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Compile Data Set for Download or QSAR

Found 1063 hits Enz. Inhib. hit(s) with Target = 'Adrenergic receptor alpha-2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50227383
PNG
(CHEMBL556758)
Show SMILES Cl.CN1C(Cc2c1cccc2Cl)C1=NCCN1
Show InChI InChI=1S/C12H14ClN3.ClH/c1-16-10-4-2-3-9(13)8(10)7-11(16)12-14-5-6-15-12;/h2-4,11H,5-7H2,1H3,(H,14,15);1H
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0.160n/an/an/an/an/an/an/an/a



Reckitt and Colman plc

Curated by ChEMBL


Assay Description
Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.


J Med Chem 31: 944-8 (1988)


Article DOI: 10.1021/jm00400a009
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226939
PNG
(CHEMBL36616)
Show SMILES CCN1C(Cc2ccccc12)C1=NCCN1
Show InChI InChI=1S/C13H17N3/c1-2-16-11-6-4-3-5-10(11)9-12(16)13-14-7-8-15-13/h3-6,12H,2,7-9H2,1H3,(H,14,15)
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0.240n/an/an/an/an/an/an/an/a



Reckitt and Colman plc

Curated by ChEMBL


Assay Description
Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.


J Med Chem 31: 944-8 (1988)


Article DOI: 10.1021/jm00400a009
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(Homo sapiens-Homo sapiens (Human))
BDBM50213212
PNG
(CHEMBL50390)
Show SMILES Cc1c(NC2=NCCN2)ccc2OCCOc12
Show InChI InChI=1S/C12H15N3O2/c1-8-9(15-12-13-4-5-14-12)2-3-10-11(8)17-7-6-16-10/h2-3H,4-7H2,1H3,(H2,13,14,15)
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0.25n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228318
PNG
(CHEMBL279807)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17-,18+/m1/s1
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0.355n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat liver dihydrofolate reductase.


J Med Chem 32: 2034-6 (1989)


Article DOI: 10.1021/jm00129a002
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228318
PNG
(CHEMBL279807)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17-,18+/m1/s1
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0.355n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50019492
PNG
((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Show SMILES COC1(COc2ccccc2O1)C1=NCCN1
Show InChI InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14)
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0.360n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]idazoxan from alpha-2 adrenergic receptor from rat brain cerebral cortex.


J Med Chem 29: 2000-3 (1986)


Article DOI: 10.1021/jm00160a033
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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0.400n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]prazosin from rat brain cortical membranes


J Med Chem 30: 1555-62 (1987)


Article DOI: 10.1021/jm00392a005
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50227384
PNG
(CHEMBL172132)
Show SMILES CCN1C(Cc2c1cccc2Cl)C1=NCCN1
Show InChI InChI=1S/C13H16ClN3/c1-2-17-11-5-3-4-10(14)9(11)8-12(17)13-15-6-7-16-13/h3-5,12H,2,6-8H2,1H3,(H,15,16)
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0.420n/an/an/an/an/an/an/an/a



Reckitt and Colman plc

Curated by ChEMBL


Assay Description
Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.


J Med Chem 31: 944-8 (1988)


Article DOI: 10.1021/jm00400a009
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226938
PNG
(CHEMBL38829)
Show SMILES CN1C(Cc2ccccc12)C1=NCCN1
Show InChI InChI=1S/C12H15N3/c1-15-10-5-3-2-4-9(10)8-11(15)12-13-6-7-14-12/h2-5,11H,6-8H2,1H3,(H,13,14)
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0.450n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranes


J Med Chem 30: 1555-62 (1987)


Article DOI: 10.1021/jm00392a005
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229080
PNG
(CHEMBL349665)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C23H28N2O3S/c1-28-19-8-10-20(11-9-19)29(26,27)25-13-4-6-18-16-24-14-12-17-5-2-3-7-21(17)23(24)15-22(18)25/h2-3,5,7-11,18,22-23H,4,6,12-16H2,1H3/t18-,22+,23+/m1/s1
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0.457n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226949
PNG
(CHEMBL416072)
Show SMILES C=CCN1C(Cc2ccccc12)C1=NCCN1
Show InChI InChI=1S/C14H17N3/c1-2-9-17-12-6-4-3-5-11(12)10-13(17)14-15-7-8-16-14/h2-6,13H,1,7-10H2,(H,15,16)
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0.470n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranes


J Med Chem 30: 1555-62 (1987)


Article DOI: 10.1021/jm00392a005
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226801
PNG
(CHEMBL7707)
Show SMILES Oc1ccc2[C@@H](CCCc2c1O)C1=NCCN1
Show InChI InChI=1S/C13H16N2O2/c16-11-5-4-8-9(12(11)17)2-1-3-10(8)13-14-6-7-15-13/h4-5,10,16-17H,1-3,6-7H2,(H,14,15)/t10-/m1/s1
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0.550n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for alpha-2 adrenergic receptor in rat cortex using [3H]rauwolscine.


J Med Chem 30: 1011-7 (1987)


Article DOI: 10.1021/jm00389a009
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50122243
PNG
(4-Chloro-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)
Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1
Show InChI InChI=1S/C33H45ClN6O4/c1-26(2)44-29-12-7-6-11-27(29)37-18-16-36(17-19-37)14-8-4-3-5-9-15-40-33(42)31(34)28(25-35-40)38-20-22-39(23-21-38)32(41)30-13-10-24-43-30/h6-7,10-13,24-26H,3-5,8-9,14-23H2,1-2H3
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0.560n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay.


Bioorg Med Chem Lett 13: 171-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00932-0
BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229162
PNG
(CHEMBL349747)
Show SMILES COCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc(OC)ccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O4S/c1-25-10-11-27(23,24)22-8-3-4-16-14-21-9-7-15-12-17(26-2)5-6-18(15)20(21)13-19(16)22/h5-6,12,16,19-20H,3-4,7-11,13-14H2,1-2H3/t16-,19+,20+/m1/s1
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0.603n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229147
PNG
(CHEMBL348793)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15-,16+/m1/s1
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0.646n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229143
PNG
(CHEMBL162971)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15+,16+/m1/s1
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0.661n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228316
PNG
(CHEMBL62912)
Show SMILES COc1ccc2C3CC4C(CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3
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0.661n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
In vitro inhibition of Escherichia coli dihydrofolate reductase.


J Med Chem 32: 2034-6 (1989)


Article DOI: 10.1021/jm00129a002
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229179
PNG
(DELEQUAMINE | Delequamine)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18+/m1/s1
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0.661n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226938
PNG
(CHEMBL38829)
Show SMILES CN1C(Cc2ccccc12)C1=NCCN1
Show InChI InChI=1S/C12H15N3/c1-15-10-5-3-2-4-9(10)8-11(15)12-13-6-7-14-12/h2-5,11H,6-8H2,1H3,(H,13,14)
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0.690n/an/an/an/an/an/an/an/a



Reckitt and Colman plc

Curated by ChEMBL


Assay Description
Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.


J Med Chem 31: 944-8 (1988)


Article DOI: 10.1021/jm00400a009
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229152
PNG
(CHEMBL349004)
Show SMILES Cc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O2S/c1-13-5-6-16-14(10-13)7-9-19-12-15-4-3-8-20(23(2,21)22)17(15)11-18(16)19/h5-6,10,15,17-18H,3-4,7-9,11-12H2,1-2H3/t15-,17+,18+/m1/s1
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0.708n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226962
PNG
(CHEMBL41224)
Show SMILES CN1C(Cc2cccc(Cl)c12)C1=NCCN1
Show InChI InChI=1S/C12H14ClN3/c1-16-10(12-14-5-6-15-12)7-8-3-2-4-9(13)11(8)16/h2-4,10H,5-7H2,1H3,(H,14,15)
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0.720n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranes


J Med Chem 30: 1555-62 (1987)


Article DOI: 10.1021/jm00392a005
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50019492
PNG
((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Show SMILES COC1(COc2ccccc2O1)C1=NCCN1
Show InChI InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14)
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0.800n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]idazoxan from alpha-2 adrenergic receptor from rat brain cerebral cortex.


J Med Chem 29: 2000-3 (1986)


Article DOI: 10.1021/jm00160a033
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226939
PNG
(CHEMBL36616)
Show SMILES CCN1C(Cc2ccccc12)C1=NCCN1
Show InChI InChI=1S/C13H17N3/c1-2-16-11-6-4-3-5-10(11)9-12(16)13-14-7-8-15-13/h3-6,12H,2,7-9H2,1H3,(H,14,15)
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0.910n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranes


J Med Chem 30: 1555-62 (1987)


Article DOI: 10.1021/jm00392a005
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50019855
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-5-fluoro-1-methyl...)
Show SMILES CN1C(Cc2cc(F)ccc12)C1=NCCN1
Show InChI InChI=1S/C12H14FN3/c1-16-10-3-2-9(13)6-8(10)7-11(16)12-14-4-5-15-12/h2-3,6,11H,4-5,7H2,1H3,(H,14,15)
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0.910n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranes


J Med Chem 30: 1555-62 (1987)


Article DOI: 10.1021/jm00392a005
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226961
PNG
(CHEMBL38788)
Show SMILES CCCN1C(Cc2ccccc12)C1=NCCN1
Show InChI InChI=1S/C14H19N3/c1-2-9-17-12-6-4-3-5-11(12)10-13(17)14-15-7-8-16-14/h3-6,13H,2,7-10H2,1H3,(H,15,16)
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0.960n/an/an/an/an/an/an/an/a



Reckitt and Colman plc

Curated by ChEMBL


Assay Description
Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.


J Med Chem 31: 944-8 (1988)


Article DOI: 10.1021/jm00400a009
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50021195
PNG
(2-Hydroxy-ethanesulfonic acid (1,3,4,5,6,11b-hexah...)
Show SMILES CN([C@@H]1CCN2CCc3c(oc4ccccc34)[C@@H]2C1)S(=O)(=O)CCO
Show InChI InChI=1S/C18H24N2O4S/c1-19(25(22,23)11-10-21)13-6-8-20-9-7-15-14-4-2-3-5-17(14)24-18(15)16(20)12-13/h2-5,13,16,21H,6-12H2,1H3/t13-,16+/m1/s1
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1.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of human plasma renin


J Med Chem 28: 1756-9 (1986)


Article DOI: 10.1021/jm00150a002
BindingDB Entry DOI: 10.7270/Q2JW8CWS
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229074
PNG
(CHEMBL163570)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)CCl)CN3CCc2c1
Show InChI InChI=1S/C18H25ClN2O3S/c1-24-15-4-5-16-13(9-15)6-8-20-11-14-3-2-7-21(25(22,23)12-19)17(14)10-18(16)20/h4-5,9,14,17-18H,2-3,6-8,10-12H2,1H3/t14-,17-,18+/m1/s1
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1.10n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229155
PNG
(CHEMBL164420)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)N(C)C)CN3CCc2c1
Show InChI InChI=1S/C19H29N3O3S/c1-20(2)26(23,24)22-9-4-5-15-13-21-10-8-14-11-16(25-3)6-7-17(14)19(21)12-18(15)22/h6-7,11,15,18-19H,4-5,8-10,12-13H2,1-3H3/t15-,18-,19+/m1/s1
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1.10n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(Homo sapiens-Homo sapiens (Human))
BDBM50052882
PNG
(AGN-193080 | CHEMBL298936 | Imidazolidin-2-ylidene...)
Show SMILES Cc1c(ccc2OCCNc12)N=C1NCCN1
Show InChI InChI=1S/C12H16N4O/c1-8-9(16-12-14-4-5-15-12)2-3-10-11(8)13-6-7-17-10/h2-3,13H,4-7H2,1H3,(H2,14,15,16)
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1.20n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(Homo sapiens-Homo sapiens (Human))
BDBM50052880
PNG
(CHEMBL49137 | Imidazolidin-2-ylidene-(5-methyl-qui...)
Show SMILES Cc1c(ccc2nccnc12)N=C1NCCN1
Show InChI InChI=1S/C12H13N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-5H,6-7H2,1H3,(H2,15,16,17)
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1.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cells


Citation and Details
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(Homo sapiens-Homo sapiens (Human))
BDBM50052880
PNG
(CHEMBL49137 | Imidazolidin-2-ylidene-(5-methyl-qui...)
Show SMILES Cc1c(ccc2nccnc12)N=C1NCCN1
Show InChI InChI=1S/C12H13N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-5H,6-7H2,1H3,(H2,15,16,17)
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1.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparation


Citation and Details
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229171
PNG
(CHEMBL411954)
Show SMILES CCCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-2-3-13-25(23,24)22-11-6-8-17-15-21-12-10-16-7-4-5-9-18(16)20(21)14-19(17)22/h4-5,7,9,17,19-20H,2-3,6,8,10-15H2,1H3/t17-,19+,20+/m1/s1
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1.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM31046
PNG
(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1
Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
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1.40n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229178
PNG
(CHEMBL161278)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)c4cccs4)CN3CCc2c1
Show InChI InChI=1S/C21H26N2O3S2/c1-26-17-6-7-18-15(12-17)8-10-22-14-16-4-2-9-23(19(16)13-20(18)22)28(24,25)21-5-3-11-27-21/h3,5-7,11-12,16,19-20H,2,4,8-10,13-14H2,1H3/t16-,19-,20+/m1/s1
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1.5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226945
PNG
(CHEMBL38406)
Show SMILES CN1C(CCc2ccccc12)C1=NCCN1
Show InChI InChI=1S/C13H17N3/c1-16-11-5-3-2-4-10(11)6-7-12(16)13-14-8-9-15-13/h2-5,12H,6-9H2,1H3,(H,14,15)
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1.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranes


J Med Chem 30: 1555-62 (1987)


Article DOI: 10.1021/jm00392a005
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50225285
PNG
(CHEBI:3757 | CLONIDINE | Catapres | Catapres-Tts-1...)
Show SMILES Clc1cccc(Cl)c1NC1=NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
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1.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity was measured as the inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor of rat cortical membranes


J Med Chem 29: 1394-8 (1986)


Article DOI: 10.1021/jm00158a013
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229146
PNG
(CHEMBL163290)
Show SMILES CCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H26N2O2S/c1-2-23(21,22)20-10-5-7-15-13-19-11-9-14-6-3-4-8-16(14)18(19)12-17(15)20/h3-4,6,8,15,17-18H,2,5,7,9-13H2,1H3/t15-,17+,18+/m1/s1
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1.5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229141
PNG
(CHEMBL162965)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)C=C)CN3CCc2c1
Show InChI InChI=1S/C19H26N2O3S/c1-3-25(22,23)21-9-4-5-15-13-20-10-8-14-11-16(24-2)6-7-17(14)19(20)12-18(15)21/h3,6-7,11,15,18-19H,1,4-5,8-10,12-13H2,2H3/t15-,18+,19+/m1/s1
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1.5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229149
PNG
(CHEMBL159919)
Show SMILES O=S(=O)(N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12)c1ccccc1
Show InChI InChI=1S/C22H26N2O2S/c25-27(26,19-9-2-1-3-10-19)24-13-6-8-18-16-23-14-12-17-7-4-5-11-20(17)22(23)15-21(18)24/h1-5,7,9-11,18,21-22H,6,8,12-16H2/t18-,21+,22+/m1/s1
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1.5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229170
PNG
(CHEMBL348831)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)Cc4ccccc4)CN3CCc2c1
Show InChI InChI=1S/C24H30N2O3S/c1-29-21-9-10-22-19(14-21)11-13-25-16-20-8-5-12-26(23(20)15-24(22)25)30(27,28)17-18-6-3-2-4-7-18/h2-4,6-7,9-10,14,20,23-24H,5,8,11-13,15-17H2,1H3/t20-,23-,24+/m1/s1
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1.5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229077
PNG
(CHEMBL348726)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C19H26N2O4S/c1-26(22,23)21-5-2-3-14-12-20-6-4-13-9-18-19(25-8-7-24-18)10-15(13)17(20)11-16(14)21/h9-10,14,16-17H,2-8,11-12H2,1H3/t14-,16+,17+/m1/s1
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1.60n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50021196
PNG
(2-Hydroxy-ethanesulfonic acid (1,3,4,5,6,11b-hexah...)
Show SMILES CN(C1CCN2CCc3c(oc4ccccc34)C2C1)S(=O)(=O)CCO
Show InChI InChI=1S/C18H24N2O4S/c1-19(25(22,23)11-10-21)13-6-8-20-9-7-15-14-4-2-3-5-17(14)24-18(15)16(20)12-13/h2-5,13,16,21H,6-12H2,1H3
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1.60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of hog kidney renin


J Med Chem 28: 1756-9 (1986)


Article DOI: 10.1021/jm00150a002
BindingDB Entry DOI: 10.7270/Q2JW8CWS
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50122242
PNG
(4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...)
Show SMILES CCOc1ccccc1OCCN1CCN(CC1)c1cnn(CCCCCCCN2CCN(CC2)c2ccccc2OC)c(=O)c1Cl
Show InChI InChI=1S/C36H51ClN6O4/c1-3-46-33-15-9-10-16-34(33)47-28-27-40-21-25-42(26-22-40)31-29-38-43(36(44)35(31)37)18-12-6-4-5-11-17-39-19-23-41(24-20-39)30-13-7-8-14-32(30)45-2/h7-10,13-16,29H,3-6,11-12,17-28H2,1-2H3
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1.60n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Binding affinity towards Alpha-2 adrenergic receptor in rat cerebral cortex using [3H]rauwolscine


Bioorg Med Chem Lett 13: 171-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00932-0
BindingDB Entry DOI: 10.7270/Q2TM79GX
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50016897
PNG
(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Show SMILES Clc1cccc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
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1.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]clonidine binding Alpha-2 adrenergic receptor of crude rat brain membrane


J Med Chem 25: 75-81 (1982)


Article DOI: 10.1021/jm00343a015
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229148
PNG
(CHEMBL350388)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)CC(C)C)CN3CCc2c1
Show InChI InChI=1S/C21H32N2O3S/c1-15(2)14-27(24,25)23-9-4-5-17-13-22-10-8-16-11-18(26-3)6-7-19(16)21(22)12-20(17)23/h6-7,11,15,17,20-21H,4-5,8-10,12-14H2,1-3H3/t17-,20+,21+/m1/s1
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1.70n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229072
PNG
(CHEMBL162841)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-4-6-14-12-18-10-8-13-5-2-3-7-15(13)17(18)11-16(14)19/h2-3,5,7,14,16-17H,4,6,8-12H2,1H3/t14-,16+,17+/m1/s1
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1.70n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229079
PNG
(CHEMBL352278)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-15(2)14-25(23,24)22-10-5-7-17-13-21-11-9-16-6-3-4-8-18(16)20(21)12-19(17)22/h3-4,6,8,15,17,19-20H,5,7,9-14H2,1-2H3/t17-,19+,20+/m1/s1
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1.70n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229134
PNG
(CHEMBL262446)
Show SMILES CN(C)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H27N3O2S/c1-19(2)24(22,23)21-10-5-7-15-13-20-11-9-14-6-3-4-8-16(14)18(20)12-17(15)21/h3-4,6,8,15,17-18H,5,7,9-13H2,1-2H3/t15-,17+,18+/m1/s1
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1.80n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


Citation and Details

Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50225285
PNG
(CHEBI:3757 | CLONIDINE | Catapres | Catapres-Tts-1...)
Show SMILES Clc1cccc(Cl)c1NC1=NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
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1.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranes


J Med Chem 30: 1555-62 (1987)


Article DOI: 10.1021/jm00392a005
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226961
PNG
(CHEMBL38788)
Show SMILES CCCN1C(Cc2ccccc12)C1=NCCN1
Show InChI InChI=1S/C14H19N3/c1-2-9-17-12-6-4-3-5-11(12)10-13(17)14-15-7-8-16-14/h3-6,13H,2,7-10H2,1H3,(H,15,16)
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1.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranes


J Med Chem 30: 1555-62 (1987)


Article DOI: 10.1021/jm00392a005
More data for this
Ligand-Target Pair
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