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Compile Data Set for Download or QSAR

Found 1603 hits Enz. Inhib. hit(s) with Target = 'Platelet activating factor receptor'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50021572
PNG
((2S,3S)-2-(3,4-Dimethoxy-phenyl)-3-methyl-5-propyl...)
Show SMILES CCCc1cc2[C@H](C)[C@H](Oc2cc1O)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H24O4/c1-5-6-13-9-15-12(2)20(24-18(15)11-16(13)21)14-7-8-17(22-3)19(10-14)23-4/h7-12,20-21H,5-6H2,1-4H3/t12-,20-/m0/s1
MMDB

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n/an/a 0.0000700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.


J Med Chem 30: 136-42 (1987)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50280478
PNG
(BB-823 | CHEMBL157078 | N-((S)-1-Ethoxymethyl-3-me...)
Show SMILES CCOC[C@H](CC(C)C)NS(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C22H30N4O3S/c1-5-29-15-19(12-16(2)3)25-30(27,28)20-8-6-18(7-9-20)14-26-17(4)24-21-13-23-11-10-22(21)26/h6-11,13,16,19,25H,5,12,14-15H2,1-4H3/t19-/m0/s1
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n/an/a 0.0150n/an/an/an/an/an/a


TBA

Assay Description
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.


Citation and Details
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50011635
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C27H20ClN5OS/c1-17-30-31-24-16-29-26(20-9-3-4-10-22(20)28)21-15-19(35-27(21)33(17)24)8-6-14-32-23-11-5-2-7-18(23)12-13-25(32)34/h2-5,7,9-11,15H,12-14,16H2,1H3
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n/an/a 0.200n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM85035
PNG
(CAS_65154-06-5 | PAF | bloodplatelet-activatingfac...)
Show SMILES CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
Show InChI InChI=1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
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n/an/a 0.280n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs


Citation and Details
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033236
PNG
(8,9-Dichloro-2-methyl-5-[4-(2-methyl-imidazo[4,5-c...)
Show SMILES Cc1cn-2c(CC(=Nc3cc(Cl)c(Cl)cc-23)c2ccc(cc2)-n2c(C)nc3cnccc23)n1
Show InChI InChI=1S/C25H18Cl2N6/c1-14-13-32-24-10-19(27)18(26)9-21(24)31-20(11-25(32)29-14)16-3-5-17(6-4-16)33-15(2)30-22-12-28-8-7-23(22)33/h3-10,12-13H,11H2,1-2H3
MMDB

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n/an/a 0.300n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50011650
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(C)c1=O)c1ccccc1Cl
Show InChI InChI=1S/C26H19ClN6OS/c1-16-29-30-23-15-28-24(18-9-3-4-10-20(18)27)19-14-17(35-25(19)33(16)23)8-7-13-32-22-12-6-5-11-21(22)31(2)26(32)34/h3-6,9-12,14H,13,15H2,1-2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033242
PNG
(3-Cyclohexyl-6-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2c(nn3CCCCN(c23)C(=O)C1)C1CCCCC1
Show InChI InChI=1S/C29H31N7O/c1-19-31-24-18-30-14-13-25(24)36(19)22-11-9-20(10-12-22)23-17-26(37)34-15-5-6-16-35-29(34)28(32-23)27(33-35)21-7-3-2-4-8-21/h9-14,18,21H,2-8,15-17H2,1H3
MMDB

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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033212
PNG
(7,8-Dichloro-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1Cc2cc(Cl)c(Cl)cc2NC(=O)C1
Show InChI InChI=1S/C23H18Cl2N4O/c1-13-27-21-12-26-7-6-22(21)29(13)17-4-2-14(3-5-17)15-8-16-9-18(24)19(25)11-20(16)28-23(30)10-15/h2-7,9,11-12,15H,8,10H2,1H3,(H,28,30)
MMDB

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Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.


J Med Chem 38: 3514-23 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50004622
PNG
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OCCOC)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C32H31ClN4O5/c1-5-41-32(39)29-28(23-8-6-7-9-24(23)33)27(31(38)42-17-16-40-4)19(2)35-30(29)21-10-12-22(13-11-21)37-20(3)36-25-18-34-15-14-26(25)37/h6-15,18,27-28H,5,16-17H2,1-4H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.


J Med Chem 35: 3115-29 (1992)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033211
PNG
(7,8-Dichloro-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Cl)c(Cl)cc2NC(=S)C1
Show InChI InChI=1S/C22H15Cl2N5S/c1-12-26-20-11-25-7-6-21(20)29(12)14-4-2-13(3-5-14)17-10-22(30)28-19-9-16(24)15(23)8-18(19)27-17/h2-9,11H,10H2,1H3,(H,28,30)
MMDB

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Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.


J Med Chem 38: 3514-23 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033257
PNG
(1,8-Dimethyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES CN1c2c(N=C(CC1=O)c1ccc(cc1)-n1c(C)nc3cnccc13)c(nn2C)-c1ccccc1
Show InChI InChI=1S/C27H23N7O/c1-17-29-22-16-28-14-13-23(22)34(17)20-11-9-18(10-12-20)21-15-24(35)32(2)27-26(30-21)25(31-33(27)3)19-7-5-4-6-8-19/h4-14,16H,15H2,1-3H3
MMDB

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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033213
PNG
(7,8-Dichloro-1-methyl-4-[4-(2-methyl-imidazo[4,5-c...)
Show SMILES CN1c2cc(Cl)c(Cl)cc2CC(CC1=O)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C24H20Cl2N4O/c1-14-28-21-13-27-8-7-22(21)30(14)18-5-3-15(4-6-18)16-9-17-10-19(25)20(26)12-23(17)29(2)24(31)11-16/h3-8,10,12-13,16H,9,11H2,1-2H3
MMDB

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Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.


J Med Chem 38: 3514-23 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033240
PNG
(1-Methyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2c(NC(=O)C1)n(C)nc2-c1ccccc1
Show InChI InChI=1S/C26H21N7O/c1-16-28-21-15-27-13-12-22(21)33(16)19-10-8-17(9-11-19)20-14-23(34)30-26-25(29-20)24(31-32(26)2)18-6-4-3-5-7-18/h3-13,15H,14H2,1-2H3,(H,30,34)
MMDB

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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033223
PNG
(7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2NC(=S)C1
Show InChI InChI=1S/C24H21N5S/c1-14-10-20-21(11-15(14)2)28-24(30)12-19(27-20)17-4-6-18(7-5-17)29-16(3)26-22-13-25-9-8-23(22)29/h4-11,13H,12H2,1-3H3,(H,28,30)
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.


J Med Chem 38: 3514-23 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50011611
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c(=O)n(C)c1=O)c1ccccc1Cl
Show InChI InChI=1S/C27H19ClN6O2S/c1-16-30-31-23-15-29-24(18-9-3-5-11-21(18)28)20-14-17(37-26(20)34(16)23)8-7-13-33-22-12-6-4-10-19(22)25(35)32(2)27(33)36/h3-6,9-12,14H,13,15H2,1-2H3
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n/an/a 0.600n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033238
PNG
(3-(4-Chloro-phenyl)-1,8-dimethyl-5-[4-(2-methyl-im...)
Show SMILES CN1c2c(N=C(CC1=O)c1ccc(cc1)-n1c(C)nc3cnccc13)c(nn2C)-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H22ClN7O/c1-16-30-22-15-29-13-12-23(22)35(16)20-10-6-17(7-11-20)21-14-24(36)33(2)27-26(31-21)25(32-34(27)3)18-4-8-19(28)9-5-18/h4-13,15H,14H2,1-3H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033264
PNG
(3-Cyclohexyl-1,8-dimethyl-5-[4-(2-methyl-imidazo[4...)
Show SMILES CN1c2c(N=C(CC1=O)c1ccc(cc1)-n1c(C)nc3cnccc13)c(nn2C)C1CCCCC1
Show InChI InChI=1S/C27H29N7O/c1-17-29-22-16-28-14-13-23(22)34(17)20-11-9-18(10-12-20)21-15-24(35)32(2)27-26(30-21)25(31-33(27)3)19-7-5-4-6-8-19/h9-14,16,19H,4-8,15H2,1-3H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033214
PNG
(7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2NC(=O)C1
Show InChI InChI=1S/C24H21N5O/c1-14-10-20-21(11-15(14)2)28-24(30)12-19(27-20)17-4-6-18(7-5-17)29-16(3)26-22-13-25-9-8-23(22)29/h4-11,13H,12H2,1-3H3,(H,28,30)
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n/an/a 0.700n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.


J Med Chem 38: 3514-23 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50011634
PNG
(4-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)COc2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C26H18ClN5O2S/c1-16-29-30-23-14-28-25(18-8-2-3-9-20(18)27)19-13-17(35-26(19)32(16)23)7-6-12-31-21-10-4-5-11-22(21)34-15-24(31)33/h2-5,8-11,13H,12,14-15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50011623
PNG
(2a-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCC12CCCc3cccc(NC1=O)c23)c1ccccc1Cl
Show InChI InChI=1S/C29H22ClN5OS/c1-17-33-34-24-16-31-26(20-10-2-3-11-22(20)30)21-15-19(37-27(21)35(17)24)9-6-14-29-13-5-8-18-7-4-12-23(25(18)29)32-28(29)36/h2-4,7,10-12,15H,5,8,13-14,16H2,1H3,(H,32,36)
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n/an/a 0.700n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033260
PNG
(3-Isobutoxymethyl-1,8-dimethyl-5-[4-(2-methyl-imid...)
Show SMILES CC(C)COCc1nn(C)c2N(C)C(=O)CC(=Nc12)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C26H29N7O2/c1-16(2)14-35-15-22-25-26(32(5)30-22)31(4)24(34)12-20(29-25)18-6-8-19(9-7-18)33-17(3)28-21-13-27-11-10-23(21)33/h6-11,13,16H,12,14-15H2,1-5H3
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n/an/a 0.800n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033206
PNG
(7,8-Dichloro-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Cl)c(Cl)cc2NC(=O)C1
Show InChI InChI=1S/C22H15Cl2N5O/c1-12-26-20-11-25-7-6-21(20)29(12)14-4-2-13(3-5-14)17-10-22(30)28-19-9-16(24)15(23)8-18(19)27-17/h2-9,11H,10H2,1H3,(H,28,30)
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n/an/a 0.900n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.


J Med Chem 38: 3514-23 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50280339
PNG
((S)-2-[4-(2-Benzenesulfonyl-ethoxy)-3-methoxy-5-(p...)
Show SMILES CCCS(=O)(=O)c1cc(cc(OC)c1OCCS(=O)(=O)c1ccccc1)C1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C31H38O10S2/c1-6-15-43(34,35)29-20-22(19-28(38-4)31(29)40-14-16-42(32,33)23-10-8-7-9-11-23)25-13-12-24(41-25)21-17-26(36-2)30(39-5)27(18-21)37-3/h7-11,17-20,24-25H,6,12-16H2,1-5H3/t24-,25?/m0/s1
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n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibitory activity of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptor


Citation and Details
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50011640
PNG
(4-(2-Chloro-phenyl)-2-(3-indazol-1-yl-prop-1-ynyl)...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1ncc2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C25H17ClN6S/c1-16-29-30-23-15-27-24(19-9-3-4-10-21(19)26)20-13-18(33-25(20)32(16)23)8-6-12-31-22-11-5-2-7-17(22)14-28-31/h2-5,7,9-11,13-14H,12,15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50011603
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(-c2ccccc2)c1=O)c1ccccc1Cl
Show InChI InChI=1S/C31H21ClN6OS/c1-20-34-35-28-19-33-29(23-13-5-6-14-25(23)32)24-18-22(40-30(24)37(20)28)12-9-17-36-26-15-7-8-16-27(26)38(31(36)39)21-10-3-2-4-11-21/h2-8,10-11,13-16,18H,17,19H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50013923
PNG
(3-(1-Butyl-4-methoxy-naphthalen-2-yl)-N-(1-methyl-...)
Show SMILES CCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccccc12
Show InChI InChI=1S/C28H34N2O2/c1-4-5-13-24-23(19-27(32-3)26-15-7-6-14-25(24)26)16-17-28(31)30-21(2)10-8-11-22-12-9-18-29-20-22/h6-7,9,12,14-21H,4-5,8,10-11,13H2,1-3H3,(H,30,31)/b17-16+/t21-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood


J Med Chem 33: 2856-64 (1990)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033234
PNG
(1,3-Dimethyl-7-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nn(C)c2N=C(CC(=O)Nc12)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C21H19N7O/c1-12-20-21(27(3)26-12)24-16(10-19(29)25-20)14-4-6-15(7-5-14)28-13(2)23-17-11-22-9-8-18(17)28/h4-9,11H,10H2,1-3H3,(H,25,29)
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n/an/a 1n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50011653
PNG
(2-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1ccc2ccccc2c1=O)c1ccccc1Cl
Show InChI InChI=1S/C27H18ClN5OS/c1-17-30-31-24-16-29-25(21-10-4-5-11-23(21)28)22-15-19(35-27(22)33(17)24)8-6-13-32-14-12-18-7-2-3-9-20(18)26(32)34/h2-5,7,9-12,14-15H,13,16H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033233
PNG
(8,9-Dichloro-1-methyl-5-[4-(2-methyl-imidazo[4,5-c...)
Show SMILES Cc1cnc2CC(=Nc3cc(Cl)c(Cl)cc3-n12)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C25H18Cl2N6/c1-14-12-29-25-11-20(31-21-9-18(26)19(27)10-24(21)32(14)25)16-3-5-17(6-4-16)33-15(2)30-22-13-28-8-7-23(22)33/h3-10,12-13H,11H2,1-2H3
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033249
PNG
(5,7,9-Trimethyl-2-[4-(2-methyl-imidazo[4,5-c]pyrid...)
Show SMILES CN1c2nc(C)cc(C)c2N=C(CC1=O)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C24H22N6O/c1-14-11-15(2)26-24-23(14)28-19(12-22(31)29(24)4)17-5-7-18(8-6-17)30-16(3)27-20-13-25-10-9-21(20)30/h5-11,13H,12H2,1-4H3
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033229
PNG
(8,9-Dimethyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2-n2ccnc2C1
Show InChI InChI=1S/C26H22N6/c1-16-12-22-25(13-17(16)2)31-11-10-28-26(31)14-21(30-22)19-4-6-20(7-5-19)32-18(3)29-23-15-27-9-8-24(23)32/h4-13,15H,14H2,1-3H3
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50004615
PNG
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OC(C)(C)C)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C33H33ClN4O4/c1-7-41-31(39)29-28(23-10-8-9-11-24(23)34)27(32(40)42-33(4,5)6)19(2)36-30(29)21-12-14-22(15-13-21)38-20(3)37-25-18-35-17-16-26(25)38/h8-18,27-28H,7H2,1-6H3
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.


J Med Chem 35: 3115-29 (1992)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033245
PNG
(8-Bromo-5-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyri...)
Show SMILES CN1c2ncc(Br)cc2N=C(CC1=O)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C22H17BrN6O/c1-13-26-19-12-24-8-7-20(19)29(13)16-5-3-14(4-6-16)17-10-21(30)28(2)22-18(27-17)9-15(23)11-25-22/h3-9,11-12H,10H2,1-2H3
MMDB

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n/an/a 1.40n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033255
PNG
(1,8-Dimethyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES CN1c2c(N=C(CC1=O)c1ccc(cc1)-n1c(C)nc3cnccc13)c(nn2C)-c1cccs1
Show InChI InChI=1S/C25H21N7OS/c1-15-27-19-14-26-11-10-20(19)32(15)17-8-6-16(7-9-17)18-13-22(33)30(2)25-24(28-18)23(29-31(25)3)21-5-4-12-34-21/h4-12,14H,13H2,1-3H3
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50004630
PNG
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OC)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C30H27ClN4O4/c1-5-39-30(37)27-26(21-8-6-7-9-22(21)31)25(29(36)38-4)17(2)33-28(27)19-10-12-20(13-11-19)35-18(3)34-23-16-32-15-14-24(23)35/h6-16,25-26H,5H2,1-4H3
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n/an/a 1.60n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.


J Med Chem 35: 3115-29 (1992)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033232
PNG
(8,9-Dichloro-5-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Cl)c(Cl)cc2-n2ccnc2C1
Show InChI InChI=1S/C24H16Cl2N6/c1-14-29-21-13-27-7-6-22(21)32(14)16-4-2-15(3-5-16)19-12-24-28-8-9-31(24)23-11-18(26)17(25)10-20(23)30-19/h2-11,13H,12H2,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets


J Med Chem 38: 3524-35 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50004617
PNG
(4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-pyridi...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-c1cccnc1C
Show InChI InChI=1S/C33H29ClN4O3/c1-4-41-33(40)30-29(25-10-5-6-12-26(25)34)28(32(39)38-27-13-7-8-18-36-27)21(3)37-31(30)23-16-14-22(15-17-23)24-11-9-19-35-20(24)2/h5-19,28-29H,4H2,1-3H3,(H,36,38,39)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.


J Med Chem 35: 3115-29 (1992)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50033207
PNG
(7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2N=C(N)C1
Show InChI InChI=1S/C24H22N6/c1-14-10-20-21(11-15(14)2)29-24(25)12-19(28-20)17-4-6-18(7-5-17)30-16(3)27-22-13-26-9-8-23(22)30/h4-11,13H,12H2,1-3H3,(H2,25,29)
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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.


J Med Chem 38: 3514-23 (1995)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003524
PNG
(CHEMBL544141 | [4-(2,2-Diphenyl-propionyl)-piperaz...)
Show SMILES CC(C(=O)N1CCN(CC1)C(C#N)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O/c1-26(22-10-4-2-5-11-22,23-12-6-3-7-13-23)25(31)30-17-15-29(16-18-30)24(19-27)21-9-8-14-28-20-21/h2-14,20,24H,15-18H2,1H3
MMDB

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n/an/a 1.90n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50018350
PNG
(5-(4-Methoxy-phenyl)-5-phenyl-penta-2,4-dienoic ac...)
Show SMILES COc1ccc(cc1)C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)\c1ccccc1
Show InChI InChI=1S/C28H30N2O2/c1-22(9-6-10-23-11-8-20-29-21-23)30-28(31)15-7-14-27(24-12-4-3-5-13-24)25-16-18-26(32-2)19-17-25/h3-5,7-8,11-22H,6,9-10H2,1-2H3,(H,30,31)/b15-7+,27-14+/t22-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand


J Med Chem 32: 1820-35 (1989)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50004633
PNG
((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,29-30H,4H2,1-3H3,(H,37,40,42)
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n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit


Citation and Details
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50408421
PNG
(CHEMBL2113725)
Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1c(F)c(F)cc(F)c1F)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C33H38F4N2O8S/c1-6-7-10-39(41)33(40)38-22-13-18(23-8-9-24(47-23)19-15-26(43-3)31(45-5)27(16-19)44-4)14-25(42-2)30(22)46-11-12-48-32-28(36)20(34)17-21(35)29(32)37/h13-17,23-24,41H,6-12H2,1-5H3,(H,38,40)/t23-,24-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Displacement of [3H]-PAF from PAF receptor of human platelet membranes


Citation and Details
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50011669
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2ccc1=O)c1ccccc1Cl
Show InChI InChI=1S/C27H18ClN5OS/c1-17-30-31-24-16-29-26(20-9-3-4-10-22(20)28)21-15-19(35-27(21)33(17)24)8-6-14-32-23-11-5-2-7-18(23)12-13-25(32)34/h2-5,7,9-13,15H,14,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50004633
PNG
((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,29-30H,4H2,1-3H3,(H,37,40,42)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit


Citation and Details
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50018388
PNG
(5,5-Bis-(3-methoxy-phenyl)-penta-2,4-dienoic acid ...)
Show SMILES COc1cccc(c1)C(=C\C=C\C(=O)NCCCCc1cccnc1)c1cccc(OC)c1
Show InChI InChI=1S/C28H30N2O3/c1-32-25-13-5-11-23(19-25)27(24-12-6-14-26(20-24)33-2)15-7-16-28(31)30-18-4-3-9-22-10-8-17-29-21-22/h5-8,10-17,19-21H,3-4,9,18H2,1-2H3,(H,30,31)/b16-7+
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Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand


J Med Chem 32: 1820-35 (1989)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005224
PNG
(2-({Acetyl-[5-(16-methoxy-hexadecyloxy)-tetrahydro...)
Show SMILES CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(C1)OCCCCCCCCCCCCCCCCOC
Show InChI InChI=1S/C33H57N2O6/c1-4-34-22-18-17-21-31(34)26-35(29(2)36)33(37)41-28-30-25-32(40-27-30)39-24-20-16-14-12-10-8-6-5-7-9-11-13-15-19-23-38-3/h17-18,21-22,30,32H,4-16,19-20,23-28H2,1-3H3/q+1
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n/an/a 2.10n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50004637
PNG
(4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidaz...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-c1c(C)nc2ccccn12
Show InChI InChI=1S/C35H30ClN5O3/c1-4-44-35(43)31-30(25-11-5-6-12-26(25)36)29(34(42)40-27-13-7-9-19-37-27)21(2)39-32(31)23-15-17-24(18-16-23)33-22(3)38-28-14-8-10-20-41(28)33/h5-20,29-30H,4H2,1-3H3,(H,37,40,42)
MMDB

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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.


J Med Chem 35: 3115-29 (1992)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50286206
PNG
((R)-5-tert-Butylcarbamoyl-4-(2-chloro-phenyl)-6-me...)
Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc3ccccc23)N=C(C)C([C@H]1c1ccccc1Cl)C(=O)NC(C)(C)C
Show InChI InChI=1S/C31H37ClN4O4/c1-7-40-30(38)28-24(18-39-17-16-36-20(3)34-23-14-10-11-15-25(23)36)33-19(2)26(29(37)35-31(4,5)6)27(28)21-12-8-9-13-22(21)32/h8-15,26-27H,7,16-18H2,1-6H3,(H,35,37)/t26?,27-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit


Citation and Details
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50004650
PNG
(6-Methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1OC(F)(F)F)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C35H29F3N6O4/c1-4-47-34(46)31-30(24-9-5-6-10-27(24)48-35(36,37)38)29(33(45)43-28-11-7-8-17-40-28)20(2)41-32(31)22-12-14-23(15-13-22)44-21(3)42-25-19-39-18-16-26(25)44/h5-19,29-30H,4H2,1-3H3,(H,40,43,45)
MMDB

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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.


J Med Chem 35: 3115-29 (1992)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50280480
PNG
(CHEMBL156461 | YM-461 | [4-(3-Phenyl-propyl)-piper...)
Show SMILES O=C([C@@H]1CSC(N1)c1cccnc1)N1CCN(CCCc2ccccc2)CC1
Show InChI InChI=1S/C22H28N4OS/c27-22(20-17-28-21(24-20)19-9-4-10-23-16-19)26-14-12-25(13-15-26)11-5-8-18-6-2-1-3-7-18/h1-4,6-7,9-10,16,20-21,24H,5,8,11-15,17H2/t20-,21?/m0/s1
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TBA

Assay Description
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.


Citation and Details
More data for this
Ligand-Target Pair
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