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Compile Data Set for Download or QSAR

Found 356 hits Enz. Inhib. hit(s) with Target = 'Potassium-transporting ATPase alpha chain 1/beta chain'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367787
PNG
(CHEMBL1202672)
Show SMILES C(COc1ccc(cc1)-c1csc(n1)-c1ccccc1)Cn1ccnc1
Show InChI InChI=1S/C21H19N3OS/c1-2-5-18(6-3-1)21-23-20(15-26-21)17-7-9-19(10-8-17)25-14-4-12-24-13-11-22-16-24/h1-3,5-11,13,15-16H,4,12,14H2
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n/an/a 20n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367813
PNG
(CHEMBL1202661)
Show SMILES CCCN(CCC)CCCCOc1ccc(\C=C\c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C25H32N2OS/c1-3-17-27(18-4-2)19-7-8-20-28-22-14-11-21(12-15-22)13-16-25-26-23-9-5-6-10-24(23)29-25/h5-6,9-16H,3-4,7-8,17-20H2,1-2H3/b16-13+
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n/an/a 30n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM22893
PNG
(CHEMBL512 | Ranitidine | ZANTAC | dimethyl[(5-{[(2...)
Show SMILES CN\C([CH-][N+]([O-])=O)=[NH+]/CCSCc1ccc(CN(C)C)o1
Show InChI InChI=1S/C13H21N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9H,6-8,10H2,1-3H3,(H,14,15)/q-1/p+1
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n/an/a 40n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367772
PNG
(CHEMBL1202647)
Show SMILES CCCCN(CCCC)CCCOc1ccc(\C=C\c2nc3ccc(OC)cc3o2)cc1
Show InChI InChI=1S/C27H36N2O3/c1-4-6-17-29(18-7-5-2)19-8-20-31-23-12-9-22(10-13-23)11-16-27-28-25-15-14-24(30-3)21-26(25)32-27/h9-16,21H,4-8,17-20H2,1-3H3/b16-11+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367783
PNG
(CHEMBL1202621)
Show SMILES C(COc1ccc(cc1)-c1csc(n1)-c1ccccc1)CN1CCCCC1
Show InChI InChI=1S/C23H26N2OS/c1-3-8-20(9-4-1)23-24-22(18-27-23)19-10-12-21(13-11-19)26-17-7-16-25-14-5-2-6-15-25/h1,3-4,8-13,18H,2,5-7,14-17H2
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Rattus norvegicus)
BDBM50000672
PNG
(6-Methoxy-4-methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quin...)
Show SMILES COc1cccc2c3n(ccc3c(C)nc12)-c1ccccc1C
Show InChI InChI=1S/C20H18N2O/c1-13-7-4-5-9-17(13)22-12-11-15-14(2)21-19-16(20(15)22)8-6-10-18(19)23-3/h4-12H,1-3H3
PDB

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n/an/a 64n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Inhibition of rat isolated gastric(H+/K+)-ATPase.


J Med Chem 35: 1845-52 (1992)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50008978
PNG
((+/-)-(2-Methyl-8-phenyl-7,8-dihydro-6H-9-oxa-1,3a...)
Show SMILES Cc1nc2c3OC(CCc3ccn2c1CC#N)c1ccccc1
Show InChI InChI=1S/C19H17N3O/c1-13-16(9-11-20)22-12-10-15-7-8-17(14-5-3-2-4-6-14)23-18(15)19(22)21-13/h2-6,10,12,17H,7-9H2,1H3
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n/an/a 64n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of H+/K+ ATPase as reduced acid formation in rabbit gastric glands


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50008977
PNG
((8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-yl)-...)
Show SMILES Cc1nc2c(OCc3ccccc3)cccn2c1CC#N
Show InChI InChI=1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3
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n/an/a 65n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of H+/K+ ATPase as reduced acid formation in rabbit gastric glands


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367787
PNG
(CHEMBL1202672)
Show SMILES C(COc1ccc(cc1)-c1csc(n1)-c1ccccc1)Cn1ccnc1
Show InChI InChI=1S/C21H19N3OS/c1-2-5-18(6-3-1)21-23-20(15-26-21)17-7-9-19(10-8-17)25-14-4-12-24-13-11-22-16-24/h1-3,5-11,13,15-16H,4,12,14H2
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n/an/a 80n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367790
PNG
(CHEMBL1202681)
Show SMILES CCN(CC)CCCCOc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C23H28N2O2/c1-3-25(4-2)17-7-8-18-26-20-14-11-19(12-15-20)13-16-23-24-21-9-5-6-10-22(21)27-23/h5-6,9-16H,3-4,7-8,17-18H2,1-2H3/b16-13+
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n/an/a 80n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367772
PNG
(CHEMBL1202647)
Show SMILES CCCCN(CCCC)CCCOc1ccc(\C=C\c2nc3ccc(OC)cc3o2)cc1
Show InChI InChI=1S/C27H36N2O3/c1-4-6-17-29(18-7-5-2)19-8-20-31-23-12-9-22(10-13-23)11-16-27-28-25-15-14-24(30-3)21-26(25)32-27/h9-16,21H,4-8,17-20H2,1-3H3/b16-11+
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n/an/a 80n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367801
PNG
(CHEMBL1202667)
Show SMILES CCN(CC)CCCOc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C22H26N2OS/c1-3-24(4-2)15-8-16-25-20-13-11-18(12-14-20)21-17-26-22(23-21)19-9-6-5-7-10-19/h5-7,9-14,17H,3-4,8,15-16H2,1-2H3
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n/an/a 90n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50008978
PNG
((+/-)-(2-Methyl-8-phenyl-7,8-dihydro-6H-9-oxa-1,3a...)
Show SMILES Cc1nc2c3OC(CCc3ccn2c1CC#N)c1ccccc1
Show InChI InChI=1S/C19H17N3O/c1-13-16(9-11-20)22-12-10-15-7-8-17(14-5-3-2-4-6-14)23-18(15)19(22)21-13/h2-6,10,12,17H,7-9H2,1H3
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n/an/a 92n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified H+/K+ ATPase at pH 7.4 as released inorganic phosphate from ATP using hog stomach gastric membrane vesicles


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367817
PNG
(CHEMBL1202658)
Show SMILES CCCN(CCC)CCCCOc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C25H32N2O2/c1-3-17-27(18-4-2)19-7-8-20-28-22-14-11-21(12-15-22)13-16-25-26-23-9-5-6-10-24(23)29-25/h5-6,9-16H,3-4,7-8,17-20H2,1-2H3/b16-13+
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n/an/a 110n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367783
PNG
(CHEMBL1202621)
Show SMILES C(COc1ccc(cc1)-c1csc(n1)-c1ccccc1)CN1CCCCC1
Show InChI InChI=1S/C23H26N2OS/c1-3-8-20(9-4-1)23-24-22(18-27-23)19-10-12-21(13-11-19)26-17-7-16-25-14-5-2-6-15-25/h1,3-4,8-13,18H,2,5-7,14-17H2
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n/an/a 110n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367790
PNG
(CHEMBL1202681)
Show SMILES CCN(CC)CCCCOc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C23H28N2O2/c1-3-25(4-2)17-7-8-18-26-20-14-11-19(12-15-20)13-16-23-24-21-9-5-6-10-22(21)27-23/h5-6,9-16H,3-4,7-8,17-18H2,1-2H3/b16-13+
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n/an/a 120n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367801
PNG
(CHEMBL1202667)
Show SMILES CCN(CC)CCCOc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C22H26N2OS/c1-3-24(4-2)15-8-16-25-20-13-11-18(12-14-20)21-17-26-22(23-21)19-9-6-5-7-10-19/h5-7,9-14,17H,3-4,8,15-16H2,1-2H3
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n/an/a 120n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367770
PNG
(CHEMBL1202663)
Show SMILES CCCCN(CCCC)CCCCOc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C27H36N2OS/c1-3-5-18-29(19-6-4-2)20-10-11-21-30-25-16-14-23(15-17-25)26-22-31-27(28-26)24-12-8-7-9-13-24/h7-9,12-17,22H,3-6,10-11,18-21H2,1-2H3
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367813
PNG
(CHEMBL1202661)
Show SMILES CCCN(CCC)CCCCOc1ccc(\C=C\c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C25H32N2OS/c1-3-17-27(18-4-2)19-7-8-20-28-22-14-11-21(12-15-22)13-16-25-26-23-9-5-6-10-24(23)29-25/h5-6,9-16H,3-4,7-8,17-20H2,1-2H3/b16-13+
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n/an/a 120n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367788
PNG
(CHEMBL1202659)
Show SMILES C(COc1ccc(\C=C\c2nc3ccccc3s2)cc1)Cn1ccnc1
Show InChI InChI=1S/C21H19N3OS/c1-2-5-20-19(4-1)23-21(26-20)11-8-17-6-9-18(10-7-17)25-15-3-13-24-14-12-22-16-24/h1-2,4-12,14,16H,3,13,15H2/b11-8+
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n/an/a 130n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50008969
PNG
((2-Methyl-8-phenethyl-imidazo[1,2-a]pyridin-3-yl)-...)
Show SMILES Cc1nc2c(CCc3ccccc3)cccn2c1CC#N
Show InChI InChI=1S/C18H17N3/c1-14-17(11-12-19)21-13-5-8-16(18(21)20-14)10-9-15-6-3-2-4-7-15/h2-8,13H,9-11H2,1H3
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n/an/a 130n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of H+/K+ ATPase as reduced acid formation in rabbit gastric glands


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367770
PNG
(CHEMBL1202663)
Show SMILES CCCCN(CCCC)CCCCOc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C27H36N2OS/c1-3-5-18-29(19-6-4-2)20-10-11-21-30-25-16-14-23(15-17-25)26-22-31-27(28-26)24-12-8-7-9-13-24/h7-9,12-17,22H,3-6,10-11,18-21H2,1-2H3
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367804
PNG
(CHEMBL1202607)
Show SMILES CCCN(CCC)CCCOc1ccc(\C=C\c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C24H30N2OS/c1-3-16-26(17-4-2)18-7-19-27-21-13-10-20(11-14-21)12-15-24-25-22-8-5-6-9-23(22)28-24/h5-6,8-15H,3-4,7,16-19H2,1-2H3/b15-12+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367773
PNG
(CHEMBL1202656)
Show SMILES CCCN(CCC)CCCOc1ccc(cc1)-c1nc2ccccc2s1
Show InChI InChI=1S/C22H28N2OS/c1-3-14-24(15-4-2)16-7-17-25-19-12-10-18(11-13-19)22-23-20-8-5-6-9-21(20)26-22/h5-6,8-13H,3-4,7,14-17H2,1-2H3
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367786
PNG
(CHEMBL1202651)
Show SMILES CCCCN(CCCC)CCCOc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C26H34N2O2/c1-3-5-18-28(19-6-4-2)20-9-21-29-23-15-12-22(13-16-23)14-17-26-27-24-10-7-8-11-25(24)30-26/h7-8,10-17H,3-6,9,18-21H2,1-2H3/b17-14+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367786
PNG
(CHEMBL1202651)
Show SMILES CCCCN(CCCC)CCCOc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C26H34N2O2/c1-3-5-18-28(19-6-4-2)20-9-21-29-23-15-12-22(13-16-23)14-17-26-27-24-10-7-8-11-25(24)30-26/h7-8,10-17H,3-6,9,18-21H2,1-2H3/b17-14+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367815
PNG
(CHEMBL1202654)
Show SMILES CCN(CC)CCCOc1ccc(\C=C\c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C22H26N2OS/c1-3-24(4-2)16-7-17-25-19-13-10-18(11-14-19)12-15-22-23-20-8-5-6-9-21(20)26-22/h5-6,8-15H,3-4,7,16-17H2,1-2H3/b15-12+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367792
PNG
(CHEMBL1202629)
Show SMILES C(CCN1CCCC1)COc1ccc(\C=C\c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C23H26N2OS/c1-2-8-22-21(7-1)24-23(27-22)14-11-19-9-12-20(13-10-19)26-18-6-5-17-25-15-3-4-16-25/h1-2,7-14H,3-6,15-18H2/b14-11+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Rattus norvegicus)
BDBM50000668
PNG
(2-(6-Methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quinolin-4-...)
Show SMILES Cc1ccccc1-n1ccc2c(NCCO)nc3c(C)cccc3c12
Show InChI InChI=1S/C21H21N3O/c1-14-6-3-4-9-18(14)24-12-10-17-20(24)16-8-5-7-15(2)19(16)23-21(17)22-11-13-25/h3-10,12,25H,11,13H2,1-2H3,(H,22,23)
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SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Inhibition of rat isolated gastric(H+/K+)-ATPase.


J Med Chem 35: 1845-52 (1992)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367797
PNG
(CHEMBL1202671)
Show SMILES C(CCN1CCCCC1)COc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C24H28N2O2/c1-4-16-26(17-5-1)18-6-7-19-27-21-13-10-20(11-14-21)12-15-24-25-22-8-2-3-9-23(22)28-24/h2-3,8-15H,1,4-7,16-19H2/b15-12+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367807
PNG
(CHEMBL1202678)
Show SMILES C(CCN1CCCC1)COc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C23H26N2O2/c1-2-8-22-21(7-1)24-23(27-22)14-11-19-9-12-20(13-10-19)26-18-6-5-17-25-15-3-4-16-25/h1-2,7-14H,3-6,15-18H2/b14-11+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Rattus norvegicus)
BDBM50000675
PNG
(CHEMBL54511 | Methyl-(6-methyl-1-o-tolyl-2,3-dihyd...)
Show SMILES CNc1nc2c(C)cccc2c2N(CCc12)c1ccccc1C
Show InChI InChI=1S/C20H21N3/c1-13-7-4-5-10-17(13)23-12-11-16-19(23)15-9-6-8-14(2)18(15)22-20(16)21-3/h4-10H,11-12H2,1-3H3,(H,21,22)
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SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Inhibition of rat isolated gastric(H+/K+)-ATPase.


J Med Chem 35: 1845-52 (1992)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367794
PNG
(CHEMBL1202660)
Show SMILES CCN(CC)CCCCOc1ccc(\C=C\c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C23H28N2OS/c1-3-25(4-2)17-7-8-18-26-20-14-11-19(12-15-20)13-16-23-24-21-9-5-6-10-22(21)27-23/h5-6,9-16H,3-4,7-8,17-18H2,1-2H3/b16-13+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367799
PNG
(CHEMBL1202668)
Show SMILES CCCN(CCC)CCCOc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C24H30N2OS/c1-3-15-26(16-4-2)17-8-18-27-22-13-11-20(12-14-22)23-19-28-24(25-23)21-9-6-5-7-10-21/h5-7,9-14,19H,3-4,8,15-18H2,1-2H3
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367812
PNG
(CHEMBL1202655)
Show SMILES C(COc1ccc(\C=C\c2nc3ccccc3s2)cc1)CN1CCCCC1
Show InChI InChI=1S/C23H26N2OS/c1-4-15-25(16-5-1)17-6-18-26-20-12-9-19(10-13-20)11-14-23-24-21-7-2-3-8-22(21)27-23/h2-3,7-14H,1,4-6,15-18H2/b14-11+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367798
PNG
(CHEMBL1202679)
Show SMILES CCCCN(CCCC)CCCCOc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C27H36N2O2/c1-3-5-19-29(20-6-4-2)21-9-10-22-30-24-16-13-23(14-17-24)15-18-27-28-25-11-7-8-12-26(25)31-27/h7-8,11-18H,3-6,9-10,19-22H2,1-2H3/b18-15+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50018887
PNG
(2-(1H-Benzoimidazole-2-sulfinylmethyl)-4-methoxy-3...)
Show SMILES COc1c(C)cc(N)c(CS(=O)c2nc3ccccc3[nH]2)c1C
Show InChI InChI=1S/C17H19N3O2S/c1-10-8-13(18)12(11(2)16(10)22-3)9-23(21)17-19-14-6-4-5-7-15(14)20-17/h4-8H,9,18H2,1-3H3,(H,19,20)
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Searle Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosa


J Med Chem 31: 1215-20 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367771
PNG
(CHEMBL1202666)
Show SMILES C(CCn1ccnc1)COc1ccc(\C=C\c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C22H21N3OS/c1-2-6-21-20(5-1)24-22(27-21)12-9-18-7-10-19(11-8-18)26-16-4-3-14-25-15-13-23-17-25/h1-2,5-13,15,17H,3-4,14,16H2/b12-9+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367812
PNG
(CHEMBL1202655)
Show SMILES C(COc1ccc(\C=C\c2nc3ccccc3s2)cc1)CN1CCCCC1
Show InChI InChI=1S/C23H26N2OS/c1-4-15-25(16-5-1)17-6-18-26-20-12-9-19(10-13-20)11-14-23-24-21-7-2-3-8-22(21)27-23/h2-3,7-14H,1,4-6,15-18H2/b14-11+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367773
PNG
(CHEMBL1202656)
Show SMILES CCCN(CCC)CCCOc1ccc(cc1)-c1nc2ccccc2s1
Show InChI InChI=1S/C22H28N2OS/c1-3-14-24(15-4-2)16-7-17-25-19-12-10-18(11-13-19)22-23-20-8-5-6-9-21(20)26-22/h5-6,8-13H,3-4,7,14-17H2,1-2H3
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367804
PNG
(CHEMBL1202607)
Show SMILES CCCN(CCC)CCCOc1ccc(\C=C\c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C24H30N2OS/c1-3-16-26(17-4-2)18-7-19-27-21-13-10-20(11-14-21)12-15-24-25-22-8-5-6-9-23(22)28-24/h5-6,8-15H,3-4,7,16-19H2,1-2H3/b15-12+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367776
PNG
(CHEMBL1202677)
Show SMILES CCCN(CCC)CCCOc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C24H30N2O2/c1-3-16-26(17-4-2)18-7-19-27-21-13-10-20(11-14-21)12-15-24-25-22-8-5-6-9-23(22)28-24/h5-6,8-15H,3-4,7,16-19H2,1-2H3/b15-12+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Rattus norvegicus)
BDBM50000677
PNG
(4-(6-Methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quinolin-4-...)
Show SMILES Cc1ccccc1-n1ccc2c(NCCCCO)nc3c(C)cccc3c12
Show InChI InChI=1S/C23H25N3O/c1-16-8-3-4-11-20(16)26-14-12-19-22(26)18-10-7-9-17(2)21(18)25-23(19)24-13-5-6-15-27/h3-4,7-12,14,27H,5-6,13,15H2,1-2H3,(H,24,25)
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n/an/a 220n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Inhibition of rat isolated gastric(H+/K+)-ATPase.


J Med Chem 35: 1845-52 (1992)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Rattus norvegicus)
BDBM50000673
PNG
(6-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]qu...)
Show SMILES Cc1ccccc1N1CCc2c1c1cccc(C)c1nc2N
Show InChI InChI=1S/C19H19N3/c1-12-6-3-4-9-16(12)22-11-10-15-18(22)14-8-5-7-13(2)17(14)21-19(15)20/h3-9H,10-11H2,1-2H3,(H2,20,21)
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n/an/a 220n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Inhibition of rat isolated gastric(H+/K+)-ATPase.


J Med Chem 35: 1845-52 (1992)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367811
PNG
(CHEMBL1202615)
Show SMILES C(CCOc1ccc(\C=C\c2nc3ccccc3o2)cc1)CCn1ccnc1
Show InChI InChI=1S/C23H23N3O2/c1(4-15-26-16-14-24-18-26)5-17-27-20-11-8-19(9-12-20)10-13-23-25-21-6-2-3-7-22(21)28-23/h2-3,6-14,16,18H,1,4-5,15,17H2/b13-10+
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n/an/a 230n/an/an/an/an/an/a



Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367778
PNG
(CHEMBL1202673)
Show SMILES CCCCN(CCCC)CCCOc1ccc(cc1)-c1nc(sc1C)-c1ccccc1
Show InChI InChI=1S/C27H36N2OS/c1-4-6-18-29(19-7-5-2)20-11-21-30-25-16-14-23(15-17-25)26-22(3)31-27(28-26)24-12-9-8-10-13-24/h8-10,12-17H,4-7,11,18-21H2,1-3H3
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367799
PNG
(CHEMBL1202668)
Show SMILES CCCN(CCC)CCCOc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C24H30N2OS/c1-3-15-26(16-4-2)17-8-18-27-22-13-11-20(12-14-22)23-19-28-24(25-23)21-9-6-5-7-10-21/h5-7,9-14,19H,3-4,8,15-18H2,1-2H3
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367785
PNG
(CHEMBL1202642)
Show SMILES CCCCN(CCCC)CCCOc1ccc(cc1)-c1csc(n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C27H36N2O2S/c1-4-6-17-29(18-7-5-2)19-8-20-31-25-15-9-22(10-16-25)26-21-32-27(28-26)23-11-13-24(30-3)14-12-23/h9-16,21H,4-8,17-20H2,1-3H3
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367807
PNG
(CHEMBL1202678)
Show SMILES C(CCN1CCCC1)COc1ccc(\C=C\c2nc3ccccc3o2)cc1
Show InChI InChI=1S/C23H26N2O2/c1-2-8-22-21(7-1)24-23(27-22)14-11-19-9-12-20(13-10-19)26-18-6-5-17-25-15-3-4-16-25/h1-2,7-14H,3-6,15-18H2/b14-11+
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
Potassium-transporting ATPase alpha chain 1/beta chain


(Homo sapiens)
BDBM50367809
PNG
(CHEMBL1202675)
Show SMILES CCCCN(CCCC)CCCOc1ccc(cc1)-c1nc(sc1CC)-c1ccccc1
Show InChI InChI=1S/C28H38N2OS/c1-4-7-19-30(20-8-5-2)21-12-22-31-25-17-15-23(16-18-25)27-26(6-3)32-28(29-27)24-13-10-9-11-14-24/h9-11,13-18H,4-8,12,19-22H2,1-3H3
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Ortho Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...


J Med Chem 31: 1778-85 (1988)

More data for this
Ligand-Target Pair
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