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Compile Data Set for Download or QSAR

Found 37 hits Enz. Inhib. hit(s) with Target = 'Phospholipase A2 group 1B'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phospholipase A2 group 1B


(Mus musculus)
BDBM50263000
PNG
(2-(1-benzyl-2-ethyl-1H-6,7-benzoindol-4-yloxy)-N-(...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C31H27N3O6S/c1-2-24-27(30(36)31(32)37)28-25(40-19-26(35)33-41(38,39)22-14-7-4-8-15-22)17-21-13-9-10-16-23(21)29(28)34(24)18-20-11-5-3-6-12-20/h3-17H,2,18-19H2,1H3,(H2,32,37)(H,33,35)
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n/an/a 100n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50055391
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-ind...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OC(C)C(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H22N2O5/c1-3-15-19(20(25)21(23)26)18-16(24(15)12-14-8-5-4-6-9-14)10-7-11-17(18)29-13(2)22(27)28/h4-11,13H,3,12H2,1-2H3,(H2,23,26)(H,27,28)
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n/an/a 100n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50055366
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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n/an/a 140n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant sPLA2 G1B


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50055366
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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n/an/a 140n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50263002
PNG
((2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-6,7-benz...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C25H22N2O5/c1-2-18-21(24(30)25(26)31)22-19(32-14-20(28)29)12-16-10-6-7-11-17(16)23(22)27(18)13-15-8-4-3-5-9-15/h3-12H,2,13-14H2,1H3,(H2,26,31)(H,28,29)
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n/an/a 160n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50186585
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-meth...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc(C)cc2n1Cc1ccccc1
Show InChI InChI=1S/C22H22N2O5/c1-3-15-20(21(27)22(23)28)19-16(24(15)11-14-7-5-4-6-8-14)9-13(2)10-17(19)29-12-18(25)26/h4-10H,3,11-12H2,1-2H3,(H2,23,28)(H,25,26)
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n/an/a 200n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant sPLA2 G1B


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50262804
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-isobutyl-1H-...)
Show SMILES CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C27H26N2O5/c1-16(2)12-20-23(26(32)27(28)33)24-21(34-15-22(30)31)13-18-10-6-7-11-19(18)25(24)29(20)14-17-8-4-3-5-9-17/h3-11,13,16H,12,14-15H2,1-2H3,(H2,28,33)(H,30,31)
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n/an/a 290n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50263053
PNG
(2-(3-Biphenyl-2-ylmethyl-2-ethyl-8-methoxy-indoliz...)
Show SMILES CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OC)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C26H24N2O3/c1-3-19-21(16-18-12-7-8-13-20(18)17-10-5-4-6-11-17)28-15-9-14-22(31-2)24(28)23(19)25(29)26(27)30/h4-15H,3,16H2,1-2H3,(H2,27,30)
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n/an/a>320n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50262844
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-isobutyl-1H-...)
Show SMILES CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C23H24N2O5/c1-14(2)11-17-21(22(28)23(24)29)20-16(9-6-10-18(20)30-13-19(26)27)25(17)12-15-7-4-3-5-8-15/h3-10,14H,11-13H2,1-2H3,(H2,24,29)(H,26,27)
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n/an/a 580n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50263001
PNG
(2-(1-benzyl-2-isobutyl-1H-6,7-benzoindol-4-yloxy)-...)
Show SMILES CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C33H31N3O6S/c1-21(2)17-26-29(32(38)33(34)39)30-27(42-20-28(37)35-43(40,41)24-14-7-4-8-15-24)18-23-13-9-10-16-25(23)31(30)36(26)19-22-11-5-3-6-12-22/h3-16,18,21H,17,19-20H2,1-2H3,(H2,34,39)(H,35,37)
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n/an/a 920n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50262842
PNG
(Benzenesulfonyl-2-(3-(2-amino-2-oxoacetyl)-1-benzy...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C27H25N3O6S/c1-2-20-25(26(32)27(28)33)24-21(30(20)16-18-10-5-3-6-11-18)14-9-15-22(24)36-17-23(31)29-37(34,35)19-12-7-4-8-13-19/h3-15H,2,16-17H2,1H3,(H2,28,33)(H,29,31)
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n/an/a 950n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50053137
PNG
((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-ethyl-indol...)
Show SMILES CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C27H24N2O5/c1-2-19-21(15-18-11-6-7-12-20(18)17-9-4-3-5-10-17)29-14-8-13-22(34-16-23(30)31)25(29)24(19)26(32)27(28)33/h3-14H,2,15-16H2,1H3,(H2,28,33)(H,30,31)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50263052
PNG
(2-[3-Biphenyl-2-ylmethyl-2-ethyl-8-(2-oxo-propoxy)...)
Show SMILES CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(C)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C28H26N2O4/c1-3-21-23(16-20-12-7-8-13-22(20)19-10-5-4-6-11-19)30-15-9-14-24(34-17-18(2)31)26(30)25(21)27(32)28(29)33/h4-15H,3,16-17H2,1-2H3,(H2,29,33)
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50263051
PNG
(2-(1-(2-amino-2-oxoacetyl)-2-(isobutyl)-3-(ophenyl...)
Show SMILES CC(C)Cc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(O)=O)c2c1C(=O)C(N)=O
Show InChI InChI=1S/C29H28N2O5/c1-18(2)15-22-23(16-20-11-6-7-12-21(20)19-9-4-3-5-10-19)31-14-8-13-24(36-17-25(32)33)27(31)26(22)28(34)29(30)35/h3-14,18H,15-17H2,1-2H3,(H2,30,35)(H,32,33)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50263003
PNG
(2-(2-ethyl-3-(o-phenylbenzyl)-8-(2-oxopropoxy)indo...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OC)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C24H22N2O3/c1-3-18-20(23(27)24(25)28)21-19(29-2)13-16-11-7-8-12-17(16)22(21)26(18)14-15-9-5-4-6-10-15/h4-13H,3,14H2,1-2H3,(H2,25,28)
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50262843
PNG
(Benzenesulfonyl-2-(3-(2-amino-2-oxoacetyl)-1-benzy...)
Show SMILES CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C29H29N3O6S/c1-19(2)16-23-27(28(34)29(30)35)26-22(32(23)17-20-10-5-3-6-11-20)14-9-15-24(26)38-18-25(33)31-39(36,37)21-12-7-4-8-13-21/h3-15,19H,16-18H2,1-2H3,(H2,30,35)(H,31,33)
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n/an/a>1.60E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse group1B phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50186586
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2,6-dimethyl-1...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc(C)cc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-12-8-15-19(16(9-12)28-11-17(24)25)18(20(26)21(22)27)13(2)23(15)10-14-6-4-3-5-7-14/h3-9H,10-11H2,1-2H3,(H2,22,27)(H,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant sPLA2 G1B


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Mus musculus)
BDBM50055383
PNG
((3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-yloxy)...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C20H18N2O5/c1-12-17(19(25)20(21)26)18-14(8-5-9-15(18)27-11-16(23)24)22(12)10-13-6-3-2-4-7-13/h2-9H,10-11H2,1H3,(H2,21,26)(H,23,24)
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant sPLA2 G1B


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50281623
PNG
(2-(4-fluorophenyl)-6-(2-naphthylsulfanyl)-1-hexana...)
Show SMILES NCC(CCCCSc1ccc2ccccc2c1)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FNS/c23-21-11-8-18(9-12-21)20(16-24)7-3-4-14-25-22-13-10-17-5-1-2-6-19(17)15-22/h1-2,5-6,8-13,15,20H,3-4,7,14,16,24H2
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n/an/a 2.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50281621
PNG
(6-[4-(tert-butyl)phenylsulfanyl]-2-(4-fluorophenyl...)
Show SMILES CC(C)(C)c1ccc(SCCCCC(CN)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H30FNS/c1-22(2,3)19-9-13-21(14-10-19)25-15-5-4-6-18(16-24)17-7-11-20(23)12-8-17/h7-14,18H,4-6,15-16,24H2,1-3H3
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n/an/a 4.80E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50281622
PNG
(2-(4-fluorophenyl)-6-(4-methylphenylsulfanyl)-1-he...)
Show SMILES Cc1ccc(SCCCCC(CN)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H24FNS/c1-15-5-11-19(12-6-15)22-13-3-2-4-17(14-21)16-7-9-18(20)10-8-16/h5-12,17H,2-4,13-14,21H2,1H3
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n/an/a 5.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50281625
PNG
(2-(4-fluorophenyl)-7-(4-methylphenylsulfanyl)-1-he...)
Show SMILES Cc1ccc(SCCCCCC(CN)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H26FNS/c1-16-6-12-20(13-7-16)23-14-4-2-3-5-18(15-22)17-8-10-19(21)11-9-17/h6-13,18H,2-5,14-15,22H2,1H3
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n/an/a 6.60E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50281626
PNG
(2-(4-fluorophenyl)-5-(2-naphthylsulfanyl)-1-pentan...)
Show SMILES NCC(CCCSc1ccc2ccccc2c1)c1ccc(F)cc1
Show InChI InChI=1S/C21H22FNS/c22-20-10-7-17(8-11-20)19(15-23)6-3-13-24-21-12-9-16-4-1-2-5-18(16)14-21/h1-2,4-5,7-12,14,19H,3,6,13,15,23H2
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n/an/a 1.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
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n/an/a>2.50E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50281624
PNG
(2-(4-fluorophenyl)-5-(4-methylphenylsulfanyl)-1-pe...)
Show SMILES Cc1ccc(SCCCC(CN)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H22FNS/c1-14-4-10-18(11-5-14)21-12-2-3-16(13-20)15-6-8-17(19)9-7-15/h4-11,16H,2-3,12-13,20H2,1H3
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n/an/a 2.83E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50281624
PNG
(2-(4-fluorophenyl)-5-(4-methylphenylsulfanyl)-1-pe...)
Show SMILES Cc1ccc(SCCCC(CN)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H22FNS/c1-14-4-10-18(11-5-14)21-12-2-3-16(13-20)15-6-8-17(19)9-7-15/h4-11,16H,2-3,12-13,20H2,1H3
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n/an/a 5.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50015214
PNG
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12
Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
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n/an/a 1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50183247
PNG
(2-{4-[3-(4-oxo-4H-chromen-2-yl)phenyl]phenyl}-4H-c...)
Show SMILES O=c1cc(oc2ccccc12)-c1ccc(cc1)-c1cccc(c1)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C30H18O4/c31-25-17-29(33-27-10-3-1-8-23(25)27)20-14-12-19(13-15-20)21-6-5-7-22(16-21)30-18-26(32)24-9-2-4-11-28(24)34-30/h1-18H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50129952
PNG
(2-(3-(5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-c...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(O)c4c(cc(O)cc4=O)o3)c2o1
Show InChI InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-33,35-37H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50183249
PNG
(2,2'-Diphenyl-[6,6']bichromenyl-4,4'-dione | CHEMB...)
Show SMILES O=c1cc(oc2ccc(cc12)-c1ccc2oc(cc(=O)c2c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C30H18O4/c31-25-17-29(19-7-3-1-4-8-19)33-27-13-11-21(15-23(25)27)22-12-14-28-24(16-22)26(32)18-30(34-28)20-9-5-2-6-10-20/h1-18H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50183246
PNG
(6-[3-(4-Oxo-4H-chromen-2-yl)-phenyl]-2-phenyl-chro...)
Show SMILES O=c1cc(oc2ccccc12)-c1cccc(c1)-c1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C30H18O4/c31-25-17-30(33-27-12-5-4-11-23(25)27)22-10-6-9-20(15-22)21-13-14-28-24(16-21)26(32)18-29(34-28)19-7-2-1-3-8-19/h1-18H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50183244
PNG
(3-(4-(4-oxo-4H-chromen-2-yl)phenyl)-2-phenyl-4H-ch...)
Show SMILES O=c1cc(oc2ccccc12)-c1ccc(cc1)-c1c(oc2ccccc2c1=O)-c1ccccc1
Show InChI InChI=1S/C30H18O4/c31-24-18-27(33-25-12-6-4-10-22(24)25)19-14-16-20(17-15-19)28-29(32)23-11-5-7-13-26(23)34-30(28)21-8-2-1-3-9-21/h1-18H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50183250
PNG
(2-(3-(4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)pheno...)
Show SMILES Oc1cc2oc(cc(O)c2c(=O)c1)-c1ccc(Oc2cc(ccc2O)-c2cc(O)c3c(cc(O)cc3=O)o2)cc1
Show InChI InChI=1S/C30H18O10/c31-16-8-20(34)29-22(36)12-24(39-27(29)10-16)14-1-4-18(5-2-14)38-26-7-15(3-6-19(26)33)25-13-23(37)30-21(35)9-17(32)11-28(30)40-25/h1-13,31-33,36-37H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50183248
PNG
(2-{4-[4-(4-oxo-4H-chromen-2-yl)phenyl]phenyl}-4H-c...)
Show SMILES O=c1cc(oc2ccccc12)-c1ccc(cc1)-c1ccc(cc1)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C30H18O4/c31-25-17-29(33-27-7-3-1-5-23(25)27)21-13-9-19(10-14-21)20-11-15-22(16-12-20)30-18-26(32)24-6-2-4-8-28(24)34-30/h1-18H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM50183245
PNG
(6-[4-(4-Oxo-4H-chromen-2-yl)-phenyl]-2-phenyl-chro...)
Show SMILES O=c1cc(oc2ccccc12)-c1ccc(cc1)-c1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C30H18O4/c31-25-17-30(33-27-9-5-4-8-23(25)27)21-12-10-19(11-13-21)22-14-15-28-24(16-22)26(32)18-29(34-28)20-6-2-1-3-7-20/h1-18H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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n/an/a 2.50E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2 group 1B


(Rattus norvegicus)
BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/a>7.50E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat


Citation and Details
More data for this
Ligand-Target Pair