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Compile Data Set for Download or QSAR

Found 27 hits Enz. Inhib. hit(s) with Target = 'alternatively spliced Trp4'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
alternatively spliced Trp4


(Mus musculus)
BDBM79626
PNG
(2-(1-azepanyl)-4,6-dimethylquinoline;2,2,2-trifluo...)
Show SMILES Cc1ccc2nc(cc(C)c2c1)N1CCCCCC1
Show InChI InChI=1S/C17H22N2/c1-13-7-8-16-15(11-13)14(2)12-17(18-16)19-9-5-3-4-6-10-19/h7-8,11-12H,3-6,9-10H2,1-2H3
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n/an/a 900n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79629
PNG
(2-(1-azepanyl)-6-fluoro-4-methylquinoline;2,2,2-tr...)
Show SMILES Cc1cc(nc2ccc(F)cc12)N1CCCCCC1
Show InChI InChI=1S/C16H19FN2/c1-12-10-16(19-8-4-2-3-5-9-19)18-15-7-6-13(17)11-14(12)15/h6-7,10-11H,2-5,8-9H2,1H3
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n/an/a 1.63E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79628
PNG
(2-(1-azepanyl)-4-methylquinoline;2,2,2-trifluoroac...)
Show SMILES Cc1cc(nc2ccccc12)N1CCCCCC1
Show InChI InChI=1S/C16H20N2/c1-13-12-16(18-10-6-2-3-7-11-18)17-15-9-5-4-8-14(13)15/h4-5,8-9,12H,2-3,6-7,10-11H2,1H3
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n/an/a 1.96E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77625
PNG
(6-ethyl-4-methyl-2-(1-pyrrolidinyl)quinoline;2,2,2...)
Show SMILES CCc1ccc2nc(cc(C)c2c1)N1CCCC1
Show InChI InChI=1S/C16H20N2/c1-3-13-6-7-15-14(11-13)12(2)10-16(17-15)18-8-4-5-9-18/h6-7,10-11H,3-5,8-9H2,1-2H3
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n/an/a 2.05E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM72595
PNG
(2-(1-azepanyl)-7-methoxy-4-methylquinoline;oxalic ...)
Show SMILES COc1ccc2c(C)cc(nc2c1)N1CCCCCC1
Show InChI InChI=1S/C17H22N2O/c1-13-11-17(19-9-5-3-4-6-10-19)18-16-12-14(20-2)7-8-15(13)16/h7-8,11-12H,3-6,9-10H2,1-2H3
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n/an/a 2.38E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77617
PNG
(4-methyl-2-(1-piperidinyl)quinoline | 4-methyl-2-p...)
Show SMILES Cc1cc(nc2ccccc12)N1CCCCC1
Show InChI InChI=1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3
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n/an/a 2.63E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77618
PNG
(4-methyl-2-(4-methyl-1-piperidinyl)quinoline;2,2,2...)
Show SMILES CC1CCN(CC1)c1cc(C)c2ccccc2n1
Show InChI InChI=1S/C16H20N2/c1-12-7-9-18(10-8-12)16-11-13(2)14-5-3-4-6-15(14)17-16/h3-6,11-12H,7-10H2,1-2H3
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n/an/a 3.14E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79627
PNG
(2-(1-azepanyl)-6-ethyl-4-methylquinoline;2,2,2-tri...)
Show SMILES CCc1ccc2nc(cc(C)c2c1)N1CCCCCC1
Show InChI InChI=1S/C18H24N2/c1-3-15-8-9-17-16(13-15)14(2)12-18(19-17)20-10-6-4-5-7-11-20/h8-9,12-13H,3-7,10-11H2,1-2H3
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n/an/a 3.30E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77620
PNG
(4-methyl-2-(1-pyrrolidinyl)quinoline;2,2,2-trifluo...)
Show SMILES Cc1cc(nc2ccccc12)N1CCCC1
Show InChI InChI=1S/C14H16N2/c1-11-10-14(16-8-4-5-9-16)15-13-7-3-2-6-12(11)13/h2-3,6-7,10H,4-5,8-9H2,1H3
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n/an/a 3.59E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77624
PNG
(4,6-dimethyl-2-(1-pyrrolidinyl)quinoline;2,2,2-tri...)
Show SMILES Cc1ccc2nc(cc(C)c2c1)N1CCCC1
Show InChI InChI=1S/C15H18N2/c1-11-5-6-14-13(9-11)12(2)10-15(16-14)17-7-3-4-8-17/h5-6,9-10H,3-4,7-8H2,1-2H3
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n/an/a 3.71E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79623
PNG
(6-ethyl-4-methyl-2-(1-piperidinyl)quinoline;2,2,2-...)
Show SMILES CCc1ccc2nc(cc(C)c2c1)N1CCCCC1
Show InChI InChI=1S/C17H22N2/c1-3-14-7-8-16-15(12-14)13(2)11-17(18-16)19-9-5-4-6-10-19/h7-8,11-12H,3-6,9-10H2,1-2H3
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n/an/a 3.73E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79624
PNG
(6-fluoranyl-4-methyl-2-pyrrolidin-1-yl-quinoline;2...)
Show SMILES Cc1cc(nc2ccc(F)cc12)N1CCCC1
Show InChI InChI=1S/C14H15FN2/c1-10-8-14(17-6-2-3-7-17)16-13-5-4-11(15)9-12(10)13/h4-5,8-9H,2-3,6-7H2,1H3
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n/an/a 3.94E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77621
PNG
(4-methyl-2-[(2S)-2-methyl-1-pyrrolidinyl]quinoline...)
Show SMILES C[C@H]1CCCN1c1cc(C)c2ccccc2n1
Show InChI InChI=1S/C15H18N2/c1-11-10-15(17-9-5-6-12(17)2)16-14-8-4-3-7-13(11)14/h3-4,7-8,10,12H,5-6,9H2,1-2H3/t12-/m0/s1
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n/an/a 4.26E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77614
PNG
((4-Fluoro-benzyl)-[5-(4-fluoro-phenyl)-1-methyl-1H...)
Show SMILES Cn1c(NCc2ccc(F)cc2)ncc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H15F2N3/c1-22-16(13-4-8-15(19)9-5-13)11-21-17(22)20-10-12-2-6-14(18)7-3-12/h2-9,11H,10H2,1H3,(H,20,21)
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n/an/a 4.28E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77616
PNG
(4-chloranyl-N'-cyclohexyl-benzenecarboximidamide;h...)
Show SMILES NC(=NC1CCCCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C13H17ClN2/c14-11-8-6-10(7-9-11)13(15)16-12-4-2-1-3-5-12/h6-9,12H,1-5H2,(H2,15,16)
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n/an/a 4.56E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77623
PNG
(4,6-dimethyl-2-(1-piperidinyl)quinoline;2,2,2-trif...)
Show SMILES Cc1ccc2nc(cc(C)c2c1)N1CCCCC1
Show InChI InChI=1S/C16H20N2/c1-12-6-7-15-14(10-12)13(2)11-16(17-15)18-8-4-3-5-9-18/h6-7,10-11H,3-5,8-9H2,1-2H3
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n/an/a 5.49E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77626
PNG
(6-fluoranyl-4-methyl-2-piperidin-1-yl-quinoline;2,...)
Show SMILES Cc1cc(nc2ccc(F)cc12)N1CCCCC1
Show InChI InChI=1S/C15H17FN2/c1-11-9-15(18-7-3-2-4-8-18)17-14-6-5-12(16)10-13(11)14/h5-6,9-10H,2-4,7-8H2,1H3
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n/an/a 6.18E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79618
PNG
(N,N-diethyl-4-methyl-2-quinolinamine;2,2,2-trifluo...)
Show SMILES CCN(CC)c1cc(C)c2ccccc2n1
Show InChI InChI=1S/C14H18N2/c1-4-16(5-2)14-10-11(3)12-8-6-7-9-13(12)15-14/h6-10H,4-5H2,1-3H3
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n/an/a 7.54E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77622
PNG
(4-methyl-2-(4-pyridin-4-yl-1-piperazinyl)quinoline...)
Show SMILES Cc1cc(nc2ccccc12)N1CCN(CC1)c1ccncc1
Show InChI InChI=1S/C19H20N4/c1-15-14-19(21-18-5-3-2-4-17(15)18)23-12-10-22(11-13-23)16-6-8-20-9-7-16/h2-9,14H,10-13H2,1H3
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n/an/a 8.18E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79620
PNG
(2-[4-(4-methyl-2-quinolinyl)-1-piperazinyl]benzoni...)
Show SMILES Cc1cc(nc2ccccc12)N1CCN(CC1)c1ccccc1C#N
Show InChI InChI=1S/C21H20N4/c1-16-14-21(23-19-8-4-3-7-18(16)19)25-12-10-24(11-13-25)20-9-5-2-6-17(20)15-22/h2-9,14H,10-13H2,1H3
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n/an/a 8.90E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79622
PNG
(1-(4-methyl-2-quinolinyl)-3-piperidinol;2,2,2-trif...)
Show SMILES Cc1cc(nc2ccccc12)N1CCCC(O)C1
Show InChI InChI=1S/C15H18N2O/c1-11-9-15(17-8-4-5-12(18)10-17)16-14-7-3-2-6-13(11)14/h2-3,6-7,9,12,18H,4-5,8,10H2,1H3
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n/an/a 9.40E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79619
PNG
(2-[4-(2-methoxyphenyl)-1-piperazinyl]-4-methylquin...)
Show SMILES COc1ccccc1N1CCN(CC1)c1cc(C)c2ccccc2n1
Show InChI InChI=1S/C21H23N3O/c1-16-15-21(22-18-8-4-3-7-17(16)18)24-13-11-23(12-14-24)19-9-5-6-10-20(19)25-2/h3-10,15H,11-14H2,1-2H3
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n/an/a 9.89E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79625
PNG
(4,8-dimethyl-2-(1-pyrrolidinyl)quinoline;2,2,2-tri...)
Show SMILES Cc1cccc2c(C)cc(nc12)N1CCCC1
Show InChI InChI=1S/C15H18N2/c1-11-6-5-7-13-12(2)10-14(16-15(11)13)17-8-3-4-9-17/h5-7,10H,3-4,8-9H2,1-2H3
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n/an/a 9.96E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79617
PNG
(2-(3,5-dimethyl-1-piperidinyl)-4-methylquinoline;2...)
Show SMILES CC1CC(C)CN(C1)c1cc(C)c2ccccc2n1
Show InChI InChI=1S/C17H22N2/c1-12-8-13(2)11-19(10-12)17-9-14(3)15-6-4-5-7-16(15)18-17/h4-7,9,12-13H,8,10-11H2,1-3H3
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n/an/a 1.19E+4n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79621
PNG
(4-(4-methyl-2-quinolinyl)-2,3-dihydro-1,4-benzoxaz...)
Show SMILES Cc1cc(nc2ccccc12)N1CCOc2ccccc12
Show InChI InChI=1S/C18H16N2O/c1-13-12-18(19-15-7-3-2-6-14(13)15)20-10-11-21-17-9-5-4-8-16(17)20/h2-9,12H,10-11H2,1H3
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UniProtKB/SwissProt

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UniChem
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PCBioAssay
n/an/a 2.45E+4n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77615
PNG
(2-phenyl-N-(2-phenylsulfanylphenyl)acetamide | 2-p...)
Show SMILES O=C(Cc1ccccc1)Nc1ccccc1Sc1ccccc1
Show InChI InChI=1S/C20H17NOS/c22-20(15-16-9-3-1-4-10-16)21-18-13-7-8-14-19(18)23-17-11-5-2-6-12-17/h1-14H,15H2,(H,21,22)
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PCBioAssay
n/an/a 3.87E+4n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM77619
PNG
(4-(4-methyl-2-quinolinyl)morpholine;2,2,2-trifluor...)
Show SMILES Cc1cc(nc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C14H16N2O/c1-11-10-14(16-6-8-17-9-7-16)15-13-5-3-2-4-12(11)13/h2-5,10H,6-9H2,1H3
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PC cid
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PCBioAssay
n/an/a 1.40E+5n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): ...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair