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Compile Data Set for Download or QSAR

Found 956 hits Enz. Inhib. hit(s) with Target = 'Phospholipase A2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cPLA2 C2


(Homo sapiens (human))
BDBM50226792
PNG
(4-(3-(1-benzhydryl-5-chloro-2-(2-((3,4-dichlorophe...)
Show SMILES OC(=O)c1ccc(CCCc2c(CCNS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C40H35Cl3N2O4S/c41-32-19-21-37-34(25-32)33(13-7-8-27-14-17-31(18-15-27)40(46)47)38(22-23-44-50(48,49)26-28-16-20-35(42)36(43)24-28)45(37)39(29-9-3-1-4-10-29)30-11-5-2-6-12-30/h1-6,9-12,14-21,24-25,39,44H,7-8,13,22-23,26H2,(H,46,47)
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n/an/a 0.540n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185354
PNG
(3-methylhydrogen 1-[3-(4-decyloxyphenoxy)-2-oxopro...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34)
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n/an/a 0.900n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet


J Med Chem 49: 2611-20 (2006)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185348
PNG
(3-(methoxycarbonyl)-1-(3-(4-octylphenoxy)-2-oxopro...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C28H33NO6/c1-3-4-5-6-7-8-9-20-10-13-23(14-11-20)35-19-22(30)17-29-18-25(28(33)34-2)24-16-21(27(31)32)12-15-26(24)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,31,32)
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n/an/a 1.10n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet


J Med Chem 49: 2611-20 (2006)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053109
PNG
(CHEMBL331755 | [1-Aminooxalyl-3-(2-benzyl-benzyl)-...)
Show SMILES CCc1c(Cc2ccccc2Cc2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C28H26N2O5/c1-2-21-22(16-20-12-7-6-11-19(20)15-18-9-4-3-5-10-18)30-14-8-13-23(35-17-24(31)32)26(30)25(21)27(33)28(29)34/h3-14H,2,15-17H2,1H3,(H2,29,34)(H,31,32)
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n/an/a 1.30n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053136
PNG
((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-methyl-indo...)
Show SMILES COC(=O)COc1cccn2c(Cc3ccccc3-c3ccccc3)c(C)c(C(=O)C(N)=O)c12
Show InChI InChI=1S/C27H24N2O5/c1-17-21(15-19-11-6-7-12-20(19)18-9-4-3-5-10-18)29-14-8-13-22(34-16-23(30)33-2)25(29)24(17)26(31)27(28)32/h3-14H,15-16H2,1-2H3,(H2,28,32)
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n/an/a 1.40n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50085993
PNG
((E)-N-(((2S,4R)-4-((biphenyl-2-ylmethyl)(isobutyl)...)
Show SMILES CC(C)CN(Cc1ccccc1-c1ccccc1)[C@@H]1C[C@@H](CNC(=O)C=Cc2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C49H44F2N4O5S/c1-31(2)28-54(29-35-12-6-7-13-39(35)34-10-4-3-5-11-34)38-26-37(27-52-45(56)23-20-32-16-18-33(19-17-32)24-44-47(58)53-49(60)61-44)55(30-38)48(59)41-15-9-8-14-40(41)46(57)42-22-21-36(50)25-43(42)51/h3-25,31,37-38H,26-30H2,1-2H3,(H,52,56)(H,53,58,60)/t37-,38+/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50085984
PNG
(CHEMBL9161 | N-[1-[2-(2,4-Difluoro-benzoyl)-benzoy...)
Show SMILES CC(C)Cc1cccc(c1O[C@@H]1C[C@@H](CNC(=O)c2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1F)-c1ccccc1C(C)C
Show InChI InChI=1S/C49H45F2N3O6S/c1-28(2)22-32-10-9-15-39(37-12-6-5-11-36(37)29(3)4)45(32)60-35-25-34(26-52-46(56)31-18-16-30(17-19-31)23-43-47(57)53-49(59)61-43)54(27-35)48(58)40-14-8-7-13-38(40)44(55)41-21-20-33(50)24-42(41)51/h5-21,23-24,28-29,34-35H,22,25-27H2,1-4H3,(H,52,56)(H,53,57,59)/t34-,35+/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053106
PNG
(CHEMBL120112 | [1-Aminooxalyl-2-ethyl-3-(3-trifluo...)
Show SMILES CCc1c(Cc2cccc(c2)C(F)(F)F)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C22H19F3N2O5/c1-2-14-15(10-12-5-3-6-13(9-12)22(23,24)25)27-8-4-7-16(32-11-17(28)29)19(27)18(14)20(30)21(26)31/h3-9H,2,10-11H2,1H3,(H2,26,31)(H,28,29)
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n/an/a 3n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053137
PNG
((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-ethyl-indol...)
Show SMILES CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C27H24N2O5/c1-2-19-21(15-18-11-6-7-12-20(18)17-9-4-3-5-10-17)29-14-8-13-22(34-16-23(30)31)25(29)24(19)26(32)27(28)33/h3-14H,2,15-16H2,1H3,(H2,28,33)(H,30,31)
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n/an/a 3n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053108
PNG
((1-Aminooxalyl-3-benzyl-2-methyl-indolizin-8-yloxy...)
Show SMILES Cc1c(Cc2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C20H18N2O5/c1-12-14(10-13-6-3-2-4-7-13)22-9-5-8-15(27-11-16(23)24)18(22)17(12)19(25)20(21)26/h2-9H,10-11H2,1H3,(H2,21,26)(H,23,24)
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n/an/a 3n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053102
PNG
(CHEMBL121245 | [1-Aminooxalyl-3-(3-chloro-benzyl)-...)
Show SMILES CCc1c(Cc2cccc(Cl)c2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C21H19ClN2O5/c1-2-14-15(10-12-5-3-6-13(22)9-12)24-8-4-7-16(29-11-17(25)26)19(24)18(14)20(27)21(23)28/h3-9H,2,10-11H2,1H3,(H2,23,28)(H,25,26)
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n/an/a 3n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50085986
PNG
(CHEMBL267258 | N-{4-(Biphenyl-2-ylmethyl-isobutyl-...)
Show SMILES CC(C)CN(Cc1ccccc1-c1ccccc1)[C@@H]1C[C@@H](CNC(=O)C=Cc2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C49H45FN4O5S/c1-32(2)29-53(30-37-12-6-7-13-41(37)35-10-4-3-5-11-35)40-27-39(28-51-45(55)25-20-33-16-18-34(19-17-33)26-44-47(57)52-49(59)60-44)54(31-40)48(58)43-15-9-8-14-42(43)46(56)36-21-23-38(50)24-22-36/h3-26,32,39-40H,27-31H2,1-2H3,(H,51,55)(H,52,57,59)/t39-,40+/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053114
PNG
((1-Aminooxalyl-3-biphenyl-3-ylmethyl-2-ethyl-indol...)
Show SMILES CCc1c(Cc2cccc(c2)-c2ccccc2)n2cccc(OCC(=O)OC)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C28H26N2O5/c1-3-21-22(16-18-9-7-12-20(15-18)19-10-5-4-6-11-19)30-14-8-13-23(35-17-24(31)34-2)26(30)25(21)27(32)28(29)33/h4-15H,3,16-17H2,1-2H3,(H2,29,33)
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n/an/a 4.20n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185354
PNG
(3-methylhydrogen 1-[3-(4-decyloxyphenoxy)-2-oxopro...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34)
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n/an/a 4.30n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay


J Med Chem 49: 2611-20 (2006)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185348
PNG
(3-(methoxycarbonyl)-1-(3-(4-octylphenoxy)-2-oxopro...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C28H33NO6/c1-3-4-5-6-7-8-9-20-10-13-23(14-11-20)35-19-22(30)17-29-18-25(28(33)34-2)24-16-21(27(31)32)12-15-26(24)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,31,32)
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n/an/a 4.90n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay


J Med Chem 49: 2611-20 (2006)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185348
PNG
(3-(methoxycarbonyl)-1-(3-(4-octylphenoxy)-2-oxopro...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C28H33NO6/c1-3-4-5-6-7-8-9-20-10-13-23(14-11-20)35-19-22(30)17-29-18-25(28(33)34-2)24-16-21(27(31)32)12-15-26(24)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,31,32)
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n/an/a 5n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cPLA2-alpha assessed as arachidonic acid release by vesicle assay


Bioorg Med Chem 15: 2883-91 (2007)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185348
PNG
(3-(methoxycarbonyl)-1-(3-(4-octylphenoxy)-2-oxopro...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C28H33NO6/c1-3-4-5-6-7-8-9-20-10-13-23(14-11-20)35-19-22(30)17-29-18-25(28(33)34-2)24-16-21(27(31)32)12-15-26(24)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,31,32)
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n/an/a 5n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC


Bioorg Med Chem 18: 945-52 (2010)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50277800
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indazole-5-c...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ncc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C25H30N2O4/c1-2-3-4-5-6-7-8-19-9-12-23(13-10-19)31-18-22(28)17-27-24-14-11-20(25(29)30)15-21(24)16-26-27/h9-16H,2-8,17-18H2,1H3,(H,29,30)
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n/an/a 5n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC


Bioorg Med Chem 18: 945-52 (2010)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50277800
PNG
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indazole-5-c...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ncc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C25H30N2O4/c1-2-3-4-5-6-7-8-19-9-12-23(13-10-19)31-18-22(28)17-27-24-14-11-20(25(29)30)15-21(24)16-26-27/h9-16H,2-8,17-18H2,1H3,(H,29,30)
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n/an/a 5n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release


Bioorg Med Chem Lett 19: 2107-11 (2009)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053133
PNG
((1-Aminooxalyl-3-benzyl-2-ethyl-indolizin-8-yloxy)...)
Show SMILES CCc1c(Cc2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C21H20N2O5/c1-2-14-15(11-13-7-4-3-5-8-13)23-10-6-9-16(28-12-17(24)25)19(23)18(14)20(26)21(22)27/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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n/an/a 5n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053096
PNG
(CHEMBL123774 | [1-Aminooxalyl-3-(4-butyl-benzyl)-2...)
Show SMILES CCCCc1ccc(Cc2c(CC)c(C(=O)C(N)=O)c3c(OCC(O)=O)cccn23)cc1
Show InChI InChI=1S/C25H28N2O5/c1-3-5-7-16-9-11-17(12-10-16)14-19-18(4-2)22(24(30)25(26)31)23-20(32-15-21(28)29)8-6-13-27(19)23/h6,8-13H,3-5,7,14-15H2,1-2H3,(H2,26,31)(H,28,29)
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n/an/a 5n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053123
PNG
((1-Aminooxalyl-2-ethyl-3-naphthalen-1-ylmethyl-ind...)
Show SMILES CCc1c(Cc2cccc3ccccc23)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C25H22N2O5/c1-2-17-19(13-16-9-5-8-15-7-3-4-10-18(15)16)27-12-6-11-20(32-14-21(28)29)23(27)22(17)24(30)25(26)31/h3-12H,2,13-14H2,1H3,(H2,26,31)(H,28,29)
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n/an/a 5n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50085987
PNG
(4-(2,4-Dioxo-thiazolidin-5-ylidenemethyl)-N-[1-[2-...)
Show SMILES CC(C)Cc1cccc(c1O[C@@H]1C[C@@H](CNC(=O)c2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1)-c1ccccc1C(C)C
Show InChI InChI=1S/C49H46FN3O6S/c1-29(2)24-34-10-9-15-41(39-12-6-5-11-38(39)30(3)4)45(34)59-37-26-36(27-51-46(55)33-18-16-31(17-19-33)25-43-47(56)52-49(58)60-43)53(28-37)48(57)42-14-8-7-13-40(42)44(54)32-20-22-35(50)23-21-32/h5-23,25,29-30,36-37H,24,26-28H2,1-4H3,(H,51,55)(H,52,56,58)/t36-,37+/m0/s1
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n/an/a 5.30n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053137
PNG
((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-ethyl-indol...)
Show SMILES CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C27H24N2O5/c1-2-19-21(15-18-11-6-7-12-20(18)17-9-4-3-5-10-17)29-14-8-13-22(34-16-23(30)31)25(29)24(19)26(32)27(28)33/h3-14H,2,15-16H2,1H3,(H2,28,33)(H,30,31)
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n/an/a 6n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50292791
PNG
(4-{3-[2-{2-[({2-[(4-Acetylpiperazin-1-yl)methyl]be...)
Show SMILES CC(=O)N1CCN(Cc2ccccc2CS(=O)(=O)NCCc2c(CCCc3ccc(cc3)C(O)=O)c3cc(Cl)ccc3n2C(c2ccccc2)c2ccccc2)CC1
Show InChI InChI=1S/C47H49ClN4O5S/c1-34(53)51-29-27-50(28-30-51)32-39-16-8-9-17-40(39)33-58(56,57)49-26-25-45-42(18-10-11-35-19-21-38(22-20-35)47(54)55)43-31-41(48)23-24-44(43)52(45)46(36-12-4-2-5-13-36)37-14-6-3-7-15-37/h2-9,12-17,19-24,31,46,49H,10-11,18,25-30,32-33H2,1H3,(H,54,55)
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n/an/a 6n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053102
PNG
(CHEMBL121245 | [1-Aminooxalyl-3-(3-chloro-benzyl)-...)
Show SMILES CCc1c(Cc2cccc(Cl)c2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C21H19ClN2O5/c1-2-14-15(10-12-5-3-6-13(22)9-12)24-8-4-7-16(29-11-17(25)26)19(24)18(14)20(27)21(23)28/h3-9H,2,10-11H2,1H3,(H2,23,28)(H,25,26)
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n/an/a 6n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053147
PNG
((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-cyclopropyl...)
Show SMILES NC(=O)C(=O)c1c(C2CC2)c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(O)=O)c12
Show InChI InChI=1S/C28H24N2O5/c29-28(34)27(33)25-24(18-12-13-18)21(30-14-6-11-22(26(25)30)35-16-23(31)32)15-19-9-4-5-10-20(19)17-7-2-1-3-8-17/h1-11,14,18H,12-13,15-16H2,(H2,29,34)(H,31,32)
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n/an/a 6n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053109
PNG
(CHEMBL331755 | [1-Aminooxalyl-3-(2-benzyl-benzyl)-...)
Show SMILES CCc1c(Cc2ccccc2Cc2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C28H26N2O5/c1-2-21-22(16-20-12-7-6-11-19(20)15-18-9-4-3-5-10-18)30-14-8-13-23(35-17-24(31)32)26(30)25(21)27(33)28(29)34/h3-14H,2,15-17H2,1H3,(H2,29,34)(H,31,32)
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n/an/a 6n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50085994
PNG
(CHEMBL8970 | N-{4-(Biphenyl-2-ylmethyl-isobutyl-am...)
Show SMILES CC(C)CN(Cc1ccccc1-c1ccccc1)[C@@H]1C[C@@H](CNC(=O)c2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C47H42F2N4O5S/c1-29(2)26-52(27-33-12-6-7-13-37(33)31-10-4-3-5-11-31)36-24-35(25-50-44(55)32-18-16-30(17-19-32)22-42-45(56)51-47(58)59-42)53(28-36)46(57)39-15-9-8-14-38(39)43(54)40-21-20-34(48)23-41(40)49/h3-23,29,35-36H,24-28H2,1-2H3,(H,50,55)(H,51,56,58)/t35-,36+/m0/s1
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n/an/a 6.20n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)


J Med Chem 43: 1041-4 (2000)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185351
PNG
(3-acetyl-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-ind...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(C)=O)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C28H33NO5/c1-3-4-5-6-7-8-9-21-10-13-24(14-11-21)34-19-23(31)17-29-18-26(20(2)30)25-16-22(28(32)33)12-15-27(25)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,32,33)
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n/an/a 6.40n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet


J Med Chem 49: 2611-20 (2006)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056707
PNG
(CHEMBL3326971)
Show SMILES CCCOc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C28H29NO3/c1-2-18-32-25-14-12-24(13-15-25)29-20-23(11-8-21-6-4-3-5-7-21)26-19-22(9-16-27(26)29)10-17-28(30)31/h3-7,9,12-16,19-20H,2,8,10-11,17-18H2,1H3,(H,30,31)
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n/an/a 7n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056741
PNG
(CHEMBL3327088)
Show SMILES CC(C)Oc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C28H29NO3/c1-20(2)32-25-14-12-24(13-15-25)29-19-23(11-8-21-6-4-3-5-7-21)26-18-22(9-16-27(26)29)10-17-28(30)31/h3-7,9,12-16,18-20H,8,10-11,17H2,1-2H3,(H,30,31)
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n/an/a 7n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053095
PNG
((1-Aminooxalyl-2-ethyl-3-naphthalen-2-ylmethyl-ind...)
Show SMILES CCc1c(Cc2ccc3ccccc3c2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C25H22N2O5/c1-2-18-19(13-15-9-10-16-6-3-4-7-17(16)12-15)27-11-5-8-20(32-14-21(28)29)23(27)22(18)24(30)25(26)31/h3-12H,2,13-14H2,1H3,(H2,26,31)(H,28,29)
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n/an/a 7.30n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185350
PNG
(1-(3-(4-(decyloxy)phenoxy)-2-oxopropyl)-1H-indole-...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C28H35NO5/c1-2-3-4-5-6-7-8-9-18-33-25-11-13-26(14-12-25)34-21-24(30)20-29-17-16-22-19-23(28(31)32)10-15-27(22)29/h10-17,19H,2-9,18,20-21H2,1H3,(H,31,32)
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n/an/a 7.80n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet


J Med Chem 49: 2611-20 (2006)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053108
PNG
((1-Aminooxalyl-3-benzyl-2-methyl-indolizin-8-yloxy...)
Show SMILES Cc1c(Cc2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C20H18N2O5/c1-12-14(10-13-6-3-2-4-7-13)22-9-5-8-15(27-11-16(23)24)18(22)17(12)19(25)20(21)26/h2-9H,10-11H2,1H3,(H2,21,26)(H,23,24)
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n/an/a 8n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053133
PNG
((1-Aminooxalyl-3-benzyl-2-ethyl-indolizin-8-yloxy)...)
Show SMILES CCc1c(Cc2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C21H20N2O5/c1-2-14-15(11-13-7-4-3-5-8-13)23-10-6-9-16(28-12-17(24)25)19(23)18(14)20(26)21(22)27/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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n/an/a 8n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053136
PNG
((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-methyl-indo...)
Show SMILES COC(=O)COc1cccn2c(Cc3ccccc3-c3ccccc3)c(C)c(C(=O)C(N)=O)c12
Show InChI InChI=1S/C27H24N2O5/c1-17-21(15-19-11-6-7-12-20(19)18-9-4-3-5-10-18)29-14-8-13-22(34-16-23(30)33-2)25(29)24(17)26(31)27(28)32/h3-14H,15-16H2,1-2H3,(H2,28,32)
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n/an/a 8n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053147
PNG
((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-cyclopropyl...)
Show SMILES NC(=O)C(=O)c1c(C2CC2)c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(O)=O)c12
Show InChI InChI=1S/C28H24N2O5/c29-28(34)27(33)25-24(18-12-13-18)21(30-14-6-11-22(26(25)30)35-16-23(31)32)15-19-9-4-5-10-20(19)17-7-2-1-3-8-17/h1-11,14,18H,12-13,15-16H2,(H2,29,34)(H,31,32)
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n/an/a 9n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053114
PNG
((1-Aminooxalyl-3-biphenyl-3-ylmethyl-2-ethyl-indol...)
Show SMILES CCc1c(Cc2cccc(c2)-c2ccccc2)n2cccc(OCC(=O)OC)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C28H26N2O5/c1-3-21-22(16-18-9-7-12-20(15-18)19-10-5-4-6-11-19)30-14-8-13-23(35-17-24(31)34-2)26(30)25(21)27(32)28(29)33/h4-15H,3,16-17H2,1-2H3,(H2,29,33)
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n/an/a 9n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053106
PNG
(CHEMBL120112 | [1-Aminooxalyl-2-ethyl-3-(3-trifluo...)
Show SMILES CCc1c(Cc2cccc(c2)C(F)(F)F)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C22H19F3N2O5/c1-2-14-15(10-12-5-3-6-13(9-12)22(23,24)25)27-8-4-7-16(32-11-17(28)29)19(27)18(14)20(30)21(26)31/h3-9H,2,10-11H2,1H3,(H2,26,31)(H,28,29)
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n/an/a 9n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185349
PNG
(3-formyl-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-ind...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C=O)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C27H31NO5/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)33-19-23(30)17-28-16-22(18-29)25-15-21(27(31)32)11-14-26(25)28/h9-16,18H,2-8,17,19H2,1H3,(H,31,32)
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n/an/a 9.70n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet


J Med Chem 49: 2611-20 (2006)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053140
PNG
((1-Aminooxalyl-3-[2,2']bithiophenyl-4-ylmethyl-2-e...)
Show SMILES CCc1c(Cc2csc(c2)-c2cccs2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C23H20N2O5S2/c1-2-14-15(9-13-10-18(32-12-13)17-6-4-8-31-17)25-7-3-5-16(30-11-19(26)27)21(25)20(14)22(28)23(24)29/h3-8,10,12H,2,9,11H2,1H3,(H2,24,29)(H,26,27)
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n/an/a 10n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053116
PNG
((1-Aminooxalyl-3-cyclohexylmethyl-2-methyl-indoliz...)
Show SMILES Cc1c(CC2CCCCC2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C20H24N2O5/c1-12-14(10-13-6-3-2-4-7-13)22-9-5-8-15(27-11-16(23)24)18(22)17(12)19(25)20(21)26/h5,8-9,13H,2-4,6-7,10-11H2,1H3,(H2,21,26)(H,23,24)
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n/an/a 10n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50226793
PNG
(4-(3-(1-benzhydryl-5-chloro-2-(2-((2,6-dimethylphe...)
Show SMILES Cc1cccc(C)c1CS(=O)(=O)NCCc1c(CCCc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C42H41ClN2O4S/c1-29-11-9-12-30(2)38(29)28-50(48,49)44-26-25-40-36(18-10-13-31-19-21-34(22-20-31)42(46)47)37-27-35(43)23-24-39(37)45(40)41(32-14-5-3-6-15-32)33-16-7-4-8-17-33/h3-9,11-12,14-17,19-24,27,41,44H,10,13,18,25-26,28H2,1-2H3,(H,46,47)
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n/an/a 10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50292792
PNG
(4-(3-{5-Chloro-1-(diphenylmethyl)-2-[2-({[2-(morph...)
Show SMILES OC(=O)c1ccc(CCCc2c(CCNS(=O)(=O)Cc3ccccc3CN3CCOCC3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C45H46ClN3O5S/c46-39-22-23-42-41(30-39)40(17-9-10-33-18-20-36(21-19-33)45(50)51)43(49(42)44(34-11-3-1-4-12-34)35-13-5-2-6-14-35)24-25-47-55(52,53)32-38-16-8-7-15-37(38)31-48-26-28-54-29-27-48/h1-8,11-16,18-23,30,44,47H,9-10,17,24-29,31-32H2,(H,50,51)
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n/an/a 10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)

More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM50053096
PNG
(CHEMBL123774 | [1-Aminooxalyl-3-(4-butyl-benzyl)-2...)
Show SMILES CCCCc1ccc(Cc2c(CC)c(C(=O)C(N)=O)c3c(OCC(O)=O)cccn23)cc1
Show InChI InChI=1S/C25H28N2O5/c1-3-5-7-16-9-11-17(12-10-16)14-19-18(4-2)22(24(30)25(26)31)23-20(32-15-21(28)29)8-6-13-27(19)23/h6,8-13H,3-5,7,14-15H2,1-2H3,(H2,26,31)(H,28,29)
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n/an/a 11n/an/an/an/an/an/a



Shionogi & Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.


J Med Chem 39: 3636-58 (1996)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50110846
PNG
(4-(3-(4-(decyloxy)phenoxy)-2-oxopropoxy)benzoic ac...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C26H34O6/c1-2-3-4-5-6-7-8-9-18-30-23-14-16-25(17-15-23)32-20-22(27)19-31-24-12-10-21(11-13-24)26(28)29/h10-17H,2-9,18-20H2,1H3,(H,28,29)
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n/an/a 11n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cPLA2-alpha assessed as arachidonic acid release by vesicle assay


Bioorg Med Chem 15: 2883-91 (2007)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056712
PNG
(CHEMBL3326966)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(O)cc1
Show InChI InChI=1S/C25H23NO3/c27-22-12-10-21(11-13-22)26-17-20(9-6-18-4-2-1-3-5-18)23-16-19(7-14-24(23)26)8-15-25(28)29/h1-5,7,10-14,16-17,27H,6,8-9,15H2,(H,28,29)
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n/an/a 11n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50110846
PNG
(4-(3-(4-(decyloxy)phenoxy)-2-oxopropoxy)benzoic ac...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C26H34O6/c1-2-3-4-5-6-7-8-9-18-30-23-14-16-25(17-15-23)32-20-22(27)19-31-24-12-10-21(11-13-24)26(28)29/h10-17H,2-9,18-20H2,1H3,(H,28,29)
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n/an/a 11n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay


J Med Chem 49: 2611-20 (2006)

More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50185345
PNG
(3-cyano-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indo...)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C#N)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C27H30N2O4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)33-19-23(30)18-29-17-22(16-28)25-15-21(27(31)32)11-14-26(25)29/h9-15,17H,2-8,18-19H2,1H3,(H,31,32)
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n/an/a 11n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet


J Med Chem 49: 2611-20 (2006)

More data for this
Ligand-Target Pair
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