 deletion)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase Type 5 (PDE5A) Mutant (661-681 deletion)


(Homo sapiens (human))
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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KEGG
MMDB
PC cid
PC sid
PDB
UniChem

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Article
PubMed
n/an/a 188n/an/an/an/a7.824



University of North Carolina at Chapel Hill



Assay Description
Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...


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More data for this
Ligand-Target Pair
Phosphodiesterase Type 5 (PDE5A) Mutant (661-681 deletion)


(Homo sapiens (human))
BDBM15338
PNG
(5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbutyl...)
Show SMILES COc1ccc(cc1)-c1oc2c(CCC(C)C)c(O)cc(O)c2c(=O)c1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C27H32O10/c1-12(2)5-10-16-17(28)11-18(29)19-21(31)26(37-27-23(33)22(32)20(30)13(3)35-27)24(36-25(16)19)14-6-8-15(34-4)9-7-14/h6-9,11-13,20,22-23,27-30,32-33H,5,10H2,1-4H3/t13-,20-,22+,23+,27-/m0/s1
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MMDB
PC cid
PC sid
PDB
UniChem

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AffyNet 
Article
PubMed
n/an/a 5.50E+4n/an/an/an/a7.824



University of North Carolina at Chapel Hill



Assay Description
Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase Type 5 (PDE5A) Mutant (661-681 deletion)


(Homo sapiens (human))
BDBM15336
PNG
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)
Show SMILES CC(C)Cn1c2nc[nH]c2c(=O)n(C)c1=O
Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
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CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 9.50E+4n/an/an/an/a7.824



University of North Carolina at Chapel Hill



Assay Description
Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...


Citation and Details
More data for this
Ligand-Target Pair