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Compile Data Set for Download or QSAR

Found 378 hits Enz. Inhib. hit(s) with Target = 'Phospholipase C'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50037076
PNG
(CHEMBL3355737)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1cc(cc(Nc2cc([nH]n2)C2CCCC2)n1)S(=O)(=O)c1ccccc1
Show InChI InChI=1/C25H31N5O3S/c31-19-12-10-18(11-13-19)26-23-14-21(34(32,33)20-8-2-1-3-9-20)15-24(27-23)28-25-16-22(29-30-25)17-6-4-5-7-17/h1-3,8-9,14-19,31H,4-7,10-13H2,(H3,26,27,28,29,30)/t18-,19-
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n/an/a 180n/an/an/an/an/an/a



Evotec UK Ltd

Curated by ChEMBL


Assay Description
Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50037063
PNG
(CHEMBL3355726)
Show SMILES Cc1cc(Nc2cc(cc(N[C@H]3CC[C@H](O)CC3)n2)S(=O)(=O)c2ccccc2)n[nH]1
Show InChI InChI=1/C21H25N5O3S/c1-14-11-21(26-25-14)24-20-13-18(30(28,29)17-5-3-2-4-6-17)12-19(23-20)22-15-7-9-16(27)10-8-15/h2-6,11-13,15-16,27H,7-10H2,1H3,(H3,22,23,24,25,26)/t15-,16-
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n/an/a 540n/an/an/an/an/an/a



Evotec UK Ltd

Curated by ChEMBL


Assay Description
Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256870
PNG
(5-(3-chlorophenyl)-3-(5-(isoxazol-3-yl)thiophen-2-...)
Show SMILES Clc1cccc(c1)-c1nc(no1)-c1ccc(s1)-c1ccon1
Show InChI InChI=1S/C15H8ClN3O2S/c16-10-3-1-2-9(8-10)15-17-14(19-21-15)13-5-4-12(22-13)11-6-7-20-18-11/h1-8H
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n/an/a 1.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256872
PNG
(7-nitro-N-phenethyl-1H-indole-2-carboxamide | CHEM...)
Show SMILES [O-][N+](=O)c1cccc2cc([nH]c12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C17H15N3O3/c21-17(18-10-9-12-5-2-1-3-6-12)14-11-13-7-4-8-15(20(22)23)16(13)19-14/h1-8,11,19H,9-10H2,(H,18,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256873
PNG
(CHEMBL475790 | N-(4-chlorophenyl)-7-nitro-1H-indol...)
Show SMILES [O-][N+](=O)c1cccc2cc([nH]c12)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C15H10ClN3O3/c16-10-4-6-11(7-5-10)17-15(20)12-8-9-2-1-3-13(19(21)22)14(9)18-12/h1-8,18H,(H,17,20)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM84007
PNG
(CEFIXIME | Cefiximum [Latin] | MLS002222332 | SMR0...)
Show SMILES Nc1nc(cs1)C(=N\OCC(O)=O)\C(=O)N[C@H]1[C@H]2SCC(C=C)=C(N2C1=O)C(O)=O
Show InChI InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1
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n/an/a 1.21E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM52817
PNG
(2-[(5Z)-5-[(E)-3-(2-furanyl)prop-2-enylidene]-4-ox...)
Show SMILES OC(=O)CC(N1C(=S)S\C(=C/C=C/c2ccco2)C1=O)C(O)=O
Show InChI InChI=1S/C14H11NO6S2/c16-11(17)7-9(13(19)20)15-12(18)10(23-14(15)22)5-1-3-8-4-2-6-21-8/h1-6,9H,7H2,(H,16,17)(H,19,20)/b3-1+,10-5-
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n/an/a 1.51E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM34905
PNG
(1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...)
Show SMILES CCCc1nn(C)c2nc(=O)n(C)c(=O)c2n1
Show InChI InChI=1S/C10H13N5O2/c1-4-5-6-11-7-8(15(3)13-6)12-10(17)14(2)9(7)16/h4-5H2,1-3H3
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n/an/a 1.51E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256871
PNG
(5-(5-nitrothiophen-3-yl)-3-(pyridin-2-yl)-1,2,4-ox...)
Show SMILES [O-][N+](=O)c1cc(cs1)-c1nc(no1)-c1ccccn1
Show InChI InChI=1S/C11H6N4O3S/c16-15(17)9-5-7(6-19-9)11-13-10(14-18-11)8-3-1-2-4-12-8/h1-6H
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n/an/a 2.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256803
PNG
(4-chloro-N-(4-oxo-4H-benzo[d][1,3]thiazin-2-yl)ben...)
Show SMILES Clc1ccc(cc1)C(=O)Nc1nc2ccccc2c(=O)s1
Show InChI InChI=1S/C15H9ClN2O2S/c16-10-7-5-9(6-8-10)13(19)18-15-17-12-4-2-1-3-11(12)14(20)21-15/h1-8H,(H,17,18,19)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C


(Bacillus cereus)
BDBM50332106
PNG
(1-(hydroxy(2-(trimethylammonio)ethyl)amino)-1-oxoh...)
Show SMILES CCCCCCCCCCCCCCC([NH3+])C(=O)N(O)CC[N+](C)(C)C
Show InChI InChI=1S/C21H46N3O2/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)21(25)23(26)18-19-24(2,3)4/h20,26H,5-19,22H2,1-4H3/q+1/p+1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Institute of Advance Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of Bacillus cereus phosphatidylcholine preferred phospholipase C after 100 seconds


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256801
PNG
(4-((5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benz...)
Show SMILES O=C1OC(=N\C1=C\c1ccc(cc1)C#N)c1ccccc1
Show InChI InChI=1S/C17H10N2O2/c18-11-13-8-6-12(7-9-13)10-15-17(20)21-16(19-15)14-4-2-1-3-5-14/h1-10H/b15-10+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM114297
PNG
(2-[(3R,6S)-1-acetyl-6-(tosylcarbamoyl)-3,6-dihydro...)
Show SMILES COC(=O)C([C@@H]1CN([C@@H](C=C1)C(=O)NS(=O)(=O)c1ccc(C)cc1)C(C)=O)C(=O)OC
Show InChI InChI=1S/C20H24N2O8S/c1-12-5-8-15(9-6-12)31(27,28)21-18(24)16-10-7-14(11-22(16)13(2)23)17(19(25)29-3)20(26)30-4/h5-10,14,16-17H,11H2,1-4H3,(H,21,24)/t14-,16-/m0/s1
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n/an/a 2.03E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM18136
PNG
(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H17N5O9P2/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50037060
PNG
(CHEMBL3355311)
Show SMILES Cc1cc(Nc2cc(Cc3ccccc3)nc(N[C@H]3CC[C@H](O)CC3)n2)n[nH]1
Show InChI InChI=1/C21H26N6O/c1-14-11-20(27-26-14)24-19-13-17(12-15-5-3-2-4-6-15)23-21(25-19)22-16-7-9-18(28)10-8-16/h2-6,11,13,16,18,28H,7-10,12H2,1H3,(H3,22,23,24,25,26,27)/t16-,18-
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n/an/a 2.60E+3n/an/an/an/an/an/a



Evotec UK Ltd

Curated by ChEMBL


Assay Description
Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM114292
PNG
(2-(2-cyano-3-pyridinyl)-2-methylpropanoic acid met...)
Show SMILES COC(=O)C(C)(C)c1cccnc1C#N
Show InChI InChI=1S/C11H12N2O2/c1-11(2,10(14)15-3)8-5-4-6-13-9(8)7-12/h4-6H,1-3H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256804
PNG
(3-(2,2-dimethylchroman-6-yl)-1-(4-methoxyphenylsul...)
Show SMILES COc1ccc(cc1)S(=O)(=O)n1ccc(n1)-c1ccc2OC(C)(C)CCc2c1
Show InChI InChI=1S/C21H22N2O4S/c1-21(2)12-10-16-14-15(4-9-20(16)27-21)19-11-13-23(22-19)28(24,25)18-7-5-17(26-3)6-8-18/h4-9,11,13-14H,10,12H2,1-3H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM52754
PNG
(3-amino-4-hydroxy-5-nitro-besylic acid | 3-amino-4...)
Show SMILES Nc1cc(cc(c1O)[N+]([O-])=O)S(O)(=O)=O
Show InChI InChI=1S/C6H6N2O6S/c7-4-1-3(15(12,13)14)2-5(6(4)9)8(10)11/h1-2,9H,7H2,(H,12,13,14)
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n/an/a 3.97E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C


(Bacillus cereus)
BDBM50332103
PNG
(1-(benzyloxy(2-(trimethylammonio)ethyl)amino)-1-ox...)
Show SMILES CCCCCCCCCCCCCCCCCCC([NH3+])C(=O)N(CC[N+](C)(C)C)OCc1ccccc1
Show InChI InChI=1S/C32H60N3O2/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-26-31(33)32(36)34(27-28-35(2,3)4)37-29-30-24-21-20-22-25-30/h20-22,24-25,31H,5-19,23,26-29,33H2,1-4H3/q+1/p+1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Institute of Advance Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of Bacillus cereus phosphatidylcholine preferred phospholipase C after 100 seconds


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C


(Bacillus cereus)
BDBM50332102
PNG
(1-(benzyloxy(2-(trimethylammonio)ethyl)amino)-1-ox...)
Show SMILES CCCCCCCCCCCCCCC([NH3+])C(=O)N(CC[N+](C)(C)C)OCc1ccccc1
Show InChI InChI=1S/C28H52N3O2/c1-5-6-7-8-9-10-11-12-13-14-15-19-22-27(29)28(32)30(23-24-31(2,3)4)33-25-26-20-17-16-18-21-26/h16-18,20-21,27H,5-15,19,22-25,29H2,1-4H3/q+1/p+1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Institute of Advance Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of Bacillus cereus phosphatidylcholine preferred phospholipase C after 100 seconds


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256875
PNG
(6-(4-methoxyphenyl)-3-phenylthieno[2,3-e][1,2,4]tr...)
Show SMILES COc1ccc(cc1)-c1cc2nnc(nc2s1)-c1ccccc1
Show InChI InChI=1S/C18H13N3OS/c1-22-14-9-7-12(8-10-14)16-11-15-18(23-16)19-17(21-20-15)13-5-3-2-4-6-13/h2-11H,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C


(Bacillus cereus)
BDBM50332107
PNG
(1-(hydroxy(2-(trimethylammonio)ethyl)amino)-1-oxoi...)
Show SMILES CCCCCCCCCCCCCCCCCCC([NH3+])C(=O)N(O)CC[N+](C)(C)C
Show InChI InChI=1S/C25H54N3O2/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-24(26)25(29)27(30)22-23-28(2,3)4/h24,30H,5-23,26H2,1-4H3/q+1/p+1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Institute of Advance Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of Bacillus cereus phosphatidylcholine preferred phospholipase C after 100 seconds


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM60205
PNG
(MLS001006819 | N,N'-bis(4-keto-2-thioxo-thiazolidi...)
Show SMILES Oc1csc(=S)n1NC(=O)C(=O)Nn1c(O)csc1=S
Show InChI InChI=1S/C8H6N4O4S4/c13-3-1-19-7(17)11(3)9-5(15)6(16)10-12-4(14)2-20-8(12)18/h1-2,13-14H,(H,9,15)(H,10,16)
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n/an/a 4.36E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM114299
PNG
((3R,6S)-1-acetyl-3-(1H-indol-3-yl)-N-(4-methylphen...)
Show SMILES CC(=O)N1C[C@H](C=C[C@H]1C(=O)NS(=O)(=O)c1ccc(C)cc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H23N3O4S/c1-15-7-10-18(11-8-15)31(29,30)25-23(28)22-12-9-17(14-26(22)16(2)27)20-13-24-21-6-4-3-5-19(20)21/h3-13,17,22,24H,14H2,1-2H3,(H,25,28)/t17-,22-/m0/s1
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n/an/a 4.54E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM51771
PNG
(1,6-dimethyl-3-(2-pyridinyl)pyrimido[5,4-e][1,2,4]...)
Show SMILES Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccccn1
Show InChI InChI=1S/C12H10N6O2/c1-17-11(19)8-10(15-12(17)20)18(2)16-9(14-8)7-5-3-4-6-13-7/h3-6H,1-2H3
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n/an/a 4.54E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C


(Bacillus cereus)
BDBM50332097
PNG
(2-(N-(benzyloxy)-2-(tert-butyloxycarbonylamino)dod...)
Show SMILES CCCCCCCCCCC(NC(=O)OC(C)(C)C)C(=O)N(CC[N+](C)(C)C)OCc1ccccc1
Show InChI InChI=1S/C29H51N3O4/c1-8-9-10-11-12-13-14-18-21-26(30-28(34)36-29(2,3)4)27(33)31(22-23-32(5,6)7)35-24-25-19-16-15-17-20-25/h15-17,19-20,26H,8-14,18,21-24H2,1-7H3/p+1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Institute of Advance Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of Bacillus cereus phosphatidylcholine preferred phospholipase C after 100 seconds


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256874
PNG
(CHEMBL475466 | N-(benzo[d]thiazol-2-yl)-5-methoxy-...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)Nc1nc2ccccc2s1
Show InChI InChI=1S/C17H13N3O2S/c1-22-11-6-7-12-10(8-11)9-14(18-12)16(21)20-17-19-13-4-2-3-5-15(13)23-17/h2-9,18H,1H3,(H,19,20,21)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM50099737
PNG
(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Show SMILES Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C14H9NO2/c15-8-5-6-10-9-3-1-2-4-11(9)13(16)14(17)12(10)7-8/h1-7H,15H2
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n/an/a 5.14E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM22857
PNG
(1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...)
Show SMILES O=C1C(=O)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C14H8O2/c15-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14(13)16/h1-8H
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n/an/a 6.37E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C


(Bacillus cereus)
BDBM50332109
PNG
(CHEMBL1287861 | Tert-butyl 1-(benzyloxy[3-(dimethy...)
Show SMILES CCCCCCCCCCC(NC(=O)OC(C)(C)C)C(=O)N(CCCN(C)C)OCc1ccccc1
Show InChI InChI=1S/C29H51N3O4/c1-7-8-9-10-11-12-13-17-21-26(30-28(34)36-29(2,3)4)27(33)32(23-18-22-31(5)6)35-24-25-19-15-14-16-20-25/h14-16,19-20,26H,7-13,17-18,21-24H2,1-6H3,(H,30,34)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Institute of Advance Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of Bacillus cereus phosphatidylcholine preferred phospholipase C after 100 seconds


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50066433
PNG
(CHEMBL112884 | Hexadecanoic acid (R)-2-[(3-fluoro-...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC1C(O)C(O)C(O)C(F)C1O)OC(=O)CCCCCCCCCCCCCCC
Show InChI InChI=1S/C41H78FO12P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(43)51-31-33(32-52-55(49,50)54-41-38(46)36(42)37(45)39(47)40(41)48)53-35(44)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h33,36-41,45-48H,3-32H2,1-2H3,(H,49,50)/t33-,36?,37?,38?,39?,40?,41?/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM61258
PNG
((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
Show SMILES Nc1ncnc2n(cnc12)C1OC(COP(O)([O-])=O)C(O)C1O
Show InChI InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-1
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n/an/a 8.72E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256805
PNG
(1-(2-Chloro-benzoyl)-3-(1,1-dioxo-1H-1lambda*6*-be...)
Show SMILES Clc1ccccc1C(=O)NC(=O)Nc1ccc2C=CS(=O)(=O)c2c1
Show InChI InChI=1S/C16H11ClN2O4S/c17-13-4-2-1-3-12(13)15(20)19-16(21)18-11-6-5-10-7-8-24(22,23)14(10)9-11/h1-9H,(H2,18,19,20,21)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269158
PNG
(3-beta-hydroxy-27-p-(E)-coumaroyloxyurs-12-en-28-o...)
Show SMILES C[C@@H]1CC[C@@]2(CC[C@]3(CC(=O)C=Cc4ccc(O)cc4)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-24-15-20-38(34(43)44)21-22-39(23-28(41)12-9-26-7-10-27(40)11-8-26)29(33(38)25(24)2)13-14-31-36(5)18-17-32(42)35(3,4)30(36)16-19-37(31,39)6/h7-13,24-25,30-33,40,42H,14-23H2,1-6H3,(H,43,44)/t24-,25+,30+,31-,32+,33+,36+,37-,38+,39+/m1/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50066431
PNG
(((S)-3-Methoxy-4-octadecyloxy-butyl)-phosphonic ac...)
Show SMILES CCCCCCCCCCCCCCCCCCOC[C@H](CCP(O)(=O)OC1C(O)CC(O)C(O)C1O)OC
Show InChI InChI=1S/C29H59O9P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-37-23-24(36-2)19-21-39(34,35)38-29-26(31)22-25(30)27(32)28(29)33/h24-33H,3-23H2,1-2H3,(H,34,35)/t24-,25?,26?,27?,28?,29?/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C


(Bacillus cereus)
BDBM50332101
PNG
(1-(benzyloxy(2-(trimethylammonio)ethyl)amino)-1-ox...)
Show SMILES CCCCCCCCCCC([NH3+])C(=O)N(CC[N+](C)(C)C)OCc1ccccc1
Show InChI InChI=1S/C24H44N3O2/c1-5-6-7-8-9-10-11-15-18-23(25)24(28)26(19-20-27(2,3)4)29-21-22-16-13-12-14-17-22/h12-14,16-17,23H,5-11,15,18-21,25H2,1-4H3/q+1/p+1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Institute of Advance Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of Bacillus cereus phosphatidylcholine preferred phospholipase C after 100 seconds


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM22860
PNG
(1,2-Dione-Based Compound, 17 | 5,6-dihydro-1=10-ph...)
Show SMILES O=C1C(=O)c2cccnc2-c2ncccc12
Show InChI InChI=1S/C12H6N2O2/c15-11-7-3-1-5-13-9(7)10-8(12(11)16)4-2-6-14-10/h1-6H
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n/an/a 1.12E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256819
PNG
(2-(4-nitrophenyl)-4-(thiophen-2-ylmethylene)oxazol...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1=N\C(=C\c2cccs2)C(=O)O1
Show InChI InChI=1S/C14H8N2O4S/c17-14-12(8-11-2-1-7-21-11)15-13(20-14)9-3-5-10(6-4-9)16(18)19/h1-8H/b12-8+
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n/an/a 1.20E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM114252
PNG
(1-keto-3-(4-phenoxyphenyl)-1,3-thiazolidin-4-one |...)
Show SMILES O=C1CS(=O)CN1c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C15H13NO3S/c17-15-10-20(18)11-16(15)12-6-8-14(9-7-12)19-13-4-2-1-3-5-13/h1-9H,10-11H2
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n/an/a 1.25E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM18137
PNG
(AMP | CHEMBL752 | [(2R,3S,4R,5R)-5-adenin-9-yl-3,4...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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n/an/a 1.32E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM48003
PNG
(2-Methyl-8-morpholin-4-yl-5,6-dioxo-5,6-dihydro-qu...)
Show SMILES COC(=O)c1cc(C)nc2C(=CC(=O)C(=O)c12)N1CCOCC1
Show InChI InChI=1S/C16H16N2O5/c1-9-7-10(16(21)22-2)13-14(17-9)11(8-12(19)15(13)20)18-3-5-23-6-4-18/h7-8H,3-6H2,1-2H3
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n/an/a 1.37E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM50331546
PNG
(2-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)benzenes...)
Show SMILES Oc1ccc2c(-c3ccccc3S(O)(=O)=O)c3ccc(=O)c(O)c3oc2c1O
Show InChI InChI=1S/C19H12O8S/c20-12-7-5-10-15(9-3-1-2-4-14(9)28(24,25)26)11-6-8-13(21)17(23)19(11)27-18(10)16(12)22/h1-8,20,22-23H,(H,24,25,26)
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n/an/a 1.42E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269154
PNG
(3-beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic ...)
Show SMILES COc1cc(C=CC(=O)C[C@@]23CC[C@]4(CC[C@@H](C)[C@H](C)[C@H]4C2=CC[C@@H]2[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC[C@@]32C)C(O)=O)ccc1O
Show InChI InChI=1S/C40H56O6/c1-24-14-19-39(35(44)45)20-21-40(23-27(41)10-8-26-9-12-29(42)30(22-26)46-7)28(34(39)25(24)2)11-13-32-37(5)17-16-33(43)36(3,4)31(37)15-18-38(32,40)6/h8-12,22,24-25,31-34,42-43H,13-21,23H2,1-7H3,(H,44,45)/t24-,25+,31+,32-,33+,34+,37+,38-,39+,40+/m1/s1
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n/an/a 1.43E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM114270
PNG
(4-methoxybenzyl 1H-1,2,4-triazol-3-yl sulfone | 5-...)
Show SMILES COc1ccc(CS(=O)(=O)c2nnc[nH]2)cc1
Show InChI InChI=1S/C10H11N3O3S/c1-16-9-4-2-8(3-5-9)6-17(14,15)10-11-7-12-13-10/h2-5,7H,6H2,1H3,(H,11,12,13)
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n/an/a 1.55E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM114266
PNG
(3,3'-[(5-bromo-3-ethoxy-2-hydroxyphenyl)methyl...)
Show SMILES CCOc1cc(Br)cc(C(c2c([nH]c3ccccc23)C(O)=O)c2c([nH]c3ccccc23)C(O)=O)c1O
Show InChI InChI=1S/C27H21BrN2O6/c1-2-36-19-12-13(28)11-16(25(19)31)20(21-14-7-3-5-9-17(14)29-23(21)26(32)33)22-15-8-4-6-10-18(15)30-24(22)27(34)35/h3-12,20,29-31H,2H2,1H3,(H,32,33)(H,34,35)
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n/an/a 1.86E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM53380
PNG
(MLS001332477 | SMR000857110 | Sennoside A | cid_16...)
Show SMILES OC[C@H]1OC(Oc2cccc3[C@@H]([C@@H]4c5cccc(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c5c(O)cc(cc45)C(O)=O)c4cc(cc(O)c4C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42?/m1/s1
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n/an/a 1.88E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50451248
PNG
(CHEMBL2368948)
Show SMILES CCCCCCCCCCCCCCCCCCOC[C@H](COP(O)(=O)O[C@@H]1[C@H](O)C[C@@H](O)[C@H](O)[C@@H]1O)OC
Show InChI InChI=1S/C28H57O10P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-36-21-23(35-2)22-37-39(33,34)38-28-25(30)20-24(29)26(31)27(28)32/h23-32H,3-22H2,1-2H3,(H,33,34)/t23-,24-,25-,26+,27+,28-/m1/s1
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n/an/a 1.99E+4n/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens)
BDBM50647
PNG
(2,3,4,5-tetrahydroxy-6-benzo[7]annulenone | 2,3,4,...)
Show SMILES Oc1cc2cccc(=O)c(O)c2c(O)c1O
Show InChI InChI=1S/C11H8O5/c12-6-3-1-2-5-4-7(13)10(15)11(16)8(5)9(6)14/h1-4,13,15-16H,(H,12,14)
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n/an/a 2.09E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269156
PNG
(3-beta-hydroxy-27-p-(E)-coumaroyloxyolean-12-en-28...)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(CC(=O)C=Cc4ccc(O)cc4)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-34(2)19-20-38(33(43)44)21-22-39(23-27(41)12-9-25-7-10-26(40)11-8-25)28(29(38)24-34)13-14-31-36(5)17-16-32(42)35(3,4)30(36)15-18-37(31,39)6/h7-13,29-32,40,42H,14-24H2,1-6H3,(H,43,44)/t29-,30-,31+,32-,36-,37+,38-,39-/m0/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C


(Bacillus cereus)
BDBM50332098
PNG
(2-(N-(benzyloxy)-2-(tert-butyloxycarbonylamino)hex...)
Show SMILES CCCCCCCCCCCCCCC(NC(=O)OC(C)(C)C)C(=O)N(CC[N+](C)(C)C)OCc1ccccc1
Show InChI InChI=1S/C33H59N3O4/c1-8-9-10-11-12-13-14-15-16-17-18-22-25-30(34-32(38)40-33(2,3)4)31(37)35(26-27-36(5,6)7)39-28-29-23-20-19-21-24-29/h19-21,23-24,30H,8-18,22,25-28H2,1-7H3/p+1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Institute of Advance Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of Bacillus cereus phosphatidylcholine preferred phospholipase C after 100 seconds


Citation and Details
More data for this
Ligand-Target Pair
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