Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase Type 6 (PDE6) (Canis lupus familiaris (Dog)) | BDBM14397![]() (5-(5-acetyl-2-ethoxyphenyl)-1-methyl-3-propyl-1H,6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 6 (PDE6) (Canis lupus familiaris (Dog)) | BDBM14396![]() (5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 6 (PDE6) (Canis lupus familiaris (Dog)) | BDBM14390![]() (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 6 (PDE6) (Canis lupus familiaris (Dog)) | BDBM14394![]() (5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(pyrid...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 183 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 6 (PDE6) (Canis lupus familiaris (Dog)) | BDBM14392![]() (3-ethyl-5-{5-[(4-ethylpiperazine-1-)sulfonyl]-2-(2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 386 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 6 (PDE6) (Canis lupus familiaris (Dog)) | BDBM14393![]() (5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(1-eth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 840 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 6 (PDE6) (Canis lupus familiaris (Dog)) | BDBM14395![]() (5-[2-Butoxy-5-(1-hydroxyethyl)-3-pyridinyl]-3-ethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) | |||||||||||
More data for this Ligand-Target Pair |