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Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with Target = 'Atrial natriuretic peptide receptor 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228215
PNG
(CHEMBL3349651)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)[C@@H](C)CC
Show InChI InChI=1S/C107H165N35O34S2/c1-8-53(5)84-102(173)124-43-79(151)125-55(7)86(157)129-64(30-31-76(109)148)92(163)138-71(47-144)90(161)123-44-81(153)127-65(35-52(3)4)88(159)122-45-82(154)128-74(100(171)134-68(39-77(110)149)96(167)139-73(49-146)98(169)133-67(37-57-21-14-11-15-22-57)95(166)130-62(24-17-33-118-106(113)114)91(162)136-70(104(175)176)38-58-26-28-59(147)29-27-58)50-177-178-51-75(140-99(170)72(48-145)137-87(158)60(108)46-143)101(172)132-66(36-56-19-12-10-13-20-56)89(160)121-41-78(150)120-42-80(152)126-61(23-16-32-117-105(111)112)93(164)142-85(54(6)9-2)103(174)135-69(40-83(155)156)97(168)131-63(94(165)141-84)25-18-34-119-107(115)116/h10-15,19-22,26-29,52-55,60-75,84-85,143-147H,8-9,16-18,23-25,30-51,108H2,1-7H3,(H2,109,148)(H2,110,149)(H,120,150)(H,121,160)(H,122,159)(H,123,161)(H,124,173)(H,125,151)(H,126,152)(H,127,153)(H,128,154)(H,129,157)(H,130,166)(H,131,168)(H,132,172)(H,133,169)(H,134,171)(H,135,174)(H,136,162)(H,137,158)(H,138,163)(H,139,167)(H,140,170)(H,141,165)(H,142,164)(H,155,156)(H,175,176)(H4,111,112,117)(H4,113,114,118)(H4,115,116,119)/t53-,54-,55-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,84-,85-/m0/s1
UniProtKB/SwissProt

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UniChem

Patents


Similars

Article
PubMed
0.25n/an/an/an/an/an/an/an/a



G. D. Searle and Company

Curated by ChEMBL


Assay Description
Apparent binding constant against multiple binding sites


J Med Chem 32: 1094-8 (1989)


Article DOI: 10.1021/jm00125a026
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228184
PNG
(CHEMBL3349623)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)CC
Show InChI InChI=1S/C128H205N45O39S2/c1-10-64(7)99-121(209)151-52-94(183)152-66(9)101(189)156-77(36-37-91(130)180)109(197)167-85(56-175)105(193)150-53-96(185)154-78(43-62(3)4)103(191)149-54-97(186)155-89(119(207)164-82(48-92(131)181)114(202)169-86(57-176)116(204)163-81(46-68-25-16-13-17-26-68)113(201)159-74(29-20-40-144-126(136)137)107(195)166-84(123(211)212)47-69-32-34-70(179)35-33-69)60-213-214-61-90(171-118(206)88(59-178)170-117(205)87(58-177)168-108(196)75(30-21-41-145-127(138)139)157-106(194)73(28-19-39-143-125(134)135)158-112(200)79(44-63(5)6)161-102(190)71(129)55-174)120(208)162-80(45-67-23-14-12-15-24-67)104(192)148-50-93(182)147-51-95(184)153-72(27-18-38-142-124(132)133)110(198)173-100(65(8)11-2)122(210)165-83(49-98(187)188)115(203)160-76(111(199)172-99)31-22-42-146-128(140)141/h12-17,23-26,32-35,62-66,71-90,99-100,174-179H,10-11,18-22,27-31,36-61,129H2,1-9H3,(H2,130,180)(H2,131,181)(H,147,182)(H,148,192)(H,149,191)(H,150,193)(H,151,209)(H,152,183)(H,153,184)(H,154,185)(H,155,186)(H,156,189)(H,157,194)(H,158,200)(H,159,201)(H,160,203)(H,161,190)(H,162,208)(H,163,204)(H,164,207)(H,165,210)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,173,198)(H,187,188)(H,211,212)(H4,132,133,142)(H4,134,135,143)(H4,136,137,144)(H4,138,139,145)(H4,140,141,146)/t64-,65-,66-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,99-,100-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.0540n/an/an/an/an/an/a



G. D. Searle& Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)


J Med Chem 32: 869-74 (1989)


Article DOI: 10.1021/jm00124a023
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228174
PNG
(CHEMBL413432)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](N)CO)[C@@H](C)CC
Show InChI InChI=1S/C107H165N35O34S2/c1-8-53(5)84-102(173)124-43-79(151)125-55(7)86(157)129-64(30-31-76(109)148)92(163)138-71(47-144)90(161)123-44-81(153)127-65(35-52(3)4)88(159)122-45-82(154)128-74(100(171)134-68(39-77(110)149)96(167)139-73(49-146)98(169)133-67(37-57-21-14-11-15-22-57)95(166)130-62(24-17-33-118-106(113)114)91(162)136-70(104(175)176)38-58-26-28-59(147)29-27-58)50-177-178-51-75(140-99(170)72(48-145)137-87(158)60(108)46-143)101(172)132-66(36-56-19-12-10-13-20-56)89(160)121-41-78(150)120-42-80(152)126-61(23-16-32-117-105(111)112)93(164)142-85(54(6)9-2)103(174)135-69(40-83(155)156)97(168)131-63(94(165)141-84)25-18-34-119-107(115)116/h10-15,19-22,26-29,52-55,60-75,84-85,143-147H,8-9,16-18,23-25,30-51,108H2,1-7H3,(H2,109,148)(H2,110,149)(H,120,150)(H,121,160)(H,122,159)(H,123,161)(H,124,173)(H,125,151)(H,126,152)(H,127,153)(H,128,154)(H,129,157)(H,130,166)(H,131,168)(H,132,172)(H,133,169)(H,134,171)(H,135,174)(H,136,162)(H,137,158)(H,138,163)(H,139,167)(H,140,170)(H,141,165)(H,142,164)(H,155,156)(H,175,176)(H4,111,112,117)(H4,113,114,118)(H4,115,116,119)/t53-,54-,55-,60+,61-,62-,63+,64+,65-,66+,67-,68-,69-,70-,71-,72-,73-,74+,75+,84-,85+/m0/s1
UniProtKB/SwissProt

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UniChem

Similars

Article
PubMed
n/an/a 0.290n/an/an/an/an/an/a



G. D. Searle& Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)


J Med Chem 32: 869-74 (1989)


Article DOI: 10.1021/jm00124a023
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228181
PNG
(CHEMBL3349961)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)[C@@H](C)CC
Show InChI InChI=1S/C83H135N29O30S2/c1-8-39(5)64-79(139)97-29-59(120)98-41(7)66(126)102-46(19-20-56(85)117)71(131)108-51(33-114)70(130)96-30-61(122)100-47(23-38(3)4)68(128)95-31-62(123)101-54(77(137)105-49(25-57(86)118)74(134)109-53(35-116)81(141)142)36-143-144-37-55(110-76(136)52(34-115)107-67(127)43(84)32-113)78(138)104-48(24-42-15-11-10-12-16-42)69(129)94-27-58(119)93-28-60(121)99-44(17-13-21-91-82(87)88)72(132)112-65(40(6)9-2)80(140)106-50(26-63(124)125)75(135)103-45(73(133)111-64)18-14-22-92-83(89)90/h10-12,15-16,38-41,43-55,64-65,113-116H,8-9,13-14,17-37,84H2,1-7H3,(H2,85,117)(H2,86,118)(H,93,119)(H,94,129)(H,95,128)(H,96,130)(H,97,139)(H,98,120)(H,99,121)(H,100,122)(H,101,123)(H,102,126)(H,103,135)(H,104,138)(H,105,137)(H,106,140)(H,107,127)(H,108,131)(H,109,134)(H,110,136)(H,111,133)(H,112,132)(H,124,125)(H,141,142)(H4,87,88,91)(H4,89,90,92)/t39-,40-,41-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,64-,65-/m0/s1
UniProtKB/SwissProt

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Article
PubMed
n/an/a 36n/an/an/an/an/an/a



G. D. Searle& Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)


J Med Chem 32: 869-74 (1989)


Article DOI: 10.1021/jm00124a023
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228182
PNG
(CHEMBL3349622)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)CC
Show InChI InChI=1S/C84H143N33O25S2/c1-8-41(5)63-79(141)102-34-60(123)103-43(7)66(128)105-50(23-24-58(86)121)71(133)114-56(65(87)127)38-143-144-39-57(115-77(139)55(37-120)113-76(138)54(36-119)112-70(132)48(21-15-27-98-83(92)93)106-69(131)47(20-14-26-97-82(90)91)107-74(136)51(29-40(3)4)109-67(129)45(85)35-118)78(140)110-52(30-44-17-11-10-12-18-44)68(130)101-32-59(122)100-33-61(124)104-46(19-13-25-96-81(88)89)72(134)117-64(42(6)9-2)80(142)111-53(31-62(125)126)75(137)108-49(73(135)116-63)22-16-28-99-84(94)95/h10-12,17-18,40-43,45-57,63-64,118-120H,8-9,13-16,19-39,85H2,1-7H3,(H2,86,121)(H2,87,127)(H,100,122)(H,101,130)(H,102,141)(H,103,123)(H,104,124)(H,105,128)(H,106,131)(H,107,136)(H,108,137)(H,109,129)(H,110,140)(H,111,142)(H,112,132)(H,113,138)(H,114,133)(H,115,139)(H,116,135)(H,117,134)(H,125,126)(H4,88,89,96)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t41-,42-,43-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-,64-/m0/s1
UniProtKB/SwissProt

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PC sid
UniChem

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Article
PubMed
n/an/a 52n/an/an/an/an/an/a



G. D. Searle& Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)


J Med Chem 32: 869-74 (1989)


Article DOI: 10.1021/jm00124a023
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228183
PNG
(DRIGAQSGLGCNSFRY | Drigaqsglgcnsfry)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C73H114N24O24S/c1-6-36(4)58(97-65(114)43(15-11-23-82-73(79)80)90-60(109)41(74)27-57(106)107)70(119)85-29-54(103)86-37(5)59(108)89-44(20-21-52(75)101)64(113)95-49(32-98)62(111)84-30-55(104)87-45(24-35(2)3)61(110)83-31-56(105)88-51(34-122)69(118)93-47(28-53(76)102)67(116)96-50(33-99)68(117)92-46(25-38-12-8-7-9-13-38)66(115)91-42(14-10-22-81-72(77)78)63(112)94-48(71(120)121)26-39-16-18-40(100)19-17-39/h7-9,12-13,16-19,35-37,41-51,58,98-100,122H,6,10-11,14-15,20-34,74H2,1-5H3,(H2,75,101)(H2,76,102)(H,83,110)(H,84,111)(H,85,119)(H,86,103)(H,87,104)(H,88,105)(H,89,108)(H,90,109)(H,91,115)(H,92,117)(H,93,118)(H,94,112)(H,95,113)(H,96,116)(H,97,114)(H,106,107)(H,120,121)(H4,77,78,81)(H4,79,80,82)/t36-,37-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,58-/m0/s1
UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a>100n/an/an/an/an/an/a



G. D. Searle& Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)


J Med Chem 32: 869-74 (1989)


Article DOI: 10.1021/jm00124a023
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228180
PNG
(GRIDRIG)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(C)=O)[C@@H](C)CC)C(=O)NCC(N)=O
Show InChI InChI=1S/C34H62N14O10/c1-6-17(3)26(31(57)43-15-23(35)50)47-29(55)21(11-9-13-41-34(38)39)45-30(56)22(14-25(52)53)46-32(58)27(18(4)7-2)48-28(54)20(10-8-12-40-33(36)37)44-24(51)16-42-19(5)49/h17-18,20-22,26-27H,6-16H2,1-5H3,(H2,35,50)(H,42,49)(H,43,57)(H,44,51)(H,45,56)(H,46,58)(H,47,55)(H,48,54)(H,52,53)(H4,36,37,40)(H4,38,39,41)/t17-,18-,20-,21-,22-,26-,27-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>100n/an/an/an/an/an/a



G. D. Searle& Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)


J Med Chem 32: 869-74 (1989)


Article DOI: 10.1021/jm00124a023
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228178
PNG
(CHEMBL428843 | S-Fggridrigaqsglg-Nsfry)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C98H152N32O30/c1-8-50(5)78(129-88(152)60(25-18-34-110-98(106)107)122-91(155)66(40-77(142)143)125-94(158)79(51(6)9-2)130-87(151)58(23-16-32-108-96(102)103)117-74(139)42-111-72(137)41-112-83(147)63(123-81(145)57(99)46-131)36-53-19-12-10-13-20-53)93(157)115-43-73(138)116-52(7)80(144)120-61(30-31-70(100)135)86(150)127-68(47-132)84(148)114-45-75(140)118-62(35-49(3)4)82(146)113-44-76(141)119-65(39-71(101)136)90(154)128-69(48-133)92(156)124-64(37-54-21-14-11-15-22-54)89(153)121-59(24-17-33-109-97(104)105)85(149)126-67(95(159)160)38-55-26-28-56(134)29-27-55/h10-15,19-22,26-29,49-52,57-69,78-79,131-134H,8-9,16-18,23-25,30-48,99H2,1-7H3,(H2,100,135)(H2,101,136)(H,111,137)(H,112,147)(H,113,146)(H,114,148)(H,115,157)(H,116,138)(H,117,139)(H,118,140)(H,119,141)(H,120,144)(H,121,153)(H,122,155)(H,123,145)(H,124,156)(H,125,158)(H,126,149)(H,127,150)(H,128,154)(H,129,152)(H,130,151)(H,142,143)(H,159,160)(H4,102,103,108)(H4,104,105,109)(H4,106,107,110)/t50-,51-,52-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,78-,79-/m0/s1
UniProtKB/SwissProt

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n/an/a>100n/an/an/an/an/an/a



G. D. Searle& Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)


J Med Chem 32: 869-74 (1989)


Article DOI: 10.1021/jm00124a023
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228175
PNG
(CHEMBL265243)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CS)[C@@H](C)CC)C(=O)NCC(N)=O
Show InChI InChI=1S/C46H77N17O12S/c1-5-24(3)36(43(74)56-20-32(48)64)62-41(72)29(15-11-17-54-46(51)52)59-42(73)31(19-35(67)68)61-44(75)37(25(4)6-2)63-40(71)28(14-10-16-53-45(49)50)58-34(66)22-55-33(65)21-57-39(70)30(60-38(69)27(47)23-76)18-26-12-8-7-9-13-26/h7-9,12-13,24-25,27-31,36-37,76H,5-6,10-11,14-23,47H2,1-4H3,(H2,48,64)(H,55,65)(H,56,74)(H,57,70)(H,58,66)(H,59,73)(H,60,69)(H,61,75)(H,62,72)(H,63,71)(H,67,68)(H4,49,50,53)(H4,51,52,54)/t24-,25-,27-,28-,29-,30-,31-,36-,37-/m0/s1
UniProtKB/SwissProt

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n/an/a>100n/an/an/an/an/an/a



G. D. Searle& Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)


J Med Chem 32: 869-74 (1989)


Article DOI: 10.1021/jm00124a023
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 2


(Homo sapiens)
BDBM50228179
PNG
(CHEMBL3349962)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CSSC[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)[C@@H](C)CC
Show InChI InChI=1S/C79H132N30O26S2/c1-7-38(5)60-75(134)95-30-57(117)98-49(32-111)65(124)93-28-56(116)97-45(23-37(3)4)64(123)92-29-58(118)99-53(74(133)103-47(25-54(81)114)70(129)106-51(34-113)72(131)102-46(24-40-15-10-9-11-16-40)69(128)100-42(62(82)121)17-12-20-89-77(83)84)36-137-136-35-52(107-73(132)50(33-112)105-63(122)41(80)31-110)66(125)94-27-55(115)96-43(18-13-21-90-78(85)86)67(126)109-61(39(6)8-2)76(135)104-48(26-59(119)120)71(130)101-44(68(127)108-60)19-14-22-91-79(87)88/h9-11,15-16,37-39,41-53,60-61,110-113H,7-8,12-14,17-36,80H2,1-6H3,(H2,81,114)(H2,82,121)(H,92,123)(H,93,124)(H,94,125)(H,95,134)(H,96,115)(H,97,116)(H,98,117)(H,99,118)(H,100,128)(H,101,130)(H,102,131)(H,103,133)(H,104,135)(H,105,122)(H,106,129)(H,107,132)(H,108,127)(H,109,126)(H,119,120)(H4,83,84,89)(H4,85,86,90)(H4,87,88,91)/t38-,39-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,60-,61-/m0/s1
UniProtKB/SwissProt

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UniChem

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PubMed
n/an/a>100n/an/an/an/an/an/a



G. D. Searle& Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)


J Med Chem 32: 869-74 (1989)


Article DOI: 10.1021/jm00124a023
More data for this
Ligand-Target Pair