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Found 374 hits Enz. Inhib. hit(s) with Target = 'alpha-Glucosidase (α-glucosidase)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108221
PNG
(5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)-c3ccccc3)cn12
Show InChI InChI=1S/C23H26N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-3,6-7,9-13,19-22,26-29H,4-5,8,14H2
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n/an/a 6n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108222
PNG
(2-[3-(4-cyclohexylphenyl)propyl]-5-(hydroxymethyl)...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)C3CCCCC3)cn12
Show InChI InChI=1S/C23H32N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h9-13,16,19-22,26-29H,1-8,14H2
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n/an/a 52n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM60585
PNG
(2-(3'-Fluorophenyl)-7-methyl-1H-benzo[d]imidazole ...)
Show SMILES Cc1cccc2nc([nH]c12)-c1cccc(F)c1
Show InChI InChI=1S/C14H11FN2/c1-9-4-2-7-12-13(9)17-14(16-12)10-5-3-6-11(15)8-10/h2-8H,1H3,(H,16,17)
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n/an/a 165n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM), Puncak Alam Campus



Assay Description
The 135 無 of 50 mM phosphate saline buffer pH (6.8), solution of enzyme (20 無), and 20 無 of test sample with 70% DMSO was added to 96-well plate. ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108219
PNG
(5-(hydroxymethyl)-2-[3-(4-methylphenyl)propyl]- 5H...)
Show SMILES Cc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1
Show InChI InChI=1S/C18H24N2O4/c1-11-5-7-12(8-6-11)3-2-4-13-9-20-14(10-21)15(22)16(23)17(24)18(20)19-13/h5-9,14-17,21-24H,2-4,10H2,1H3
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n/an/a 280n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108220
PNG
(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
Show SMILES COc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1
Show InChI InChI=1S/C18H24N2O5/c1-25-13-7-5-11(6-8-13)3-2-4-12-9-20-14(10-21)15(22)16(23)17(24)18(20)19-12/h5-9,14-17,21-24H,2-4,10H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108216
PNG
(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCc3ccccc3)cn12
Show InChI InChI=1S/C16H20N2O4/c19-9-12-13(20)14(21)15(22)16-17-11(8-18(12)16)7-6-10-4-2-1-3-5-10/h1-5,8,12-15,19-22H,6-7,9H2
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n/an/a 570n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108223
PNG
(2-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)- 5H...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(F)cc3)cn12
Show InChI InChI=1S/C17H21FN2O4/c18-11-6-4-10(5-7-11)2-1-3-12-8-20-13(9-21)14(22)15(23)16(24)17(20)19-12/h4-8,13-16,21-24H,1-3,9H2
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n/an/a 730n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108218
PNG
(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Show SMILES CCCCCCCCc1cn2C(CO)C(O)C(O)C(O)c2n1
Show InChI InChI=1S/C16H28N2O4/c1-2-3-4-5-6-7-8-11-9-18-12(10-19)13(20)14(21)15(22)16(18)17-11/h9,12-15,19-22H,2-8,10H2,1H3
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n/an/a 970n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108224
PNG
(N-phenyl-4-[6,7,8-trihydroxy-5-(hydroxymethyl)- 5H...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCCC(=O)Nc3ccccc3)cn12
Show InChI InChI=1S/C18H23N3O5/c22-10-13-15(24)16(25)17(26)18-20-12(9-21(13)18)7-4-8-14(23)19-11-5-2-1-3-6-11/h1-3,5-6,9,13,15-17,22,24-26H,4,7-8,10H2,(H,19,23)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM178004
PNG
(2-(3-((3-(trifluoromethyl)benzyl)oxy)phenyl)-4H-ch...)
Show SMILES FC(F)(F)c1ccc(c(COc2cccc(c2)-c2cc(=O)c3ccccc3o2)c1)C(F)(F)F
Show InChI InChI=1S/C23H15F3O3/c24-23(25,26)17-7-3-5-15(11-17)14-28-18-8-4-6-16(12-18)22-13-20(27)19-9-1-2-10-21(19)29-22/h1-13H,14H2
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n/an/a 1.26E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The α-glucosidase inhibition assay had been carried out using baker窺 yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM152497
PNG
((E)-N'-(6-Bromo-2-oxoindolin-3-ylidene)-2-(2,4...)
Show SMILES Clc1ccc(CC(=O)N\N=C2\C(=O)Nc3cc(Br)ccc23)c(Cl)c1
Show InChI InChI=1S/C16H10BrCl2N3O2/c17-9-2-4-11-13(6-9)20-16(24)15(11)22-21-14(23)5-8-1-3-10(18)7-12(8)19/h1-4,6-7H,5H2,(H,21,23)(H,20,22,24)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Hazara University



Assay Description
10 無 of test samples (5 mg/mL DMSO solution) were reconstituted in 100 無 of 100 mM-phosphate buffer (pH6.8) in 96-well microplate and incubated wit...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM173530
PNG
((E)-N'-(3,4,5-trihydroxybenzylidene)-1H-indole...)
Show SMILES Oc1cc(\C=N\NC(=O)c2cc3ccccc3[nH]2)cc(O)c1O
Show InChI InChI=1S/C16H13N3O4/c20-13-5-9(6-14(21)15(13)22)8-17-19-16(23)12-7-10-3-1-2-4-11(10)18-12/h1-8,18,20-22H,(H,19,23)/b17-8+
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n/an/a 2.30E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The 135 無 of 50 mM phosphate saline buffer pH (6.8) was added in the 96-well plate and 20 無 of test sample with 70% DMSO added into the wells. The ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50438504
PNG
(CHEMBL2414818)
Show SMILES OC[C@H]1O[C@@H](CNC(=O)\C=C\c2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H21NO6/c18-9-12-15(21)16(22)14(20)11(23-12)8-17-13(19)7-6-10-4-2-1-3-5-10/h1-7,11-12,14-16,18,20-22H,8-9H2,(H,17,19)/b7-6+/t11-,12+,14-,15+,16+/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as 4-nitrophenol release from 4-nitrophenyl alpha-D-glucopyranoside preincubated fo...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150768
PNG
(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(3-h...)
Show SMILES Oc1cccc(c1)C(=O)CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H12N4O2S/c22-11-5-3-4-10(8-11)14(23)9-24-17-19-16-15(20-21-17)12-6-1-2-7-13(12)18-16/h1-8,22H,9H2,(H,18,19,21)
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n/an/a 2.46E+3n/an/an/an/an/a310.15



Hazara University



Assay Description
Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM152499
PNG
((E)-N'-(2-oxoindolin-3-ylidene)dodecanehydrazi...)
Show SMILES CCCCCCCCCCCC(=O)N\N=C1\C(=O)Nc2ccccc12
Show InChI InChI=1S/C20H29N3O2/c1-2-3-4-5-6-7-8-9-10-15-18(24)22-23-19-16-13-11-12-14-17(16)21-20(19)25/h11-14H,2-10,15H2,1H3,(H,22,24)(H,21,23,25)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Hazara University



Assay Description
10 無 of test samples (5 mg/mL DMSO solution) were reconstituted in 100 無 of 100 mM-phosphate buffer (pH6.8) in 96-well microplate and incubated wit...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM152496
PNG
((E)-N'-(6-bromo-2-oxoindolin-3-ylidene)-2-(3,4...)
Show SMILES Clc1ccc(CC(=O)N\N=C2\C(=O)Nc3cc(Br)ccc23)cc1Cl
Show InChI InChI=1S/C16H10BrCl2N3O2/c17-9-2-3-10-13(7-9)20-16(24)15(10)22-21-14(23)6-8-1-4-11(18)12(19)5-8/h1-5,7H,6H2,(H,21,23)(H,20,22,24)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Hazara University



Assay Description
10 無 of test samples (5 mg/mL DMSO solution) were reconstituted in 100 無 of 100 mM-phosphate buffer (pH6.8) in 96-well microplate and incubated wit...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108217
PNG
(2-(3,3-dimethylbutyl)-5-(hydroxymethyl)- 5H,6H,7H,...)
Show SMILES CC(C)(C)CCc1cn2C(CO)C(O)C(O)C(O)c2n1
Show InChI InChI=1S/C14H24N2O4/c1-14(2,3)5-4-8-6-16-9(7-17)10(18)11(19)12(20)13(16)15-8/h6,9-12,17-20H,4-5,7H2,1-3H3
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n/an/a 3.42E+3n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM178010
PNG
(2-(3-((2,3-difluorobenzyl)oxy)phenyl)-4H-chromen-4...)
Show SMILES Fc1cccc(COc2cccc(c2)-c2cc(=O)c3ccccc3o2)c1F
Show InChI InChI=1S/C22H14F2O3/c23-18-9-4-6-15(22(18)24)13-26-16-7-3-5-14(11-16)21-12-19(25)17-8-1-2-10-20(17)27-21/h1-12H,13H2
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n/an/a 3.49E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The α-glucosidase inhibition assay had been carried out using baker窺 yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM50308256
PNG
(1-O-Methyl-2,3-O-isopropylidene-5-(4-cyclohexene-1...)
Show SMILES CO[C@@H]1O[C@H](Cn2cc(nn2)C2=CCCCC2)[C@H]2OC(C)(C)O[C@@H]12
Show InChI InChI=1S/C17H25N3O4/c1-17(2)23-14-13(22-16(21-3)15(14)24-17)10-20-9-12(18-19-20)11-7-5-4-6-8-11/h7,9,13-16H,4-6,8,10H2,1-3H3/t13-,14-,15-,16-/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Universidade Federal do Rio de Janeiro

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase MAL12 assessed as inhibition of p-nitrophenol release by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50063756
PNG
(CHEMBL3397482)
Show SMILES OC(=O)CC1Oc2ccccc2-c2ccc3N(Cc4ccc(cc4)C(F)(F)F)C(=O)C(=O)c3c12
Show InChI InChI=1/C25H16F3NO5/c26-25(27,28)14-7-5-13(6-8-14)12-29-17-10-9-16-15-3-1-2-4-18(15)34-19(11-20(30)31)21(16)22(17)23(32)24(29)33/h1-10,19H,11-12H2,(H,30,31)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science and Technology)

Curated by ChEMBL


Assay Description
Inhibition of bakers yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate after 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM50308259
PNG
(1-O-Methyl-2,3-O-isopropylidene-5-[4-(1-hydroxycyc...)
Show SMILES CO[C@@H]1O[C@H](Cn2cc(nn2)C2(O)CCCCC2)[C@H]2OC(C)(C)O[C@@H]12
Show InChI InChI=1S/C17H27N3O5/c1-16(2)24-13-11(23-15(22-3)14(13)25-16)9-20-10-12(18-19-20)17(21)7-5-4-6-8-17/h10-11,13-15,21H,4-9H2,1-3H3/t11-,13-,14-,15-/m1/s1
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n/an/a 5.20E+3n/an/an/an/an/an/a



Universidade Federal do Rio de Janeiro

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase MAL12 assessed as inhibition of p-nitrophenol release by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM179781
PNG
(2-(2'-Chlorophenyl)-7-methyl-1H-benzo[d]imidaz...)
Show SMILES Cc1cccc2nc([nH]c12)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2/c1-9-5-4-8-12-13(9)17-14(16-12)10-6-2-3-7-11(10)15/h2-8H,1H3,(H,16,17)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM), Puncak Alam Campus



Assay Description
The 135 無 of 50 mM phosphate saline buffer pH (6.8), solution of enzyme (20 無), and 20 無 of test sample with 70% DMSO was added to 96-well plate. ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM178004
PNG
(2-(3-((3-(trifluoromethyl)benzyl)oxy)phenyl)-4H-ch...)
Show SMILES FC(F)(F)c1ccc(c(COc2cccc(c2)-c2cc(=O)c3ccccc3o2)c1)C(F)(F)F
Show InChI InChI=1S/C23H15F3O3/c24-23(25,26)17-7-3-5-15(11-17)14-28-18-8-4-6-16(12-18)22-13-20(27)19-9-1-2-10-21(19)29-22/h1-13H,14H2
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n/an/a 5.45E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The α-glucosidase inhibition assay had been carried out using baker窺 yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50438503
PNG
(CHEMBL2414819)
Show SMILES OC[C@H]1O[C@@H](CNC(=O)\C=C\c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H21NO7/c18-8-12-15(22)16(23)14(21)11(24-12)7-17-13(20)6-3-9-1-4-10(19)5-2-9/h1-6,11-12,14-16,18-19,21-23H,7-8H2,(H,17,20)/b6-3+/t11-,12+,14-,15+,16+/m0/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as 4-nitrophenol release from 4-nitrophenyl alpha-D-glucopyranoside preincubated fo...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM50308258
PNG
(1-O-Methyl-2,3-O-isopropylidene-5-(4-phenoxymethyl...)
Show SMILES CO[C@@H]1O[C@H](Cn2cc(COc3ccccc3)nn2)[C@H]2OC(C)(C)O[C@@H]12
Show InChI InChI=1S/C18H23N3O5/c1-18(2)25-15-14(24-17(22-3)16(15)26-18)10-21-9-12(19-20-21)11-23-13-7-5-4-6-8-13/h4-9,14-17H,10-11H2,1-3H3/t14-,15-,16-,17-/m1/s1
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n/an/a 5.70E+3n/an/an/an/an/an/a



Universidade Federal do Rio de Janeiro

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase MAL12 assessed as inhibition of p-nitrophenol release by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM181062
PNG
((E)-N'-(3,5-Dichloro-2-hydroxybenzylidene)-4-(...)
Show SMILES Oc1c(Cl)cc(Cl)cc1\C=N\NC(=O)c1nc(cs1)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C20H11Cl2N3O4S/c21-12-5-11(17(26)14(22)7-12)8-23-25-18(27)19-24-15(9-30-19)13-6-10-3-1-2-4-16(10)29-20(13)28/h1-9,26H,(H,25,27)/b23-8+
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n/an/a 6.24E+3n/an/an/an/an/an/a



Jishou University



Assay Description
The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM181064
PNG
((E)-N'-(5-Chloro-2-hydroxybenzylidene)-4-(2-ox...)
Show SMILES Oc1ccc(Cl)cc1\C=N\NC(=O)c1nc(cs1)-c1cc2ccccc2oc1=O
Show InChI InChI=1S/C20H12ClN3O4S/c21-13-5-6-16(25)12(7-13)9-22-24-18(26)19-23-15(10-29-19)14-8-11-3-1-2-4-17(11)28-20(14)27/h1-10,25H,(H,24,26)/b22-9+
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n/an/a 8.23E+3n/an/an/an/an/an/a



Jishou University



Assay Description
The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84968
PNG
(Urea derivative, 12)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(F)cc3F)cc2)cc1O
Show InChI InChI=1S/C21H16F2N2O3/c22-15-6-9-18(17(23)12-15)25-21(28)24-16-7-3-13(4-8-16)1-2-14-5-10-19(26)20(27)11-14/h1-12,26-27H,(H2,24,25,28)/b2-1+
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3.20E+3n/a 8.40E+3n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175324
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C23H20N4O4/c1-12-7-17-18(8-13(12)2)26-22(25-17)15-3-5-16(6-4-15)23(31)27-24-11-14-9-19(28)21(30)20(29)10-14/h3-11,28-30H,1-2H3,(H,25,26)(H,27,31)/b24-11+
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n/an/a 8.40E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175317
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES COc1ccc(O)c(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c1
Show InChI InChI=1S/C24H22N4O3/c1-14-10-20-21(11-15(14)2)27-23(26-20)16-4-6-17(7-5-16)24(30)28-25-13-18-12-19(31-3)8-9-22(18)29/h4-13,29H,1-3H3,(H,26,27)(H,28,30)/b25-13+
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n/an/a 8.44E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175315
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c(O)c1
Show InChI InChI=1S/C24H22N4O3/c1-14-10-20-21(11-15(14)2)27-23(26-20)16-4-6-17(7-5-16)24(30)28-25-13-18-8-9-19(31-3)12-22(18)29/h4-13,29H,1-3H3,(H,26,27)(H,28,30)/b25-13+
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n/an/a 8.44E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM178007
PNG
(2-(3-((3-((trifluoromethyl)thio)benzyl)oxy)phenyl)...)
Show SMILES FC(F)(F)Sc1cccc(COc2cccc(c2)-c2cc(=O)c3ccccc3o2)c1
Show InChI InChI=1S/C23H15F3O3S/c24-23(25,26)30-18-8-3-5-15(11-18)14-28-17-7-4-6-16(12-17)22-13-20(27)19-9-1-2-10-21(19)29-22/h1-13H,14H2
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n/an/a 8.66E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The α-glucosidase inhibition assay had been carried out using baker窺 yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175311
PNG
((E)-N'-(2,4-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(O)cc1O
Show InChI InChI=1S/C23H20N4O3/c1-13-9-19-20(10-14(13)2)26-22(25-19)15-3-5-16(6-4-15)23(30)27-24-12-17-7-8-18(28)11-21(17)29/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
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n/an/a 8.74E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175309
PNG
((E)-N'-(2,5-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cc(O)ccc1O
Show InChI InChI=1S/C23H20N4O3/c1-13-9-19-20(10-14(13)2)26-22(25-19)15-3-5-16(6-4-15)23(30)27-24-12-17-11-18(28)7-8-21(17)29/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
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n/an/a 8.74E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM23406
PNG
((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23?,24-,25-/m1/s1
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n/an/a 9.37E+3n/an/an/an/an/an/a



King Abdulaziz University



Assay Description
α-Glucosidase inhibitory activity was evaluated at 37 蚓, by using 0.1M phosphatebuffer (pH6.8) [28]. The enzyme(EC3.2.1.20, Saccharomyces cerev...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175310
PNG
((E)-N'-(2,3-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cccc(O)c1O
Show InChI InChI=1S/C23H20N4O3/c1-13-10-18-19(11-14(13)2)26-22(25-18)15-6-8-16(9-7-15)23(30)27-24-12-17-4-3-5-20(28)21(17)29/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
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n/an/a 9.99E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM181061
PNG
((E)-N'-(3,5-Di-tert-butyl-2-hydroxybenzylidene...)
Show SMILES CC(C)(C)c1cc(\C=N\NC(=O)c2nc(cs2)-c2cc3ccccc3oc2=O)c(O)c(c1)C(C)(C)C
Show InChI InChI=1S/C28H29N3O4S/c1-27(2,3)18-11-17(23(32)20(13-18)28(4,5)6)14-29-31-24(33)25-30-21(15-36-25)19-12-16-9-7-8-10-22(16)35-26(19)34/h7-15,32H,1-6H3,(H,31,33)/b29-14+
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n/an/a 1.02E+4n/an/an/an/an/an/a



Jishou University



Assay Description
The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...


Citation and Details
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-glucosidase)


(Saccharomyces cerevisiae (Yeast))
BDBM193879
PNG
(2-[2-(2,4-Dichlorobenzyl)-6-nitro-1H-benzimidazol-...)
Show SMILES NNC(=O)Cn1c(Cc2ccc(Cl)cc2Cl)nc2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C16H13Cl2N5O3/c17-10-2-1-9(12(18)6-10)5-15-20-13-4-3-11(23(25)26)7-14(13)22(15)8-16(24)21-19/h1-4,6-7H,5,8,19H2,(H,21,24)
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n/an/a 1.05E+4n/an/an/an/an/an/a



Recep Tayyip Erdogan University



Assay Description
α-Glucosidase inhibition assay was performed spectrophotometrically. α-Glucosidase from Saccharomyces cerevisiae (Sigma-Aldrich) was dissol...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM181068
PNG
((E)-N'-(4-Chlorobenzylidene)-4-(2-oxo-2H-chrom...)
Show SMILES Clc1ccc(\C=N\NC(=O)c2nc(cs2)-c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C20H12ClN3O3S/c21-14-7-5-12(6-8-14)10-22-24-18(25)19-23-16(11-28-19)15-9-13-3-1-2-4-17(13)27-20(15)26/h1-11H,(H,24,25)/b22-10+
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n/an/a 1.06E+4n/an/an/an/an/an/a



Jishou University



Assay Description
The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM152498
PNG
((E)-N'-(6-bromo-2-oxoindolin-3-ylidene)-2- hyd...)
Show SMILES Oc1ccccc1C(=O)N\N=C1\C(=O)Nc2cc(Br)ccc12
Show InChI InChI=1S/C15H10BrN3O3/c16-8-5-6-9-11(7-8)17-15(22)13(9)18-19-14(21)10-3-1-2-4-12(10)20/h1-7,20H,(H,19,21)(H,17,18,22)
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n/an/a 1.18E+4n/an/an/an/an/an/a



Hazara University



Assay Description
10 無 of test samples (5 mg/mL DMSO solution) were reconstituted in 100 無 of 100 mM-phosphate buffer (pH6.8) in 96-well microplate and incubated wit...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM181069
PNG
((E)-N'-(3-Chlorobenzylidene)-4-(2-oxo-2H-chrom...)
Show SMILES Clc1cccc(\C=N\NC(=O)c2nc(cs2)-c2cc3ccccc3oc2=O)c1
Show InChI InChI=1S/C20H12ClN3O3S/c21-14-6-3-4-12(8-14)10-22-24-18(25)19-23-16(11-28-19)15-9-13-5-1-2-7-17(13)27-20(15)26/h1-11H,(H,24,25)/b22-10+
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n/an/a 1.20E+4n/an/an/an/an/an/a



Jishou University



Assay Description
The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50063761
PNG
(CHEMBL3397478)
Show SMILES COC(=O)CC1Oc2ccccc2-c2ccc3N(Cc4ccccc4)C(=O)C(=O)c3c12
Show InChI InChI=1/C25H19NO5/c1-30-21(27)13-20-22-17(16-9-5-6-10-19(16)31-20)11-12-18-23(22)24(28)25(29)26(18)14-15-7-3-2-4-8-15/h2-12,20H,13-14H2,1H3
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n/an/a 1.21E+4n/an/an/an/an/an/a



Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science and Technology)

Curated by ChEMBL


Assay Description
Inhibition of bakers yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate after 30 mins by spectrophotometry


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Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175312
PNG
((E)-N'-(3,4-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C23H20N4O3/c1-13-9-18-19(10-14(13)2)26-22(25-18)16-4-6-17(7-5-16)23(30)27-24-12-15-3-8-20(28)21(29)11-15/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
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n/an/a 1.25E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


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More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108225
PNG
(2,2-dimethyl-N-phenyl-5-[6,7,8-trihydroxy-5- (hydr...)
Show SMILES CC(C)(CCCc1cn2C(CO)C(O)C(O)C(O)c2n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C21H29N3O5/c1-21(2,20(29)23-13-7-4-3-5-8-13)10-6-9-14-11-24-15(12-25)16(26)17(27)18(28)19(24)22-14/h3-5,7-8,11,15-18,25-28H,6,9-10,12H2,1-2H3,(H,23,29)
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n/an/a 1.28E+4n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


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More data for this
Ligand-Target Pair
alpha-Glucosidase (α-glucosidase)


(Saccharomyces cerevisiae (Yeast))
BDBM23406
PNG
((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23?,24-,25-/m1/s1
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n/an/a 1.33E+4n/an/an/an/an/an/a



Recep Tayyip Erdogan University



Assay Description
α-Glucosidase inhibition assay was performed spectrophotometrically. α-Glucosidase from Saccharomyces cerevisiae (Sigma-Aldrich) was dissol...


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More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM173549
PNG
(1-(4-(bis(4-Hydroxy-2-oxo-2H-chromen-3-yl)methyl)p...)
Show SMILES COc1ccc(NC(=S)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)cc1
Show InChI InChI=1S/C32H21ClN2O6S/c33-18-11-15-20(16-12-18)35-32(42)34-19-13-9-17(10-14-19)25(26-28(36)21-5-1-3-7-23(21)40-30(26)38)27-29(37)22-6-2-4-8-24(22)41-31(27)39/h1-16,25,36-37H,(H2,34,35,42)
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n/an/a 1.35E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Taha et al. with slight modification. Various concentration of tes...


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More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM181073
PNG
((E)-N'-(3-bromobenzylidene)-4-(2-oxo-2H-chrome...)
Show SMILES Brc1cccc(\C=N\NC(=O)c2nc(cs2)-c2cc3ccccc3oc2=O)c1
Show InChI InChI=1S/C20H12BrN3O3S/c21-14-6-3-4-12(8-14)10-22-24-18(25)19-23-16(11-28-19)15-9-13-5-1-2-7-17(13)27-20(15)26/h1-11H,(H,24,25)/b22-10+
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n/an/a 1.40E+4n/an/an/an/an/an/a



Jishou University



Assay Description
The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...


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More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84969
PNG
(Urea derivative, 13)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2)cc1O
Show InChI InChI=1S/C21H17ClN2O3/c22-16-6-10-18(11-7-16)24-21(27)23-17-8-3-14(4-9-17)1-2-15-5-12-19(25)20(26)13-15/h1-13,25-26H,(H2,23,24,27)/b2-1+
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4.60E+3n/a 1.43E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM50308255
PNG
(1-O-Methyl-2,3-O-isopropylidene-5-(4-phenyl-1H-1,2...)
Show SMILES CO[C@@H]1O[C@H](Cn2cc(nn2)-c2ccccc2)[C@H]2OC(C)(C)O[C@@H]12
Show InChI InChI=1S/C17H21N3O4/c1-17(2)23-14-13(22-16(21-3)15(14)24-17)10-20-9-12(18-19-20)11-7-5-4-6-8-11/h4-9,13-16H,10H2,1-3H3/t13-,14-,15-,16-/m1/s1
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n/an/a 1.49E+4n/an/an/an/an/an/a



Universidade Federal do Rio de Janeiro

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase MAL12 assessed as inhibition of p-nitrophenol release by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175329
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES COc1cccc(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c1
Show InChI InChI=1S/C24H22N4O2/c1-15-11-21-22(12-16(15)2)27-23(26-21)18-7-9-19(10-8-18)24(29)28-25-14-17-5-4-6-20(13-17)30-3/h4-14H,1-3H3,(H,26,27)(H,28,29)/b25-14+
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n/an/a 1.51E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Citation and Details
More data for this
Ligand-Target Pair
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