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Compile Data Set for Download or QSAR

Found 29 hits Enz. Inhib. hit(s) with Target = 'Plasmepsin V'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099406
PNG
(CHEMBL3344272)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1)C(C)C)[C@@H](O)CC(=O)NCCc1ccccc1
Show InChI InChI=1/C34H53N7O6S.C2HF3O2/c1-23(2)20-28(29(42)21-30(43)37-19-17-25-12-7-5-8-13-25)39-33(45)31(24(3)4)40-32(44)27(16-11-18-38-34(35)36)41-48(46,47)22-26-14-9-6-10-15-26;3-2(4,5)1(6)7/h5-10,12-15,23-24,27-29,31,41-42H,11,16-22H2,1-4H3,(H,37,43)(H,39,45)(H,40,44)(H4,35,36,38);(H,6,7)/t27-,28-,29-,31-;/s2
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n/an/a 19n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium vivax)
BDBM50099406
PNG
(CHEMBL3344272)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1)C(C)C)[C@@H](O)CC(=O)NCCc1ccccc1
Show InChI InChI=1/C34H53N7O6S.C2HF3O2/c1-23(2)20-28(29(42)21-30(43)37-19-17-25-12-7-5-8-13-25)39-33(45)31(24(3)4)40-32(44)27(16-11-18-38-34(35)36)41-48(46,47)22-26-14-9-6-10-15-26;3-2(4,5)1(6)7/h5-10,12-15,23-24,27-29,31,41-42H,11,16-22H2,1-4H3,(H,37,43)(H,39,45)(H,40,44)(H4,35,36,38);(H,6,7)/t27-,28-,29-,31-;/s2
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n/an/a 24n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium vivax plasmepsin V by fluorogenic PEXEL cleavage assay


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099378
PNG
(CHEMBL3344165)
Show SMILES OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1S/C6H13O3S.HI/c1-10-3-4(8)6(9)5(10)2-7;/h4-9H,2-3H2,1H3;1H/q+1;/p-1/t4-,5-,6+,10?;/m1./s1
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n/an/a 26n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099272
PNG
(CHEMBL3344164)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)C(C)C)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1S/C29H30N2/c1-3-9-21(10-4-1)17-18-31-24-15-16-25(31)20-23(19-24)28-26-13-7-8-14-27(26)30-29(28)22-11-5-2-6-12-22/h1-14,23-25,30H,15-20H2/t23?,24-,25?/m1/s1
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n/an/a 29n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099380
PNG
(CHEMBL3344166)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1S/C8H16O6S2/c9-5-8(14-16(11,12)13)7(10)6-15-3-1-2-4-15/h7-10H,1-6H2/t7-,8+/m0/s1
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n/an/a 77n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099381
PNG
(CHEMBL3344261)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1S/C9H18O9S2/c10-1-7(18-20(15,16)17)5(12)3-19-4-6(13)9(14)8(19)2-11/h5-14H,1-4H2/t5-,6?,7+,8?,9?,19?/m1/s1
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n/an/a 230n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099391
PNG
(CHEMBL3344266)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NCCc1ccc(Cl)cc1
Show InChI InChI=1/C33H48ClN7O6.C2HF3O2/c1-21(2)18-27(28(42)19-29(43)37-17-15-23-11-13-25(34)14-12-23)40-30(44)22(3)39-31(45)26(10-7-16-38-32(35)36)41-33(46)47-20-24-8-5-4-6-9-24;3-2(4,5)1(6)7/h4-6,8-9,11-14,21-22,26-28,42H,7,10,15-20H2,1-3H3,(H,37,43)(H,39,45)(H,40,44)(H,41,46)(H4,35,36,38);(H,6,7)/t22-,26-,27-,28-;/s2
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n/an/a 348n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099395
PNG
(CHEMBL3344270)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccccc1)[C@@H](O)CC(=O)NCCc1ccccc1
Show InChI InChI=1/C31H47N7O6S.C2HF3O2/c1-21(2)19-26(27(39)20-28(40)34-18-16-23-11-6-4-7-12-23)37-29(41)22(3)36-30(42)25(15-10-17-35-31(32)33)38-45(43,44)24-13-8-5-9-14-24;3-2(4,5)1(6)7/h4-9,11-14,21-22,25-27,38-39H,10,15-20H2,1-3H3,(H,34,40)(H,36,42)(H,37,41)(H4,32,33,35);(H,6,7)/t22-,25-,26-,27-;/s2
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n/an/a 378n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099387
PNG
(CHEMBL3344262)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NCc1ccccc1
Show InChI InChI=1/C32H47N7O6.C2HF3O2/c1-21(2)17-26(27(40)18-28(41)36-19-23-11-6-4-7-12-23)38-29(42)22(3)37-30(43)25(15-10-16-35-31(33)34)39-32(44)45-20-24-13-8-5-9-14-24;3-2(4,5)1(6)7/h4-9,11-14,21-22,25-27,40H,10,15-20H2,1-3H3,(H,36,41)(H,37,43)(H,38,42)(H,39,44)(H4,33,34,35);(H,6,7)/t22-,25-,26-,27-;/s2
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n/an/a 530n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099394
PNG
(CHEMBL3344269)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)COCc1ccccc1)[C@@H](O)CC(=O)NCCc1ccccc1
Show InChI InChI=1/C34H51N7O6.C2HF3O2/c1-23(2)19-28(29(42)20-30(43)37-18-16-25-11-6-4-7-12-25)41-32(45)24(3)39-33(46)27(15-10-17-38-34(35)36)40-31(44)22-47-21-26-13-8-5-9-14-26;3-2(4,5)1(6)7/h4-9,11-14,23-24,27-29,42H,10,15-22H2,1-3H3,(H,37,43)(H,39,46)(H,40,44)(H,41,45)(H4,35,36,38);(H,6,7)/t24-,27-,28-,29-;/s2
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n/an/a 550n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099148
PNG
(CHEMBL3344151)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](O)CC(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1/C24H45N9O7/c1-12(2)10-17(18(35)11-20(37)32-15(21(26)38)7-8-19(25)36)33-22(39)13(3)30-23(40)16(31-14(4)34)6-5-9-29-24(27)28/h12-13,15-18,35H,5-11H2,1-4H3,(H2,25,36)(H2,26,38)(H,30,40)(H,31,34)(H,32,37)(H,33,39)(H4,27,28,29)/t13-,15-,16-,17-,18-/s2
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n/an/a 556n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099390
PNG
(CHEMBL3344265)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC(C)c1ccccc1
Show InChI InChI=1/C33H49N7O6.C2HF3O2/c1-21(2)18-27(28(41)19-29(42)37-22(3)25-14-9-6-10-15-25)39-30(43)23(4)38-31(44)26(16-11-17-36-32(34)35)40-33(45)46-20-24-12-7-5-8-13-24;3-2(4,5)1(6)7/h5-10,12-15,21-23,26-28,41H,11,16-20H2,1-4H3,(H,37,42)(H,38,44)(H,39,43)(H,40,45)(H4,34,35,36);(H,6,7)/t22?,23-,26-,27-,28-;/s2
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n/an/a 569n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099171
PNG
(CHEMBL3344152)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](O)CC(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1/C22H42N8O6.C2HF3O2/c1-11(2)9-16(17(32)10-18(33)27-12(3)19(23)34)30-20(35)13(4)28-21(36)15(29-14(5)31)7-6-8-26-22(24)25;3-2(4,5)1(6)7/h11-13,15-17,32H,6-10H2,1-5H3,(H2,23,34)(H,27,33)(H,28,36)(H,29,31)(H,30,35)(H4,24,25,26);(H,6,7)/t12-,13-,15-,16-,17-;/s2
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The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099240
PNG
(CHEMBL3344157)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1S/C11H13ClN3O5P/c12-6-1-2-9-8(3-6)14-10(4-7(13)11(16)17)15(9)5-21(18,19)20/h1-3,7H,4-5,13H2,(H,16,17)(H2,18,19,20)/t7-/m1/s1
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n/an/a 614n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099388
PNG
(CHEMBL3344263)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NCCc1ccccc1
Show InChI InChI=1/C33H49N7O6.C2HF3O2/c1-22(2)19-27(28(41)20-29(42)36-18-16-24-11-6-4-7-12-24)39-30(43)23(3)38-31(44)26(15-10-17-37-32(34)35)40-33(45)46-21-25-13-8-5-9-14-25;3-2(4,5)1(6)7/h4-9,11-14,22-23,26-28,41H,10,15-21H2,1-3H3,(H,36,42)(H,38,44)(H,39,43)(H,40,45)(H4,34,35,37);(H,6,7)/t23-,26-,27-,28-;/s2
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n/an/a 622n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099403
PNG
(CHEMBL3344271)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1)[C@@H](O)CC(=O)NCCc1ccccc1
Show InChI InChI=1/C32H49N7O6S.C2HF3O2/c1-22(2)19-27(28(40)20-29(41)35-18-16-24-11-6-4-7-12-24)38-30(42)23(3)37-31(43)26(15-10-17-36-32(33)34)39-46(44,45)21-25-13-8-5-9-14-25;3-2(4,5)1(6)7/h4-9,11-14,22-23,26-28,39-40H,10,15-21H2,1-3H3,(H,35,41)(H,37,43)(H,38,42)(H4,33,34,36);(H,6,7)/t23-,26-,27-,28-;/s2
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n/an/a 625n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099389
PNG
(CHEMBL3344264)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1Cc2ccccc2C1
Show InChI InChI=1/C34H49N7O6.C2HF3O2/c1-21(2)16-28(29(42)19-30(43)39-26-17-24-12-7-8-13-25(24)18-26)40-31(44)22(3)38-32(45)27(14-9-15-37-33(35)36)41-34(46)47-20-23-10-5-4-6-11-23;3-2(4,5)1(6)7/h4-8,10-13,21-22,26-29,42H,9,14-20H2,1-3H3,(H,38,45)(H,39,43)(H,40,44)(H,41,46)(H4,35,36,37);(H,6,7)/t22-,27-,28-,29-;/s2
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n/an/a 772n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099393
PNG
(CHEMBL3344268)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)c1ccccc1)[C@@H](O)CC(=O)NCCc1ccccc1
Show InChI InChI=1/C32H47N7O5.C2HF3O2/c1-21(2)19-26(27(40)20-28(41)35-18-16-23-11-6-4-7-12-23)39-29(42)22(3)37-31(44)25(15-10-17-36-32(33)34)38-30(43)24-13-8-5-9-14-24;3-2(4,5)1(6)7/h4-9,11-14,21-22,25-27,40H,10,15-20H2,1-3H3,(H,35,41)(H,37,44)(H,38,43)(H,39,42)(H4,33,34,36);(H,6,7)/t22-,25-,26-,27-;/s2
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n/an/a 774n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099236
PNG
(CHEMBL3344153)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](O)CC(=O)NCCCC(N)=O
Show InChI InChI=1/C23H44N8O6.C2HF3O2/c1-13(2)11-17(18(33)12-20(35)27-9-6-8-19(24)34)31-21(36)14(3)29-22(37)16(30-15(4)32)7-5-10-28-23(25)26;3-2(4,5)1(6)7/h13-14,16-18,33H,5-12H2,1-4H3,(H2,24,34)(H,27,35)(H,29,37)(H,30,32)(H,31,36)(H4,25,26,28);(H,6,7)/t14-,16-,17-,18-;/s2
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n/an/a 865n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099237
PNG
(CHEMBL3344154)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1/C25H47N7O5.C2HF3O2/c1-15(2)13-20(21(34)14-22(35)31-18-9-6-5-7-10-18)32-23(36)16(3)29-24(37)19(30-17(4)33)11-8-12-28-25(26)27;3-2(4,5)1(6)7/h15-16,18-21,34H,5-14H2,1-4H3,(H,29,37)(H,30,33)(H,31,35)(H,32,36)(H4,26,27,28);(H,6,7)/t16-,19-,20-,21-;/s2
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n/an/a 967n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099392
PNG
(CHEMBL3344267)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)N(C)CCc1ccc(Cl)cc1
Show InChI InChI=1/C34H50ClN7O6.C2HF3O2/c1-22(2)19-28(29(43)20-30(44)42(4)18-16-24-12-14-26(35)15-13-24)40-31(45)23(3)39-32(46)27(11-8-17-38-33(36)37)41-34(47)48-21-25-9-6-5-7-10-25;3-2(4,5)1(6)7/h5-7,9-10,12-15,22-23,27-29,43H,8,11,16-21H2,1-4H3,(H,39,46)(H,40,45)(H,41,47)(H4,36,37,38);(H,6,7)/t23-,27-,28-,29-;/s2
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n/an/a 2.01E+3n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099239
PNG
(CHEMBL3344156)
Show SMILES Cl.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1/C31H51N5O6.ClH/c1-21(2)18-26(27(37)19-28(38)34-24-14-8-5-9-15-24)35-29(39)22(3)33-30(40)25(16-10-11-17-32)36-31(41)42-20-23-12-6-4-7-13-23;/h4,6-7,12-13,21-22,24-27,37H,5,8-11,14-20,32H2,1-3H3,(H,33,40)(H,34,38)(H,35,39)(H,36,41);1H/t22-,25-,26-,27-;/s2
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099241
PNG
(CHEMBL3344158)
Show SMILES OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1/C32H53N7O6.C2HF3O2/c1-21(2)18-26(27(40)19-28(41)37-24-14-8-5-9-15-24)38-29(42)22(3)36-30(43)25(16-10-11-17-35-31(33)34)39-32(44)45-20-23-12-6-4-7-13-23;3-2(4,5)1(6)7/h4,6-7,12-13,21-22,24-27,40H,5,8-11,14-20H2,1-3H3,(H,36,43)(H,37,41)(H,38,42)(H,39,44)(H4,33,34,35);(H,6,7)/t22-,25-,26-,27-;/s2
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099238
PNG
(CHEMBL3344155)
Show SMILES Cl.CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCN)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1/C30H49N5O6.ClH/c1-20(2)17-25(26(36)18-27(37)33-23-13-8-5-9-14-23)34-28(38)21(3)32-29(39)24(15-10-16-31)35-30(40)41-19-22-11-6-4-7-12-22;/h4,6-7,11-12,20-21,23-26,36H,5,8-10,13-19,31H2,1-3H3,(H,32,39)(H,33,37)(H,34,38)(H,35,40);1H/t21-,24-,25-,26-;/s2
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099249
PNG
(CHEMBL3344162)
Show SMILES OC(=O)C(F)(F)F.C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1/C34H49N7O6.C2HF3O2/c1-23(38-32(45)27(18-11-19-37-33(35)36)41-34(46)47-22-25-14-7-3-8-15-25)31(44)40-28(20-24-12-5-2-6-13-24)29(42)21-30(43)39-26-16-9-4-10-17-26;3-2(4,5)1(6)7/h2-3,5-8,12-15,23,26-29,42H,4,9-11,16-22H2,1H3,(H,38,45)(H,39,43)(H,40,44)(H,41,46)(H4,35,36,37);(H,6,7)/t23-,27-,28-,29-;/s2
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099247
PNG
(CHEMBL3344161)
Show SMILES OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1/C31H51N7O6.C2HF3O2/c1-4-20(2)27(25(39)18-26(40)36-23-14-9-6-10-15-23)38-28(41)21(3)35-29(42)24(16-11-17-34-30(32)33)37-31(43)44-19-22-12-7-5-8-13-22;3-2(4,5)1(6)7/h5,7-8,12-13,20-21,23-25,27,39H,4,6,9-11,14-19H2,1-3H3,(H,35,42)(H,36,40)(H,37,43)(H,38,41)(H4,32,33,34);(H,6,7)/t20-,21-,24-,25-,27-;/s2
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099243
PNG
(CHEMBL3344160)
Show SMILES OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1/C30H49N7O6.C2HF3O2/c1-19(2)26(24(38)17-25(39)35-22-13-8-5-9-14-22)37-27(40)20(3)34-28(41)23(15-10-16-33-29(31)32)36-30(42)43-18-21-11-6-4-7-12-21;3-2(4,5)1(6)7/h4,6-7,11-12,19-20,22-24,26,38H,5,8-10,13-18H2,1-3H3,(H,34,41)(H,35,39)(H,36,42)(H,37,40)(H4,31,32,33);(H,6,7)/t20-,23-,24-,26-;/s2
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099242
PNG
(CHEMBL3344159)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCc1ccccc1)NC(=O)OCc1ccccc1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1/C35H50N4O6/c1-24(2)21-30(31(40)22-32(41)37-28-17-11-6-12-18-28)38-33(42)25(3)36-34(43)29(20-19-26-13-7-4-8-14-26)39-35(44)45-23-27-15-9-5-10-16-27/h4-5,7-10,13-16,24-25,28-31,40H,6,11-12,17-23H2,1-3H3,(H,36,43)(H,37,41)(H,38,42)(H,39,44)/t25-,29-,30-,31-/s2
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair
Plasmepsin V


(Plasmodium falciparum (isolate 3D7))
BDBM50099252
PNG
(CHEMBL3344163)
Show SMILES OC(=O)C(F)(F)F.C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(=O)NC1CCCCC1
Show InChI InChI=1/C34H55N7O6.C2HF3O2/c1-23(38-32(45)27(18-11-19-37-33(35)36)41-34(46)47-22-25-14-7-3-8-15-25)31(44)40-28(20-24-12-5-2-6-13-24)29(42)21-30(43)39-26-16-9-4-10-17-26;3-2(4,5)1(6)7/h3,7-8,14-15,23-24,26-29,42H,2,4-6,9-13,16-22H2,1H3,(H,38,45)(H,39,43)(H,40,44)(H,41,46)(H4,35,36,37);(H,6,7)/t23-,27-,28-,29-;/s2
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville 3052, Victoria, Australia.

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate


Citation and Details
More data for this
Ligand-Target Pair