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Found 7 hits Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily B member 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily B member 1


(Homo sapiens)
BDBM50088573
PNG
(CHEMBL3577208)
Show SMILES COc1cccc(OC)c1C(=O)c1c(O)cc(C)c(OC)c1C1=C(c2c(C1=O)c(OC)c(C)cc2O)c1c(OC)cccc1OC
Show InChI InChI=1S/C36H34O10/c1-17-16-20(38)26(33(39)28-23(43-5)13-10-14-24(28)44-6)31(35(17)45-7)30-29(27-21(41-3)11-9-12-22(27)42-4)25-19(37)15-18(2)36(46-8)32(25)34(30)40/h9-16,37-38H,1-8H3
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UniChem

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PubMed
n/an/a 590n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of Kv2.1 channel in human INS1 cells assessed as inhibition of outward K+ current by electrophysiology/patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1


(Homo sapiens)
BDBM50088572
PNG
(CHEMBL3577209)
Show SMILES COc1cccc(OC)c1C(=O)c1c(O)cc(C)c(OC)c1CC(=O)c1c(OC)c(C)cc(O)c1C(=O)c1c(OC)cccc1OC
Show InChI InChI=1S/C36H36O11/c1-18-15-21(37)28(33(40)31-24(42-3)11-9-12-25(31)43-4)20(35(18)46-7)17-23(39)30-29(22(38)16-19(2)36(30)47-8)34(41)32-26(44-5)13-10-14-27(32)45-6/h9-16,37-38H,17H2,1-8H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of Kv2.1 channel in human INS1 cells assessed as inhibition of outward K+ current by electrophysiology/patch clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1


(Rattus norvegicus)
BDBM50213094
PNG
((1R,2R)-1-(3,4-dichlorophenethoxy)-2-(4-morpholiny...)
Show SMILES Clc1ccc(CCO[C@@H]2CCCC[C@H]2N2CCOCC2)cc1Cl
Show InChI InChI=1S/C18H25Cl2NO2/c19-15-6-5-14(13-16(15)20)7-10-23-18-4-2-1-3-17(18)21-8-11-22-12-9-21/h5-6,13,17-18H,1-4,7-12H2/t17-,18-/m1/s1
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CHEMBL
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PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv2.1 by patch-clamp method


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1


(Rattus norvegicus)
BDBM50213093
PNG
((1R,2R)-1-(1-naphthalenethoxy)-2-(3-ketopyrrolidin...)
Show SMILES O=C1CCN(C1)[C@@H]1CCCC[C@H]1OCCc1cccc2ccccc12
Show InChI InChI=1S/C22H27NO2/c24-19-12-14-23(16-19)21-10-3-4-11-22(21)25-15-13-18-8-5-7-17-6-1-2-9-20(17)18/h1-2,5-9,21-22H,3-4,10-16H2/t21-,22-/m1/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv2.1 by patch-clamp method


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1


(Rattus norvegicus)
BDBM50213092
PNG
((1R,2R)-1-(1-naphthalenethoxy)-2-(4-morpholinyl)cy...)
Show SMILES C(Cc1cccc2ccccc12)O[C@@H]1CCCC[C@H]1N1CCOCC1
Show InChI InChI=1S/C22H29NO2/c1-2-9-20-18(6-1)7-5-8-19(20)12-15-25-22-11-4-3-10-21(22)23-13-16-24-17-14-23/h1-2,5-9,21-22H,3-4,10-17H2/t21-,22-/m1/s1
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CHEMBL
PC cid
PC sid
UniChem
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Article
PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv2.1 by patch-clamp method


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1


(Rattus norvegicus)
BDBM50213093
PNG
((1R,2R)-1-(1-naphthalenethoxy)-2-(3-ketopyrrolidin...)
Show SMILES O=C1CCN(C1)[C@@H]1CCCC[C@H]1OCCc1cccc2ccccc12
Show InChI InChI=1S/C22H27NO2/c24-19-12-14-23(16-19)21-10-3-4-11-22(21)25-15-13-18-8-5-7-17-6-1-2-9-20(17)18/h1-2,5-9,21-22H,3-4,10-16H2/t21-,22-/m1/s1
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PC sid
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PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv2.1 by patch-clamp method


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1


(Rattus norvegicus)
BDBM50213095
PNG
((1S,2S)-1-(1-Naphthalenethoxy)-2-(3-ketopyrrolidin...)
Show SMILES O=C1CCN(C1)[C@H]1CCCC[C@@H]1OCCc1cccc2ccccc12
Show InChI InChI=1S/C22H27NO2/c24-19-12-14-23(16-19)21-10-3-4-11-22(21)25-15-13-18-8-5-7-17-6-1-2-9-20(17)18/h1-2,5-9,21-22H,3-4,10-16H2/t21-,22-/m0/s1
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PC cid
PC sid
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Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv2.1 by patch-clamp method


Citation and Details
More data for this
Ligand-Target Pair