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Found 554 hits Enz. Inhib. hit(s) with Target = 'Potassium channel protein TASK-1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050546
PNG
(CHEMBL3182699)
Show SMILES CC(C)Oc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C24H21F3N2O4/c1-15(2)32-20-12-5-3-10-18(20)22(30)28-16-8-7-9-17(14-16)29-23(31)19-11-4-6-13-21(19)33-24(25,26)27/h3-15H,1-2H3,(H,28,30)(H,29,31)
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n/an/a 1n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050542
PNG
(CHEMBL3183497)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C23H22N2O4/c1-3-29-21-14-7-5-12-19(21)23(27)25-17-10-8-9-16(15-17)24-22(26)18-11-4-6-13-20(18)28-2/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 2n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050547
PNG
(CHEMBL3182449)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N2O3/c1-2-31-20-13-6-4-11-18(20)22(30)28-16-9-7-8-15(14-16)27-21(29)17-10-3-5-12-19(17)23(24,25)26/h3-14H,2H2,1H3,(H,27,29)(H,28,30)
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n/an/a 2n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50312125
PNG
(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050541
PNG
(CHEMBL3188749)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O4/c1-30-18-11-4-2-9-16(18)20(28)26-14-7-6-8-15(13-14)27-21(29)17-10-3-5-12-19(17)31-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050538
PNG
(CHEMBL3182091)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccs2)c1
Show InChI InChI=1S/C19H16N2O2S/c1-13-5-2-6-14(11-13)18(22)20-15-7-3-8-16(12-15)21-19(23)17-9-4-10-24-17/h2-12H,1H3,(H,20,22)(H,21,23)
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n/an/a 5n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50123519
PNG
(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Show SMILES COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C30H26F2N2O3/c1-37-24-14-10-20(11-15-24)16-29(35)33-18-21-6-2-3-7-25(21)26-8-4-5-9-27(26)30(36)34-19-22-12-13-23(31)17-28(22)32/h2-15,17H,16,18-19H2,1H3,(H,33,35)(H,34,36)
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n/an/a 7n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050544
PNG
(CHEMBL3187764)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(C)C)c1
Show InChI InChI=1S/C24H24N2O3/c1-16(2)19-11-4-5-12-20(19)23(27)25-17-9-8-10-18(15-17)26-24(28)21-13-6-7-14-22(21)29-3/h4-16H,1-3H3,(H,25,27)(H,26,28)
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n/an/a 7n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050503
PNG
(CHEMBL3187482)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O3/c1-3-28-21-13-5-4-12-20(21)23(27)25-19-11-7-10-18(15-19)24-22(26)17-9-6-8-16(2)14-17/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 9n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050540
PNG
(CHEMBL3182359)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C22H20N2O4/c1-27-19-12-5-3-10-17(19)21(25)23-15-8-7-9-16(14-15)24-22(26)18-11-4-6-13-20(18)28-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 10n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050547
PNG
(CHEMBL3182449)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N2O3/c1-2-31-20-13-6-4-11-18(20)22(30)28-16-9-7-8-15(14-16)27-21(29)17-10-3-5-12-19(17)23(24,25)26/h3-14H,2H2,1H3,(H,27,29)(H,28,30)
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n/an/a 10n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 10n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050545
PNG
(CHEMBL3186000)
Show SMILES CC(C)c1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C24H21F3N2O3/c1-15(2)18-10-3-4-11-19(18)22(30)28-16-8-7-9-17(14-16)29-23(31)20-12-5-6-13-21(20)32-24(25,26)27/h3-15H,1-2H3,(H,28,30)(H,29,31)
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n/an/a 11n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050503
PNG
(CHEMBL3187482)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O3/c1-3-28-21-13-5-4-12-20(21)23(27)25-19-11-7-10-18(15-19)24-22(26)17-9-6-8-16(2)14-17/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 11n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218442
PNG
(US9284333, 16hb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C2CC2)C2CC2)n2CCOCc12)c1ccccc1
Show InChI InChI=1/C25H31N3O3/c1-2-20(16-6-4-3-5-7-16)26-24(29)19-14-21(28-12-13-31-15-22(19)28)25(30)27-23(17-8-9-17)18-10-11-18/h3-7,14,17-18,20,23H,2,8-13,15H2,1H3,(H,26,29)(H,27,30)/t20-/s2
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n/an/a 13n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218623
PNG
(US9284333, 16mb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](CC)c2ccccc2)n2CCCCc12)c1ccccc1
Show InChI InChI=1/C28H33N3O2/c1-3-23(20-13-7-5-8-14-20)29-27(32)22-19-26(31-18-12-11-17-25(22)31)28(33)30-24(4-2)21-15-9-6-10-16-21/h5-10,13-16,19,23-24H,3-4,11-12,17-18H2,1-2H3,(H,29,32)(H,30,33)/t23-,24+/s2
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n/an/a 13n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218253
PNG
(US9284333, 16c)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1/C24H27ClF3N3O3/c1-3-19(15-6-7-17(18(25)11-15)24(26,27)28)29-22(32)16-12-20(31-9-10-34-13-21(16)31)23(33)30-8-4-5-14(30)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,29,32)/t14-,19+/s2
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050530
PNG
(CHEMBL3188857)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 14n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218341
PNG
(US9284333, 16cg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(F)c(Cl)c1
Show InChI InChI=1/C23H27ClFN3O3/c1-3-19(15-6-7-18(25)17(24)11-15)26-22(29)16-12-20(28-9-10-31-13-21(16)28)23(30)27-8-4-5-14(27)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,26,29)/t14-,19+/s2
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n/an/a 15n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 16n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179693
PNG
(US9127001, 8b)
Show SMILES CC(C)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C24H22F2N4O/c1-15(2)24(31)29-9-8-22-20(14-29)23(17-5-3-4-16(10-17)12-27)28-30(22)13-18-6-7-19(25)11-21(18)26/h3-7,10-11,15H,8-9,13-14H2,1-2H3
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n/an/a 19n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9127001 (2015)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050433
PNG
(CHEMBL3186489)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccccc1
Show InChI InChI=1S/C20H16N2O2/c23-19(15-8-3-1-4-9-15)21-17-12-7-13-18(14-17)22-20(24)16-10-5-2-6-11-16/h1-14H,(H,21,23)(H,22,24)
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n/an/a 21n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218340
PNG
(US9284333, 16cf)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(s1)C(F)(F)F
Show InChI InChI=1/C22H26F3N3O3S/c1-3-15(18-6-7-19(32-18)22(23,24)25)26-20(29)14-11-16(28-9-10-31-12-17(14)28)21(30)27-8-4-5-13(27)2/h6-7,11,13,15H,3-5,8-10,12H2,1-2H3,(H,26,29)/t13-,15+/s2
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n/an/a 21n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050508
PNG
(CHEMBL3186695)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-6-4-7-15(12-14)20(25)23-16-8-5-9-17(13-16)24-21(26)18-10-2-3-11-19(18)22/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 23n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218405
PNG
(US9284333, 16fc)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2CC)n2CCOCc12)c1ccccc1
Show InChI InChI=1/C24H31N3O3/c1-3-18-11-8-12-26(18)24(29)21-15-19(22-16-30-14-13-27(21)22)23(28)25-20(4-2)17-9-6-5-7-10-17/h5-7,9-10,15,18,20H,3-4,8,11-14,16H2,1-2H3,(H,25,28)/t18-,20+/s2
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n/an/a 25n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050522
PNG
(CHEMBL3182551)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(F)c2)c1
Show InChI InChI=1S/C21H17FN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 25n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 27n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218535
PNG
(US9284333, 16kt)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCSc12)c1ccccc1
Show InChI InChI=1/C25H26FN3O2S/c1-3-21(18-7-5-4-6-8-18)28-23(30)20-15-22(29-13-14-32-25(20)29)24(31)27-16(2)17-9-11-19(26)12-10-17/h4-12,15-16,21H,3,13-14H2,1-2H3,(H,27,31)(H,28,30)/t16-,21-/s2
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n/an/a 27n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050504
PNG
(CHEMBL3182725)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O3/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)30-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 29n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050451
PNG
(CHEMBL3182777)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1cccs1
Show InChI InChI=1S/C18H14N2O2S/c21-17(13-6-2-1-3-7-13)19-14-8-4-9-15(12-14)20-18(22)16-10-5-11-23-16/h1-12H,(H,19,21)(H,20,22)
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n/an/a 29n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050495
PNG
(CHEMBL3185736)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O2/c1-15-6-3-8-17(12-15)21(25)23-19-10-5-11-20(14-19)24-22(26)18-9-4-7-16(2)13-18/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 30n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218343
PNG
(US9284333, 16ci)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C23H27Cl2N3O3/c1-3-19(15-6-7-17(24)18(25)11-15)26-22(29)16-12-20(28-9-10-31-13-21(16)28)23(30)27-8-4-5-14(27)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,26,29)/t14-,19+/s2
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n/an/a 30n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050540
PNG
(CHEMBL3182359)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C22H20N2O4/c1-27-19-12-5-3-10-17(19)21(25)23-15-8-7-9-16(14-15)24-22(26)18-11-4-6-13-20(18)28-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 30n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050498
PNG
(CHEMBL3187806)
Show SMILES COc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-6-3-7-16(12-15)21(25)23-18-9-5-10-19(14-18)24-22(26)17-8-4-11-20(13-17)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 31n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218540
PNG
(US9284333, 16ky)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CSCc12)c1ccccc1
Show InChI InChI=1/C25H26FN3O2S/c1-3-21(18-7-5-4-6-8-18)28-24(30)20-13-22(29-15-32-14-23(20)29)25(31)27-16(2)17-9-11-19(26)12-10-17/h4-13,16,21H,3,14-15H2,1-2H3,(H,27,31)(H,28,30)/t16-,21-/s2
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n/an/a 33n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218618
PNG
(US9284333, 16gk)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCCC2CC2)n2CCOCc12)c1ccccc1
Show InChI InChI=1/C23H29N3O3/c1-2-19(17-6-4-3-5-7-17)25-22(27)18-14-20(26-12-13-29-15-21(18)26)23(28)24-11-10-16-8-9-16/h3-7,14,16,19H,2,8-13,15H2,1H3,(H,24,28)(H,25,27)/t19-/s2
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n/an/a 36n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050447
PNG
(CHEMBL1716797)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccco1
Show InChI InChI=1S/C18H14N2O3/c21-17(13-6-2-1-3-7-13)19-14-8-4-9-15(12-14)20-18(22)16-10-5-11-23-16/h1-12H,(H,19,21)(H,20,22)
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n/an/a 37n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218534
PNG
(US9284333, 16ks)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCSc12)c1ccccc1
Show InChI InChI=1/C22H27N3O2S/c1-3-18(16-9-5-4-6-10-16)23-20(26)17-14-19(25-12-13-28-22(17)25)21(27)24-11-7-8-15(24)2/h4-6,9-10,14-15,18H,3,7-8,11-13H2,1-2H3,(H,23,26)/t15-,18+/s2
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n/an/a 37n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218282
PNG
(US9284333, 16w)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cc(F)ccc1Cl
Show InChI InChI=1/C23H27ClFN3O3/c1-3-19(16-11-15(25)6-7-18(16)24)26-22(29)17-12-20(28-9-10-31-13-21(17)28)23(30)27-8-4-5-14(27)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,26,29)/t14-,19+/s2
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n/an/a 40n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218467
PNG
(US9284333, 16ic)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2cccc(OC)n2)n2CCOCc12)c1ccccc1
Show InChI InChI=1/C27H32N4O4/c1-4-20(18-10-7-6-8-11-18)29-26(32)19-16-23(31-14-15-35-17-24(19)31)27(33)30-21(5-2)22-12-9-13-25(28-22)34-3/h6-13,16,20-21H,4-5,14-15,17H2,1-3H3,(H,29,32)(H,30,33)/t20-,21-/s2
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n/an/a 40n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218463
PNG
(US9284333, 16hy)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2cnc(OC)cn2)n2CCOCc12)c1ccccc1
Show InChI InChI=1/C26H31N5O4/c1-4-19(17-9-7-6-8-10-17)29-25(32)18-13-22(31-11-12-35-16-23(18)31)26(33)30-20(5-2)21-14-28-24(34-3)15-27-21/h6-10,13-15,19-20H,4-5,11-12,16H2,1-3H3,(H,29,32)(H,30,33)/t19-,20-/s2
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n/an/a 41n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218643
PNG
(US9284333, 16mz)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](C)C2CC2)n2CCCCc12)c1ccccc1
Show InChI InChI=1/C24H31N3O2/c1-3-20(18-9-5-4-6-10-18)26-23(28)19-15-22(27-14-8-7-11-21(19)27)24(29)25-16(2)17-12-13-17/h4-6,9-10,15-17,20H,3,7-8,11-14H2,1-2H3,(H,25,29)(H,26,28)/t16-,20+/s2
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n/an/a 42n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218431
PNG
(US9284333, 16gl)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1ccccc1
Show InChI InChI=1/C26H28FN3O3/c1-3-22(19-7-5-4-6-8-19)29-25(31)21-15-23(30-13-14-33-16-24(21)30)26(32)28-17(2)18-9-11-20(27)12-10-18/h4-12,15,17,22H,3,13-14,16H2,1-2H3,(H,28,32)(H,29,31)/t17-,22-/s2
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n/an/a 42n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218279
PNG
(US9284333, 16t)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1c(F)cccc1F
Show InChI InChI=1/C23H27F2N3O3/c1-3-18(21-16(24)7-4-8-17(21)25)26-22(29)15-12-19(28-10-11-31-13-20(15)28)23(30)27-9-5-6-14(27)2/h4,7-8,12,14,18H,3,5-6,9-11,13H2,1-2H3,(H,26,29)/t14-,18+/s2
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n/an/a 44n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050437
PNG
(CHEMBL1532914)
Show SMILES Fc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15FN2O2/c21-16-9-4-8-15(12-16)20(25)23-18-11-5-10-17(13-18)22-19(24)14-6-2-1-3-7-14/h1-13H,(H,22,24)(H,23,25)
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n/an/a 45n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218547
PNG
(US9284333, 16lg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)c2C(C)OCCn12)c1ccccc1
Show InChI InChI=1/C27H30FN3O3/c1-4-23(20-8-6-5-7-9-20)30-27(33)24-16-22(25-18(3)34-15-14-31(24)25)26(32)29-17(2)19-10-12-21(28)13-11-19/h5-13,16-18,23H,4,14-15H2,1-3H3,(H,29,32)(H,30,33)/t17-,18?,23-/s2
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n/an/a 46n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218532
PNG
(US9284333, 16kq)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)c2COCCn12)c1ccccc1
Show InChI InChI=1/C26H28FN3O3/c1-3-22(19-7-5-4-6-8-19)29-26(32)23-15-21(24-16-33-14-13-30(23)24)25(31)28-17(2)18-9-11-20(27)12-10-18/h4-12,15,17,22H,3,13-14,16H2,1-2H3,(H,28,31)(H,29,32)/t17-,22-/s2
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n/an/a 46n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179694
PNG
(US9127001, 8c)
Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CC2)-c2cccc(c2)C#N)c(F)c1
Show InChI InChI=1S/C24H20F2N4O/c25-19-7-6-18(21(26)11-19)13-30-22-8-9-29(24(31)16-4-5-16)14-20(22)23(28-30)17-3-1-2-15(10-17)12-27/h1-3,6-7,10-11,16H,4-5,8-9,13-14H2
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n/an/a 47n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9127001 (2015)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218617
PNG
(US9284333, 16gj)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H]2CCc3ccccc23)n2CCOCc12)c1ccccc1
Show InChI InChI=1/C27H29N3O3/c1-2-22(19-9-4-3-5-10-19)28-26(31)21-16-24(30-14-15-33-17-25(21)30)27(32)29-23-13-12-18-8-6-7-11-20(18)23/h3-11,16,22-23H,2,12-15,17H2,1H3,(H,28,31)(H,29,32)/t22-,23+/s2
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n/an/a 48n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


US Patent US9284333 (2016)

More data for this
Ligand-Target Pair
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