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Found 27 hits Enz. Inhib. hit(s) with Target = 'Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM92358
PNG
(HGXPRT Inhibitor, 3)
Show SMILES OC[C@H](CCP([O-])([O-])=O)[NH2+]c1c[nH]c2c1nc[nH]c2=O
Show InChI InChI=1S/C10H13N4O5P/c15-4-6(1-2-20(17,18)19)14-7-3-11-9-8(7)12-5-13-10(9)16/h3,5-6,14-15H,1-2,4H2,(H2,17,18,19)/p-1/t6-/m0/s1
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Article
PubMed
0.650 -54.5n/an/an/an/an/a7.637



Albert Einstein College of Medicine



Assay Description
PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...


Chem Biol 19: 721-30 (2012)


Article DOI: 10.1016/j.chembiol.2012.04.012
BindingDB Entry DOI: 10.7270/Q2639NB8
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM92357
PNG
(HGXPRT Inhibitor, 2)
Show SMILES [O-]P([O-])(=O)CCC[NH2+]c1c[nH]c2c1nc[nH]c2=O
Show InChI InChI=1S/C9H11N4O4P/c14-9-8-7(12-5-13-9)6(4-11-8)10-2-1-3-18(15,16)17/h4-5,10H,1-3H2,(H2,15,16,17)/p-1
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Article
PubMed
10.6 -47.3n/an/an/an/an/a7.637



Albert Einstein College of Medicine



Assay Description
PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...


Chem Biol 19: 721-30 (2012)


Article DOI: 10.1016/j.chembiol.2012.04.012
BindingDB Entry DOI: 10.7270/Q2639NB8
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194490
PNG
(US9200020, Table 1, Compound 1)
Show SMILES Nc1nc2n(CCOCCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C4H12BO4P/c5-1-2-9-3-4-10(6,7)8/h1-5H2,(H2,6,7,8)
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100n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194500
PNG
(US9200020, Table 3 compound 9)
Show SMILES Nc1nc2n(CCN(CCCC(O)=O)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C9H21BNO5P/c10-4-7-11(5-1-3-9(12)13)6-2-8-17(14,15)16/h1-8,10H2,(H,12,13)(H2,14,15,16)
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100n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60887
PNG
(US9200020, Table 3, Compound 2B)
Show SMILES COC(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O
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UniChem
100 -41.6n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194493
PNG
(US9200020, Table 3 compound 2)
Show SMILES COC(=O)CCN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O
Show InChI InChI=1S/C9H21BNO5P/c1-16-9(12)3-6-11(7-4-10)5-2-8-17(13,14)15/h2-8,10H2,1H3,(H2,13,14,15)
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100n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194499
PNG
(US9200020, Table 3 compound 8)
Show SMILES Nc1nc2n(CCN(CCC(O)=O)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C8H19BNO5P/c9-3-6-10(5-2-8(11)12)4-1-7-16(13,14)15/h1-7,9H2,(H,11,12)(H2,13,14,15)
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200n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194496
PNG
(US9200020, Table 3 compound 5)
Show SMILES Nc1nc2n(CCN(CCC#N)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C8H18BN2O3P/c9-3-7-11(5-1-4-10)6-2-8-15(12,13)14/h1-3,5-9H2,(H2,12,13,14)
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200n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194501
PNG
(US9200020, Table 3 compound 10)
Show SMILES Nc1nc2n(CCN(CCO)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C7H19BNO4P/c8-2-4-9(5-6-10)3-1-7-14(11,12)13/h10H,1-8H2,(H2,11,12,13)
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200n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60890
PNG
(US9200020, Table 3 compound 5B)
Show SMILES OP(O)(=O)CCN(CCC#N)CCn1c[nH]c2c1nc[nH]c2=O
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UniChem
200 -39.8n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60880
PNG
(US9200020, Table 1, Compound 1B)
Show SMILES OP(O)(=O)CCOCCn1c[nH]c2c1nc[nH]c2=O
PDB
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300 -38.7n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194502
PNG
(US9200020, Table 3 compound 11)
Show SMILES Nc1nc2n(CCN(CCP(O)(O)=O)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C7H20BNO6P2/c8-2-4-9(5-7-17(13,14)15)3-1-6-16(10,11)12/h1-8H2,(H2,10,11,12)(H2,13,14,15)
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300n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60893
PNG
(US9200020, Table 3 compound 8B)
Show SMILES OC(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O
PDB
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UniChem
400 -38.0n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60897
PNG
(US9200020, Table 3 compound 11B)
Show SMILES OP(O)(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O
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400 -38.0n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60892
PNG
(US9200020, Table 3 compound 7B)
Show SMILES OC(=O)CN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O
PDB
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600 -36.9n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194498
PNG
(US9200020, Table 3 compound 7)
Show SMILES Nc1nc2n(CCN(CCP(O)(O)=O)CC(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C7H17BNO5P/c8-2-4-9(6-7(10)11)3-1-5-15(12,13)14/h1-6,8H2,(H,10,11)(H2,12,13,14)
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700n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194494
PNG
(US9200020, Table 3 compound 3)
Show SMILES COC(=O)CCCN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O
Show InChI InChI=1S/C10H23BNO5P/c1-17-10(13)4-2-6-12(8-5-11)7-3-9-18(14,15)16/h2-9,11H2,1H3,(H2,14,15,16)
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1.30E+3n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194492
PNG
(US9200020, Table 3 compound 1)
Show SMILES CCOC(=O)CN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O
Show InChI InChI=1S/C9H21BNO5P/c1-2-16-9(12)8-11(6-4-10)5-3-7-17(13,14)15/h2-8,10H2,1H3,(H2,13,14,15)
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1.70E+3n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60886
PNG
(US9200020, Table 3, Compound 1B)
Show SMILES CCOC(=O)CN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O
PDB
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1.90E+3 -34.0n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60896
PNG
(US9200020, Table 3 compound 10B)
Show SMILES OCCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O
PDB
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UniChem
2.60E+3 -33.2n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194497
PNG
(US9200020, Table 3 compound 6)
Show SMILES Nc1nc2n(CCN(CCCC#N)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C9H20BN2O3P/c10-4-8-12(6-2-1-5-11)7-3-9-16(13,14)15/h1-4,6-10H2,(H2,13,14,15)
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4.00E+3n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60891
PNG
(US9200020, Table 3 compound 6B)
Show SMILES OP(O)(=O)CCN(CCCC#N)CCn1c[nH]c2c1nc[nH]c2=O
PDB
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UniChem

Similars

6.00E+3 -31.0n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194491
PNG
(US9200020, Table 1, Compound 2)
Show SMILES Nc1nc2n(CCNCCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C4H13BNO3P/c5-1-2-6-3-4-10(7,8)9/h6H,1-5H2,(H2,7,8,9)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
1.60E+4n/an/an/an/an/an/a7.4n/a



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The Ki values were determined using a spectrophotometric assay at 25 C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60884
PNG
(US9200020, Table 1, Compound 2B)
Show SMILES OP(O)(=O)CCNCCn1c[nH]c2c1nc[nH]c2=O
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
>2.00E+5>-22.0n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60894
PNG
(US9200020, Table 3 compound 9B)
Show SMILES OC(=O)CCCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

>2.10E+5>-21.8n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM60888
PNG
(US9200020, Table 3, Compound 3B)
Show SMILES COC(=O)CCCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

>2.20E+5>-21.7n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)


(Plasmodium falciparum)
BDBM194495
PNG
(US9200020, Table 3 compound 4)
Show SMILES OP(O)(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CC#N
Show InChI InChI=1S/C7H16BN2O3P/c8-2-5-10(6-3-9)4-1-7-14(11,12)13/h1-2,4-8H2,(H2,11,12,13)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
>2.50E+5>-21.4n/an/an/an/an/an/a37



THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

US Patent


Assay Description
The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...


US Patent US9200020 (2015)


BindingDB Entry DOI: 10.7270/Q2TM78XB
More data for this
Ligand-Target Pair