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Compile Data Set for Download or QSAR

Found 1893 hits Enz. Inhib. hit(s) with Target = 'Plasminogen'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen


(Homo sapiens (human))
BDBM50120225
PNG
(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Show SMILES CC(O)C(N(C)C(=O)C(Cc1ccc(cc1)[N+]([O-])=O)NC(=O)CCC[N-]C(N)=[NH2+])C(=O)NC(C)c1ccccc1
Show InChI InChI=1S/C27H37N7O6/c1-17(20-8-5-4-6-9-20)31-25(37)24(18(2)35)33(3)26(38)22(32-23(36)10-7-15-30-27(28)29)16-19-11-13-21(14-12-19)34(39)40/h4-6,8-9,11-14,17-18,22,24,35H,7,10,15-16H2,1-3H3,(H6,28,29,30,31,32,36,37)
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n/an/a 0.230n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration of the compound required to inhibit Plasmin was determined


Bioorg Med Chem Lett 12: 3183-6 (2002)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093542
PNG
(CHEMBL3585742)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(F)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1/C25H26FN7O3/c1-31-21-12-16(24(35)29-18(13-28)4-2-3-11-27)5-10-20(21)30-22(31)14-33-23(34)15-32(25(33)36)19-8-6-17(26)7-9-19/h5-10,12,18H,2-4,11,14-15,27H2,1H3,(H,29,35)/t18-/s2
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n/an/a 1n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093543
PNG
(CHEMBL3585747)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)nc2cc(ccc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1/C31H31N7O4/c1-36-27-15-10-21(30(40)34-22(18-33)7-5-6-16-32)17-26(27)35-28(36)19-38-29(39)20-37(31(38)41)23-11-13-25(14-12-23)42-24-8-3-2-4-9-24/h2-4,8-15,17,22H,5-7,16,19-20,32H2,1H3,(H,34,40)/t22-/s2
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093545
PNG
(CHEMBL3585743)
Show SMILES NCCCC[C@H](NC(=O)c1nc2cc(CN3C(=O)CN(C3=O)c3ccc(F)cc3)ccc2o1)C#N
Show InChI InChI=1/C24H23FN6O4/c25-16-5-7-18(8-6-16)30-14-21(32)31(24(30)34)13-15-4-9-20-19(11-15)29-23(35-20)22(33)28-17(12-27)3-1-2-10-26/h4-9,11,17H,1-3,10,13-14,26H2,(H,28,33)/t17-/s2
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093546
PNG
(CHEMBL3585741)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc3n(Cc4ccncc4)c(=O)oc3c2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1/C31H30N10O5/c1-38-23(12-20-15-35-27(37-28(20)38)29(43)36-21(14-33)4-2-3-9-32)17-41-26(42)18-39(30(41)44)22-5-6-24-25(13-22)46-31(45)40(24)16-19-7-10-34-11-8-19/h5-8,10-13,15,21H,2-4,9,16-18,32H2,1H3,(H,36,43)/t21-/s2
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093547
PNG
(CHEMBL3585740)
Show SMILES CC(C)Cn1c2ccc(cc2oc1=O)N1CC(=O)N(Cc2cc3cnc(nc3n2C)C(=O)N[C@@H](CCCCN)C#N)C1=O
Show InChI InChI=1/C29H33N9O5/c1-17(2)14-37-22-8-7-20(11-23(22)43-29(37)42)36-16-24(39)38(28(36)41)15-21-10-18-13-32-25(34-26(18)35(21)3)27(40)33-19(12-31)6-4-5-9-30/h7-8,10-11,13,17,19H,4-6,9,14-16,30H2,1-3H3,(H,33,40)/t19-/s2
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM92479
PNG
(Tannic Acid, A)
Show SMILES Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OCC1OC(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)C(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)C(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)C1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1
Show InChI InChI=1S/C76H52O46/c77-32-1-22(2-33(78)53(32)92)67(103)113-47-16-27(11-42(87)58(47)97)66(102)112-21-52-63(119-72(108)28-12-43(88)59(98)48(17-28)114-68(104)23-3-34(79)54(93)35(80)4-23)64(120-73(109)29-13-44(89)60(99)49(18-29)115-69(105)24-5-36(81)55(94)37(82)6-24)65(121-74(110)30-14-45(90)61(100)50(19-30)116-70(106)25-7-38(83)56(95)39(84)8-25)76(118-52)122-75(111)31-15-46(91)62(101)51(20-31)117-71(107)26-9-40(85)57(96)41(86)10-26/h1-20,52,63-65,76-101H,21H2
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n/an/a 7n/an/an/an/a7.823



University of Michigan



Assay Description
Enzyme activity assay using human and murine PAI-1.


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM50132855
PNG
(1-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OCC(=O)Nc1cc(ccc1[N+]([O-])=O)N1CCC(CC1)C(O)=O
Show InChI InChI=1S/C24H35N3O6/c1-15(2)19-6-4-16(3)12-22(19)33-14-23(28)25-20-13-18(5-7-21(20)27(31)32)26-10-8-17(9-11-26)24(29)30/h5,7,13,15-17,19,22H,4,6,8-12,14H2,1-3H3,(H,25,28)(H,29,30)/t16-,19+,22-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assay


Bioorg Med Chem Lett 13: 3361-5 (2003)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM175527
PNG
(US9120744, CDE-003)
Show SMILES Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33+,34+,35-,41-/s2
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US Patent
n/an/a 10n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...


US Patent US9120744 (2015)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM175526
PNG
(US9120744, CDE-002)
Show SMILES Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33-,34+,35+,41+/s2
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US Patent
n/an/a 10n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...


US Patent US9120744 (2015)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM92485
PNG
(CDE-066 | US9120744, CDE-066)
Show SMILES Oc1cc(cc(O)c1O)C(=O)OC[C@H]1OC(OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33+,34+,35-,41?/m1/s1
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n/an/a 10n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...


US Patent US9120744 (2015)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50124990
PNG
(CHEMBL355376 | N-[4-Guanidino-1-(thiazole-2-carbon...)
Show SMILES NC(=N)NCCCC(NC(=O)CN1CCN(CC1=O)S(=O)(=O)c1cccc2cccnc12)C(=O)c1nccs1
Show InChI InChI=1S/C24H28N8O5S2/c25-24(26)29-9-3-6-17(22(35)23-28-10-13-38-23)30-19(33)14-31-11-12-32(15-20(31)34)39(36,37)18-7-1-4-16-5-2-8-27-21(16)18/h1-2,4-5,7-8,10,13,17H,3,6,9,11-12,14-15H2,(H,30,33)(H4,25,26,29)
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n/an/a 10n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Plasmin


Bioorg Med Chem Lett 13: 723-8 (2003)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM50132862
PNG
(4-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OCC(=O)Nc1cc(Oc2ccc(cc2)C(O)=O)ccc1[N+]([O-])=O
Show InChI InChI=1S/C25H30N2O7/c1-15(2)20-10-4-16(3)12-23(20)33-14-24(28)26-21-13-19(9-11-22(21)27(31)32)34-18-7-5-17(6-8-18)25(29)30/h5-9,11,13,15-16,20,23H,4,10,12,14H2,1-3H3,(H,26,28)(H,29,30)/t16-,20+,23-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assay


Bioorg Med Chem Lett 13: 3361-5 (2003)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM175528
PNG
(US9120744, CDE-004)
Show SMILES Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33+,34+,35-,41+/s2
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US Patent
n/an/a 10n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...


US Patent US9120744 (2015)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM175525
PNG
(US9120744, CDE-001 (or 073))
Show SMILES Oc1cc(cc(O)c1O)C(=O)OC[C@H]1OC(OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33-,34+,35-,41?/s2
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n/an/a 10n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...


US Patent US9120744 (2015)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093549
PNG
(CHEMBL3585738)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc3n(C)c(=O)oc3c2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1/C26H27N9O5/c1-32-18(9-15-12-29-22(31-23(15)32)24(37)30-16(11-28)5-3-4-8-27)13-35-21(36)14-34(25(35)38)17-6-7-19-20(10-17)40-26(39)33(19)2/h6-7,9-10,12,16H,3-5,8,13-14,27H2,1-2H3,(H,30,37)/t16-/s2
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n/an/a 13n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50009200
PNG
(CHEMBL3238374)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C30H30N8O4/c1-36-23(15-20-17-33-27(35-28(20)36)29(40)34-21(16-32)7-5-6-14-31)18-38-26(39)19-37(30(38)41)22-10-12-25(13-11-22)42-24-8-3-2-4-9-24/h2-4,8-13,15,17,21H,5-7,14,18-19,31H2,1H3,(H,34,40)/t21-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50291006
PNG
(4-[2-(1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarb...)
Show SMILES COC(=O)C[C@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCCC1C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C23H34N6O7S/c1-36-19(30)13-17(27-37(34,35)14-15-7-3-2-4-8-15)22(33)28-11-6-10-18(28)20(31)26-16-9-5-12-29(21(16)32)23(24)25/h2-4,7-8,16-18,21,27,32H,5-6,9-14H2,1H3,(H3,24,25)(H,26,31)/t16-,17-,18?,21?/m0/s1
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro for the inhibitory concentration required to inhibit human serine protease enzyme plasmin by 50%


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093548
PNG
(CHEMBL3585739)
Show SMILES CCCn1c2ccc(cc2oc1=O)N1CC(=O)N(Cc2cc3cnc(nc3n2C)C(=O)N[C@@H](CCCCN)C#N)C1=O
Show InChI InChI=1/C28H31N9O5/c1-3-10-35-21-8-7-19(12-22(21)42-28(35)41)36-16-23(38)37(27(36)40)15-20-11-17-14-31-24(33-25(17)34(20)2)26(39)32-18(13-30)6-4-5-9-29/h7-8,11-12,14,18H,3-6,9-10,15-16,29H2,1-2H3,(H,32,39)/t18-/s2
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n/an/a 16n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093550
PNG
(CHEMBL3585737)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc3oc(=O)n(Cc4ccncc4)c3c2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1/C31H30N10O5/c1-38-23(12-20-15-35-27(37-28(20)38)29(43)36-21(14-33)4-2-3-9-32)17-41-26(42)18-39(30(41)44)22-5-6-25-24(13-22)40(31(45)46-25)16-19-7-10-34-11-8-19/h5-8,10-13,15,21H,2-4,9,16-18,32H2,1H3,(H,36,43)/t21-/s2
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n/an/a 23n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093544
PNG
(CHEMBL3585744)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1/C31H31N7O4/c1-36-27-17-21(30(40)34-22(18-33)7-5-6-16-32)10-15-26(27)35-28(36)19-38-29(39)20-37(31(38)41)23-11-13-25(14-12-23)42-24-8-3-2-4-9-24/h2-4,8-15,17,22H,5-7,16,19-20,32H2,1H3,(H,34,40)/t22-/s2
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n/an/a 25n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50228863
PNG
((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Show SMILES CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O
Show InChI InChI=1S/C21H32N6O3/c1-24-17(13-15-7-3-2-4-8-15)20(30)27-12-6-10-18(27)19(29)26-16(14-28)9-5-11-25-21(22)23/h2-4,7-8,14,16-18,24H,5-6,9-13H2,1H3,(H,26,29)(H4,22,23,25)/t16-,17+,18-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration of the compound required to inhibit Plasmin was determined


Bioorg Med Chem Lett 12: 3183-6 (2002)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093552
PNG
(CHEMBL3585735)
Show SMILES CCCn1c2cc(ccc2oc1=O)N1CC(=O)N(Cc2cc3cnc(nc3n2C)C(=O)N[C@@H](CCCCN)C#N)C1=O
Show InChI InChI=1/C28H31N9O5/c1-3-10-35-21-12-19(7-8-22(21)42-28(35)41)36-16-23(38)37(27(36)40)15-20-11-17-14-31-24(33-25(17)34(20)2)26(39)32-18(13-30)6-4-5-9-29/h7-8,11-12,14,18H,3-6,9-10,15-16,29H2,1-2H3,(H,32,39)/t18-/s2
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n/an/a 26n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093551
PNG
(CHEMBL3585736)
Show SMILES CC(C)Cn1c2cc(ccc2oc1=O)N1CC(=O)N(Cc2cc3cnc(nc3n2C)C(=O)N[C@@H](CCCCN)C#N)C1=O
Show InChI InChI=1/C29H33N9O5/c1-17(2)14-37-22-11-20(7-8-23(22)43-29(37)42)36-16-24(39)38(28(36)41)15-21-10-18-13-32-25(34-26(18)35(21)3)27(40)33-19(12-31)6-4-5-9-30/h7-8,10-11,13,17,19H,4-6,9,14-16,30H2,1-3H3,(H,33,40)/t19-/s2
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n/an/a 29n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM31487
PNG
(substituted biphenyl derivative, 36aa)
Show SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccsc1
Show InChI InChI=1S/C30H28N4O4S/c1-17(2)15-33-28(35)20-6-10-24(26(14-20)30(37)38)23-9-5-19(21-11-12-39-16-21)13-25(23)29(36)34-22-7-3-18(4-8-22)27(31)32/h3-14,16-17H,15H2,1-2H3,(H3,31,32)(H,33,35)(H,34,36)(H,37,38)
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n/an/a 35n/an/an/an/a7.823



BioCryst Pharmaceuticals



Assay Description
The assay is an amidolytic assay based upon the absorbance of derivatized thiols from the hydrolysis of Z-Lys-SBzl (Bachem) in the presence of 5,5-Di...


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50374312
PNG
(CHEMBL270834)
Show SMILES NC(N)=NCCC[C@@H](NS(=O)(=O)CCc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nc2ccccc2o1
Show InChI InChI=1S/C29H40N10O6S/c30-28(31)34-15-6-11-21(25(41)27-38-20-10-4-5-13-23(20)45-27)37-24(40)18-36-26(42)22(12-7-16-35-29(32)33)39-46(43,44)17-14-19-8-2-1-3-9-19/h1-5,8-10,13,21-22,39H,6-7,11-12,14-18H2,(H,36,42)(H,37,40)(H4,30,31,34)(H4,32,33,35)/t21-,22+/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50194743
PNG
(CHEMBL214814 | diphenyl 1-[(N-alpha-toluenesulfony...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C34H39N6O8PS/c1-24(37-33(43)30(22-41)40-50(45,46)23-26-11-5-2-6-12-26)32(42)39-31(21-25-17-19-27(20-18-25)38-34(35)36)49(44,47-28-13-7-3-8-14-28)48-29-15-9-4-10-16-29/h2-20,24,30-31,40-41H,21-23H2,1H3,(H,37,43)(H,39,42)(H4,35,36,38)/t24-,30+,31?/m0/s1
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n/an/a 37n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasmin


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50194743
PNG
(CHEMBL214814 | diphenyl 1-[(N-alpha-toluenesulfony...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C34H39N6O8PS/c1-24(37-33(43)30(22-41)40-50(45,46)23-26-11-5-2-6-12-26)32(42)39-31(21-25-17-19-27(20-18-25)38-34(35)36)49(44,47-28-13-7-3-8-14-28)48-29-15-9-4-10-16-29/h2-20,24,30-31,40-41H,21-23H2,1H3,(H,37,43)(H,39,42)(H4,35,36,38)/t24-,30+,31?/m0/s1
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n/an/a 37n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasmin


Citation and Details
More data for this
Ligand-Target Pair
Enolase 1 (ENO1)


(Homo sapiens (Human))
BDBM204924
PNG
(SF2312)
Show SMILES O[C@H]1C[C@@H](C(=O)N1O)P(O)(O)=O
Show InChI InChI=1/C4H8NO6P/c6-3-1-2(12(9,10)11)4(7)5(3)8/h2-3,6,8H,1H2,(H2,9,10,11)/t2-,3-/s2
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n/an/a 37.9n/an/an/an/an/an/a



University of Texas MD Anderson Cancer Center



Assay Description
Enolase activity was measured by two different methods: a fluorometric NADH-linked assay or adirect spectrophotometric assay via formation of PEP. In...


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM50127745
PNG
((E)-3-[3-(4-Chloro-phenoxy)-5,6-bis-(4-phenylsulfa...)
Show SMILES OC(=O)C(=C\c1sc2cc(OCc3ccc(Sc4ccccc4)cc3)c(OCc3ccc(Sc4ccccc4)cc3)cc2c1Oc1ccc(Cl)cc1)\c1ccncc1
Show InChI InChI=1S/C48H34ClNO5S3/c49-35-15-17-36(18-16-35)55-47-42-27-43(53-30-32-11-19-39(20-12-32)56-37-7-3-1-4-8-37)44(54-31-33-13-21-40(22-14-33)57-38-9-5-2-6-10-38)29-45(42)58-46(47)28-41(48(51)52)34-23-25-50-26-24-34/h1-29H,30-31H2,(H,51,52)/b41-28+
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n/an/a 39n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...


Bioorg Med Chem Lett 13: 1705-8 (2003)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50009171
PNG
(CHEMBL3238362)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(F)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C24H25FN8O3/c1-31-19(13-33-20(34)14-32(24(33)36)18-7-5-16(25)6-8-18)10-15-12-28-21(30-22(15)31)23(35)29-17(11-27)4-2-3-9-26/h5-8,10,12,17H,2-4,9,13-14,26H2,1H3,(H,29,35)/t17-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093553
PNG
(CHEMBL3585734)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc3oc(=O)n(C)c3c2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1/C26H27N9O5/c1-32-18(9-15-12-29-22(31-23(15)32)24(37)30-16(11-28)5-3-4-8-27)13-35-21(36)14-34(25(35)38)17-6-7-20-19(10-17)33(2)26(39)40-20/h6-7,9-10,12,16H,3-5,8,13-14,27H2,1-2H3,(H,30,37)/t16-/s2
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n/an/a 43n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM175546
PNG
(US9120744, CDE-061)
Show SMILES Oc1cc(cc(O)c1O)C(=O)O[C@H]1CC[C@H](CC1)OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1/C20H20O10/c21-13-5-9(6-14(22)17(13)25)19(27)29-11-1-2-12(4-3-11)30-20(28)10-7-15(23)18(26)16(24)8-10/h5-8,11-12,21-26H,1-4H2/t11-,12+
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US Patent
n/an/a 50n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...


US Patent US9120744 (2015)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM175544
PNG
(US9120744, CDE-058)
Show SMILES Oc1cc(cc(O)c1O)C(=O)O[C@H]1CCC[C@H](C1)OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1/C20H20O10/c21-13-4-9(5-14(22)17(13)25)19(27)29-11-2-1-3-12(8-11)30-20(28)10-6-15(23)18(26)16(24)7-10/h4-7,11-12,21-26H,1-3,8H2/t11-,12+
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US Patent
n/an/a 50n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...


US Patent US9120744 (2015)

More data for this
Ligand-Target Pair
Enolase 1 (ENO1)


(Homo sapiens (Human))
BDBM204923
PNG
(phosphonoacetohydroxamate (PhAH))
Show SMILES ONC(=O)CP(O)(O)=O
Show InChI InChI=1S/C2H6NO5P/c4-2(3-5)1-9(6,7)8/h5H,1H2,(H,3,4)(H2,6,7,8)
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n/an/a 53.2n/an/an/an/an/an/a



University of Texas MD Anderson Cancer Center



Assay Description
Enolase activity was measured by two different methods: a fluorometric NADH-linked assay or adirect spectrophotometric assay via formation of PEP. In...


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50046358
PNG
(CHEMBL110780 | {2-[2-(1-Formyl-4-guanidino-butylca...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C28H38N6O5/c1-28(2,3)39-27(38)33-23(20-13-12-18-8-4-5-9-19(18)16-20)25(37)34-15-7-11-22(34)24(36)32-21(17-35)10-6-14-31-26(29)30/h4-5,8-9,12-13,16-17,21-23H,6-7,10-11,14-15H2,1-3H3,(H,32,36)(H,33,38)(H4,29,30,31)/t21?,22-,23+/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against plasmin


J Med Chem 36: 314-9 (1993)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093540
PNG
(CHEMBL3585746)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccncc3)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1/C30H30N8O4/c1-36-26-16-20(29(40)34-21(17-32)4-2-3-13-31)5-10-25(26)35-27(36)18-38-28(39)19-37(30(38)41)22-6-8-23(9-7-22)42-24-11-14-33-15-12-24/h5-12,14-16,21H,2-4,13,18-19,31H2,1H3,(H,34,40)/t21-/s2
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n/an/a 56n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM31497
PNG
(substituted biphenyl derivative, 36ak)
Show SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1cscc1CO
Show InChI InChI=1S/C31H30N4O5S/c1-17(2)13-34-29(37)20-6-10-24(26(12-20)31(39)40)23-9-5-19(27-16-41-15-21(27)14-36)11-25(23)30(38)35-22-7-3-18(4-8-22)28(32)33/h3-12,15-17,36H,13-14H2,1-2H3,(H3,32,33)(H,34,37)(H,35,38)(H,39,40)
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n/an/a 60n/an/an/an/a7.823



BioCryst Pharmaceuticals



Assay Description
The assay is an amidolytic assay based upon the absorbance of derivatized thiols from the hydrolysis of Z-Lys-SBzl (Bachem) in the presence of 5,5-Di...


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM175558
PNG
(US9120744, CDE-075)
Show SMILES CC(C)(C)OC(=O)NCC(COC(=O)c1cc(O)c(O)c(O)c1)OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1/C22H25NO12/c1-22(2,3)35-21(32)23-8-12(34-20(31)11-6-15(26)18(29)16(27)7-11)9-33-19(30)10-4-13(24)17(28)14(25)5-10/h4-7,12,24-29H,8-9H2,1-3H3,(H,23,32)
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n/an/a 70n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...


US Patent US9120744 (2015)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM31467
PNG
(substituted biphenyl derivative, 36g)
Show SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)C(C)=C
Show InChI InChI=1S/C29H30N4O4/c1-16(2)15-32-27(34)20-8-12-23(25(14-20)29(36)37)22-11-7-19(17(3)4)13-24(22)28(35)33-21-9-5-18(6-10-21)26(30)31/h5-14,16H,3,15H2,1-2,4H3,(H3,30,31)(H,32,34)(H,33,35)(H,36,37)
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n/an/a 70n/an/an/an/a7.823



BioCryst Pharmaceuticals



Assay Description
The assay is an amidolytic assay based upon the absorbance of derivatized thiols from the hydrolysis of Z-Lys-SBzl (Bachem) in the presence of 5,5-Di...


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093541
PNG
(CHEMBL3585745)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccncc3)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1/C29H29N9O4/c1-36-22(14-19-16-33-26(35-27(19)36)28(40)34-20(15-31)4-2-3-11-30)17-38-25(39)18-37(29(38)41)21-5-7-23(8-6-21)42-24-9-12-32-13-10-24/h5-10,12-14,16,20H,2-4,11,17-18,30H2,1H3,(H,34,40)/t20-/s2
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n/an/a 74n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50046362
PNG
(CHEMBL319930 | {1-Cyclohexyl-2-[2-(1-formyl-4-guan...)
Show SMILES CC(C)(C)OC(=O)N[C@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O
Show InChI InChI=1S/C24H42N6O5/c1-24(2,3)35-23(34)29-19(16-9-5-4-6-10-16)21(33)30-14-8-12-18(30)20(32)28-17(15-31)11-7-13-27-22(25)26/h15-19H,4-14H2,1-3H3,(H,28,32)(H,29,34)(H4,25,26,27)/t17-,18-,19+/m0/s1
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n/an/a 81n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against plasmin


J Med Chem 36: 314-9 (1993)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50046362
PNG
(CHEMBL319930 | {1-Cyclohexyl-2-[2-(1-formyl-4-guan...)
Show SMILES CC(C)(C)OC(=O)N[C@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O
Show InChI InChI=1S/C24H42N6O5/c1-24(2,3)35-23(34)29-19(16-9-5-4-6-10-16)21(33)30-14-8-12-18(30)20(32)28-17(15-31)11-7-13-27-22(25)26/h15-19H,4-14H2,1-3H3,(H,28,32)(H,29,34)(H4,25,26,27)/t17-,18-,19+/m0/s1
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n/an/a 81n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against plasmin


J Med Chem 36: 314-9 (1993)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM175548
PNG
(US9120744, CDE-059)
Show SMILES Oc1ccc(cc1O)S(=O)(=O)NNS(=O)(=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C12H12N2O8S2/c15-9-3-1-7(5-11(9)17)23(19,20)13-14-24(21,22)8-2-4-10(16)12(18)6-8/h1-6,13-18H
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US Patent
n/an/a 90n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...


US Patent US9120744 (2015)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM50070942
PNG
((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Show SMILES Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1
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n/an/a 91n/an/an/an/a7.823



University of Michigan



Assay Description
Enzyme activity assay using human and murine PAI-1.


Citation and Details
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50046367
PNG
(CHEMBL321322 | [2-[2-(1-Formyl-4-guanidino-butylca...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O)c1ccc(O)cc1
Show InChI InChI=1S/C24H36N6O6/c1-24(2,3)36-23(35)29-19(15-8-10-17(32)11-9-15)21(34)30-13-5-7-18(30)20(33)28-16(14-31)6-4-12-27-22(25)26/h8-11,14,16,18-19,32H,4-7,12-13H2,1-3H3,(H,28,33)(H,29,35)(H4,25,26,27)/t16-,18-,19+/m0/s1
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n/an/a 94n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against plasmin


J Med Chem 36: 314-9 (1993)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50046372
PNG
(CHEMBL318998 | {2-[2-(1-Formyl-4-guanidino-butylca...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O)c1ccccc1
Show InChI InChI=1S/C24H36N6O5/c1-24(2,3)35-23(34)29-19(16-9-5-4-6-10-16)21(33)30-14-8-12-18(30)20(32)28-17(15-31)11-7-13-27-22(25)26/h4-6,9-10,15,17-19H,7-8,11-14H2,1-3H3,(H,28,32)(H,29,34)(H4,25,26,27)/t17-,18-,19+/m0/s1
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n/an/a 98n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against plasmin


J Med Chem 36: 314-9 (1993)

More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50029506
PNG
(CHEMBL318998 | tert-butyloxy carbonyl-D-ethylpheny...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C=O)c1ccccc1
Show InChI InChI=1S/C24H36N6O5/c1-24(2,3)35-23(34)29-19(16-9-5-4-6-10-16)21(33)30-14-8-12-18(30)20(32)28-17(15-31)11-7-13-27-22(25)26/h4-6,9-10,15,17-19H,7-8,11-14H2,1-3H3,(H,28,32)(H,29,34)(H4,25,26,27)/t17-,18-,19+/m0/s1
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n/an/a 98n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Enzyme Inhibitory activity measured against Plasmin


J Med Chem 38: 4446-53 (1995)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM50127735
PNG
((E)-3-[3-(4-Chloro-phenoxy)-5,6-bis-(4-phenoxy-ben...)
Show SMILES OC(=O)C(=C\c1sc2cc(OCc3ccc(Oc4ccccc4)cc3)c(OCc3ccc(Oc4ccccc4)cc3)cc2c1Oc1ccc(Cl)cc1)\c1ccncc1
Show InChI InChI=1S/C48H34ClNO7S/c49-35-15-21-40(22-16-35)57-47-42-27-43(53-30-32-11-17-38(18-12-32)55-36-7-3-1-4-8-36)44(54-31-33-13-19-39(20-14-33)56-37-9-5-2-6-10-37)29-45(42)58-46(47)28-41(48(51)52)34-23-25-50-26-24-34/h1-29H,30-31H2,(H,51,52)/b41-28+
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n/an/a 100n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...


Bioorg Med Chem Lett 13: 1705-8 (2003)

More data for this
Ligand-Target Pair
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM50132875
PNG
(2-{2-[(4-{[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cycl...)
Show SMILES COc1cccc(CNc2ccc(CNC(=O)CO[C@@H]3C[C@H](C)CC[C@H]3C(C)C)cc2)c1Oc1ccc(cc1C(O)=O)[N+]([O-])=O
Show InChI InChI=1S/C34H41N3O8/c1-21(2)27-14-8-22(3)16-31(27)44-20-32(38)36-18-23-9-11-25(12-10-23)35-19-24-6-5-7-30(43-4)33(24)45-29-15-13-26(37(41)42)17-28(29)34(39)40/h5-7,9-13,15,17,21-22,27,31,35H,8,14,16,18-20H2,1-4H3,(H,36,38)(H,39,40)/t22-,27+,31-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assay


Bioorg Med Chem Lett 13: 3361-5 (2003)

More data for this
Ligand-Target Pair
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