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Found 5070 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146708
PNG
(US8957073, 4.42)
Show SMILES CC1(C)CC(=CCO1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H24N4O/c1-23(2)13-17(9-12-28-23)21-22(25-11-10-24-21)18-14-27(15-18)20-8-7-16-5-3-4-6-19(16)26-20/h3-11,18H,12-15H2,1-2H3
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US Patent
n/an/a 0.00100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146707
PNG
(US8957073, 4.41)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1C1=CCOCC1
Show InChI InChI=1S/C21H20N4O/c1-2-4-18-15(3-1)5-6-19(24-18)25-13-17(14-25)21-20(22-9-10-23-21)16-7-11-26-12-8-16/h1-7,9-10,17H,8,11-14H2
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US Patent
n/an/a 0.00110n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00120n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47146
PNG
(US8957073, 4.14 | US8957073, 4.45)
Show SMILES COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-8-4-7-18(26-20)22-21(23-11-12-24-22)16-13-27(14-16)19-10-9-15-5-2-3-6-17(15)25-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00120n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47147
PNG
(US8957073, 4.28 | US8957073, 4.44)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16F4N4/c24-18-10-15(9-17(11-18)23(25,26)27)21-22(29-8-7-28-21)16-12-31(13-16)20-6-5-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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n/an/a 0.00122n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146672
PNG
(US8957073, 4.6)
Show SMILES COc1ccc(c(OC)n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H21N5O2/c1-29-20-10-8-17(23(27-20)30-2)22-21(24-11-12-25-22)16-13-28(14-16)19-9-7-15-5-3-4-6-18(15)26-19/h3-12,16H,13-14H2,1-2H3
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n/an/a 0.00135n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146689
PNG
(US8957073, 4.23)
Show SMILES Oc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H17ClN4O/c23-17-11-15(5-7-19(17)28)21-22(25-10-9-24-21)16-12-27(13-16)20-8-6-14-3-1-2-4-18(14)26-20/h1-11,16,28H,12-13H2
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n/an/a 0.00230n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146687
PNG
(US8957073, 4.21)
Show SMILES Cc1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00230n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146667
PNG
(US8957073, 4.1)
Show SMILES COc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-22-17(6-4-10-25-22)21-20(23-11-12-24-21)16-13-27(14-16)19-9-8-15-5-2-3-7-18(15)26-19/h2-12,16H,13-14H2,1H3
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n/an/a 0.00234n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146677
PNG
(US8957073, 4.11)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H20N4O2S/c1-30(28,29)19-9-6-17(7-10-19)22-23(25-13-12-24-22)18-14-27(15-18)21-11-8-16-4-2-3-5-20(16)26-21/h2-13,18H,14-15H2,1H3
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n/an/a 0.00262n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146678
PNG
(US8957073, 4.12)
Show SMILES Nc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2,(H2,22,25)
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n/an/a 0.00278n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146668
PNG
(US8957073, 4.2)
Show SMILES Cc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-6-7-17(12-25-15)21-22(24-11-10-23-21)18-13-27(14-18)20-9-8-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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n/an/a 0.00279n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50397973
PNG
(CHEMBL2180441)
Show SMILES Cc1nc2ccc(cc2nc1\C=C\c1nc(N[C@@H]2CCS(=O)(=O)C2)cc(n1)N1CCCC1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N6O2S/c1-15-18(30-20-12-16(24(25,26)27)4-5-19(20)28-15)6-7-21-31-22(29-17-8-11-36(34,35)14-17)13-23(32-21)33-9-2-3-10-33/h4-7,12-13,17H,2-3,8-11,14H2,1H3,(H,29,31,32)/b7-6+/t17-/m1/s1
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Article
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n/an/a 0.00330n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146695
PNG
(US8957073, 4.29)
Show SMILES COc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4O/c1-16-13-18(7-9-21(16)29-2)23-24(26-12-11-25-23)19-14-28(15-19)22-10-8-17-5-3-4-6-20(17)27-22/h3-13,19H,14-15H2,1-2H3
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n/an/a 0.00350n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146679
PNG
(US8957073, 4.13)
Show SMILES Nc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H18N6/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13,22H2
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n/an/a 0.00376n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146698
PNG
(US8957073, 4.32)
Show SMILES Fc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16ClFN4/c23-17-11-15(5-7-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00410n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146670
PNG
(US8957073, 4.4)
Show SMILES Fc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2
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n/an/a 0.00418n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146688
PNG
(US8957073, 4.22)
Show SMILES Cc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00420n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146697
PNG
(US8957073, 4.31)
Show SMILES Cc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00510n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146701
PNG
(US8957073, 4.35)
Show SMILES Cc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4/c1-16-7-8-19(13-17(16)2)23-24(26-12-11-25-23)20-14-28(15-20)22-10-9-18-5-3-4-6-21(18)27-22/h3-13,20H,14-15H2,1-2H3
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n/an/a 0.00550n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146691
PNG
(US8957073, 4.25)
Show SMILES CCOc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21FN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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n/an/a 0.00620n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146704
PNG
(US8957073, 4.38)
Show SMILES Cc1cc(ccc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00640n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146669
PNG
(US8957073, 4.3)
Show SMILES Cc1ncccc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-18(6-4-10-23-15)22-21(24-11-12-25-22)17-13-27(14-17)20-9-8-16-5-2-3-7-19(16)26-20/h2-12,17H,13-14H2,1H3
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n/an/a 0.00648n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146702
PNG
(US8957073, 4.36)
Show SMILES Cc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00670n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146709
PNG
(US8957073, 4.43)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cn[nH]c1
Show InChI InChI=1S/C19H16N6/c1-2-4-16-13(3-1)5-6-17(24-16)25-11-15(12-25)19-18(20-7-8-21-19)14-9-22-23-10-14/h1-10,15H,11-12H2,(H,22,23)
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n/an/a 0.00700n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146703
PNG
(US8957073, 4.37)
Show SMILES Cc1cc(Cl)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00720n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146674
PNG
(US8957073, 4.8)
Show SMILES COc1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-20-9-7-16(12-25-20)21-22(24-11-10-23-21)17-13-27(14-17)19-8-6-15-4-2-3-5-18(15)26-19/h2-12,17H,13-14H2,1H3
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n/an/a 0.00787n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146676
PNG
(US8957073, 4.10)
Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cccnc1
Show InChI InChI=1S/C21H17N5/c1-2-6-18-15(4-1)7-8-19(25-18)26-13-17(14-26)21-20(23-10-11-24-21)16-5-3-9-22-12-16/h1-12,17H,13-14H2
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n/an/a 0.00787n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146700
PNG
(US8957073, 4.34)
Show SMILES Clc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16Cl2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00840n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146706
PNG
(US8957073, 4.40)
Show SMILES FC(F)(F)c1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16ClF3N4/c24-18-7-5-15(11-17(18)23(25,26)27)21-22(29-10-9-28-21)16-12-31(13-16)20-8-6-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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n/an/a 0.00910n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146699
PNG
(US8957073, 4.33)
Show SMILES Fc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16F2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00990n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146692
PNG
(US8957073, 4.26)
Show SMILES CCOc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21ClN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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n/an/a 0.0106n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146696
PNG
(US8957073, 4.30)
Show SMILES CC(C)Oc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23FN4O/c1-16(2)31-21-12-18(11-20(26)13-21)24-25(28-10-9-27-24)19-14-30(15-19)23-8-7-17-5-3-4-6-22(17)29-23/h3-13,16,19H,14-15H2,1-2H3
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n/an/a 0.0110n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146675
PNG
(US8957073, 4.9)
Show SMILES Cc1cc(cnc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H18FN5/c1-14-10-16(11-26-22(14)23)20-21(25-9-8-24-20)17-12-28(13-17)19-7-6-15-4-2-3-5-18(15)27-19/h2-11,17H,12-13H2,1H3
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n/an/a 0.0122n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47147
PNG
(US8957073, 4.28 | US8957073, 4.44)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H16F4N4/c24-18-10-15(9-17(11-18)23(25,26)27)21-22(29-8-7-28-21)16-12-31(13-16)20-6-5-14-3-1-2-4-19(14)30-20/h1-11,16H,12-13H2
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n/an/a 0.0122n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146673
PNG
(US8957073, 4.7)
Show SMILES Fc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13H2
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n/an/a 0.0123n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146671
PNG
(US8957073, 4.5)
Show SMILES FC(F)(F)c1ccc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16F3N5/c23-22(24,25)18-7-5-15(11-28-18)20-21(27-10-9-26-20)16-12-30(13-16)19-8-6-14-3-1-2-4-17(14)29-19/h1-11,16H,12-13H2
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n/an/a 0.0142n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146690
PNG
(US8957073, 4.24)
Show SMILES COc1cc(cc(c1)C(F)(F)F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H19F3N4O/c1-32-19-11-16(10-18(12-19)24(25,26)27)22-23(29-9-8-28-22)17-13-31(14-17)21-7-6-15-4-2-3-5-20(15)30-21/h2-12,17H,13-14H2,1H3
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n/an/a 0.0149n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146685
PNG
(US8957073, 4.19)
Show SMILES Cc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-10-17(12-23-11-15)21-22(25-9-8-24-21)18-13-27(14-18)20-7-6-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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n/an/a 0.0163n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146693
PNG
(US8957073, 4.27)
Show SMILES CCCOc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23ClN4O/c1-2-13-31-22-9-7-18(14-20(22)26)24-25(28-12-11-27-24)19-15-30(16-19)23-10-8-17-5-3-4-6-21(17)29-23/h3-12,14,19H,2,13,15-16H2,1H3
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n/an/a 0.0171n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124548
PNG
(US8759532, 226)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@@H]2CCC(=O)C2)cc1
Show InChI InChI=1S/C24H19N3O3/c28-17-10-7-16(14-17)19-4-3-13-25-24(19)30-18-11-8-15(9-12-18)22(29)23-26-20-5-1-2-6-21(20)27-23/h1-6,8-9,11-13,16H,7,10,14H2,(H,26,27)/t16-/m1/s1
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n/an/a 0.0210n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146682
PNG
(US8957073, 4.16)
Show SMILES CN(C)c1ncc(cn1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H21N7/c1-28(2)22-25-11-16(12-26-22)20-21(24-10-9-23-20)17-13-29(14-17)19-8-7-15-5-3-4-6-18(15)27-19/h3-12,17H,13-14H2,1-2H3
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US Patent
n/an/a 0.0228n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124500
PNG
(US8759532, 176 | US8759532, 223)
Show SMILES CC(=O)N1CCC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,19H,5-6,15-16H2,1H3,(H,28,29)/t19-/m0/s1
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US Patent
n/an/a 0.0240n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146686
PNG
(US8957073, 4.20)
Show SMILES COc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-28-18-10-16(11-23-12-18)21-22(25-9-8-24-21)17-13-27(14-17)20-7-6-15-4-2-3-5-19(15)26-20/h2-12,17H,13-14H2,1H3
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US Patent
n/an/a 0.0247n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146683
PNG
(US8957073, 4.17)
Show SMILES Cc1ccncc1-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5/c1-15-8-9-23-12-18(15)22-21(24-10-11-25-22)17-13-27(14-17)20-7-6-16-4-2-3-5-19(16)26-20/h2-12,17H,13-14H2,1H3
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n/an/a 0.0263n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124523
PNG
(US8759532, 201)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCC(=O)CC2)cc1
Show InChI InChI=1S/C25H21N3O3/c29-18-11-7-16(8-12-18)20-4-3-15-26-25(20)31-19-13-9-17(10-14-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-10,13-16H,7-8,11-12H2,(H,27,28)
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US Patent
n/an/a 0.0285n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM142586
PNG
(US8933224, 4)
Show SMILES COc1ccc2CCN(Cc2c1OCCF)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1S/C22H26FN5O3/c1-14-26-19(16-6-9-30-12-16)20-22(24-13-25-28(14)20)27-8-5-15-3-4-18(29-2)21(17(15)11-27)31-10-7-23/h3-4,13,16H,5-12H2,1-2H3/t16-/m1/s1
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US Patent
n/an/a 0.0386n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115431
PNG
(US8637500, 301 | US8637500, 454 | US8637500, 455)
Show SMILES CC(=O)N1CCCC(C1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C24H26N4O2/c1-17-7-12-23(26-15-17)27-20-8-10-21(11-9-20)30-24-22(6-3-13-25-24)19-5-4-14-28(16-19)18(2)29/h3,6-13,15,19H,4-5,14,16H2,1-2H3,(H,26,27)
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US Patent
n/an/a 0.0400n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM142493
PNG
(US8933224, 86)
Show SMILES CC(C)c1nn(C)c2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12
Show InChI InChI=1/C20H27N7O/c1-12(2)17-15-9-26(7-5-16(15)25(4)24-17)20-19-18(14-6-8-28-10-14)23-13(3)27(19)22-11-21-20/h11-12,14H,5-10H2,1-4H3/t14-/s2
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n/an/a 0.0444n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115430
PNG
(US8637500, 299)
Show SMILES CN(C)C(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C24H28N6O2/c1-17-4-9-21(27-16-17)28-19-5-7-20(8-6-19)32-23-22(25-12-13-26-23)18-10-14-30(15-11-18)24(31)29(2)3/h4-9,12-13,16,18H,10-11,14-15H2,1-3H3,(H,27,28)
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US Patent
n/an/a 0.0450n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)

More data for this
Ligand-Target Pair
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