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Compile Data Set for Download or QSAR

Found 76 hits Enz. Inhib. hit(s) with Target = 'Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118351
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CC1(CCC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O2S2/c1-10(3-2-4-10)13-9-12-6-5-7(11)17-8(6)18(15,16)14-9/h5H,2-4H2,1H3,(H2,12,13,14)
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n/an/a 3n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50012957
PNG
(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Show SMILES COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
Show InChI InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
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n/an/a 4.30n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human SUR1/Kir6.2 expressed in CHO cells


J Med Chem 44: 1627-53 (2001)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50190500
PNG
(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Show SMILES CC(C)(NC1=Nc2cc(Cl)sc2S(=O)(=O)N1)c1ccccc1
Show InChI InChI=1S/C14H14ClN3O2S2/c1-14(2,9-6-4-3-5-7-9)17-13-16-10-8-11(15)21-12(10)22(19,20)18-13/h3-8H,1-2H3,(H2,16,17,18)
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n/an/a 81n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP


J Med Chem 49: 4127-39 (2006)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118349
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES Clc1cc2N=C(NC3CCC3)NS(=O)(=O)c2s1
Show InChI InChI=1S/C9H10ClN3O2S2/c10-7-4-6-8(16-7)17(14,15)13-9(12-6)11-5-2-1-3-5/h4-5H,1-3H2,(H2,11,12,13)
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n/an/a 120n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118348
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CCC(C)(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C10H14ClN3O2S2/c1-4-10(2,3)13-9-12-6-5-7(11)17-8(6)18(15,16)14-9/h5H,4H2,1-3H3,(H2,12,13,14)
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n/an/a 180n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118360
PNG
(CHEMBL336586 | tert-Butyl-(2-chloro-7,7-dioxo-4,7-...)
Show SMILES CC(C)(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H12ClN3O2S2/c1-9(2,3)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,1-3H3,(H2,11,12,13)
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n/an/a 230n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 286n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP


J Med Chem 49: 4127-39 (2006)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 320n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118343
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CC(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C8H10ClN3O2S2/c1-4(2)10-8-11-5-3-6(9)15-7(5)16(13,14)12-8/h3-4H,1-2H3,(H2,10,11,12)
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n/an/a 340n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50023475
PNG
(CHEMBL2111887)
Show SMILES CC[C@@H](C)NC1=NS(=O)(=O)c2sc(Cl)cc2N1
Show InChI InChI=1/C9H12ClN3O2S2/c1-3-5(2)11-9-12-6-4-7(10)16-8(6)17(14,15)13-9/h4-5H,3H2,1-2H3,(H2,11,12,13)/t5-/s2
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n/an/a 640n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118355
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CCCNC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C8H10ClN3O2S2/c1-2-3-10-8-11-5-4-6(9)15-7(5)16(13,14)12-8/h4H,2-3H2,1H3,(H2,10,11,12)
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n/an/a 2.27E+3n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50099573
PNG
(1N-[4-methoxy-3-methylamino(thioxo)methylsulfamoyl...)
Show SMILES CNC(=S)NS(=O)(=O)c1cc(CCNC(=O)c2cc(Cl)ccc2OC)ccc1OC
Show InChI InChI=1S/C19H22ClN3O5S2/c1-21-19(29)23-30(25,26)17-10-12(4-6-16(17)28-3)8-9-22-18(24)14-11-13(20)5-7-15(14)27-2/h4-7,10-11H,8-9H2,1-3H3,(H,22,24)(H2,21,23,29)
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n/an/a 8.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human SUR1/Kir6.2 expressed in CHO cells


J Med Chem 44: 1627-53 (2001)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118351
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CC1(CCC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O2S2/c1-10(3-2-4-10)13-9-12-6-5-7(11)17-8(6)18(15,16)14-9/h5H,2-4H2,1H3,(H2,12,13,14)
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n/an/a 1.08E+4n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118349
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES Clc1cc2N=C(NC3CCC3)NS(=O)(=O)c2s1
Show InChI InChI=1S/C9H10ClN3O2S2/c10-7-4-6-8(16-7)17(14,15)13-9(12-6)11-5-2-1-3-5/h4-5H,1-3H2,(H2,11,12,13)
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n/an/a 1.46E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 1.65E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118343
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CC(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C8H10ClN3O2S2/c1-4(2)10-8-11-5-3-6(9)15-7(5)16(13,14)12-8/h3-4H,1-2H3,(H2,10,11,12)
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n/an/a 1.87E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/a 1.94E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP


J Med Chem 49: 4127-39 (2006)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/a 1.98E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50023475
PNG
(CHEMBL2111887)
Show SMILES CC[C@@H](C)NC1=NS(=O)(=O)c2sc(Cl)cc2N1
Show InChI InChI=1/C9H12ClN3O2S2/c1-3-5(2)11-9-12-6-4-7(10)16-8(6)17(14,15)13-9/h4-5H,3H2,1-2H3,(H2,11,12,13)/t5-/s2
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n/an/a 2.24E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50190500
PNG
(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Show SMILES CC(C)(NC1=Nc2cc(Cl)sc2S(=O)(=O)N1)c1ccccc1
Show InChI InChI=1S/C14H14ClN3O2S2/c1-14(2,9-6-4-3-5-7-9)17-13-16-10-8-11(15)21-12(10)22(19,20)18-13/h3-8H,1-2H3,(H2,16,17,18)
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n/an/a 3.60E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells


J Med Chem 49: 4127-39 (2006)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118348
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CCC(C)(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C10H14ClN3O2S2/c1-4-10(2,3)13-9-12-6-5-7(11)17-8(6)18(15,16)14-9/h5H,4H2,1-3H3,(H2,12,13,14)
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n/an/a 3.75E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118360
PNG
(CHEMBL336586 | tert-Butyl-(2-chloro-7,7-dioxo-4,7-...)
Show SMILES CC(C)(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H12ClN3O2S2/c1-9(2,3)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,1-3H3,(H2,11,12,13)
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n/an/a 3.93E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50023475
PNG
(CHEMBL2111887)
Show SMILES CC[C@@H](C)NC1=NS(=O)(=O)c2sc(Cl)cc2N1
Show InChI InChI=1/C9H12ClN3O2S2/c1-3-5(2)11-9-12-6-4-7(10)16-8(6)17(14,15)13-9/h4-5H,3H2,1-2H3,(H2,11,12,13)/t5-/s2
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n/an/a 4.20E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118343
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CC(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C8H10ClN3O2S2/c1-4(2)10-8-11-5-3-6(9)15-7(5)16(13,14)12-8/h3-4H,1-2H3,(H2,10,11,12)
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n/an/a 5.54E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118355
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CCCNC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C8H10ClN3O2S2/c1-2-3-10-8-11-5-4-6(9)15-7(5)16(13,14)12-8/h4H,2-3H2,1H3,(H2,10,11,12)
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n/an/a 5.84E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 6.85E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 6.96E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells


J Med Chem 49: 4127-39 (2006)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/a 7.40E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells


J Med Chem 49: 4127-39 (2006)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/a 7.50E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118351
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CC1(CCC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O2S2/c1-10(3-2-4-10)13-9-12-6-5-7(11)17-8(6)18(15,16)14-9/h5H,2-4H2,1H3,(H2,12,13,14)
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n/an/a 8.59E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118348
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CCC(C)(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C10H14ClN3O2S2/c1-4-10(2,3)13-9-12-6-5-7(11)17-8(6)18(15,16)14-9/h5H,4H2,1-3H3,(H2,12,13,14)
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n/an/a 8.99E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118355
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CCCNC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C8H10ClN3O2S2/c1-2-3-10-8-11-5-4-6(9)15-7(5)16(13,14)12-8/h4H,2-3H2,1H3,(H2,10,11,12)
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n/an/a 9.24E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118349
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES Clc1cc2N=C(NC3CCC3)NS(=O)(=O)c2s1
Show InChI InChI=1S/C9H10ClN3O2S2/c10-7-4-6-8(16-7)17(14,15)13-9(12-6)11-5-2-1-3-5/h4-5H,1-3H2,(H2,11,12,13)
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n/an/a 9.43E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118360
PNG
(CHEMBL336586 | tert-Butyl-(2-chloro-7,7-dioxo-4,7-...)
Show SMILES CC(C)(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H12ClN3O2S2/c1-9(2,3)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,1-3H3,(H2,11,12,13)
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n/an/a 1.35E+6n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139705
PNG
(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-1H-py...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C10H5F3N4O4/c11-10(12,13)9-8(17(20)21)7(14-15-9)5-1-3-6(4-2-5)16(18)19/h1-4H,(H,14,15)
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n/an/an/an/a 700n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139708
PNG
(3-(4-Nitro-phenyl)-5-trifluoromethyl-1H-pyrazole |...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc([nH]n1)C(F)(F)F
Show InChI InChI=1S/C10H6F3N3O2/c11-10(12,13)9-5-8(14-15-9)6-1-3-7(4-2-6)16(17)18/h1-5H,(H,14,15)
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n/an/an/an/a>3.00E+4n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139707
PNG
(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-isoxa...)
Show SMILES [O-][N+](=O)c1c([n-][o+]c1C(F)(F)F)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C10H4F3N3O5/c11-10(12,13)9-8(16(19)20)7(14-21-9)5-1-3-6(4-2-5)15(17)18/h1-4H
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n/an/an/an/a>3.00E+4n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139709
PNG
(3-(2,4-Bis-trifluoromethyl-phenyl)-4-nitro-5-trifl...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccc(cc1C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H4F9N3O2/c13-10(14,15)4-1-2-5(6(3-4)11(16,17)18)7-8(24(25)26)9(23-22-7)12(19,20)21/h1-3H,(H,22,23)
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n/an/an/an/a 540n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139710
PNG
(4-Nitro-3-phenyl-5-trifluoromethyl-1H-pyrazole | C...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C10H6F3N3O2/c11-10(12,13)9-8(16(17)18)7(14-15-9)6-4-2-1-3-5-6/h1-5H,(H,14,15)
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n/an/an/an/a 3.00E+4n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139706
PNG
(3-(2,4-Dinitro-phenyl)-4-nitro-5-trifluoromethyl-1...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C10H4F3N5O6/c11-10(12,13)9-8(18(23)24)7(14-15-9)5-2-1-4(16(19)20)3-6(5)17(21)22/h1-3H,(H,14,15)
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n/an/an/an/a 70n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50139704
PNG
(3-(2,4-Difluoro-phenyl)-4-nitro-5-trifluoromethyl-...)
Show SMILES [O-][N+](=O)c1c(n[nH]c1C(F)(F)F)-c1ccc(F)cc1F
Show InChI InChI=1S/C10H4F5N3O2/c11-4-1-2-5(6(12)3-4)7-8(18(19)20)9(17-16-7)10(13,14)15/h1-3H,(H,16,17)
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n/an/an/an/a 1.15E+3n/an/an/an/a



GlaxoSmithKline Research & Development

Curated by ChEMBL


Assay Description
Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes


Bioorg Med Chem Lett 14: 813-6 (2004)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/an/an/a 190n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization


J Med Chem 50: 2117-26 (2007)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/an/an/a 3.10E+4n/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currents


J Med Chem 50: 2117-26 (2007)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119269
PNG
(CHEMBL102025 | Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-...)
Show SMILES Fc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H12FN3O2S/c12-7-4-5-9-10(6-7)18(16,17)15-11(14-9)13-8-2-1-3-8/h4-6,8H,1-3H2,(H2,13,14,15)
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n/an/an/an/a 356n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119273
PNG
(CHEMBL101736 | N*3*-Cyclobutyl-1,1-dioxo-1,4-dihyd...)
Show SMILES Nc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H14N4O2S/c12-7-4-5-9-10(6-7)18(16,17)15-11(14-9)13-8-2-1-3-8/h4-6,8H,1-3,12H2,(H2,13,14,15)
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n/an/an/an/a 3.20E+4n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Negative log EC50 for Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119271
PNG
(CHEMBL319521 | Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...)
Show SMILES COc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C12H15N3O3S/c1-18-9-5-6-10-11(7-9)19(16,17)15-12(14-10)13-8-3-2-4-8/h5-8H,2-4H2,1H3,(H2,13,14,15)
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n/an/an/an/a 4.00E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Negative log EC50 for Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119270
PNG
(CHEMBL319596 | Cyclobutyl-(1,1-dioxo-1,4-dihydro-1...)
Show SMILES O=S1(=O)NC(NC2CCC2)=Nc2ccccc12
Show InChI InChI=1S/C11H13N3O2S/c15-17(16)10-7-2-1-6-9(10)13-11(14-17)12-8-4-3-5-8/h1-2,6-8H,3-5H2,(H2,12,13,14)
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Negative log EC50 for Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119274
PNG
(CHEMBL100793 | Cyclobutyl-(7-nitro-1,1-dioxo-1,4-d...)
Show SMILES [O-][N+](=O)c1ccc2[N-]\C(NS(=O)(=O)c2c1)=[NH+]\C1CCC1
Show InChI InChI=1S/C11H11N4O4S/c16-15(17)8-4-5-9-10(6-8)20(18,19)14-11(13-9)12-7-2-1-3-7/h4-7H,1-3H2,(H-,12,13,14)/q-1/p+1
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n/an/an/an/a 530n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119273
PNG
(CHEMBL101736 | N*3*-Cyclobutyl-1,1-dioxo-1,4-dihyd...)
Show SMILES Nc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C11H14N4O2S/c12-7-4-5-9-10(6-7)18(16,17)15-11(14-9)13-8-2-1-3-8/h4-6,8H,1-3,12H2,(H2,13,14,15)
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n/an/an/an/a 3.10E+4n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)

More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens-HUMAN)
BDBM50119271
PNG
(CHEMBL319521 | Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...)
Show SMILES COc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1
Show InChI InChI=1S/C12H15N3O3S/c1-18-9-5-6-10-11(7-9)19(16,17)15-12(14-10)13-8-3-2-4-8/h5-8H,2-4H2,1H3,(H2,13,14,15)
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n/an/an/an/a 3.87E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Beta-cell KATP channel


Bioorg Med Chem Lett 12: 2977-80 (2002)

More data for this
Ligand-Target Pair
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