BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 14 hits Enz. Inhib. hit(s) with Target = 'Phospholipase C-gamma-2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256872
PNG
(7-nitro-N-phenethyl-1H-indole-2-carboxamide | CHEM...)
Show SMILES [O-][N+](=O)c1cccc2cc([nH]c12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C17H15N3O3/c21-17(18-10-9-12-5-2-1-3-6-12)14-11-13-7-4-8-15(20(22)23)16(13)19-14/h1-8,11,19H,9-10H2,(H,18,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256873
PNG
(CHEMBL475790 | N-(4-chlorophenyl)-7-nitro-1H-indol...)
Show SMILES [O-][N+](=O)c1cccc2cc([nH]c12)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C15H10ClN3O3/c16-10-4-6-11(7-5-10)17-15(20)12-8-9-2-1-3-13(19(21)22)14(9)18-12/h1-8,18H,(H,17,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256870
PNG
(5-(3-chlorophenyl)-3-(5-(isoxazol-3-yl)thiophen-2-...)
Show SMILES Clc1cccc(c1)-c1nc(no1)-c1ccc(s1)-c1ccon1
Show InChI InChI=1S/C15H8ClN3O2S/c16-10-3-1-2-9(8-10)15-17-14(19-21-15)13-5-4-12(22-13)11-6-7-20-18-11/h1-8H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256803
PNG
(4-chloro-N-(4-oxo-4H-benzo[d][1,3]thiazin-2-yl)ben...)
Show SMILES Clc1ccc(cc1)C(=O)Nc1nc2ccccc2c(=O)s1
Show InChI InChI=1S/C15H9ClN2O2S/c16-10-7-5-9(6-8-10)13(19)18-15-17-12-4-2-1-3-11(12)14(20)21-15/h1-8H,(H,17,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256871
PNG
(5-(5-nitrothiophen-3-yl)-3-(pyridin-2-yl)-1,2,4-ox...)
Show SMILES [O-][N+](=O)c1cc(cs1)-c1nc(no1)-c1ccccn1
Show InChI InChI=1S/C11H6N4O3S/c16-15(17)9-5-7(6-19-9)11-13-10(14-18-11)8-3-1-2-4-12-8/h1-6H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256801
PNG
(4-((5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benz...)
Show SMILES O=C1OC(=N\C1=C\c1ccc(cc1)C#N)c1ccccc1
Show InChI InChI=1S/C17H10N2O2/c18-11-13-8-6-12(7-9-13)10-15-17(20)21-16(19-15)14-4-2-1-3-5-14/h1-10H/b15-10+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256804
PNG
(3-(2,2-dimethylchroman-6-yl)-1-(4-methoxyphenylsul...)
Show SMILES COc1ccc(cc1)S(=O)(=O)n1ccc(n1)-c1ccc2OC(C)(C)CCc2c1
Show InChI InChI=1S/C21H22N2O4S/c1-21(2)12-10-16-14-15(4-9-20(16)27-21)19-11-13-23(22-19)28(24,25)18-7-5-17(26-3)6-8-18/h4-9,11,13-14H,10,12H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256875
PNG
(6-(4-methoxyphenyl)-3-phenylthieno[2,3-e][1,2,4]tr...)
Show SMILES COc1ccc(cc1)-c1cc2nnc(nc2s1)-c1ccccc1
Show InChI InChI=1S/C18H13N3OS/c1-22-14-9-7-12(8-10-14)16-11-15-18(23-16)19-17(21-20-15)13-5-3-2-4-6-13/h2-11H,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256874
PNG
(CHEMBL475466 | N-(benzo[d]thiazol-2-yl)-5-methoxy-...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)Nc1nc2ccccc2s1
Show InChI InChI=1S/C17H13N3O2S/c1-22-11-6-7-12-10(8-11)9-14(18-12)16(21)20-17-19-13-4-2-3-5-15(13)23-17/h2-9,18H,1H3,(H,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50066433
PNG
(CHEMBL112884 | Hexadecanoic acid (R)-2-[(3-fluoro-...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC1C(O)C(O)C(O)C(F)C1O)OC(=O)CCCCCCCCCCCCCCC
Show InChI InChI=1S/C41H78FO12P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(43)51-31-33(32-52-55(49,50)54-41-38(46)36(42)37(45)39(47)40(41)48)53-35(44)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h33,36-41,45-48H,3-32H2,1-2H3,(H,49,50)/t33-,36?,37?,38?,39?,40?,41?/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)


J Med Chem 41: 3303-6 (1998)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256805
PNG
(1-(2-Chloro-benzoyl)-3-(1,1-dioxo-1H-1lambda*6*-be...)
Show SMILES Clc1ccccc1C(=O)NC(=O)Nc1ccc2C=CS(=O)(=O)c2c1
Show InChI InChI=1S/C16H11ClN2O4S/c17-13-4-2-1-3-12(13)15(20)19-16(21)18-11-6-5-10-7-8-24(22,23)14(10)9-11/h1-9H,(H2,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 9.50E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50066431
PNG
(((S)-3-Methoxy-4-octadecyloxy-butyl)-phosphonic ac...)
Show SMILES CCCCCCCCCCCCCCCCCCOC[C@H](CCP(O)(=O)OC1C(O)CC(O)C(O)C1O)OC
Show InChI InChI=1S/C29H59O9P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-37-23-24(36-2)19-21-39(34,35)38-29-26(31)22-25(30)27(32)28(29)33/h24-33H,3-23H2,1-2H3,(H,34,35)/t24-,25?,26?,27?,28?,29?/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)


J Med Chem 41: 3303-6 (1998)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50256819
PNG
(2-(4-nitrophenyl)-4-(thiophen-2-ylmethylene)oxazol...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1=N\C(=C\c2cccs2)C(=O)O1
Show InChI InChI=1S/C14H8N2O4S/c17-14-12(8-11-2-1-7-21-11)15-13(20-14)9-3-5-10(6-4-9)16(18)19/h1-8H/b12-8+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...


Bioorg Med Chem 17: 3169-76 (2009)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-2


(Homo sapiens)
BDBM50451248
PNG
(CHEMBL2368948)
Show SMILES CCCCCCCCCCCCCCCCCCOC[C@H](COP(O)(=O)O[C@@H]1[C@H](O)C[C@@H](O)[C@H](O)[C@@H]1O)OC
Show InChI InChI=1S/C28H57O10P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-36-21-23(35-2)22-37-39(33,34)38-28-25(30)20-24(29)26(31)27(28)32/h23-32H,3-22H2,1-2H3,(H,33,34)/t23-,24-,25-,26+,27+,28-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.99E+4n/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)


J Med Chem 41: 3303-6 (1998)

More data for this
Ligand-Target Pair