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Compile Data Set for Download or QSAR

Found 195 hits Enz. Inhib. hit(s) with Target = 'Beta-adrenergic receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-adrenergic receptor


(Mus musculus)
BDBM50010555
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES C[C@H](CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NC[C@H](O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H32F3N3O4/c1-17(29-15-22(33)16-35-23-13-11-20(12-14-23)30-18(2)32)5-3-4-6-24(34)31-21-9-7-19(8-10-21)25(26,27)28/h7-14,17,22,29,33H,3-6,15-16H2,1-2H3,(H,30,32)(H,31,34)/t17-,22+/m1/s1
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146n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010562
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES CC(CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NCC(O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H32F3N3O4/c1-17(29-15-22(33)16-35-23-13-11-20(12-14-23)30-18(2)32)5-3-4-6-24(34)31-21-9-7-19(8-10-21)25(26,27)28/h7-14,17,22,29,33H,3-6,15-16H2,1-2H3,(H,30,32)(H,31,34)
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390n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010564
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES C[C@H](CCCCC(=O)Nc1ccc(C)cc1)NC[C@H](O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H35N3O4/c1-18-8-10-22(11-9-18)28-25(31)7-5-4-6-19(2)26-16-23(30)17-32-24-14-12-21(13-15-24)27-20(3)29/h8-15,19,23,26,30H,4-7,16-17H2,1-3H3,(H,27,29)(H,28,31)/t19-,23+/m1/s1
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810n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010565
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES CC(CCCCC(=O)Nc1ccc(C)cc1)NCC(O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H35N3O4/c1-18-8-10-22(11-9-18)28-25(31)7-5-4-6-19(2)26-16-23(30)17-32-24-14-12-21(13-15-24)27-20(3)29/h8-15,19,23,26,30H,4-7,16-17H2,1-3H3,(H,27,29)(H,28,31)
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1.18E+3n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010553
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES C[C@H](CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NC[C@@H](O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H32F3N3O4/c1-17(29-15-22(33)16-35-23-13-11-20(12-14-23)30-18(2)32)5-3-4-6-24(34)31-21-9-7-19(8-10-21)25(26,27)28/h7-14,17,22,29,33H,3-6,15-16H2,1-2H3,(H,30,32)(H,31,34)/t17-,22-/m1/s1
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2.17E+3n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010550
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES C[C@@H](CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NC[C@H](O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H32F3N3O4/c1-17(29-15-22(33)16-35-23-13-11-20(12-14-23)30-18(2)32)5-3-4-6-24(34)31-21-9-7-19(8-10-21)25(26,27)28/h7-14,17,22,29,33H,3-6,15-16H2,1-2H3,(H,30,32)(H,31,34)/t17-,22-/m0/s1
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2.85E+3n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50106829
PNG
(BMS-196085 | CHEMBL322862 | N-(5-((R)-2-((R)-1-(4-...)
Show SMILES CS(=O)(=O)Nc1cc(ccc1O)[C@@H](O)CN[C@H](Cc1ccccc1)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C24H26F2N2O5S/c1-34(31,32)28-21-14-18(9-12-22(21)29)23(30)15-27-20(13-16-5-3-2-4-6-16)17-7-10-19(11-8-17)33-24(25)26/h2-12,14,20,23-24,27-30H,13,15H2,1H3/t20-,23+/m1/s1
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4.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Tested for binding affinity to murine Beta-3 adrenergic receptor


Bioorg Med Chem Lett 11: 3041-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00629-1
BindingDB Entry DOI: 10.7270/Q2794402
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010567
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES C[C@H](CCCCC(=O)Nc1ccc(C)cc1)NC[C@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H34N2O3/c1-20-14-16-23(17-15-20)29-27(31)13-6-3-8-21(2)28-18-24(30)19-32-26-12-7-10-22-9-4-5-11-25(22)26/h4-5,7,9-12,14-17,21,24,28,30H,3,6,8,13,18-19H2,1-2H3,(H,29,31)/t21-,24+/m1/s1
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9.07E+3n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010558
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES C[C@@H](CCCCC(=O)Nc1ccc(C)cc1)NC[C@@H](O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H35N3O4/c1-18-8-10-22(11-9-18)28-25(31)7-5-4-6-19(2)26-16-23(30)17-32-24-14-12-21(13-15-24)27-20(3)29/h8-15,19,23,26,30H,4-7,16-17H2,1-3H3,(H,27,29)(H,28,31)/t19-,23+/m0/s1
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9.24E+3n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
ADRB2


(Mus musculus)
BDBM82472
PNG
(BW-723C86 | CAS_5311036 | NSC_5311036)
Show SMILES CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12
Show InChI InChI=1S/C16H18N2OS/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14/h2-6,8-9,11,18H,7,10,17H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by PDSP Ki Database




Br J Pharmacol 117: 1443-8 (1996)


BindingDB Entry DOI: 10.7270/Q2DN43K8
More data for this
Ligand-Target Pair
ADRB2


(Mus musculus)
BDBM50035398
PNG
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Show SMILES CN1CCC[C@H]1c1cc(C)no1
Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 270: 310-8 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6HKJ
More data for this
Ligand-Target Pair
ADRB2


(Mus musculus)
BDBM50049750
PNG
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Show SMILES C(Oc1cccnc1)[C@@H]1CCN1
Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Neuropharmacology 35: 725-34 (1996)


BindingDB Entry DOI: 10.7270/Q237777N
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM25749
PNG
(CHEMBL6995 | N-{4-[2-hydroxy-3-(propan-2-ylamino)p...)
Show SMILES CC(C)NCC(O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
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1.35E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010554
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES C[C@@H](CCCCC(=O)Nc1ccc(C)cc1)NC[C@H](O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H35N3O4/c1-18-8-10-22(11-9-18)28-25(31)7-5-4-6-19(2)26-16-23(30)17-32-24-14-12-21(13-15-24)27-20(3)29/h8-15,19,23,26,30H,4-7,16-17H2,1-3H3,(H,27,29)(H,28,31)/t19-,23-/m0/s1
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1.56E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010559
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES C[C@@H](CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NC[C@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H31F3N2O3/c1-19(7-2-5-12-26(34)32-22-15-13-21(14-16-22)27(28,29)30)31-17-23(33)18-35-25-11-6-9-20-8-3-4-10-24(20)25/h3-4,6,8-11,13-16,19,23,31,33H,2,5,7,12,17-18H2,1H3,(H,32,34)/t19-,23-/m0/s1
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3.90E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010551
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES C[C@@H](CCCCC(=O)Nc1ccc(C)cc1)NC[C@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H34N2O3/c1-20-14-16-23(17-15-20)29-27(31)13-6-3-8-21(2)28-18-24(30)19-32-26-12-7-10-22-9-4-5-11-25(22)26/h4-5,7,9-12,14-17,21,24,28,30H,3,6,8,13,18-19H2,1-2H3,(H,29,31)/t21-,24-/m0/s1
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4.10E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010552
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES CC(CCCCC(=O)Nc1ccc(C)cc1)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H34N2O3/c1-20-14-16-23(17-15-20)29-27(31)13-6-3-8-21(2)28-18-24(30)19-32-26-12-7-10-22-9-4-5-11-25(22)26/h4-5,7,9-12,14-17,21,24,28,30H,3,6,8,13,18-19H2,1-2H3,(H,29,31)
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4.33E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010561
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES C[C@H](CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NC[C@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H31F3N2O3/c1-19(7-2-5-12-26(34)32-22-15-13-21(14-16-22)27(28,29)30)31-17-23(33)18-35-25-11-6-9-20-8-3-4-10-24(20)25/h3-4,6,8-11,13-16,19,23,31,33H,2,5,7,12,17-18H2,1H3,(H,32,34)/t19-,23+/m1/s1
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4.59E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010560
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES C[C@H](CCCCC(=O)Nc1ccc(C)cc1)NC[C@@H](O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H35N3O4/c1-18-8-10-22(11-9-18)28-25(31)7-5-4-6-19(2)26-16-23(30)17-32-24-14-12-21(13-15-24)27-20(3)29/h8-15,19,23,26,30H,4-7,16-17H2,1-3H3,(H,27,29)(H,28,31)/t19-,23-/m1/s1
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5.36E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010557
PNG
(6-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino...)
Show SMILES C[C@@H](CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NC[C@@H](O)COc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C25H32F3N3O4/c1-17(29-15-22(33)16-35-23-13-11-20(12-14-23)30-18(2)32)5-3-4-6-24(34)31-21-9-7-19(8-10-21)25(26,27)28/h7-14,17,22,29,33H,3-6,15-16H2,1-2H3,(H,30,32)(H,31,34)/t17-,22+/m0/s1
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PubMed
6.20E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50049820
PNG
(4-Amino-5-carboxamide-7-(D-ribofuranosyl)pyrrolo[2...)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12
Show InChI InChI=1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16)/t5-,7-,8-,12-/m1/s1
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PubMed
6.70E+4n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of beta-adrenergic receptor kinase(unknown origin)


J Biol Chem 282: 15271-83 (2007)


Article DOI: 10.1074/jbc.M701362200
BindingDB Entry DOI: 10.7270/Q2XD11FR
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010568
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES CC(CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H31F3N2O3/c1-19(7-2-5-12-26(34)32-22-15-13-21(14-16-22)27(28,29)30)31-17-23(33)18-35-25-11-6-9-20-8-3-4-10-24(20)25/h3-4,6,8-11,13-16,19,23,31,33H,2,5,7,12,17-18H2,1H3,(H,32,34)
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PubMed
7.80E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010566
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES C[C@H](CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NC[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H31F3N2O3/c1-19(7-2-5-12-26(34)32-22-15-13-21(14-16-22)27(28,29)30)31-17-23(33)18-35-25-11-6-9-20-8-3-4-10-24(20)25/h3-4,6,8-11,13-16,19,23,31,33H,2,5,7,12,17-18H2,1H3,(H,32,34)/t19-,23-/m1/s1
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1.30E+5n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010569
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES C[C@@H](CCCCC(=O)Nc1ccc(cc1)C(F)(F)F)NC[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H31F3N2O3/c1-19(7-2-5-12-26(34)32-22-15-13-21(14-16-22)27(28,29)30)31-17-23(33)18-35-25-11-6-9-20-8-3-4-10-24(20)25/h3-4,6,8-11,13-16,19,23,31,33H,2,5,7,12,17-18H2,1H3,(H,32,34)/t19-,23+/m0/s1
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1.79E+5n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010563
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES C[C@H](CCCCC(=O)Nc1ccc(C)cc1)NC[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H34N2O3/c1-20-14-16-23(17-15-20)29-27(31)13-6-3-8-21(2)28-18-24(30)19-32-26-12-7-10-22-9-4-5-11-25(22)26/h4-5,7,9-12,14-17,21,24,28,30H,3,6,8,13,18-19H2,1-2H3,(H,29,31)/t21-,24-/m1/s1
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1.95E+5n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor


(Mus musculus)
BDBM50010556
PNG
(6-[2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-h...)
Show SMILES C[C@@H](CCCCC(=O)Nc1ccc(C)cc1)NC[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C27H34N2O3/c1-20-14-16-23(17-15-20)29-27(31)13-6-3-8-21(2)28-18-24(30)19-32-26-12-7-10-22-9-4-5-11-25(22)26/h4-5,7,9-12,14-17,21,24,28,30H,3,6,8,13,18-19H2,1-2H3,(H,29,31)/t21-,24+/m0/s1
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1.95E+5n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).


J Med Chem 33: 216-23 (1990)


Article DOI: 10.1021/jm00163a036
BindingDB Entry DOI: 10.7270/Q2M32TQB
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258598
PNG
(US9493490, Example 10 | US9493490, G)
Show SMILES C[C@@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m1/s1
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n/an/a 13.9n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258597
PNG
(US9493490, Example 9 | US9493490, F)
Show SMILES C[C@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m0/s1
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258596
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)-7-...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258595
PNG
(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-13(5-3-11-8-20-16(19)15(9)11)21-14-4-2-10(7-18)6-12(14)17/h2-6,19H,7-8,18H2,1H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258594
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)ben...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2)c(F)c1
Show InChI InChI=1S/C15H15BFNO3/c1-9(18)10-3-5-15(14(17)6-10)21-12-4-2-11-8-20-16(19)13(11)7-12/h2-7,9,19H,8,18H2,1H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258599
PNG
(US9493490, Example 11 | US9493490, L | US9493490, ...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1cccc(CNC(=O)OC(C)(C)C)c1F
Show InChI InChI=1S/C20H23BFNO5/c1-12-15(9-8-14-11-26-21(25)17(12)14)27-16-7-5-6-13(18(16)22)10-23-19(24)28-20(2,3)4/h5-9,25H,10-11H2,1-4H3,(H,23,24)
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n/an/a>30n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258600
PNG
(US9493490, 6-(3-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1cccc(CN)c1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-12(6-5-11-8-20-16(19)14(9)11)21-13-4-2-3-10(7-18)15(13)17/h2-6,19H,7-8,18H2,1H3
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n/an/a>30n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 42n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of GRK2-mediated bovine tubulin phosphorylation by scintillation counting


J Med Chem 53: 1867-70 (2010)


Article DOI: 10.1021/jm9017515
BindingDB Entry DOI: 10.7270/Q2P26Z8Z
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-adrenergic receptor kinase 2


(Homo sapiens)
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 47n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of GRK3-mediated bovine tubulin phosphorylation by scintillation counting


J Med Chem 53: 1867-70 (2010)


Article DOI: 10.1021/jm9017515
BindingDB Entry DOI: 10.7270/Q2P26Z8Z
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173325
PNG
(CHEMBL3809965 | US10023564, Example 5)
Show SMILES COc1ccccc1CNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C28H25FN6O4/c1-15-24(27(37)33-19-8-10-22-18(11-19)14-31-35-22)25(34-28(38)32-15)16-7-9-21(29)20(12-16)26(36)30-13-17-5-3-4-6-23(17)39-2/h3-12,14,25H,13H2,1-2H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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n/an/a 60n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173309
PNG
(CHEMBL3809913 | US10023564, Example 10)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1c(C)cccc1C)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C29H27FN6O3/c1-15-5-4-6-16(2)22(15)14-31-27(37)21-12-18(7-9-23(21)30)26-25(17(3)33-29(39)35-26)28(38)34-20-8-10-24-19(11-20)13-32-36-24/h4-13,26H,14H2,1-3H3,(H,31,37)(H,32,36)(H,34,38)(H2,33,35,39)
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n/an/a 70n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173323
PNG
(CHEMBL3808621 | US10023564, Example 2)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1c(F)cccc1F)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H21F3N6O3/c1-13-23(26(38)34-16-6-8-22-15(9-16)11-32-36-22)24(35-27(39)33-13)14-5-7-21(30)17(10-14)25(37)31-12-18-19(28)3-2-4-20(18)29/h2-11,24H,12H2,1H3,(H,31,37)(H,32,36)(H,34,38)(H2,33,35,39)
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173308
PNG
(CHEMBL3810271 | US10023564, Example 9)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1c(Cl)cccc1Cl)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H21Cl2FN6O3/c1-13-23(26(38)34-16-6-8-22-15(9-16)11-32-36-22)24(35-27(39)33-13)14-5-7-21(30)17(10-14)25(37)31-12-18-19(28)3-2-4-20(18)29/h2-11,24H,12H2,1H3,(H,31,37)(H,32,36)(H,34,38)(H2,33,35,39)
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173319
PNG
(CHEMBL3809020 | US10023564, Example 11)
Show SMILES COc1cccc(OC)c1CNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C29H27FN6O5/c1-15-25(28(38)34-18-8-10-22-17(11-18)13-32-36-22)26(35-29(39)33-15)16-7-9-21(30)19(12-16)27(37)31-14-20-23(40-2)5-4-6-24(20)41-3/h4-13,26H,14H2,1-3H3,(H,31,37)(H,32,36)(H,34,38)(H2,33,35,39)
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n/an/a 130n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173310
PNG
(CHEMBL3808660 | US10023564, Example 1)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1ccccn1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C26H22FN7O3/c1-14-22(25(36)32-17-6-8-21-16(10-17)12-30-34-21)23(33-26(37)31-14)15-5-7-20(27)19(11-15)24(35)29-13-18-4-2-3-9-28-18/h2-12,23H,13H2,1H3,(H,29,35)(H,30,34)(H,32,36)(H2,31,33,37)
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n/an/a 150n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM283996
PNG
(E22 | US10023564, Example 22)
Show SMILES CCc1nc(CNC(=O)c2cc(ccc2F)C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)no1
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n/an/a 180n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173315
PNG
(CHEMBL3809100 | US10023564, Example 4)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1cccc(F)c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H22F2N6O3/c1-14-23(26(37)33-19-6-8-22-17(10-19)13-31-35-22)24(34-27(38)32-14)16-5-7-21(29)20(11-16)25(36)30-12-15-3-2-4-18(28)9-15/h2-11,13,24H,12H2,1H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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n/an/a 200n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173328
PNG
(CHEMBL3808918 | US10023564, Example 14)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCCc1c(C)cccc1C)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C30H29FN6O3/c1-16-5-4-6-17(2)22(16)11-12-32-28(38)23-14-19(7-9-24(23)31)27-26(18(3)34-30(40)36-27)29(39)35-21-8-10-25-20(13-21)15-33-37-25/h4-10,13-15,27H,11-12H2,1-3H3,(H,32,38)(H,33,37)(H,35,39)(H2,34,36,40)
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n/an/a 230n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM283998
PNG
(E24 | US10023564, Example 24)
Show SMILES COCc1noc(CNC(=O)c2cc(ccc2F)C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)n1
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173305
PNG
(CHEMBL3810107 | US10023564, Example 3)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCCc1ccccn1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H24FN7O3/c1-15-23(26(37)33-19-6-8-22-17(12-19)14-31-35-22)24(34-27(38)32-15)16-5-7-21(28)20(13-16)25(36)30-11-9-18-4-2-3-10-29-18/h2-8,10,12-14,24H,9,11H2,1H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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n/an/a 280n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM284001
PNG
(E27 | US10023564, Example 27)
Show SMILES COc1ccccc1C(C)NC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
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n/an/a 320n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50441685
PNG
(CHEMBL2435840)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(O)=O
Show InChI InChI=1S/C41H74N16O10/c1-7-23(6)32(39(66)67)57-38(65)30(19-58)56-37(64)29(16-24-18-47-20-50-24)55-34(61)26(11-9-13-49-41(45)46)52-33(60)25(10-8-12-48-40(43)44)53-36(63)28(15-22(4)5)54-35(62)27(14-21(2)3)51-31(59)17-42/h18,20-23,25-30,32,58H,7-17,19,42H2,1-6H3,(H,47,50)(H,51,59)(H,52,60)(H,53,63)(H,54,62)(H,55,61)(H,56,64)(H,57,65)(H,66,67)(H4,43,44,48)(H4,45,46,49)/t23-,25-,26+,27-,28-,29-,30-,32-/m0/s1
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Article
PubMed
n/an/a 340n/an/an/an/an/an/a



Federico II" University of Naples

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin)-mediated phosphorylation of rhodopsin in bovine-rod outer segment membranes incubated under white light conditio...


Eur J Med Chem 69: 384-92 (2013)


Article DOI: 10.1016/j.ejmech.2013.08.039
BindingDB Entry DOI: 10.7270/Q27W6DNH
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173312
PNG
(CHEMBL3810312 | US10023564, Example 18)
Show SMILES COc1cccc(CNC(=O)c2cc(ccc2F)C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C28H25FN6O4/c1-15-24(27(37)33-19-7-9-23-18(11-19)14-31-35-23)25(34-28(38)32-15)17-6-8-22(29)21(12-17)26(36)30-13-16-4-3-5-20(10-16)39-2/h3-12,14,25H,13H2,1-2H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173324
PNG
(CHEMBL3809124 | US10023564, Example 30)
Show SMILES COc1cccc(OC)c1CNC(=O)Cc1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C30H29FN6O5/c1-16-27(29(39)35-20-8-10-23-19(12-20)14-33-37-23)28(36-30(40)34-16)17-7-9-22(31)18(11-17)13-26(38)32-15-21-24(41-2)5-4-6-25(21)42-3/h4-12,14,28H,13,15H2,1-3H3,(H,32,38)(H,33,37)(H,35,39)(H2,34,36,40)
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
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