BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 142 hits Enz. Inhib. hit(s) with Target = 'cGMP-inhibited 3',5'-cyclic phosphodiesterase B'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50129817
PNG
(CHEMBL3628685)
Show SMILES COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OC3CCCC3)c2)cc1
Show InChI InChI=1S/C21H23F2NO4/c1-26-16-9-6-14(7-10-16)13-24-20(25)15-8-11-18(28-21(22)23)19(12-15)27-17-4-2-3-5-17/h6-12,17,21H,2-5,13H2,1H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>1n/an/an/an/an/an/a



Southern Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using AM-Cyclic-3',5'-AMP after 60 mins by fluorescence polarization assay


Bioorg Med Chem 23: 7332-9 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM15297
PNG
(CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 69.1n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3B


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50338586
PNG
(CHEMBL1683806 | N'-(1-(3,3-dimethyl-2-oxoindolin-5...)
Show SMILES CC(=NNS(=O)(=O)c1ccc(C)cc1)c1ccc2NC(=O)C(C)(C)c2c1
Show InChI InChI=1S/C19H21N3O3S/c1-12-5-8-15(9-6-12)26(24,25)22-21-13(2)14-7-10-17-16(11-14)19(3,4)18(23)20-17/h5-11,22H,1-4H3,(H,20,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 88.4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3B


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308950
PNG
(6-({3-[(4-Hydroxypiperidino)carbonyl]benzyl}oxy)-4...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(O)CC3)cc12
Show InChI InChI=1S/C23H24N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13,18,26H,7-10,14H2,1H3,(H,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 910n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50259148
PNG
((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O
Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3b


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1.03E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308948
PNG
(4-Methyl-6-(3-[(4-oxopiperidino)carbonyl]benzyloxy...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(=O)CC3)cc12
Show InChI InChI=1S/C23H22N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13H,7-10,14H2,1H3,(H,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.14E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308954
PNG
(4-Methyl-6-{[3-(tetrahydro-1H-1-pyrrolylcarbonyl)-...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCCC3)cc12
Show InChI InChI=1S/C22H22N2O3/c1-15-11-21(25)23-20-8-7-18(13-19(15)20)27-14-16-5-4-6-17(12-16)22(26)24-9-2-3-10-24/h4-8,11-13H,2-3,9-10,14H2,1H3,(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50351908
PNG
(CHEMBL1821774)
Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1F
Show InChI InChI=1S/C20H19F2NO3/c1-24-18-4-3-13(9-16(18)22)10-17-15-12-19(25-2)20(26-8-6-21)11-14(15)5-7-23-17/h3-5,7,9,11-12H,6,8,10H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.25E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308949
PNG
(1-(3-{[(4-Methyl-2-oxo-1,2-dihydro-6-quinolinyl)ox...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(CC3)C(O)=O)cc12
Show InChI InChI=1S/C24H24N2O5/c1-15-11-22(27)25-21-6-5-19(13-20(15)21)31-14-16-3-2-4-18(12-16)23(28)26-9-7-17(8-10-26)24(29)30/h2-6,11-13,17H,7-10,14H2,1H3,(H,25,27)(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.28E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308953
PNG
(4-Methyl-6-{[3-(morpholinocarbonyl)benzyl]oxy}-1,2...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCOCC3)cc12
Show InChI InChI=1S/C22H22N2O4/c1-15-11-21(25)23-20-6-5-18(13-19(15)20)28-14-16-3-2-4-17(12-16)22(26)24-7-9-27-10-8-24/h2-6,11-13H,7-10,14H2,1H3,(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.54E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308952
PNG
(4-Methyl-6-({3-[(4-methylpiperidino)carbonyl]-benz...)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C24H26N2O3/c1-16-8-10-26(11-9-16)24(28)19-5-3-4-18(13-19)15-29-20-6-7-22-21(14-20)17(2)12-23(27)25-22/h3-7,12-14,16H,8-11,15H2,1-2H3,(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.61E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50351895
PNG
(CHEMBL1821775)
Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1C
Show InChI InChI=1S/C21H22FNO3/c1-14-10-15(4-5-19(14)24-2)11-18-17-13-20(25-3)21(26-9-7-22)12-16(17)6-8-23-18/h4-6,8,10,12-13H,7,9,11H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.67E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308951
PNG
(4-Methyl-6-{[3-(piperidinocarbonyl)benzyl]oxy}-1,2...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCCCC3)cc12
Show InChI InChI=1S/C23H24N2O3/c1-16-12-22(26)24-21-9-8-19(14-20(16)21)28-15-17-6-5-7-18(13-17)23(27)25-10-3-2-4-11-25/h5-9,12-14H,2-4,10-11,15H2,1H3,(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.73E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308946
PNG
(4-Methyl-6-({3-[(4-ethylpiperazino)carbonyl]-benzy...)
Show SMILES CCN1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C24H27N3O3/c1-3-26-9-11-27(12-10-26)24(29)19-6-4-5-18(14-19)16-30-20-7-8-22-21(15-20)17(2)13-23(28)25-22/h4-8,13-15H,3,9-12,16H2,1-2H3,(H,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.93E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50296256
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCN2CCOCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-11-33-14-10-30-21-15-19(18-4-5-22(32-2)27-16-18)26-17-20(21)28-23(24(30)31)25-6-7-29-8-12-34-13-9-29/h4-5,15-17H,3,6-14H2,1-2H3,(H,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50300953
PNG
(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H31N5O4/c1-3-11-33-12-10-29-21-13-19(16-4-9-22(32-2)26-14-16)25-15-20(21)28-23(24(29)31)27-17-5-7-18(30)8-6-17/h4,9,13-15,17-18,30H,3,5-8,10-12H2,1-2H3,(H,27,28)/t17-,18-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50357234
PNG
(CHEMBL1916475)
Show SMILES CCCOCCn1c2cc(nnc2c(NC2CCC(O)CC2)nc1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C23H30N6O4/c1-3-11-33-12-10-29-19-13-18(15-4-9-20(32-2)24-14-15)27-28-21(19)22(26-23(29)31)25-16-5-7-17(30)8-6-16/h4,9,13-14,16-17,30H,3,5-8,10-12H2,1-2H3,(H,25,26,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50351894
PNG
(CHEMBL1821789)
Show SMILES COc1cc(Cc2nccc3cc(OC)c(OC)cc23)ccc1OCCF
Show InChI InChI=1S/C21H22FNO4/c1-24-19-11-14(4-5-18(19)27-9-7-22)10-17-16-13-21(26-3)20(25-2)12-15(16)6-8-23-17/h4-6,8,11-13H,7,9-10H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.17E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50117862
PNG
(CHEMBL3614035)
Show SMILES Fc1ccc(cc1)-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8FN7S/c14-10-3-1-8(2-4-10)11-7-22-13(16-11)21-6-9(5-15-21)12-17-19-20-18-12/h1-7H,(H,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 2.34E+3n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50351890
PNG
(CHEMBL1821787)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OCCF
Show InChI InChI=1S/C21H22FNO4/c1-24-18-5-4-14(11-21(18)27-9-7-22)10-17-16-13-20(26-3)19(25-2)12-15(16)6-8-23-17/h4-6,8,11-13H,7,9-10H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.51E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50351891
PNG
(CHEMBL1821790)
Show SMILES COc1cc(Cc2nccc3cc(OC)c(OC)cc23)ccc1OCCOCCF
Show InChI InChI=1S/C23H26FNO5/c1-26-21-13-16(4-5-20(21)30-11-10-29-9-7-24)12-19-18-15-23(28-3)22(27-2)14-17(18)6-8-25-19/h4-6,8,13-15H,7,9-12H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.52E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308947
PNG
(6-[(3-{[4-(2-Hydroxyethyl)piperazino]carbonyl}-ben...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCN(CCO)CC3)cc12
Show InChI InChI=1S/C24H27N3O4/c1-17-13-23(29)25-22-6-5-20(15-21(17)22)31-16-18-3-2-4-19(14-18)24(30)27-9-7-26(8-10-27)11-12-28/h2-6,13-15,28H,7-12,16H2,1H3,(H,25,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50351892
PNG
(CHEMBL1821791)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H19NO3/c1-21-15-6-4-13(5-7-15)10-17-16-12-19(23-3)18(22-2)11-14(16)8-9-20-17/h4-9,11-12H,10H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Washington University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50128272
PNG
(CHEMBL3628721)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-17-24(19-10-13-29-14-11-19)27(32-33)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 3.48E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308945
PNG
(4-Methyl-6-({3-[(4-methylpiperazino)carbonyl]-benz...)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C23H25N3O3/c1-16-12-22(27)24-21-7-6-19(14-20(16)21)29-15-17-4-3-5-18(13-17)23(28)26-10-8-25(2)9-11-26/h3-7,12-14H,8-11,15H2,1-2H3,(H,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.51E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50128273
PNG
(CHEMBL3628722)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-18-26(20-11-14-31-15-12-20)29(34-36)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)32-23)37-17-22(10-13-30)33-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 3.56E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50117865
PNG
(CHEMBL3614033)
Show SMILES Clc1ccc(cc1)-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8ClN7S/c14-10-3-1-8(2-4-10)11-7-22-13(16-11)21-6-9(5-15-21)12-17-19-20-18-12/h1-7H,(H,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 3.83E+3n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM123687
PNG
(US8741907, 3 | US9067945, 2)
Show SMILES CCC(CC)n1ncc2c1nc(CC1CCCCC1)[nH]c2=O
Show InChI InChI=1S/C17H26N4O/c1-3-13(4-2)21-16-14(11-18-21)17(22)20-15(19-16)10-12-8-6-5-7-9-12/h11-13H,3-10H2,1-2H3,(H,19,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a>4.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. 2 uL portions of the diluted substa...


US Patent US8741907 (2014)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM123687
PNG
(US8741907, 3 | US9067945, 2)
Show SMILES CCC(CC)n1ncc2c1nc(CC1CCCCC1)[nH]c2=O
Show InChI InChI=1S/C17H26N4O/c1-3-13(4-2)21-16-14(11-18-21)17(22)20-15(19-16)10-12-8-6-5-7-9-12/h11-13H,3-10H2,1-2H3,(H,19,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a>4.00E+3n/an/an/an/an/an/a



Boehringer Ingehleim International GmbH

US Patent


Assay Description
The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20...


US Patent US9067945 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50103185
PNG
(CHEMBL3393194)
Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4cccnc4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C26H27N5O3/c1-17-11-18(21-16-29-30-22-13-24(34-3)23(33-2)12-20(21)22)14-28-25(17)31-9-6-26(32,7-10-31)19-5-4-8-27-15-19/h4-5,8,11-16,32H,6-7,9-10H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
n/an/a 4.11E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant PDE3B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50128268
PNG
(CHEMBL3628717)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-17-26(20-10-13-30-14-11-20)28(32-33)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)31-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 4.55E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50117861
PNG
(CHEMBL3614036)
Show SMILES Fc1cccc(c1)-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8FN7S/c14-10-3-1-2-8(4-10)11-7-22-13(16-11)21-6-9(5-15-21)12-17-19-20-18-12/h1-7H,(H,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 4.65E+3n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50117860
PNG
(CHEMBL3614037)
Show SMILES Fc1ccccc1-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8FN7S/c14-10-4-2-1-3-9(10)11-7-22-13(16-11)21-6-8(5-15-21)12-17-19-20-18-12/h1-7H,(H,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 4.72E+3n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50117864
PNG
(CHEMBL3614032)
Show SMILES Clc1cccc(c1)-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8ClN7S/c14-10-3-1-2-8(4-10)11-7-22-13(16-11)21-6-9(5-15-21)12-17-19-20-18-12/h1-7H,(H,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
n/an/a 5.01E+3n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50128278
PNG
(CHEMBL3628994)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-27(24(17-30-32)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 5.61E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308956
PNG
(6-(3-(4-methylpiperazine-1-carbonyl)benzyloxy)quin...)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)ccc3c2)c1
Show InChI InChI=1S/C22H23N3O3/c1-24-9-11-25(12-10-24)22(27)18-4-2-3-16(13-18)15-28-19-6-7-20-17(14-19)5-8-21(26)23-20/h2-8,13-14H,9-12,15H2,1H3,(H,23,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.67E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50128279
PNG
(CHEMBL3628714)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C26H21FN4O/c1-31-16-24(18-10-12-28-13-11-18)26(30-31)19-6-8-22(9-7-19)32-17-21-14-20(15-27)23-4-2-3-5-25(23)29-21/h2-14,16H,15,17H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 5.68E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50117863
PNG
(CHEMBL3614034)
Show SMILES Clc1ccccc1-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8ClN7S/c14-10-4-2-1-3-9(10)11-7-22-13(16-11)21-6-8(5-15-21)12-17-19-20-18-12/h1-7H,(H,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 5.92E+3n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50103184
PNG
(CHEMBL3393195)
Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4ccc(F)nc4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C26H26FN5O3/c1-16-10-17(20-15-30-31-21-12-23(35-3)22(34-2)11-19(20)21)13-29-25(16)32-8-6-26(33,7-9-32)18-4-5-24(27)28-14-18/h4-5,10-15,33H,6-9H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
n/an/a 6.54E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant PDE3B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50117859
PNG
(CHEMBL3614038)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8N8O2S/c22-21(23)10-3-1-8(2-4-10)11-7-24-13(15-11)20-6-9(5-14-20)12-16-18-19-17-12/h1-7H,(H,16,17,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 7.27E+3n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50128293
PNG
(CHEMBL3628716)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-24(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)30-21/h2-11,13-14,16-17H,12,15,18H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 7.76E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50117858
PNG
(CHEMBL3614039)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8N8O2S/c22-21(23)10-3-1-2-8(4-10)11-7-24-13(15-11)20-6-9(5-14-20)12-16-18-19-17-12/h1-7H,(H,16,17,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 8.54E+3n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50425123
PNG
(CHEMBL2313234)
Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl
Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3B expressed in Sf9 cells by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50026821
PNG
(CHEMBL3331521)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H28N6O2/c1-3-4-9-32-20-13-19(14-25-15-20)24-28-27-23-17(2)26-21-6-5-18(12-22(21)30(23)24)16-29-7-10-31-11-8-29/h5-6,12-15H,3-4,7-11,16H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by scintillation counting method


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50259057
PNG
(3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...)
Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O
Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3b


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM162879
PNG
(US9056863, Example Ic1)
Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl
Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica N.V.

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50259108
PNG
((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...)
Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O
Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3b


Citation and Details
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50117857
PNG
(CHEMBL3614040)
Show SMILES [O-][N+](=O)c1ccccc1-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8N8O2S/c22-21(23)11-4-2-1-3-9(11)10-7-24-13(15-10)20-6-8(5-14-20)12-16-18-19-17-12/h1-7H,(H,16,17,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.02E+4n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 142 total )  |  Next  |  Last  >>
Jump to: