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Compile Data Set for Download or QSAR

Found 16 hits Enz. Inhib. hit(s) with Target = 'cFMS'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cFMS


(Homo sapiens (human))
BDBM181020
PNG
(US9133183, Example 29)
Show SMILES Cc1nc(NC(=O)N2CCN(C3CCCC3)C2=O)ccc1Oc1ccnc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C24H27N7O3/c1-16-21(34-19-9-10-25-20(13-19)17-14-26-29(2)15-17)7-8-22(27-16)28-23(32)31-12-11-30(24(31)33)18-5-3-4-6-18/h7-10,13-15,18H,3-6,11-12H2,1-2H3,(H,27,28,32)
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US Patent
n/an/a 2n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)

More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181019
PNG
(US9133183, Example 15)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCCCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C24H27N7O3/c1-29-16-17(14-27-29)21-13-19(9-10-25-21)34-20-7-8-22(26-15-20)28-23(32)31-12-11-30(24(31)33)18-5-3-2-4-6-18/h7-10,13-16,18H,2-6,11-12H2,1H3,(H,26,28,32)
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n/an/a 3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)

More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181027
PNG
(US9133183, Example 90)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)C(C)(C)C)nc2)ccn1
Show InChI InChI=1S/C20H24N6O4/c1-20(2,3)26-10-9-25(19(26)29)18(28)24-16-6-5-14(12-23-16)30-13-7-8-22-15(11-13)17(27)21-4/h5-8,11-12H,9-10H2,1-4H3,(H,21,27)(H,23,24,28)
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n/an/a 5n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)

More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181018
PNG
(US9133183, Example 1)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCOCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C23H25N7O4/c1-28-15-16(13-26-28)20-12-18(4-7-24-20)34-19-2-3-21(25-14-19)27-22(31)30-9-8-29(23(30)32)17-5-10-33-11-6-17/h2-4,7,12-15,17H,5-6,8-11H2,1H3,(H,25,27,31)
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n/an/a 6n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)

More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181034
PNG
(US9133183, Example 91)
Show SMILES Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1
Show InChI InChI=1S/C24H24F2N6O4/c1-30-14-15(13-28-30)20-10-17(2-5-27-20)36-22-12-18(25)21(11-19(22)26)29-23(33)32-7-6-31(24(32)34)16-3-8-35-9-4-16/h2,5,10-14,16H,3-4,6-9H2,1H3,(H,29,33)
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n/an/a 7n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)

More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181035
PNG
(US9133183, Example 101)
Show SMILES CN(C)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2Cl)ccn1
Show InChI InChI=1S/C23H26ClFN6O5/c1-29(2)21(32)28-20-11-15(3-6-26-20)36-19-13-17(25)18(12-16(19)24)27-22(33)31-8-7-30(23(31)34)14-4-9-35-10-5-14/h3,6,11-14H,4-5,7-10H2,1-2H3,(H,27,33)(H,26,28,32)
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n/an/a 8n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)

More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181037
PNG
(US9133183, Example 42)
Show SMILES CCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C21H23N7O3/c1-4-27-9-10-28(21(27)30)20(29)25-19-6-5-18(14(2)24-19)31-16-7-8-22-17(11-16)15-12-23-26(3)13-15/h5-8,11-13H,4,9-10H2,1-3H3,(H,24,25,29)
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n/an/a 8n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)

More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181023
PNG
(US9133183, Compound A)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccc(F)cc3)nc2)ccn1
Show InChI InChI=1S/C24H20FN7O3/c1-30-15-16(13-28-30)21-12-19(8-9-26-21)35-20-6-7-22(27-14-20)29-23(33)32-11-10-31(24(32)34)18-4-2-17(25)3-5-18/h2-9,12-15H,10-11H2,1H3,(H,27,29,33)
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n/an/a 13n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)

More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181026
PNG
(US9133183, Example 18)
Show SMILES COCCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C22H25N7O4/c1-15-19(33-17-6-7-23-18(12-17)16-13-24-27(2)14-16)4-5-20(25-15)26-21(30)29-9-8-28(22(29)31)10-11-32-3/h4-7,12-14H,8-11H2,1-3H3,(H,25,26,30)
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n/an/a 20n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)

More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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PubMed
n/an/a 49n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


Citation and Details
More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (human))
BDBM17015
PNG
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc[nH]1
Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8-
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n/an/a 1.30E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


Citation and Details
More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (human))
BDBM17749
PNG
(JNJ31117164)
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n/an/a 1.30E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


Citation and Details
More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (human))
BDBM4363
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)
Show SMILES NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a 3.30E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


Citation and Details
More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (human))
BDBM7393
PNG
(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Show SMILES O=Nc1c([nH]c2ccccc12)C1C(=O)Nc2ccccc12
Show InChI InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,13,17H,(H,18,20)
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n/an/a 4.50E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


Citation and Details
More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (human))
BDBM17747
PNG
((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11-
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n/an/a 4.60E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


Citation and Details
More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (human))
BDBM17748
PNG
(2-(3,4-Dihydroxyphenyl)-6,7-dimethylquinoxaline | ...)
Show SMILES Cc1cc2ncc(nc2cc1C)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H14N2O2/c1-9-5-12-13(6-10(9)2)18-14(8-17-12)11-3-4-15(19)16(20)7-11/h3-8,19-20H,1-2H3
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n/an/a 8.30E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


Citation and Details
More data for this
Ligand-Target Pair