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Compile Data Set for Download or QSAR

Found 162 hits Enz. Inhib. hit(s) with Target = 'Beta-adrenergic receptor kinase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50049820
PNG
(4-Amino-5-carboxamide-7-(D-ribofuranosyl)pyrrolo[2...)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12
Show InChI InChI=1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16)/t5-,7-,8-,12-/m1/s1
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6.70E+4n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of beta-adrenergic receptor kinase(unknown origin)


J Biol Chem 282: 15271-83 (2007)


Article DOI: 10.1074/jbc.M701362200
BindingDB Entry DOI: 10.7270/Q2XD11FR
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258598
PNG
(US9493490, Example 10 | US9493490, G)
Show SMILES C[C@@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m1/s1
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n/an/a 13.9n/an/an/an/an/a25



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258596
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)-7-...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3
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n/an/a>20n/an/an/an/an/a25



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258597
PNG
(US9493490, Example 9 | US9493490, F)
Show SMILES C[C@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m0/s1
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n/an/a>20n/an/an/an/an/a25



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258595
PNG
(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-13(5-3-11-8-20-16(19)15(9)11)21-14-4-2-10(7-18)6-12(14)17/h2-6,19H,7-8,18H2,1H3
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n/an/a>20n/an/an/an/an/a25



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258594
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)ben...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2)c(F)c1
Show InChI InChI=1S/C15H15BFNO3/c1-9(18)10-3-5-15(14(17)6-10)21-12-4-2-11-8-20-16(19)13(11)7-12/h2-7,9,19H,8,18H2,1H3
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n/an/a>20n/an/an/an/an/a25



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258600
PNG
(US9493490, 6-(3-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1cccc(CN)c1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-12(6-5-11-8-20-16(19)14(9)11)21-13-4-2-3-10(7-18)15(13)17/h2-6,19H,7-8,18H2,1H3
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n/an/a>30n/an/an/an/an/a25



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258599
PNG
(US9493490, Example 11 | US9493490, L | US9493490, ...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1cccc(CNC(=O)OC(C)(C)C)c1F
Show InChI InChI=1S/C20H23BFNO5/c1-12-15(9-8-14-11-26-21(25)17(12)14)27-16-7-5-6-13(18(16)22)10-23-19(24)28-20(2,3)4/h5-9,25H,10-11H2,1-4H3,(H,23,24)
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n/an/a>30n/an/an/an/an/a25



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 42n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of GRK2-mediated bovine tubulin phosphorylation by scintillation counting


J Med Chem 53: 1867-70 (2010)


Article DOI: 10.1021/jm9017515
BindingDB Entry DOI: 10.7270/Q2P26Z8Z
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173325
PNG
(CHEMBL3809965 | US10023564, Example 5)
Show SMILES COc1ccccc1CNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C28H25FN6O4/c1-15-24(27(37)33-19-8-10-22-18(11-19)14-31-35-22)25(34-28(38)32-15)16-7-9-21(29)20(12-16)26(36)30-13-17-5-3-4-6-23(17)39-2/h3-12,14,25H,13H2,1-2H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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n/an/a 60n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173309
PNG
(CHEMBL3809913 | US10023564, Example 10)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1c(C)cccc1C)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C29H27FN6O3/c1-15-5-4-6-16(2)22(15)14-31-27(37)21-12-18(7-9-23(21)30)26-25(17(3)33-29(39)35-26)28(38)34-20-8-10-24-19(11-20)13-32-36-24/h4-13,26H,14H2,1-3H3,(H,31,37)(H,32,36)(H,34,38)(H2,33,35,39)
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n/an/a 70n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173323
PNG
(CHEMBL3808621 | US10023564, Example 2)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1c(F)cccc1F)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H21F3N6O3/c1-13-23(26(38)34-16-6-8-22-15(9-16)11-32-36-22)24(35-27(39)33-13)14-5-7-21(30)17(10-14)25(37)31-12-18-19(28)3-2-4-20(18)29/h2-11,24H,12H2,1H3,(H,31,37)(H,32,36)(H,34,38)(H2,33,35,39)
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n/an/a 120n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173319
PNG
(CHEMBL3809020 | US10023564, Example 11)
Show SMILES COc1cccc(OC)c1CNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C29H27FN6O5/c1-15-25(28(38)34-18-8-10-22-17(11-18)13-32-36-22)26(35-29(39)33-15)16-7-9-21(30)19(12-16)27(37)31-14-20-23(40-2)5-4-6-24(20)41-3/h4-13,26H,14H2,1-3H3,(H,31,37)(H,32,36)(H,34,38)(H2,33,35,39)
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n/an/a 130n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173308
PNG
(CHEMBL3810271 | US10023564, Example 9)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1c(Cl)cccc1Cl)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H21Cl2FN6O3/c1-13-23(26(38)34-16-6-8-22-15(9-16)11-32-36-22)24(35-27(39)33-13)14-5-7-21(30)17(10-14)25(37)31-12-18-19(28)3-2-4-20(18)29/h2-11,24H,12H2,1H3,(H,31,37)(H,32,36)(H,34,38)(H2,33,35,39)
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n/an/a 130n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173310
PNG
(CHEMBL3808660 | US10023564, Example 1)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1ccccn1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C26H22FN7O3/c1-14-22(25(36)32-17-6-8-21-16(10-17)12-30-34-21)23(33-26(37)31-14)15-5-7-20(27)19(11-15)24(35)29-13-18-4-2-3-9-28-18/h2-12,23H,13H2,1H3,(H,29,35)(H,30,34)(H,32,36)(H2,31,33,37)
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n/an/a 150n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM283996
PNG
(E22 | US10023564, Example 22)
Show SMILES CCc1nc(CNC(=O)c2cc(ccc2F)C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)no1
Show InChI InChI=1S/C25H23FN8O4/c1-3-20-31-19(34-38-20)11-27-23(35)16-9-13(4-6-17(16)26)22-21(12(2)29-25(37)32-22)24(36)30-15-5-7-18-14(8-15)10-28-33-18/h4-10,22H,3,11H2,1-2H3,(H,27,35)(H,28,33)(H,30,36)(H2,29,32,37)
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n/an/a 180n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173315
PNG
(CHEMBL3809100 | US10023564, Example 4)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1cccc(F)c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H22F2N6O3/c1-14-23(26(37)33-19-6-8-22-17(10-19)13-31-35-22)24(34-27(38)32-14)16-5-7-21(29)20(11-16)25(36)30-12-15-3-2-4-18(28)9-15/h2-11,13,24H,12H2,1H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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n/an/a 200n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173328
PNG
(CHEMBL3808918 | US10023564, Example 14)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCCc1c(C)cccc1C)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C30H29FN6O3/c1-16-5-4-6-17(2)22(16)11-12-32-28(38)23-14-19(7-9-24(23)31)27-26(18(3)34-30(40)36-27)29(39)35-21-8-10-25-20(13-21)15-33-37-25/h4-10,13-15,27H,11-12H2,1-3H3,(H,32,38)(H,33,37)(H,35,39)(H2,34,36,40)
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n/an/a 230n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM283998
PNG
(E24 | US10023564, Example 24)
Show SMILES COCc1noc(CNC(=O)c2cc(ccc2F)C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H23FN8O5/c1-12-21(24(36)30-15-4-6-18-14(7-15)9-28-33-18)22(32-25(37)29-12)13-3-5-17(26)16(8-13)23(35)27-10-20-31-19(11-38-2)34-39-20/h3-9,22H,10-11H2,1-2H3,(H,27,35)(H,28,33)(H,30,36)(H2,29,32,37)
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n/an/a 240n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173305
PNG
(CHEMBL3810107 | US10023564, Example 3)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCCc1ccccn1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H24FN7O3/c1-15-23(26(37)33-19-6-8-22-17(12-19)14-31-35-22)24(34-27(38)32-15)16-5-7-21(28)20(13-16)25(36)30-11-9-18-4-2-3-10-29-18/h2-8,10,12-14,24H,9,11H2,1H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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n/an/a 280n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM284001
PNG
(E27 | US10023564, Example 27)
Show SMILES COc1ccccc1C(C)NC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C29H27FN6O4/c1-15(20-6-4-5-7-24(20)40-3)32-27(37)21-13-17(8-10-22(21)30)26-25(16(2)33-29(39)35-26)28(38)34-19-9-11-23-18(12-19)14-31-36-23/h4-15,26H,1-3H3,(H,31,36)(H,32,37)(H,34,38)(H2,33,35,39)
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n/an/a 320n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50441685
PNG
(CHEMBL2435840)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(O)=O
Show InChI InChI=1S/C41H74N16O10/c1-7-23(6)32(39(66)67)57-38(65)30(19-58)56-37(64)29(16-24-18-47-20-50-24)55-34(61)26(11-9-13-49-41(45)46)52-33(60)25(10-8-12-48-40(43)44)53-36(63)28(15-22(4)5)54-35(62)27(14-21(2)3)51-31(59)17-42/h18,20-23,25-30,32,58H,7-17,19,42H2,1-6H3,(H,47,50)(H,51,59)(H,52,60)(H,53,63)(H,54,62)(H,55,61)(H,56,64)(H,57,65)(H,66,67)(H4,43,44,48)(H4,45,46,49)/t23-,25-,26+,27-,28-,29-,30-,32-/m0/s1
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n/an/a 340n/an/an/an/an/an/a



Federico II" University of Naples

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin)-mediated phosphorylation of rhodopsin in bovine-rod outer segment membranes incubated under white light conditio...


Eur J Med Chem 69: 384-92 (2013)


Article DOI: 10.1016/j.ejmech.2013.08.039
BindingDB Entry DOI: 10.7270/Q27W6DNH
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173312
PNG
(CHEMBL3810312 | US10023564, Example 18)
Show SMILES COc1cccc(CNC(=O)c2cc(ccc2F)C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C28H25FN6O4/c1-15-24(27(37)33-19-7-9-23-18(11-19)14-31-35-23)25(34-28(38)32-15)17-6-8-22(29)21(12-17)26(36)30-13-16-4-3-5-20(10-16)39-2/h3-12,14,25H,13H2,1-2H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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n/an/a 420n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173324
PNG
(CHEMBL3809124 | US10023564, Example 30)
Show SMILES COc1cccc(OC)c1CNC(=O)Cc1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C30H29FN6O5/c1-16-27(29(39)35-20-8-10-23-19(12-20)14-33-37-23)28(36-30(40)34-16)17-7-9-22(31)18(11-17)13-26(38)32-15-21-24(41-2)5-4-6-25(21)42-3/h4-12,14,28H,13,15H2,1-3H3,(H,32,38)(H,33,37)(H,35,39)(H2,34,36,40)
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n/an/a 450n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50444090
PNG
(CHEMBL3093151)
Show SMILES Nc1ncc(cc1-c1nc2ccc(cc2o1)N1CCCC1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H27N7O/c25-23-20(24-29-21-4-3-19(12-22(21)32-24)30-9-1-2-10-30)11-16(13-27-23)17-14-28-31(15-17)18-5-7-26-8-6-18/h3-4,11-15,18,26H,1-2,5-10H2,(H2,25,27)
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n/an/a 460n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173311
PNG
(CHEMBL3810073 | US10023564, Example 6)
Show SMILES COc1ccc(CNC(=O)c2cc(ccc2F)C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C28H25FN6O4/c1-15-24(27(37)33-19-6-10-23-18(11-19)14-31-35-23)25(34-28(38)32-15)17-5-9-22(29)21(12-17)26(36)30-13-16-3-7-20(39-2)8-4-16/h3-12,14,25H,13H2,1-2H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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n/an/a 460n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM284006
PNG
(E32 | US10023564, Example 32)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(CC(=O)N(CCO)Cc2ccco2)c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C28H27FN6O5/c1-16-25(27(38)32-20-5-7-23-19(12-20)14-30-34-23)26(33-28(39)31-16)17-4-6-22(29)18(11-17)13-24(37)35(8-9-36)15-21-3-2-10-40-21/h2-7,10-12,14,26,36H,8-9,13,15H2,1H3,(H,30,34)(H,32,38)(H2,31,33,39)
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n/an/a 500n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50134187
PNG
(CHEMBL3735506 | US9611249, Compound 8)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(F)c2F)CC1
Show InChI InChI=1S/C23H26F2N4O2/c1-31-12-11-29-9-7-15(8-10-29)14-26-23(30)22-18-13-16(5-6-20(18)27-28-22)17-3-2-4-19(24)21(17)25/h2-6,13,15H,7-12,14H2,1H3,(H,26,30)(H,27,28)
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n/an/a 530n/an/an/an/an/an/a



Angelini S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GRK2 by LANCE assay


J Med Chem 58: 8920-37 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01208
BindingDB Entry DOI: 10.7270/Q2416ZX5
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50444108
PNG
(CHEMBL3093243)
Show SMILES COc1ccc(cc1)N(C(=O)Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1ccccc1
Show InChI InChI=1S/C34H32N8O3/c1-44-28-10-8-27(9-11-28)42(26-5-3-2-4-6-26)34(43)39-24-7-12-30-31(18-24)45-33(40-30)29-17-22(19-37-32(29)35)23-20-38-41(21-23)25-13-15-36-16-14-25/h2-12,17-21,25,36H,13-16H2,1H3,(H2,35,37)(H,39,43)
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n/an/a 660n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM284007
PNG
(E33 | US10023564, Example 33)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(CC(=O)NCC2CCN(CC2)C2CC2)c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C30H34FN7O3/c1-17-27(29(40)35-22-3-7-25-21(13-22)16-33-37-25)28(36-30(41)34-17)19-2-6-24(31)20(12-19)14-26(39)32-15-18-8-10-38(11-9-18)23-4-5-23/h2-3,6-7,12-13,16,18,23,28H,4-5,8-11,14-15H2,1H3,(H,32,39)(H,33,37)(H,35,40)(H2,34,36,41)
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n/an/a 680n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173314
PNG
(CHEMBL3808840 | US10023564, Example 16)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1ccccc1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H23FN6O3/c1-15-23(26(36)32-19-8-10-22-18(11-19)14-30-34-22)24(33-27(37)31-15)17-7-9-21(28)20(12-17)25(35)29-13-16-5-3-2-4-6-16/h2-12,14,24H,13H2,1H3,(H,29,35)(H,30,34)(H,32,36)(H2,31,33,37)
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n/an/a 690n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM283994
PNG
(E20 | US10023564, Example 20)
Show SMILES CC(CNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1)N1CCCCCC1
Show InChI InChI=1S/C29H34FN7O3/c1-17(37-11-5-3-4-6-12-37)15-31-27(38)22-14-19(7-9-23(22)30)26-25(18(2)33-29(40)35-26)28(39)34-21-8-10-24-20(13-21)16-32-36-24/h7-10,13-14,16-17,26H,3-6,11-12,15H2,1-2H3,(H,31,38)(H,32,36)(H,34,39)(H2,33,35,40)
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n/an/a 740n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173320
PNG
(GSK-180736A | GSK180736A | US10023564, Compound GS...)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C19H16FN5O2/c1-10-16(17(24-19(27)22-10)11-2-4-13(20)5-3-11)18(26)23-14-6-7-15-12(8-14)9-21-25-15/h2-9,17H,1H3,(H,21,25)(H,23,26)(H2,22,24,27)
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n/an/a 770n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM283997
PNG
(E23 | US10023564, Example 23)
Show SMILES COC(=O)C1(CCCCC1)NC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C28H29FN6O5/c1-15-22(25(37)32-18-7-9-21-17(12-18)14-30-35-21)23(33-27(39)31-15)16-6-8-20(29)19(13-16)24(36)34-28(26(38)40-2)10-4-3-5-11-28/h6-9,12-14,23H,3-5,10-11H2,1-2H3,(H,30,35)(H,32,37)(H,34,36)(H2,31,33,39)
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n/an/a 820n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50444137
PNG
(CHEMBL3093258)
Show SMILES Nc1ncc(cc1-c1nc2cc(ccc2o1)N1CCCCC1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H29N7O/c26-24-21(12-17(14-28-24)18-15-29-32(16-18)19-6-8-27-9-7-19)25-30-22-13-20(4-5-23(22)33-25)31-10-2-1-3-11-31/h4-5,12-16,19,27H,1-3,6-11H2,(H2,26,28)
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n/an/a 850n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM284009
PNG
(E35 | US10023564, Example 35)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(CC(=O)N(CC#C)Cc2ccco2)c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C29H25FN6O4/c1-3-10-36(16-22-5-4-11-40-22)25(37)14-19-12-18(6-8-23(19)30)27-26(17(2)32-29(39)34-27)28(38)33-21-7-9-24-20(13-21)15-31-35-24/h1,4-9,11-13,15,27H,10,14,16H2,2H3,(H,31,35)(H,33,38)(H2,32,34,39)
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n/an/a 960n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50444104
PNG
(CHEMBL3093247)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NC(=O)c3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H24FN7O2/c28-19-3-1-16(2-4-19)26(36)33-20-5-6-23-24(12-20)37-27(34-23)22-11-17(13-31-25(22)29)18-14-32-35(15-18)21-7-9-30-10-8-21/h1-6,11-15,21,30H,7-10H2,(H2,29,31)(H,33,36)
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n/an/a 960n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173318
PNG
(CHEMBL3809788 | US10023564, Example 17)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1c(cccc1C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C29H21F7N6O3/c1-13-23(26(44)40-16-6-8-22-15(9-16)11-38-42-22)24(41-27(45)39-13)14-5-7-21(30)17(10-14)25(43)37-12-18-19(28(31,32)33)3-2-4-20(18)29(34,35)36/h2-11,24H,12H2,1H3,(H,37,43)(H,38,42)(H,40,44)(H2,39,41,45)
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n/an/a 1.20E+3n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM284008
PNG
(E34 | US10023564, Example 34)
Show SMILES CN(Cc1nc(C)c[nH]1)C(=O)Cc1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H27FN8O3/c1-14-11-29-22(31-14)13-36(3)23(37)10-17-8-16(4-6-20(17)28)25-24(15(2)32-27(39)34-25)26(38)33-19-5-7-21-18(9-19)12-30-35-21/h4-9,11-12,25H,10,13H2,1-3H3,(H,29,31)(H,30,35)(H,33,38)(H2,32,34,39)
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n/an/a 1.20E+3n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM284000
PNG
(E26 | US10023564, Example 26)
Show SMILES CN(Cc1cc(C)[nH]n1)C(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C26H25FN8O3/c1-13-8-18(33-32-13)12-35(3)25(37)19-10-15(4-6-20(19)27)23-22(14(2)29-26(38)31-23)24(36)30-17-5-7-21-16(9-17)11-28-34-21/h4-11,23H,12H2,1-3H3,(H,28,34)(H,30,36)(H,32,33)(H2,29,31,38)
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n/an/a 1.20E+3n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM284005
PNG
(E31 | US10023564, Example 31)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(CC(=O)N2CCOC(CCO)C2)c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H29FN6O5/c1-15-24(26(37)31-19-3-5-22-18(11-19)13-29-33-22)25(32-27(38)30-15)16-2-4-21(28)17(10-16)12-23(36)34-7-9-39-20(14-34)6-8-35/h2-5,10-11,13,20,25,35H,6-9,12,14H2,1H3,(H,29,33)(H,31,37)(H2,30,32,38)
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n/an/a 1.50E+3n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50444135
PNG
(CHEMBL3093260)
Show SMILES Nc1ncc(cc1-c1nc2cc(ccc2o1)N1CCCC1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H27N7O/c25-23-20(24-29-21-12-19(3-4-22(21)32-24)30-9-1-2-10-30)11-16(13-27-23)17-14-28-31(15-17)18-5-7-26-8-6-18/h3-4,11-15,18,26H,1-2,5-10H2,(H2,25,27)
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n/an/a 1.65E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50444107
PNG
(CHEMBL3093244)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NC(=O)Nc3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H25FN8O2/c28-18-1-3-19(4-2-18)33-27(37)34-20-5-6-23-24(12-20)38-26(35-23)22-11-16(13-31-25(22)29)17-14-32-36(15-17)21-7-9-30-10-8-21/h1-6,11-15,21,30H,7-10H2,(H2,29,31)(H2,33,34,37)
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n/an/a 1.72E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173329
PNG
(CHEMBL3809697 | US10023564, Example 15)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1ncccc1C)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C27H24FN7O3/c1-14-4-3-9-29-22(14)13-30-25(36)19-11-16(5-7-20(19)28)24-23(15(2)32-27(38)34-24)26(37)33-18-6-8-21-17(10-18)12-31-35-21/h3-12,24H,13H2,1-2H3,(H,30,36)(H,31,35)(H,33,37)(H2,32,34,38)
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n/an/a 1.90E+3n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50384025
PNG
(CHEMBL2032279 | CHEMBL2079395)
Show SMILES Cc1cc2nc(oc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-6-17-19(8-18(12)28)29-21(26-17)16-7-13(9-24-20(16)22)14-10-25-27(11-14)15-2-4-23-5-3-15/h6-11,15,23,28H,2-5H2,1H3,(H2,22,24)
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n/an/a 2.14E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50444121
PNG
(CHEMBL3093155)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3cc(F)cc(F)c3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H23F2N7O/c27-17-8-18(28)10-20(9-17)33-19-1-2-23-24(11-19)36-26(34-23)22-7-15(12-31-25(22)29)16-13-32-35(14-16)21-3-5-30-6-4-21/h1-2,7-14,21,30,33H,3-6H2,(H2,29,31)
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n/an/a 2.26E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM284010
PNG
(E36 | US10023564, Example 36)
Show SMILES CC(C)CN(CC#C)C(=O)Cc1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C28H29FN6O3/c1-5-10-35(15-16(2)3)24(36)13-19-11-18(6-8-22(19)29)26-25(17(4)31-28(38)33-26)27(37)32-21-7-9-23-20(12-21)14-30-34-23/h1,6-9,11-12,14,16,26H,10,13,15H2,2-4H3,(H,30,34)(H,32,37)(H2,31,33,38)
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n/an/a 2.60E+3n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173307
PNG
(CHEMBL3809796 | US10023564, Example 8)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1nccc2ccccc12)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C30H24FN7O3/c1-16-26(29(40)36-20-7-9-24-19(12-20)14-34-38-24)27(37-30(41)35-16)18-6-8-23(31)22(13-18)28(39)33-15-25-21-5-3-2-4-17(21)10-11-32-25/h2-14,27H,15H2,1H3,(H,33,39)(H,34,38)(H,36,40)(H2,35,37,41)
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n/an/a 2.60E+3n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50384018
PNG
(CHEMBL2032286)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NC(=O)Nc3ccccc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H26N8O2/c28-25-22(12-17(14-30-25)18-15-31-35(16-18)21-8-10-29-11-9-21)26-34-23-7-6-20(13-24(23)37-26)33-27(36)32-19-4-2-1-3-5-19/h1-7,12-16,21,29H,8-11H2,(H2,28,30)(H2,32,33,36)
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n/an/a 2.63E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50173330
PNG
(CHEMBL3808657 | US10023564, Example 13)
Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C29H21F7N6O3/c1-13-23(26(44)40-19-3-5-22-16(8-19)12-38-42-22)24(41-27(45)39-13)15-2-4-21(30)20(9-15)25(43)37-11-14-6-17(28(31,32)33)10-18(7-14)29(34,35)36/h2-10,12,24H,11H2,1H3,(H,37,43)(H,38,42)(H,40,44)(H2,39,41,45)
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n/an/a 2.70E+3n/an/an/an/a7.0n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...


US Patent US10023564 (2018)

More data for this
Ligand-Target Pair
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