Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase Type 5 (PDE5A) Mutant (663-678 deletion) (Homo sapiens (human)) | BDBM14390![]() (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) | GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | 7.8 | 24 |
University of North Carolina at Chapel Hill | Assay Description Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea... | J Biol Chem 281: 21469-79 (2006) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 5 (PDE5A) Mutant (663-678 deletion) (Homo sapiens (human)) | BDBM15338![]() (5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbutyl...) | GoogleScholar AffyNet ![]() | MMDB PC cid PC sid PDB UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 7.8 | 24 |
University of North Carolina at Chapel Hill | Assay Description Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea... | J Biol Chem 281: 21469-79 (2006) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 5 (PDE5A) Mutant (663-678 deletion) (Homo sapiens (human)) | BDBM15336![]() (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...) | GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | 7.8 | 24 |
University of North Carolina at Chapel Hill | Assay Description Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea... | J Biol Chem 281: 21469-79 (2006) | |||||||||||
More data for this Ligand-Target Pair |