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Compile Data Set for Download or QSAR

Found 44 hits Enz. Inhib. hit(s) with Target = 'Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419064
PNG
(CHEMBL1823874)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C23H37N3O2/c1-4-28-21-11-7-6-10-20(21)22(27)24-18-23(12-8-5-9-13-23)26-16-14-25(15-17-26)19(2)3/h6-7,10-11,19H,4-5,8-9,12-18H2,1-3H3,(H,24,27)
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n/an/a 15.8n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419067
PNG
(CHEMBL1823878)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC)CC1
Show InChI InChI=1S/C22H35N3O2/c1-3-24-14-16-25(17-15-24)22(12-8-5-9-13-22)18-23-21(26)19-10-6-7-11-20(19)27-4-2/h6-7,10-11H,3-5,8-9,12-18H2,1-2H3,(H,23,26)
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n/an/a 31.6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419065
PNG
(CHEMBL1823875)
Show SMILES COc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C22H35N3O2/c1-18(2)24-13-15-25(16-14-24)22(11-7-4-8-12-22)17-23-21(26)19-9-5-6-10-20(19)27-3/h5-6,9-10,18H,4,7-8,11-17H2,1-3H3,(H,23,26)
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n/an/a 31.6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419068
PNG
(CHEMBL1823879)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C1CC1
Show InChI InChI=1S/C23H35N3O2/c1-2-28-21-9-5-4-8-20(21)22(27)24-18-23(12-6-3-7-13-23)26-16-14-25(15-17-26)19-10-11-19/h4-5,8-9,19H,2-3,6-7,10-18H2,1H3,(H,24,27)
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n/an/a 50.1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419069
PNG
(CHEMBL1823880)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H37N3O2/c1-2-29-22-12-5-4-11-21(22)23(28)25-19-24(13-6-3-7-14-24)27-17-15-26(16-18-27)20-9-8-10-20/h4-5,11-12,20H,2-3,6-10,13-19H2,1H3,(H,25,28)
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n/an/a 79.4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419080
PNG
(CHEMBL1823677)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(C)CC1
Show InChI InChI=1S/C21H33N3O2/c1-3-26-19-10-6-5-9-18(19)20(25)22-17-21(11-7-4-8-12-21)24-15-13-23(2)14-16-24/h5-6,9-10H,3-4,7-8,11-17H2,1-2H3,(H,22,25)
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n/an/a 126n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419053
PNG
(CHEMBL2052019 | ZD-7288)
Show SMILES CC\[N+](c1ccccc1)=c1/cc(NC)n(C)c(C)n1
Show InChI InChI=1S/C15H20N4/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15/h6-11H,5H2,1-4H3/p+1
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n/an/a 158n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419070
PNG
(CHEMBL1823881)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C1CCCC1
Show InChI InChI=1S/C25H39N3O2/c1-2-30-23-13-7-6-12-22(23)24(29)26-20-25(14-8-3-9-15-25)28-18-16-27(17-19-28)21-10-4-5-11-21/h6-7,12-13,21H,2-5,8-11,14-20H2,1H3,(H,26,29)
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n/an/a 200n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419066
PNG
(CHEMBL1823876)
Show SMILES CC(C)Oc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C24H39N3O2/c1-19(2)26-14-16-27(17-15-26)24(12-8-5-9-13-24)18-25-23(28)21-10-6-7-11-22(21)29-20(3)4/h6-7,10-11,19-20H,5,8-9,12-18H2,1-4H3,(H,25,28)
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n/an/a 251n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419085
PNG
(CHEMBL1823887)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCOCC1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C22H35N3O3/c1-4-28-20-8-6-5-7-19(20)21(26)23-17-22(9-15-27-16-10-22)25-13-11-24(12-14-25)18(2)3/h5-8,18H,4,9-17H2,1-3H3,(H,23,26)
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n/an/a 316n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419062
PNG
(CHEMBL1435630)
Show SMILES COc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(C)CC1
Show InChI InChI=1S/C20H31N3O2/c1-22-12-14-23(15-13-22)20(10-6-3-7-11-20)16-21-19(24)17-8-4-5-9-18(17)25-2/h4-5,8-9H,3,6-7,10-16H2,1-2H3,(H,21,24)
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n/an/a 398n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419055
PNG
(CHEMBL1823666)
Show SMILES CCOc1ccccc1C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1
Show InChI InChI=1S/C24H31N3O2/c1-3-29-22-11-7-6-10-21(22)23(28)25-18-24(27-14-12-26(2)13-15-27)16-19-8-4-5-9-20(19)17-24/h4-11H,3,12-18H2,1-2H3,(H,25,28)
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n/an/a 398n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419083
PNG
(CHEMBL1823882)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCNCC1
Show InChI InChI=1S/C20H31N3O2/c1-2-25-18-9-5-4-8-17(18)19(24)22-16-20(10-6-3-7-11-20)23-14-12-21-13-15-23/h4-5,8-9,21H,2-3,6-7,10-16H2,1H3,(H,22,24)
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n/an/a 398n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419074
PNG
(CHEMBL1823886)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCC1)N1CCN(C)CC1
Show InChI InChI=1S/C20H31N3O2/c1-3-25-18-9-5-4-8-17(18)19(24)21-16-20(10-6-7-11-20)23-14-12-22(2)13-15-23/h4-5,8-9H,3,6-7,10-16H2,1-2H3,(H,21,24)
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n/an/a 398n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419078
PNG
(CHEMBL1823667)
Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2OCc2ccccc2)Cc2ccccc2C1
Show InChI InChI=1S/C29H33N3O2/c1-31-15-17-32(18-16-31)29(19-24-11-5-6-12-25(24)20-29)22-30-28(33)26-13-7-8-14-27(26)34-21-23-9-3-2-4-10-23/h2-14H,15-22H2,1H3,(H,30,33)
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n/an/a 631n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419060
PNG
(CHEMBL1823674)
Show SMILES CCOc1ccccc1C(=O)NCC1(Cc2ccccc2C1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C26H35N3O2/c1-4-31-24-12-8-7-11-23(24)25(30)27-19-26(17-21-9-5-6-10-22(21)18-26)29-15-13-28(14-16-29)20(2)3/h5-12,20H,4,13-19H2,1-3H3,(H,27,30)
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n/an/a 631n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419075
PNG
(CHEMBL1823888)
Show SMILES COc1ccccc1C(=O)NCC1(CCN(CC1)c1ccccc1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C27H38N4O2/c1-22(2)29-17-19-31(20-18-29)27(13-15-30(16-14-27)23-9-5-4-6-10-23)21-28-26(32)24-11-7-8-12-25(24)33-3/h4-12,22H,13-21H2,1-3H3,(H,28,32)
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n/an/a 631n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419054
PNG
(CHEMBL1823665)
Show SMILES COc1ccccc1C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1
Show InChI InChI=1S/C23H29N3O2/c1-25-11-13-26(14-12-25)23(15-18-7-3-4-8-19(18)16-23)17-24-22(27)20-9-5-6-10-21(20)28-2/h3-10H,11-17H2,1-2H3,(H,24,27)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419084
PNG
(CHEMBL1823885)
Show SMILES COc1ccccc1C(=O)NCC1(CCc2ccccc2C1)N1CCN(C)CC1
Show InChI InChI=1S/C24H31N3O2/c1-26-13-15-27(16-14-26)24(12-11-19-7-3-4-8-20(19)17-24)18-25-23(28)21-9-5-6-10-22(21)29-2/h3-10H,11-18H2,1-2H3,(H,25,28)
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n/an/a 1.58E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419076
PNG
(CHEMBL1823889)
Show SMILES COc1ccccc1C(=O)NCC(N1CCN(C)CC1)c1ccc(C)cc1
Show InChI InChI=1S/C22H29N3O2/c1-17-8-10-18(11-9-17)20(25-14-12-24(2)13-15-25)16-23-22(26)19-6-4-5-7-21(19)27-3/h4-11,20H,12-16H2,1-3H3,(H,23,26)
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n/an/a 2.51E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419071
PNG
(CHEMBL1823883)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCCCC1
Show InChI InChI=1S/C21H32N2O2/c1-2-25-19-12-6-5-11-18(19)20(24)22-17-21(13-7-3-8-14-21)23-15-9-4-10-16-23/h5-6,11-12H,2-4,7-10,13-17H2,1H3,(H,22,24)
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n/an/a 1.58E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419087
PNG
(CHEMBL1823676)
Show SMILES CCOc1ccccc1C(=O)NCC1(Cc2ccccc2C1)N1CCCCC1
Show InChI InChI=1S/C24H30N2O2/c1-2-28-22-13-7-6-12-21(22)23(27)25-18-24(26-14-8-3-9-15-26)16-19-10-4-5-11-20(19)17-24/h4-7,10-13H,2-3,8-9,14-18H2,1H3,(H,25,27)
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n/an/a 1.58E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419086
PNG
(CHEMBL1823671)
Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2Cl)Cc2ccccc2C1
Show InChI InChI=1S/C22H26ClN3O/c1-25-10-12-26(13-11-25)22(14-17-6-2-3-7-18(17)15-22)16-24-21(27)19-8-4-5-9-20(19)23/h2-9H,10-16H2,1H3,(H,24,27)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419056
PNG
(CHEMBL1823668)
Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2OC(F)(F)F)Cc2ccccc2C1
Show InChI InChI=1S/C23H26F3N3O2/c1-28-10-12-29(13-11-28)22(14-17-6-2-3-7-18(17)15-22)16-27-21(30)19-8-4-5-9-20(19)31-23(24,25)26/h2-9H,10-16H2,1H3,(H,27,30)
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n/an/a 2.51E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419079
PNG
(CHEMBL1823673)
Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2F)Cc2ccccc2C1
Show InChI InChI=1S/C22H26FN3O/c1-25-10-12-26(13-11-25)22(14-17-6-2-3-7-18(17)15-22)16-24-21(27)19-8-4-5-9-20(19)23/h2-9H,10-16H2,1H3,(H,24,27)
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n/an/a 2.51E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419061
PNG
(CHEMBL1823675)
Show SMILES COc1ccccc1C(=O)NCC1(Cc2ccccc2C1)N1CCCCC1
Show InChI InChI=1S/C23H28N2O2/c1-27-21-12-6-5-11-20(21)22(26)24-17-23(25-13-7-2-8-14-25)15-18-9-3-4-10-19(18)16-23/h3-6,9-12H,2,7-8,13-17H2,1H3,(H,24,26)
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n/an/a 5.01E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419057
PNG
(CHEMBL1823669)
Show SMILES COc1cccc(c1)C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1
Show InChI InChI=1S/C23H29N3O2/c1-25-10-12-26(13-11-25)23(15-19-6-3-4-7-20(19)16-23)17-24-22(27)18-8-5-9-21(14-18)28-2/h3-9,14H,10-13,15-17H2,1-2H3,(H,24,27)
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n/an/a 6.31E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419063
PNG
(CHEMBL1823678)
Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2C)CCCCC1
Show InChI InChI=1S/C20H31N3O/c1-17-8-4-5-9-18(17)19(24)21-16-20(10-6-3-7-11-20)23-14-12-22(2)13-15-23/h4-5,8-9H,3,6-7,10-16H2,1-2H3,(H,21,24)
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n/an/a 6.31E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419058
PNG
(CHEMBL1823670)
Show SMILES COc1ccc(cc1)C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1
Show InChI InChI=1S/C23H29N3O2/c1-25-11-13-26(14-12-25)23(15-19-5-3-4-6-20(19)16-23)17-24-22(27)18-7-9-21(28-2)10-8-18/h3-10H,11-17H2,1-2H3,(H,24,27)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419073
PNG
(CHEMBL1823884)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H35N3O2/c1-2-31-24-14-8-7-13-23(24)25(30)27-21-26(15-9-4-10-16-26)29-19-17-28(18-20-29)22-11-5-3-6-12-22/h3,5-8,11-14H,2,4,9-10,15-21H2,1H3,(H,27,30)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419072
PNG
(CHEMBL1332972)
Show SMILES COc1ccccc1C(=O)NCC1(CCCCC1)N1CCOCC1
Show InChI InChI=1S/C19H28N2O3/c1-23-17-8-4-3-7-16(17)18(22)20-15-19(9-5-2-6-10-19)21-11-13-24-14-12-21/h3-4,7-8H,2,5-6,9-15H2,1H3,(H,20,22)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419059
PNG
(CHEMBL1823672)
Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2O)Cc2ccccc2C1
Show InChI InChI=1S/C22H27N3O2/c1-24-10-12-25(13-11-24)22(14-17-6-2-3-7-18(17)15-22)16-23-21(27)19-8-4-5-9-20(19)26/h2-9,26H,10-16H2,1H3,(H,23,27)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419081
PNG
(CHEMBL1823679)
Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2Cl)CCCCC1
Show InChI InChI=1S/C19H28ClN3O/c1-22-11-13-23(14-12-22)19(9-5-2-6-10-19)15-21-18(24)16-7-3-4-8-17(16)20/h3-4,7-8H,2,5-6,9-15H2,1H3,(H,21,24)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419082
PNG
(CHEMBL1823877)
Show SMILES CCc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C23H37N3O/c1-4-20-10-6-7-11-21(20)22(27)24-18-23(12-8-5-9-13-23)26-16-14-25(15-17-26)19(2)3/h6-7,10-11,19H,4-5,8-9,12-18H2,1-3H3,(H,24,27)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens)
BDBM50419077
PNG
(CHEMBL1823890)
Show SMILES COc1ccccc1C(=O)NCCN1CCN(C)CC1
Show InChI InChI=1S/C15H23N3O2/c1-17-9-11-18(12-10-17)8-7-16-15(19)13-5-3-4-6-14(13)20-2/h3-6H,7-12H2,1-2H3,(H,16,19)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Mus musculus)
BDBM50326986
PNG
(3,3'-((2Z,2'Z)-4,4'-((S)-2-(3,4-dimethoxyphenyl)pr...)
Show SMILES COc1ccc(cc1OC)[C@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O
Show InChI InChI=1S/C43H51N3O8/c1-30(31-12-13-36(49-2)37(22-31)50-3)29-44(16-8-10-18-45-20-14-32-23-38(51-4)40(53-6)25-34(32)27-42(45)47)17-9-11-19-46-21-15-33-24-39(52-5)41(54-7)26-35(33)28-43(46)48/h8-15,20-26,30H,16-19,27-29H2,1-7H3/b10-8-,11-9-/t30-/m1/s1
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n/an/an/an/a 1.79E+4n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Mus musculus)
BDBM50326991
PNG
(3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)
Show SMILES COc1ccc(CCN(C)C\C=C\CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC
Show InChI InChI=1S/C27H34N2O5/c1-28(14-10-20-8-9-23(31-2)24(16-20)32-3)12-6-7-13-29-15-11-21-17-25(33-4)26(34-5)18-22(21)19-27(29)30/h6-9,11,15-18H,10,12-14,19H2,1-5H3/b7-6+
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n/an/an/an/a 2.31E+3n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Mus musculus)
BDBM50326990
PNG
(3,3'-((2Z,2'Z)-4,4'-((R)-2-(3,4-dimethoxyphenyl)pr...)
Show SMILES COc1ccc(cc1OC)[C@@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O
Show InChI InChI=1S/C43H51N3O8/c1-30(31-12-13-36(49-2)37(22-31)50-3)29-44(16-8-10-18-45-20-14-32-23-38(51-4)40(53-6)25-34(32)27-42(45)47)17-9-11-19-46-21-15-33-24-39(52-5)41(54-7)26-35(33)28-43(46)48/h8-15,20-26,30H,16-19,27-29H2,1-7H3/b10-8-,11-9-/t30-/m0/s1
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n/an/an/an/a 600n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Mus musculus)
BDBM50326988
PNG
(3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...)
Show SMILES COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
Show InChI InChI=1S/C26H36N2O5/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29/h7-8,15-17H,6,9-14,18H2,1-5H3
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n/an/an/an/a 1.68E+4n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Mus musculus)
BDBM50326993
PNG
(3-((Z)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)
Show SMILES COc1ccc(CCN(C)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC
Show InChI InChI=1S/C27H34N2O5/c1-28(14-10-20-8-9-23(31-2)24(16-20)32-3)12-6-7-13-29-15-11-21-17-25(33-4)26(34-5)18-22(21)19-27(29)30/h6-9,11,15-18H,10,12-14,19H2,1-5H3/b7-6-
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n/an/an/an/a 5.60E+3n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Mus musculus)
BDBM50326992
PNG
(CHEMBL471737 | ivabradine)
Show SMILES COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC
Show InChI InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1
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n/an/an/an/a 4.50E+3n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Mus musculus)
BDBM50326985
PNG
(3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanedi...)
Show SMILES COc1ccc(CCN(C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC
Show InChI InChI=1S/C42H49N3O8/c1-48-35-12-11-30(23-36(35)49-2)13-20-43(16-7-9-18-44-21-14-31-24-37(50-3)39(52-5)26-33(31)28-41(44)46)17-8-10-19-45-22-15-32-25-38(51-4)40(53-6)27-34(32)29-42(45)47/h7-12,14-15,21-27H,13,16-20,28-29H2,1-6H3/b9-7-,10-8-
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n/an/an/an/a 1.07E+5n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


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More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Mus musculus)
BDBM50326987
PNG
(3-((Z)-4-(((S)-2-(3,4-dimethoxyphenyl)propyl)(meth...)
Show SMILES COc1ccc(cc1OC)[C@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O
Show InChI InChI=1S/C28H36N2O5/c1-20(21-9-10-24(32-3)25(15-21)33-4)19-29(2)12-7-8-13-30-14-11-22-16-26(34-5)27(35-6)17-23(22)18-28(30)31/h7-11,14-17,20H,12-13,18-19H2,1-6H3/b8-7-/t20-/m1/s1
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n/an/an/an/a 3.13E+4n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Mus musculus)
BDBM50326989
PNG
(3-((Z)-4-(((R)-2-(3,4-dimethoxyphenyl)propyl)(meth...)
Show SMILES COc1ccc(cc1OC)[C@@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O
Show InChI InChI=1S/C28H36N2O5/c1-20(21-9-10-24(32-3)25(15-21)33-4)19-29(2)12-7-8-13-30-14-11-22-16-26(34-5)27(35-6)17-23(22)18-28(30)31/h7-11,14-17,20H,12-13,18-19H2,1-6H3/b8-7-/t20-/m0/s1
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n/an/an/an/a 9.41E+3n/an/an/an/a



Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)

Curated by ChEMBL


Assay Description
Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair